bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_3523_orf1
Length=346
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_026030 cAMP-dependent protein kinase catalytic subu... 612 6e-175
cpv:cgd3_3040 protein kinase, cAMP-dependent, catalytic chain ... 473 4e-133
bbo:BBOV_III005740 17.m07511; protein kinase domain containing... 425 2e-118
pfa:PFI1685w PfPKAc, PfPKA, PKA; cAMP-dependent protein kinase... 415 2e-115
tgo:TGME49_028420 cAMP-dependent protein kinase catalytic subu... 415 2e-115
tpv:TP02_0378 cAMP-dependent protein kinase; K04345 protein ki... 372 8e-103
cel:ZK909.2 kin-1; protein KINase family member (kin-1); K0434... 355 2e-97
tgo:TGME49_086470 cAMP-dependent protein kinase catalytic subu... 355 2e-97
mmu:18749 Prkacb, Pkacb; protein kinase, cAMP dependent, catal... 352 9e-97
mmu:18747 Prkaca, Cs, PKA, PKCD, Pkaca; protein kinase, cAMP d... 352 1e-96
hsa:5566 PRKACA, MGC102831, MGC48865, PKACA; protein kinase, c... 350 3e-96
hsa:5567 PRKACB, DKFZp781I2452, MGC41879, MGC9320, PKACB; prot... 350 6e-96
xla:446502 prkacbb, MGC80071; protein kinase, cAMP-dependent, ... 350 7e-96
xla:100101276 prkaca; protein kinase, cAMP-dependent, catalyti... 349 8e-96
xla:380388 prkacb, MGC53163, XPKAbeta, kin-1, pkacb, prkacba; ... 347 3e-95
dre:564064 prkacaa, zgc:158799; protein kinase, cAMP-dependent... 347 6e-95
dre:445076 prkacab, zgc:91856; protein kinase, cAMP-dependent,... 342 9e-94
dre:563147 prkacbb, MGC110804, prkacb, wu:fz54b03, zgc:110804;... 342 1e-93
hsa:5568 PRKACG, KAPG, PKACg; protein kinase, cAMP-dependent, ... 342 2e-93
dre:393998 prkacba, MGC64054, Prkacb, zgc:64054; protein kinas... 339 1e-92
dre:561941 protein kinase, X-linked-like; K04345 protein kinas... 334 3e-91
mmu:19108 Prkx, PKX1, Pkare; protein kinase, X-linked (EC:2.7.... 327 4e-89
hsa:5613 PRKX, PKX1; protein kinase, X-linked (EC:2.7.11.1); K... 325 2e-88
sce:YPL203W TPK2, PKA2, PKA3, YKR1; Tpk2p (EC:2.7.11.11); K043... 323 8e-88
sce:YJL164C TPK1, PKA1, SRA3; Tpk1p (EC:2.7.11.11); K04345 pro... 322 1e-87
sce:YKL166C TPK3; Tpk3p (EC:2.7.11.11); K04345 protein kinase ... 317 3e-86
mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b; p... 306 7e-83
hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK, P... 306 1e-82
dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,... 304 3e-82
cel:F47F2.1 hypothetical protein; K04345 protein kinase A [EC:... 303 4e-82
dre:566430 cGMP dependent protein kinase I 303 9e-82
xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent, ty... 286 8e-77
hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,... 286 1e-76
dre:100125912 prkg2; protein kinase, cGMP-dependent, type II (... 282 1e-75
mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II; p... 282 1e-75
dre:556339 protein kinase, cGMP-dependent, type II-like; K0737... 271 2e-72
bbo:BBOV_I004190 19.m02221; cAMP-dependent protein kinase (EC:... 270 6e-72
dre:326020 fd58b04, wu:fd58b04; si:dkey-121j17.5 261 3e-69
cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);... 260 4e-69
cel:F57F5.5 pkc-1; Protein Kinase C family member (pkc-1); K06... 251 4e-66
sce:YKL126W YPK1, SLI2; Serine/threonine protein kinase that p... 249 1e-65
hsa:6446 SGK1, SGK; serum/glucocorticoid regulated kinase 1 (E... 248 2e-65
mmu:20393 Sgk1, Sgk; serum/glucocorticoid regulated kinase 1 (... 248 3e-65
xla:399130 sgk1-a, Sgk, sgk-A, sgk1; serum/glucocorticoid regu... 246 7e-65
cel:C12D8.10 akt-1; AKT kinase family member (akt-1); K04456 R... 245 2e-64
xla:444618 sgk1-b, MGC84110, Sgk, sgk-B, sgk2; serum/glucocort... 244 3e-64
tgo:TGME49_067540 protein kinase, putative (EC:4.1.1.70 2.7.11... 243 5e-64
sce:YMR104C YPK2, YKR2; Protein kinase with similarity to seri... 242 1e-63
cel:C09G4.2 hypothetical protein 241 2e-63
dre:403146 akt2l; v-akt murine thymoma viral oncogene homolog ... 241 3e-63
> tgo:TGME49_026030 cAMP-dependent protein kinase catalytic subunit,
putative (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=343
Score = 612 bits (1578), Expect = 6e-175, Method: Compositional matrix adjust.
Identities = 288/344 (83%), Positives = 316/344 (91%), Gaps = 1/344 (0%)
Query 3 MDIFRKLLPSQKDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTS 62
MD+FR+L+PS KD + + SQR R+PP+KC SNF F TLGTGSFGRVF+A+RKDDP +
Sbjct 1 MDLFRRLIPSNKDGSGDHSQRG-RLPPNKCVMSNFNFGPTLGTGSFGRVFMAKRKDDPHA 59
Query 63 PPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGG 122
PPVAIKRLKK AVIRQKQVDHILSEKRILQ+INHPFTVNMLGTFKDD YLYIVMEYVIGG
Sbjct 60 PPVAIKRLKKAAVIRQKQVDHILSEKRILQMINHPFTVNMLGTFKDDRYLYIVMEYVIGG 119
Query 123 EFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFG 182
EFFT+LRK RRFENDA++FYAAQVT IFEYLH RNIIYRDLKPENLLVD+EGYLKLTDFG
Sbjct 120 EFFTLLRKTRRFENDAARFYAAQVTLIFEYLHDRNIIYRDLKPENLLVDAEGYLKLTDFG 179
Query 183 FAKVIEHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGV 242
FAKVIE+RTYTLCGTPEYIAPEVLLNKGHGKPVDWWT+GILIYEMI+GYPPFFDDEPMGV
Sbjct 180 FAKVIEYRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTLGILIYEMILGYPPFFDDEPMGV 239
Query 243 YQKILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALI 302
YQKILGGRI FPK FDKNAK+LVKRLLTPDLA+RYGNLKNGVAD+K+H+WFA FDWNA +
Sbjct 240 YQKILGGRIAFPKFFDKNAKLLVKRLLTPDLAQRYGNLKNGVADVKDHRWFAGFDWNACL 299
Query 303 HKQLPPPYKPAFKGLDDTSNFDNYPESTEQPPPITGTLDPFTSW 346
K LP PYKP KG+DDTSNF+ YPESTEQ PP+TGT+DPFTSW
Sbjct 300 KKSLPSPYKPPVKGMDDTSNFEAYPESTEQAPPVTGTMDPFTSW 343
> cpv:cgd3_3040 protein kinase, cAMP-dependent, catalytic chain
; K04345 protein kinase A [EC:2.7.11.11]
Length=392
Score = 473 bits (1217), Expect = 4e-133, Method: Compositional matrix adjust.
Identities = 221/316 (69%), Positives = 258/316 (81%), Gaps = 2/316 (0%)
Query 31 KCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRI 90
K + +F TLGTGSFGRVFL++ K+D + AIKRLKK VIRQKQVDHI +EK I
Sbjct 79 KYSIDDFQLIRTLGTGSFGRVFLSKHKED--NSIYAIKRLKKSVVIRQKQVDHITNEKAI 136
Query 91 LQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIF 150
L I HPF V M GTFKDD YLYI+ME+VIGGEFFT LR+ R F+N+ S+FYAAQV +F
Sbjct 137 LSRIKHPFLVRMFGTFKDDRYLYIMMEFVIGGEFFTYLRRCRHFDNETSRFYAAQVVLMF 196
Query 151 EYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLLNKG 210
EYLHG+NIIYRDLKPEN+L+D +GYLKLTDFGFAK IE+RT+TLCGTPEYIAPEVLLNKG
Sbjct 197 EYLHGKNIIYRDLKPENILIDKDGYLKLTDFGFAKAIEYRTFTLCGTPEYIAPEVLLNKG 256
Query 211 HGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLT 270
HGKPVDWWT+GILIYEM+VG+PPF+DDEPMG+YQKIL G+I FPK FDKN K LVKRLLT
Sbjct 257 HGKPVDWWTLGILIYEMVVGFPPFYDDEPMGIYQKILAGKIFFPKYFDKNCKSLVKRLLT 316
Query 271 PDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPEST 330
PDL KRYGNLK GV+DIK HKWF +D+N+LI +++ PPY P DD+SNF+ YP+S
Sbjct 317 PDLTKRYGNLKGGVSDIKLHKWFYNYDFNSLISRKVDPPYIPKVNSYDDSSNFEEYPDSH 376
Query 331 EQPPPITGTLDPFTSW 346
EQP +TG DPF W
Sbjct 377 EQPTTVTGNADPFVDW 392
> bbo:BBOV_III005740 17.m07511; protein kinase domain containing
protein; K04345 protein kinase A [EC:2.7.11.11]
Length=359
Score = 425 bits (1092), Expect = 2e-118, Method: Compositional matrix adjust.
Identities = 200/331 (60%), Positives = 252/331 (76%), Gaps = 1/331 (0%)
Query 17 AAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKD-DPTSPPVAIKRLKKFAV 75
A +S + + PP+K +F F TLGTG FGRV LA K D + P AIKRLKK ++
Sbjct 29 ANDSGNLRTKNPPAKLRKEDFEFVRTLGTGGFGRVILAIPKGIDGITEPCAIKRLKKHSL 88
Query 76 IRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFE 135
I QKQVDH++SEK++L +NHPF VNMLGTFKD HYLYIVME V GG+FF LR + E
Sbjct 89 IVQKQVDHVVSEKKLLSSVNHPFIVNMLGTFKDPHYLYIVMECVFGGDFFGYLRSVDKLE 148
Query 136 NDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLC 195
++++ FYAAQ+T IF+Y+H NIIYRDLKPENLLV S+GYLKLTDFGFAKV+E RTYTLC
Sbjct 149 SESAMFYAAQITCIFDYMHSHNIIYRDLKPENLLVGSDGYLKLTDFGFAKVVELRTYTLC 208
Query 196 GTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPK 255
GTPEY+APE+LLNKGHGK VDWWT+GILIYEM+VGYPPF++++PMG+Y+KIL R++FP+
Sbjct 209 GTPEYLAPEILLNKGHGKAVDWWTLGILIYEMLVGYPPFYNEDPMGIYKKILDCRLVFPR 268
Query 256 SFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFK 315
++D +AK L K+LLT D +KR GNL G DI +WFA D++ L+ K+L PPY P K
Sbjct 269 NYDPDAKALTKQLLTFDPSKRIGNLHKGAKDIIASQWFAKMDFDKLLQKKLTPPYVPELK 328
Query 316 GLDDTSNFDNYPESTEQPPPITGTLDPFTSW 346
G +DT+ F YP+S E P + G DPF +W
Sbjct 329 GKNDTTKFGTYPDSVEVPRAVEGKADPFDNW 359
> pfa:PFI1685w PfPKAc, PfPKA, PKA; cAMP-dependent protein kinase
catalytic subunit; K04345 protein kinase A [EC:2.7.11.11]
Length=342
Score = 415 bits (1066), Expect = 2e-115, Method: Compositional matrix adjust.
Identities = 197/341 (57%), Positives = 247/341 (72%), Gaps = 1/341 (0%)
Query 6 FRKLLPSQKDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPV 65
F K L K ++SS++ + +K +F F TLGTGSFGRV LA K+ PPV
Sbjct 3 FIKNLQLNKKKDSDSSEQVLTNKKNKMKYEDFNFIRTLGTGSFGRVILATYKNG-NYPPV 61
Query 66 AIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFF 125
AIKR +K +IRQKQVDH+ SE++IL INHPF VN+ G+FKDD YLY+V+E+VIGGEFF
Sbjct 62 AIKRFEKCKIIRQKQVDHVFSERKILNYINHPFCVNLHGSFKDDSYLYLVLEFVIGGEFF 121
Query 126 TVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAK 185
T LR+N+RF ND FYAAQ+ IFEYL NI+YRDLKPENLL+D +G++K+TDFGFAK
Sbjct 122 TFLRRNKRFPNDVGCFYAAQIVLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGFAK 181
Query 186 VIEHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQK 245
++E RTYTLCGTPEYIAPE+LLN GHGK DWWT+GI IYE++VG PPF+ +EP+ +YQK
Sbjct 182 IVETRTYTLCGTPEYIAPEILLNVGHGKAADWWTLGIFIYEILVGCPPFYANEPLLIYQK 241
Query 246 ILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQ 305
IL G I FPK D N K L+K+LL+ DL KRYGNLK G ++KEH WF+ DW L++K
Sbjct 242 ILEGIIYFPKFLDNNCKHLMKKLLSHDLTKRYGNLKKGAQNVKEHPWFSNIDWVNLLNKN 301
Query 306 LPPPYKPAFKGLDDTSNFDNYPESTEQPPPITGTLDPFTSW 346
+ PYKP +K + D+SNF+ E IT DPF W
Sbjct 302 VEVPYKPKYKNIFDSSNFERVQEDLTIADKITNENDPFYDW 342
> tgo:TGME49_028420 cAMP-dependent protein kinase catalytic subunit,
putative (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=333
Score = 415 bits (1066), Expect = 2e-115, Method: Compositional matrix adjust.
Identities = 202/329 (61%), Positives = 250/329 (75%), Gaps = 10/329 (3%)
Query 27 IPPSKCTASNFVFANTLGTGSFGRVFLAR-------RKDDPTSPP--VAIKRLKKFAVIR 77
+PP + F F TLGTGSFGRV A+ DDPT P VA+K LKK A+I+
Sbjct 6 LPPGTGKEA-FEFGPTLGTGSFGRVKSAKYLKSTSTNVDDPTQVPPRVAVKLLKKAAIIK 64
Query 78 QKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFEND 137
K VDHI++EK+IL ++HP TV G+F+D YLY+VME V GGEFFT LRK +RF+ND
Sbjct 65 LKHVDHIINEKKILLALDHPLTVRCFGSFQDSRYLYLVMELVPGGEFFTHLRKAKRFDND 124
Query 138 ASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGT 197
++FYAAQ+ IF+YLH +NIIYRDLKPEN+L+D +GY+KLTDFGFAKV+E RT TLCGT
Sbjct 125 TARFYAAQIVDIFDYLHSQNIIYRDLKPENMLLDKDGYVKLTDFGFAKVVEFRTDTLCGT 184
Query 198 PEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSF 257
PEYIAPEVLLNKGHGKPVDWWT+GILIYEM+VGYPPF DD+P+G+YQKIL G+ +FPK F
Sbjct 185 PEYIAPEVLLNKGHGKPVDWWTLGILIYEMMVGYPPFLDDDPLGIYQKILAGKFVFPKFF 244
Query 258 DKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGL 317
DK+AK+LVK+LL DL+KR+GNLKNGV DIKE +WF + L K++ YKP KG+
Sbjct 245 DKDAKVLVKKLLQADLSKRWGNLKNGVRDIKECRWFCTVVFEDLRAKKVVARYKPTVKGM 304
Query 318 DDTSNFDNYPESTEQPPPITGTLDPFTSW 346
DD SNF+ YP+ + P+ DPFT+W
Sbjct 305 DDLSNFEAYPDEKDDAVPVDPMKDPFTTW 333
> tpv:TP02_0378 cAMP-dependent protein kinase; K04345 protein
kinase A [EC:2.7.11.11]
Length=352
Score = 372 bits (956), Expect = 8e-103, Method: Compositional matrix adjust.
Identities = 179/321 (55%), Positives = 235/321 (73%), Gaps = 4/321 (1%)
Query 27 IPPSKCTASNFVFANTLGTGSFGRVFLA-RRKDDPTSPPVAIKRLKKFAVIRQKQVDHIL 85
IP + F LG G FG+VFLA + ++D T+ A+KRL+K+ +I QKQVDHI+
Sbjct 35 IPKEVFEPRSIKFLKLLGEGGFGKVFLALQEQEDSTTELCAVKRLEKYPLIAQKQVDHII 94
Query 86 SEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQ 145
SE ++L ++HPF VN+LG++KDD+YLY+VMEYV GG+FF LRKN R ++ + FYAAQ
Sbjct 95 SENKLLGSVSHPFIVNLLGSYKDDYYLYLVMEYVSGGDFFAYLRKNDRLKSYDAMFYAAQ 154
Query 146 VTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEV 205
VT +FEYLH NIIYRDLKPENLL+ S+GYLKL DFGFAKV+E RT+TLCGTPEY++PE+
Sbjct 155 VTAMFEYLHDNNIIYRDLKPENLLLCSDGYLKLADFGFAKVVEFRTHTLCGTPEYMSPEI 214
Query 206 LLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLV 265
+L+ G+GK VD+WT+GILIYEM+VGYPPF+D+ P +Y KIL ++ FP +D++AK L
Sbjct 215 ILHLGYGKAVDFWTLGILIYEMLVGYPPFYDETPYNLYDKILKCKLKFPSFYDEDAKYLT 274
Query 266 KRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDN 325
RLL D +KR+GNL G+ DIK+ KWFAA D+NAL+ K L PPY P + +D +
Sbjct 275 SRLLVTDPSKRFGNLHKGIEDIKKCKWFAAMDFNALLEKDLRPPYIPEKEKVDTAT---E 331
Query 326 YPESTEQPPPITGTLDPFTSW 346
Y S P +TG DPF W
Sbjct 332 YRGSEGFPKAVTGDEDPFVDW 352
> cel:ZK909.2 kin-1; protein KINase family member (kin-1); K04345
protein kinase A [EC:2.7.11.11]
Length=381
Score = 355 bits (910), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 173/313 (55%), Positives = 225/313 (71%), Gaps = 7/313 (2%)
Query 29 PSKCTAS--NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
P++ TA +F TLGTGSFGRV L + K + A+K L K V++ KQV+H L+
Sbjct 64 PAQNTACLDDFDRIKTLGTGSFGRVMLVKHKQ--SGNYYAMKILDKQKVVKLKQVEHTLN 121
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ I+ PF VNM +FKD+ LY+V+E++ GGE F+ LR+ RF S+FYAAQ+
Sbjct 122 EKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQI 181
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+DS GYLK+TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 182 VLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEII 241
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F K L+K
Sbjct 242 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVKFPSHFSNELKDLLK 301
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KRYGNLKNGVADIK HKWF + DW A+ K++ P+ P +G D SNFD+Y
Sbjct 302 NLLQVDLTKRYGNLKNGVADIKNHKWFGSTDWIAIYQKKIEAPFLPKCRGPGDASNFDDY 361
Query 327 PESTEQPPPITGT 339
E+P I+GT
Sbjct 362 E---EEPLRISGT 371
> tgo:TGME49_086470 cAMP-dependent protein kinase catalytic subunit
(EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=514
Score = 355 bits (910), Expect = 2e-97, Method: Compositional matrix adjust.
Identities = 163/307 (53%), Positives = 219/307 (71%), Gaps = 1/307 (0%)
Query 36 NFVFANTLGTGSFGRVFLAR-RKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLI 94
+F+F T+GTGSFGRV + R PP+A+K L K +++ KQV+H+ EKRIL I
Sbjct 200 DFLFHETVGTGSFGRVCIVDLRGAAGWYPPMALKILSKHKIVKMKQVEHVKDEKRILSSI 259
Query 95 NHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLH 154
HPF VN+L F+D+ L+I+MEYV GGE F+ LR+ D ++ YAA++T F+YLH
Sbjct 260 EHPFIVNLLAAFQDEKRLFILMEYVNGGELFSHLRRRNCIPTDQARLYAAEITLAFQYLH 319
Query 155 GRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLLNKGHGKP 214
R+I+YRDLKPENLL+DS+G++K+TDFGFAKV++ RT+TLCGT EY+APE + +GHG P
Sbjct 320 QRHIVYRDLKPENLLIDSQGHIKITDFGFAKVVKDRTWTLCGTHEYLAPESITRRGHGLP 379
Query 215 VDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLTPDLA 274
VDWW +GIL++EM+ G+PPF D+ P+G+Y+KI+ G+I FP+SFD AK LVKRLLT D
Sbjct 380 VDWWALGILLFEMLAGHPPFVDENPLGIYRKIIAGKIEFPRSFDYAAKSLVKRLLTHDPL 439
Query 275 KRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPESTEQPP 334
KRYG LK+G D+K HK+F DW +K + PY P +G D+S FD Y ESTE
Sbjct 440 KRYGCLKDGAEDVKNHKFFKGIDWVKCYNKNIRAPYLPNTRGPQDSSMFDKYAESTESSS 499
Query 335 PITGTLD 341
P G +
Sbjct 500 PPIGAAE 506
> mmu:18749 Prkacb, Pkacb; protein kinase, cAMP dependent, catalytic,
beta (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=338
Score = 352 bits (904), Expect = 9e-97, Method: Compositional matrix adjust.
Identities = 164/302 (54%), Positives = 218/302 (72%), Gaps = 2/302 (0%)
Query 28 PPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSE 87
PPS +F TLGTGSFGRV L + K T A+K L K V++ KQ++H L+E
Sbjct 22 PPSNAGLEDFERKKTLGTGSFGRVMLVKHK--ATEQYYAMKILDKQKVVKLKQIEHTLNE 79
Query 88 KRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVT 147
KRILQ + PF V + +FKD+ LY+VMEYV GGE F+ LR+ RF ++FYAAQ+
Sbjct 80 KRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 139
Query 148 TIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLL 207
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++L
Sbjct 140 LTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 199
Query 208 NKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKR 267
+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 200 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 259
Query 268 LLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYP 327
LL DL KR+GNLKNGV+DIK HKWFA DW A+ +++ P+ P F+G DTSNFD+Y
Sbjct 260 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 319
Query 328 ES 329
E
Sbjct 320 EE 321
> mmu:18747 Prkaca, Cs, PKA, PKCD, Pkaca; protein kinase, cAMP
dependent, catalytic, alpha (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 352 bits (903), Expect = 1e-96, Method: Compositional matrix adjust.
Identities = 166/303 (54%), Positives = 220/303 (72%), Gaps = 4/303 (1%)
Query 29 PSKCTAS--NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
PS+ TA F TLGTGSFGRV L + K+ + A+K L K V++ KQ++H L+
Sbjct 34 PSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKE--SGNHYAMKILDKQKVVKLKQIEHTLN 91
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ +N PF V + +FKD+ LY+VMEYV GGE F+ LR+ RF ++FYAAQ+
Sbjct 92 EKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQI 151
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 211
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KR+GNLKNGV DIK HKWFA DW A+ +++ P+ P FKG DTSNFD+Y
Sbjct 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331
Query 327 PES 329
E
Sbjct 332 EEE 334
> hsa:5566 PRKACA, MGC102831, MGC48865, PKACA; protein kinase,
cAMP-dependent, catalytic, alpha (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 350 bits (899), Expect = 3e-96, Method: Compositional matrix adjust.
Identities = 166/303 (54%), Positives = 220/303 (72%), Gaps = 4/303 (1%)
Query 29 PSKCTA--SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
P++ TA F TLGTGSFGRV L + K+ T A+K L K V++ KQ++H L+
Sbjct 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKE--TGNHYAMKILDKQKVVKLKQIEHTLN 91
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ +N PF V + +FKD+ LY+VMEYV GGE F+ LR+ RF ++FYAAQ+
Sbjct 92 EKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 211
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KR+GNLKNGV DIK HKWFA DW A+ +++ P+ P FKG DTSNFD+Y
Sbjct 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331
Query 327 PES 329
E
Sbjct 332 EEE 334
> hsa:5567 PRKACB, DKFZp781I2452, MGC41879, MGC9320, PKACB; protein
kinase, cAMP-dependent, catalytic, beta (EC:2.7.11.11);
K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 350 bits (897), Expect = 6e-96, Method: Compositional matrix adjust.
Identities = 166/319 (52%), Positives = 222/319 (69%), Gaps = 18/319 (5%)
Query 11 PSQKDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRL 70
P+Q +A E +R+ TLGTGSFGRV L + K T A+K L
Sbjct 34 PTQNNAGLEDFERK----------------KTLGTGSFGRVMLVKHK--ATEQYYAMKIL 75
Query 71 KKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRK 130
K V++ KQ++H L+EKRILQ +N PF V + FKD+ LY+VMEYV GGE F+ LR+
Sbjct 76 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRR 135
Query 131 NRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHR 190
RF ++FYAAQ+ FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ R
Sbjct 136 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGR 195
Query 191 TYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGR 250
T+TLCGTPEY+APE++L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G+
Sbjct 196 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255
Query 251 IMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPY 310
+ FP F + K L++ LL DL KR+GNLKNGV+DIK HKWFA DW A+ +++ P+
Sbjct 256 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPF 315
Query 311 KPAFKGLDDTSNFDNYPES 329
P F+G DTSNFD+Y E
Sbjct 316 IPKFRGSGDTSNFDDYEEE 334
> xla:446502 prkacbb, MGC80071; protein kinase, cAMP-dependent,
catalytic, beta b; K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 350 bits (897), Expect = 7e-96, Method: Compositional matrix adjust.
Identities = 164/303 (54%), Positives = 221/303 (72%), Gaps = 4/303 (1%)
Query 29 PSKCTA--SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
P++ TA F TLGTGSFGRV L R+K++ + A+K L K V++ KQ++H L+
Sbjct 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVRQKENGSH--FAMKILDKQKVVKLKQIEHTLN 91
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ +N PF V + +FKD+ LY+VMEYV GGE F+ LR+ RF ++FYA+Q+
Sbjct 92 EKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYASQI 151
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 152 VLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 211
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KR+GNLKNGV DIK HKWF+ DW A+ K++ P+ P KG DTSNFD+Y
Sbjct 272 NLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKGPGDTSNFDDY 331
Query 327 PES 329
E
Sbjct 332 EEE 334
> xla:100101276 prkaca; protein kinase, cAMP-dependent, catalytic,
alpha (EC:2.7.11.1); K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 349 bits (896), Expect = 8e-96, Method: Compositional matrix adjust.
Identities = 164/303 (54%), Positives = 221/303 (72%), Gaps = 4/303 (1%)
Query 29 PSKCTAS--NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
P++ TA+ F TLGTGSFGRV L R K++ + A+K L K V++ KQ++H L+
Sbjct 34 PAQNTANLDQFERMKTLGTGSFGRVMLVRHKENGSH--FAMKILDKQKVVKLKQIEHTLN 91
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ +N PF V + +FKD+ LY+VMEYV GGE F+ LR+ RF ++FYA+Q+
Sbjct 92 EKRILQAVNFPFLVRLEYSFKDNTNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYASQI 151
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 152 VLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 211
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KR+GNLKNGV DIK HKWF+ DW A+ K++ P+ P KG DTSNFD+Y
Sbjct 272 NLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKGPGDTSNFDDY 331
Query 327 PES 329
E
Sbjct 332 EEE 334
> xla:380388 prkacb, MGC53163, XPKAbeta, kin-1, pkacb, prkacba;
protein kinase, cAMP-dependent, catalytic, beta; K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 347 bits (890), Expect = 3e-95, Method: Compositional matrix adjust.
Identities = 165/314 (52%), Positives = 220/314 (70%), Gaps = 3/314 (0%)
Query 17 AAESSQRQIRIPPSKCTA-SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAV 75
A E R+ PP + +F TLGTGSFGRV L + K A+K L K V
Sbjct 23 AKEDFLRKWETPPQNTASLDDFDRMKTLGTGSFGRVMLVKHKG--AEQYYAMKILDKQKV 80
Query 76 IRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFE 135
++ KQ++H L+EKRILQ +N PF V + +FKD+ LY++MEYV GGE F+ LR+ RF
Sbjct 81 VKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMIMEYVPGGEMFSHLRRIGRFS 140
Query 136 NDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLC 195
++FYAAQ+ FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLC
Sbjct 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC 200
Query 196 GTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPK 255
GTPEY+APE++L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP
Sbjct 201 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS 260
Query 256 SFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFK 315
F + K L++ LL DL KRYGNLKNGV DIK HKWFA DW A+ +++ P+ P +
Sbjct 261 HFSSDLKDLLRNLLQVDLTKRYGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKCR 320
Query 316 GLDDTSNFDNYPES 329
G DTSNFD+Y E
Sbjct 321 GPGDTSNFDDYEEE 334
> dre:564064 prkacaa, zgc:158799; protein kinase, cAMP-dependent,
catalytic, alpha, genome duplicate a (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=352
Score = 347 bits (889), Expect = 6e-95, Method: Compositional matrix adjust.
Identities = 165/303 (54%), Positives = 221/303 (72%), Gaps = 4/303 (1%)
Query 29 PSKCTAS--NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
P++ TAS +F TLGTGSFGRV L + K+ + A+K L K V++ KQ++H L+
Sbjct 35 PAQNTASLDHFERLKTLGTGSFGRVMLVKHKE--SGQHFAMKILDKQKVVKLKQIEHTLN 92
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ ++ PF V + +FKD+ LY+VMEYV GGE F+ LR+ RF ++FYAAQ+
Sbjct 93 EKRILQAVSFPFLVRLEHSFKDNTNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 152
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 153 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 212
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 213 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 272
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KR+GNLKNGV DIK HKWFA DW A+ K++ P+ P KG DTSNFD+Y
Sbjct 273 NLLQVDLTKRFGNLKNGVNDIKGHKWFATTDWIAIYQKKVEAPFIPKCKGPGDTSNFDDY 332
Query 327 PES 329
E
Sbjct 333 DEE 335
> dre:445076 prkacab, zgc:91856; protein kinase, cAMP-dependent,
catalytic, alpha, genome duplicate b (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=351
Score = 342 bits (878), Expect = 9e-94, Method: Compositional matrix adjust.
Identities = 160/303 (52%), Positives = 220/303 (72%), Gaps = 4/303 (1%)
Query 29 PSKCTAS--NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
P++ TA +F TLGTGSFGRV L R ++ T A+K L K V++ KQ++H L+
Sbjct 34 PAQNTACLEDFDRLKTLGTGSFGRVMLVRHRE--TGQHYAMKILNKQKVVKLKQIEHTLN 91
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
EKRILQ ++ PF V + +FKD+ LY+VM+YV GGE F+ LR+ RF ++FYA+Q+
Sbjct 92 EKRILQAVSFPFLVRLEYSFKDNTNLYMVMQYVQGGEMFSHLRRIGRFSEPHARFYASQI 151
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++
Sbjct 152 VLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 211
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
L+KG+ K VDWW +G+L+YEM GYPPFF D+P+ +Y+KI+ G++ FP F + K L++
Sbjct 212 LSKGYNKAVDWWALGVLMYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
LL DL KRYGNLKNGV DIK HKWF+ DW A+ +++ P+ P +G DTSNFD+Y
Sbjct 272 NLLQVDLTKRYGNLKNGVNDIKGHKWFSTTDWIAIYQRRVEAPFVPKCRGPGDTSNFDDY 331
Query 327 PES 329
E
Sbjct 332 EEE 334
> dre:563147 prkacbb, MGC110804, prkacb, wu:fz54b03, zgc:110804;
protein kinase, cAMP-dependent, catalytic, beta b; K04345
protein kinase A [EC:2.7.11.11]
Length=351
Score = 342 bits (877), Expect = 1e-93, Method: Compositional matrix adjust.
Identities = 164/314 (52%), Positives = 218/314 (69%), Gaps = 3/314 (0%)
Query 17 AAESSQRQIRIPPSKCTA-SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAV 75
A E R+ P T +F TLGTGSFGRV L + K + A+K L K V
Sbjct 23 AKEDFLRKWESPQQSTTCLDDFDRQKTLGTGSFGRVLLVKHK--ASDQYYAMKVLDKQKV 80
Query 76 IRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFE 135
++ KQV+H L+EKRILQ ++ PF V + FKD+ LY+VMEYV GGE F+ LR+ RF
Sbjct 81 VKLKQVEHTLNEKRILQAVSFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query 136 NDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLC 195
++FYAAQ+ FEYLH ++IYRDLKPENLL+D GY+++TDFGFAK ++ RT+TLC
Sbjct 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQHGYIQVTDFGFAKRVKGRTWTLC 200
Query 196 GTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPK 255
GTPEY+APE++L+KG+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ FP
Sbjct 201 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS 260
Query 256 SFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFK 315
F + K L++ LL DL KR+GNL+NGV DIK HKWFA DW A+ +++ P+ P +
Sbjct 261 HFSSDLKDLLRNLLQVDLTKRFGNLRNGVNDIKNHKWFATTDWIAIYERKVEAPFIPKCR 320
Query 316 GLDDTSNFDNYPES 329
G DTSNFD+Y E
Sbjct 321 GPGDTSNFDDYEEE 334
> hsa:5568 PRKACG, KAPG, PKACg; protein kinase, cAMP-dependent,
catalytic, gamma (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 342 bits (876), Expect = 2e-93, Method: Compositional matrix adjust.
Identities = 167/332 (50%), Positives = 226/332 (68%), Gaps = 15/332 (4%)
Query 11 PSQKDAAAESSQRQIRIP-----------PSKCTASNFVFAN--TLGTGSFGRVFLARRK 57
P++KD E S + P++ TAS+ F TLG GSFGRV L R +
Sbjct 5 PAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQ 64
Query 58 DDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVME 117
+ T A+K L K V++ KQV+HIL+EKRILQ I+ PF V + +FKD+ YLY+VME
Sbjct 65 E--TGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVME 122
Query 118 YVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLK 177
YV GGE F+ L++ RF + FYAAQV +YLH ++I+RDLKPENLL+D +GYL+
Sbjct 123 YVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQ 182
Query 178 LTDFGFAKVIEHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDD 237
+TDFGFAK ++ RT+TLCGTPEY+APE++L+KG+ K VDWW +G+LIYEM VG+PPF+ D
Sbjct 183 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYAD 242
Query 238 EPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFD 297
+P+ +Y+KI+ GR+ FP + K L++ LL DL KR+GNL+NGV DIK HKWFA
Sbjct 243 QPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTS 302
Query 298 WNALIHKQLPPPYKPAFKGLDDTSNFDNYPES 329
W A+ K++ P+ P + G D SNFD+Y E
Sbjct 303 WIAIYEKKVEAPFIPKYTGPGDASNFDDYEEE 334
> dre:393998 prkacba, MGC64054, Prkacb, zgc:64054; protein kinase,
cAMP-dependent, catalytic, beta a; K04345 protein kinase
A [EC:2.7.11.11]
Length=395
Score = 339 bits (869), Expect = 1e-92, Method: Compositional matrix adjust.
Identities = 156/301 (51%), Positives = 213/301 (70%), Gaps = 2/301 (0%)
Query 30 SKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKR 89
S +F TLGTGSFGRV L + K + A+K L K V++ KQ++H L+EK+
Sbjct 81 STACLDDFDKLKTLGTGSFGRVMLVKHKQ--SEQYFAMKILDKLKVVKLKQIEHTLNEKK 138
Query 90 ILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTI 149
ILQ ++ PF V + FKD+ LY+VM Y+ GGE F+ LR+ RF ++FYAAQ+
Sbjct 139 ILQAVSFPFLVKLECAFKDNSNLYMVMRYIQGGEMFSHLRRIGRFSEQNARFYAAQIVLT 198
Query 150 FEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLLNK 209
FEYLH ++IYRDLKPENLL+D +GY+++TDFGFAK ++ RT+TLCGTPEY+APE++L+K
Sbjct 199 FEYLHMLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK 258
Query 210 GHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLL 269
G+ K VDWW +G+LIYEM GYPPFF D+P+ +Y+KI+ G++ +P F + K L++ LL
Sbjct 259 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRYPSHFSSDLKDLLRNLL 318
Query 270 TPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPES 329
DL KR+GNLKNGV+DIK H+WFA+ DW A+ K++ P P +G DTSNFD Y E
Sbjct 319 QVDLTKRFGNLKNGVSDIKNHRWFASTDWIAIYEKKVDAPIIPKCRGPGDTSNFDEYDEE 378
Query 330 T 330
Sbjct 379 V 379
> dre:561941 protein kinase, X-linked-like; K04345 protein kinase
A [EC:2.7.11.11]
Length=357
Score = 334 bits (856), Expect = 3e-91, Method: Compositional matrix adjust.
Identities = 151/287 (52%), Positives = 203/287 (70%), Gaps = 2/287 (0%)
Query 42 TLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVN 101
T+GTG+FGRVFL KD T A+K +K VIR KQ H+ +EK +L +NHPF V
Sbjct 53 TVGTGTFGRVFLV--KDKKTRGFFALKAMKIPDVIRLKQEQHVHNEKEVLTEVNHPFLVR 110
Query 102 MLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYR 161
+ T DD +LY++MEYV GGE F+ LR F N FY+A++ EYLH + I+YR
Sbjct 111 LFWTHHDDRFLYMLMEYVNGGELFSYLRSRGHFSNSTGMFYSAEIVCAIEYLHSKEIVYR 170
Query 162 DLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMG 221
DLKPEN+L+DSEG+++LTDFGFAK + RT+TLCGTPEY+APEV+ +KGHG+ VDWW +G
Sbjct 171 DLKPENILLDSEGHIRLTDFGFAKKLSERTWTLCGTPEYLAPEVIQSKGHGRAVDWWALG 230
Query 222 ILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLK 281
+LI+EM+ GYPPFFDD P G+YQKIL G++ FP+ D K L+K+ L D +R GN+K
Sbjct 231 VLIFEMLAGYPPFFDDNPFGIYQKILAGKLEFPRHLDLYVKDLIKKFLVTDRERRLGNMK 290
Query 282 NGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPE 328
NG D+K+H+WF + +W ++ ++L PP P DTSNFD+YP+
Sbjct 291 NGADDVKKHRWFKSVNWESVPCRKLKPPIVPKVSHEGDTSNFDSYPD 337
> mmu:19108 Prkx, PKX1, Pkare; protein kinase, X-linked (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=355
Score = 327 bits (838), Expect = 4e-89, Method: Compositional matrix adjust.
Identities = 152/288 (52%), Positives = 202/288 (70%), Gaps = 2/288 (0%)
Query 42 TLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVN 101
T+GTG+FGRV L + K A+K + VIR KQ H+ +EK +L+ INHPF +
Sbjct 51 TVGTGTFGRVNLVKEKTGRQY--CALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIK 108
Query 102 MLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYR 161
+L T D+ +LY++ME+V GGE FT LR RF + AS FYA ++ EYLH + I+YR
Sbjct 109 LLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEIVYR 168
Query 162 DLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMG 221
DLKPEN+L+D EG++KLTDFGFAK + RT+TLCGTPEY+APEV+ +KGHG+ VDWW +G
Sbjct 169 DLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALG 228
Query 222 ILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLK 281
ILI+EM+ G+PPFFDD P G+YQKIL +I FP+ D +K L+K+LL D +R GN+K
Sbjct 229 ILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMK 288
Query 282 NGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPES 329
NG DIK H+WF +W ++ ++L PP P G D SNF+ YPES
Sbjct 289 NGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSGDGDISNFETYPES 336
> hsa:5613 PRKX, PKX1; protein kinase, X-linked (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=358
Score = 325 bits (832), Expect = 2e-88, Method: Compositional matrix adjust.
Identities = 150/301 (49%), Positives = 208/301 (69%), Gaps = 2/301 (0%)
Query 29 PSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEK 88
P + +F T+GTG+FGRV L + K A+K + VIR KQ H+ +EK
Sbjct 41 PPVYSLQDFDTLATVGTGTFGRVHLVKEKT--AKHFFALKVMSIPDVIRLKQEQHVHNEK 98
Query 89 RILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTT 148
+L+ ++HPF + + T+ D+ +LY++MEYV GGE F+ LR RF + FY+A++
Sbjct 99 SVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIIC 158
Query 149 IFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVLLN 208
EYLH + I+YRDLKPEN+L+D +G++KLTDFGFAK + RT+TLCGTPEY+APEV+ +
Sbjct 159 AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQS 218
Query 209 KGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRL 268
KGHG+ VDWW +GILI+EM+ G+PPFFDD P G+YQKIL G+I FP+ D + K L+K+L
Sbjct 219 KGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKL 278
Query 269 LTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPE 328
L D +R GN+KNG D+K H+WF + DW A+ ++L PP P G DTSNF+ YPE
Sbjct 279 LVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPE 338
Query 329 S 329
+
Sbjct 339 N 339
> sce:YPL203W TPK2, PKA2, PKA3, YKR1; Tpk2p (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=380
Score = 323 bits (827), Expect = 8e-88, Method: Compositional matrix adjust.
Identities = 153/304 (50%), Positives = 209/304 (68%), Gaps = 3/304 (0%)
Query 27 IPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILS 86
+ K T +F TLGTGSFGRV L R + AIK LKK V++ KQV+H
Sbjct 60 VSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRY--YAIKVLKKQQVVKMKQVEHTND 117
Query 87 EKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQV 146
E+R+L+L+ HPF + M GTF+D +++VM+Y+ GGE F++LRK++RF N +KFYAA+V
Sbjct 118 ERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEV 177
Query 147 TTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAPEVL 206
EYLH NIIYRDLKPEN+L+D G++K+TDFGFAK ++ T+TLCGTP+YIAPEV+
Sbjct 178 ILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVI 237
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVK 266
K + K VDWW++G+LIYEM+ GY PF+D PM Y+KIL G++++P F + L+
Sbjct 238 TTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVVDLLS 297
Query 267 RLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAF-KGLDDTSNFDN 325
+L+T DL +R GNL++G DIK H WF+ W L+ K + PY+P G+ DTS FD
Sbjct 298 KLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQ 357
Query 326 YPES 329
YPE
Sbjct 358 YPEE 361
> sce:YJL164C TPK1, PKA1, SRA3; Tpk1p (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=397
Score = 322 bits (826), Expect = 1e-87, Method: Compositional matrix adjust.
Identities = 151/307 (49%), Positives = 206/307 (67%), Gaps = 3/307 (0%)
Query 24 QIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDH 83
Q R+ NF TLGTGSFGRV L R + + A+K LKK V+R KQV+H
Sbjct 74 QARVTVGSIVYKNFQILRTLGTGSFGRVHLIRSRHNGRY--YAMKVLKKEIVVRLKQVEH 131
Query 84 ILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYA 143
E+ +L ++ HPF + M GTF+D ++++M+Y+ GGE F++LRK++RF N +KFYA
Sbjct 132 TNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYA 191
Query 144 AQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAP 203
A+V EYLH ++IIYRDLKPEN+L+D G++K+TDFGFAK + TYTLCGTP+YIAP
Sbjct 192 AEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAP 251
Query 204 EVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKM 263
EV+ K + K +DWW+ GILIYEM+ GY PF+D M Y+KIL + FP F+++ K
Sbjct 252 EVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKD 311
Query 264 LVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAF-KGLDDTSN 322
L+ RL+T DL++R GNL+NG D+K H WF W L+ + + PY+P +G DTS
Sbjct 312 LLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQ 371
Query 323 FDNYPES 329
FD YPE
Sbjct 372 FDKYPEE 378
> sce:YKL166C TPK3; Tpk3p (EC:2.7.11.11); K04345 protein kinase
A [EC:2.7.11.11]
Length=398
Score = 317 bits (813), Expect = 3e-86, Method: Compositional matrix adjust.
Identities = 150/306 (49%), Positives = 208/306 (67%), Gaps = 3/306 (0%)
Query 24 QIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDH 83
Q R K + S+F TLGTGSFGRV L R + A+K LKK +++ KQV+H
Sbjct 75 QYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRF--YALKTLKKHTIVKLKQVEH 132
Query 84 ILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYA 143
E+R+L +++HPF + M GTF+D +++VM+Y+ GGE F++LRK++RF N +KFYA
Sbjct 133 TNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYA 192
Query 144 AQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEHRTYTLCGTPEYIAP 203
A+V EYLH ++IIYRDLKPEN+L+D G++K+TDFGFAK + TYTLCGTP+YIAP
Sbjct 193 AEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAP 252
Query 204 EVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKM 263
EV+ K + K VDWW+ G+LIYEM+ GY PF++ M Y+ IL + FP F +A+
Sbjct 253 EVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQD 312
Query 264 LVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAF-KGLDDTSN 322
L+K+L+T DL++R GNL+NG D+K H WF W L+ + + PY+P +G DTS
Sbjct 313 LLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQ 372
Query 323 FDNYPE 328
FD YPE
Sbjct 373 FDRYPE 378
> mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b;
protein kinase, cGMP-dependent, type I (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 306 bits (784), Expect = 7e-83, Method: Compositional matrix adjust.
Identities = 151/305 (49%), Positives = 201/305 (65%), Gaps = 5/305 (1%)
Query 35 SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLI 94
S+F +TLG G FGRV L + K + S A+K LKK ++ +Q +HI SEK+I+Q
Sbjct 358 SDFNIIDTLGVGGFGRVELVQLKSEE-SKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416
Query 95 NHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLH 154
+ F V + TFKD YLY++ME +GGE +T+LR FE+ ++FY A V F YLH
Sbjct 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
Query 155 GRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTYTLCGTPEYIAPEVLLNKGHG 212
+ IIYRDLKPENL++D GY KL DFGFAK I +T+T CGTPEY+APE++LNKGH
Sbjct 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 536
Query 213 KPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKMLVKRLLT 270
D+W++GIL+YE++ G PPF +PM Y IL G I FPK KNA L+K+L
Sbjct 537 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 596
Query 271 PDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPEST 330
+ ++R GNLKNGV DI++HKWF F+W L L PP P+ DTSNFD++PE +
Sbjct 597 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDS 656
Query 331 EQPPP 335
++PPP
Sbjct 657 DEPPP 661
> hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK,
PKG, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha; protein kinase,
cGMP-dependent, type I (EC:2.7.11.12); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 306 bits (783), Expect = 1e-82, Method: Compositional matrix adjust.
Identities = 151/305 (49%), Positives = 200/305 (65%), Gaps = 5/305 (1%)
Query 35 SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLI 94
S+F +TLG G FGRV L + K + S A+K LKK ++ +Q +HI SEK+I+Q
Sbjct 358 SDFNIIDTLGVGGFGRVELVQLKSEE-SKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416
Query 95 NHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLH 154
+ F V + TFKD YLY++ME +GGE +T+LR FE+ ++FY A V F YLH
Sbjct 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
Query 155 GRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTYTLCGTPEYIAPEVLLNKGHG 212
+ IIYRDLKPENL++D GY KL DFGFAK I +T+T CGTPEY+APE++LNKGH
Sbjct 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 536
Query 213 KPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKMLVKRLLT 270
D+W++GIL+YE++ G PPF +PM Y IL G I FPK KNA L+K+L
Sbjct 537 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 596
Query 271 PDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPEST 330
+ ++R GNLKNGV DI++HKWF F+W L L PP P+ DTSNFD++PE
Sbjct 597 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 656
Query 331 EQPPP 335
++PPP
Sbjct 657 DEPPP 661
> dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,
cGMP-dependent, type Ia (EC:2.7.11.1); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=667
Score = 304 bits (779), Expect = 3e-82, Method: Compositional matrix adjust.
Identities = 155/326 (47%), Positives = 203/326 (62%), Gaps = 5/326 (1%)
Query 14 KDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKF 73
+DA A++ S S+F +TLG G FGRV L + K D A+K LKK
Sbjct 333 EDAEAKAKYEAENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKSDEMKT-FAMKILKKR 391
Query 74 AVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRR 133
++ +Q +HI SEK I+Q + F V + TFKD YLY++ME +GGE +T+LR
Sbjct 392 HIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGN 451
Query 134 FENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRT 191
F++ ++FY A V F YLH + IIYRDLKPENL++D GY KL DFGFAK I +T
Sbjct 452 FDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKT 511
Query 192 YTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG-- 249
+T CGTPEY+APE++LNKGH D+W++GIL+YE++ G PPF +PM Y IL G
Sbjct 512 WTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGID 571
Query 250 RIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPP 309
I FPK KNA L+K+L ++R GNLKNGV DI++HKWF F+W+ L L PP
Sbjct 572 MIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPP 631
Query 310 YKPAFKGLDDTSNFDNYPESTEQPPP 335
P DTSNFD++PE E PPP
Sbjct 632 IIPNVTSSTDTSNFDSFPEDNEDPPP 657
> cel:F47F2.1 hypothetical protein; K04345 protein kinase A [EC:2.7.11.11]
Length=398
Score = 303 bits (777), Expect = 4e-82, Method: Compositional matrix adjust.
Identities = 148/338 (43%), Positives = 209/338 (61%), Gaps = 5/338 (1%)
Query 12 SQKDAAAESSQRQIRIPPSK--CTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKR 69
+Q + AE + ++ I P++ + S T+G G+FGRV LAR D T A+K
Sbjct 63 NQVNELAEETHMKLSITPTRESFSLSQLERIITIGKGTFGRVELAR--DKITGAHYALKV 120
Query 70 LKKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLR 129
L V+ +Q H+ +EKR+L + HPF V M + KD ++LY++ME+V GGE F+ LR
Sbjct 121 LNIRRVVDMRQTQHVHNEKRVLLQLKHPFIVKMYASEKDSNHLYMIMEFVPGGEMFSYLR 180
Query 130 KNRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEH 189
+R F N ++FYA+++ EY+H I+YRDLKPENL++ EG++K+ DFGFAK +
Sbjct 181 ASRSFSNSMARFYASEIVCALEYIHSLGIVYRDLKPENLMLSKEGHIKMADFGFAKELRD 240
Query 190 RTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG 249
RTYT+CGTP+Y+APE L GH K VDWW +GILIYEM+VG PPF +Y I+
Sbjct 241 RTYTICGTPDYLAPESLARTGHNKGVDWWALGILIYEMMVGKPPFRGKTTSEIYDAIIEH 300
Query 250 RIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPP 309
++ FP+SF+ AK LVK+LL D +R G +KNG D+K+HKWF +W+ +H ++ PP
Sbjct 301 KLKFPRSFNLAAKDLVKKLLEVDRTQRIGCMKNGTQDVKDHKWFEKVNWDDTLHLRVEPP 360
Query 310 YKPAFKGLDDTSNFDNYPESTEQPPPITGT-LDPFTSW 346
P DT NFD+Y E T P + D F W
Sbjct 361 IVPTLYHPGDTGNFDDYEEDTTGGPLCSQRDRDLFAEW 398
> dre:566430 cGMP dependent protein kinase I
Length=528
Score = 303 bits (775), Expect = 9e-82, Method: Compositional matrix adjust.
Identities = 155/325 (47%), Positives = 203/325 (62%), Gaps = 5/325 (1%)
Query 15 DAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFA 74
DA A++ S +F +TLG G FGRV L + K + T A+K LKK
Sbjct 195 DAGAKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKT-FAMKILKKRH 253
Query 75 VIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRF 134
++ +Q +HI SEK+I+Q + F V + TFKD YLY++ME +GGE +T+LR F
Sbjct 254 IVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSF 313
Query 135 ENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTY 192
E+ ++FY A V F YLH + IIYRDLKPENL++D GY KL DFGFAK I +T+
Sbjct 314 EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW 373
Query 193 TLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--R 250
T CGTPEY+APE++LNKGH D+W++GIL+YE++ G PPF +PM Y IL G
Sbjct 374 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 433
Query 251 IMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPY 310
I FPK KNA L+K+L + ++R GNLKNGV DI++HKWF F+W L L PP
Sbjct 434 IEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPI 493
Query 311 KPAFKGLDDTSNFDNYPESTEQPPP 335
P DTSNFD++PE E PPP
Sbjct 494 IPDVASPTDTSNFDSFPEDNEDPPP 518
> xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent,
type II (EC:2.7.11.1); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=783
Score = 286 bits (732), Expect = 8e-77, Method: Compositional matrix adjust.
Identities = 147/322 (45%), Positives = 199/322 (61%), Gaps = 12/322 (3%)
Query 29 PSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEK 88
PS N TLG G FGRV L + K + + A+K +KK ++ Q +HI SEK
Sbjct 466 PSASPFENLEIVTTLGVGGFGRVELVKVKYE--NLVFAMKCIKKRHIVDNMQQEHIHSEK 523
Query 89 RILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTT 148
IL+ PF V + TFKD+ Y+Y+++E +GGE +++LR F+ +KF VT
Sbjct 524 NILKEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDETTAKFCTGCVTE 583
Query 149 IFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTYTLCGTPEYIAPEVL 206
EYLH ++YRDLKPENLL+DSEGY+KL DFGFAK + +T+T CGTPEY+APEV+
Sbjct 584 ALEYLHQIGVLYRDLKPENLLLDSEGYVKLVDFGFAKKVFPGQKTWTFCGTPEYVAPEVI 643
Query 207 LNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKML 264
LNKGH VD+W++GIL+YE++ G PPF + M +Y IL G +I F K+ K + L
Sbjct 644 LNKGHSFSVDFWSLGILLYELLTGNPPFTGPDQMIIYNLILQGIEKIEFCKNITKRPEDL 703
Query 265 VKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFD 324
+ RL + A+R G +KNG+ADIK+H+WF F+W L + LP P KP KG D S+FD
Sbjct 704 ICRLCRQNPAERLGYMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPKLKGPTDHSHFD 763
Query 325 NYPESTEQPPPITGTLDPFTSW 346
YP E PP D + W
Sbjct 764 IYPPDEEIPP------DELSGW 779
> hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,
type II (EC:2.7.11.12); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=762
Score = 286 bits (731), Expect = 1e-76, Method: Compositional matrix adjust.
Identities = 143/316 (45%), Positives = 198/316 (62%), Gaps = 12/316 (3%)
Query 35 SNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLI 94
N TLG G FGRV L + K++ + A+K ++K ++ KQ +H+ SEKRIL+ +
Sbjct 451 QNLEIIATLGVGGFGRVELVKVKNENVA--FAMKCIRKKHIVDTKQQEHVYSEKRILEEL 508
Query 95 NHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLH 154
PF V + TFKD+ Y+Y+++E +GGE +++LR F+ SKF A VT F+YLH
Sbjct 509 CSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLH 568
Query 155 GRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTYTLCGTPEYIAPEVLLNKGHG 212
IIYRDLKPENL++D+EGYLKL DFGFAK I +T+T CGTPEY+APEV+LNKGH
Sbjct 569 RLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHD 628
Query 213 KPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKMLVKRLLT 270
VD+W++GIL+YE++ G PPF + M Y IL G ++ FP+ + + L++RL
Sbjct 629 FSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCR 688
Query 271 PDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPEST 330
+ +R GNLKNG+ DIK+H+W F+W L + LP P + KG D S FD YP
Sbjct 689 QNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEK 748
Query 331 EQPPPITGTLDPFTSW 346
PP D + W
Sbjct 749 GMPP------DELSGW 758
> dre:100125912 prkg2; protein kinase, cGMP-dependent, type II
(EC:2.7.11.1); K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=768
Score = 282 bits (722), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 137/289 (47%), Positives = 193/289 (66%), Gaps = 6/289 (2%)
Query 42 TLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVN 101
TLG G FGRV L + K++ + A+K +KK ++ +Q +HI SE+RIL N PF V
Sbjct 464 TLGVGGFGRVELVKLKNENVT--FALKCIKKRHIVDNRQEEHIYSERRILLETNCPFIVK 521
Query 102 MLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYR 161
M T+KD+ Y+Y+++E +GGE +++LR FE +KF VT F+YLH IIYR
Sbjct 522 MYRTYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYR 581
Query 162 DLKPENLLVDSEGYLKLTDFGFAKVIE--HRTYTLCGTPEYIAPEVLLNKGHGKPVDWWT 219
DLKPENL++D++GY+KL DFGFAK ++ RT+T CGTPEY+APE++LNKGHG VD+W+
Sbjct 582 DLKPENLMLDTDGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWS 641
Query 220 MGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKMLVKRLLTPDLAKRY 277
+GILI+E++ G PPF + M +Y IL G ++ FPK K L+++L + ++R
Sbjct 642 LGILIFELLTGSPPFTGSDQMIIYTFILKGIEKMDFPKKITKRPGDLIRKLCRQNPSERL 701
Query 278 GNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNY 326
GNLKNG+ DIK+H+WF F W+ L + L P K KG D S FD+Y
Sbjct 702 GNLKNGITDIKKHRWFTGFSWSGLKARNLISPLKREVKGPTDHSYFDSY 750
> mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II;
protein kinase, cGMP-dependent, type II (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=762
Score = 282 bits (721), Expect = 1e-75, Method: Compositional matrix adjust.
Identities = 141/315 (44%), Positives = 197/315 (62%), Gaps = 12/315 (3%)
Query 36 NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLIN 95
N TLG G FGRV L + K++ + A+K ++K ++ KQ +H+ SEKRIL+ +
Sbjct 452 NLEIIATLGVGGFGRVELVKVKNENVA--FAMKCIRKKHIVDTKQQEHVYSEKRILEELC 509
Query 96 HPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHG 155
PF V + TFKD+ Y+Y+++E +GGE +++LR F+ SKF A VT F+YLH
Sbjct 510 SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHR 569
Query 156 RNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTYTLCGTPEYIAPEVLLNKGHGK 213
IIYRDLKPENL++D++GYLKL DFGFAK I +T+T CGTPEY+APEV+LNKGH
Sbjct 570 LGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDF 629
Query 214 PVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKMLVKRLLTP 271
VD+W++GIL+YE++ G PPF + M Y IL G ++ FP+ + + L++RL
Sbjct 630 SVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQ 689
Query 272 DLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPESTE 331
+ +R GNLKNG+ DIK+H+W F+W L + LP P + G D S FD YP
Sbjct 690 NPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKG 749
Query 332 QPPPITGTLDPFTSW 346
PP D + W
Sbjct 750 VPP------DEMSGW 758
> dre:556339 protein kinase, cGMP-dependent, type II-like; K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=730
Score = 271 bits (694), Expect = 2e-72, Method: Compositional matrix adjust.
Identities = 133/312 (42%), Positives = 200/312 (64%), Gaps = 9/312 (2%)
Query 23 RQIRIPPSKCTASNFV----FANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQ 78
R+++ + ++++F+ TLG G FGRV L + KD + A+K +KK ++
Sbjct 402 RRLKEKATALSSTSFLKELQVVATLGMGGFGRVELVKLKDSEDTA-FALKCIKKKHIVDT 460
Query 79 KQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDA 138
+Q +HI SEK ILQ N F V + TF+DD ++Y+++E +GGE +++LR F+
Sbjct 461 RQQEHIYSEKIILQQTNSNFIVRLFRTFRDDKFVYMLLEVCLGGELWSLLRDMSCFDEPT 520
Query 139 SKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVI--EHRTYTLCG 196
++F V F+YLHG+ I+YRDLKPENLL+D+EGY+K+ DFGFAK I +T+T CG
Sbjct 521 ARFCTGCVLEAFDYLHGKGIVYRDLKPENLLLDAEGYVKMADFGFAKKIGLGKKTWTFCG 580
Query 197 TPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFP 254
TPEY+APEV++NKGH D W++GILI+E+++G PPF +P+ +Y +L G ++ P
Sbjct 581 TPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFTGSDPIRIYTMVLHGIEKVDIP 640
Query 255 KSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAF 314
K K + L++RL + A+R GN KNG+ DIK+HKWF F+W L ++L P +
Sbjct 641 KRISKRPEDLIRRLCKLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLMSPLRREL 700
Query 315 KGLDDTSNFDNY 326
KG D S FD +
Sbjct 701 KGPLDHSYFDMF 712
> bbo:BBOV_I004190 19.m02221; cAMP-dependent protein kinase (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=416
Score = 270 bits (690), Expect = 6e-72, Method: Compositional matrix adjust.
Identities = 129/319 (40%), Positives = 192/319 (60%), Gaps = 4/319 (1%)
Query 12 SQKDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTS--PPVAIKR 69
++ D ++ + I P K SNF +GTGS+ V +A P S A+K
Sbjct 79 TESDTISDGTMEIIPSLPEKLDISNFDIGPIVGTGSYATVCIATLNTGPKSQRATFALKI 138
Query 70 LKKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLR 129
L K VI ++QV H+ +E+ IL + HPF VN + +F+DD +YI++EYV GGE F+ +
Sbjct 139 LHKTKVIAERQVMHLRNERHILSTVRHPFIVNYVKSFQDDINVYILLEYVSGGELFSYIY 198
Query 130 KNRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIEH 189
K + ++FY AQ ++LH + I+YRDLKPEN+L+D +G+++L DFGFAK ++H
Sbjct 199 KYGALGHTVARFYTAQAILAIDFLHFKGIVYRDLKPENMLLDQDGHIRLVDFGFAKEVKH 258
Query 190 RTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG 249
+TYT+CGT +Y+APE+ L GHG DWW++G+L+YE++ G PPF +P Y L
Sbjct 259 KTYTVCGTHDYLAPEIFLRCGHGIEADWWSLGVLVYEILTGVPPFHASDPSATYDLALAN 318
Query 250 RIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPP 309
I FP S K ++RLL + KR G + +++ H++FA DW L+ KQL PP
Sbjct 319 HIRFPLSVRVEVKDFIRRLLVVNPRKRLGG--SNSSELYSHRFFAGMDWMKLLSKQLKPP 376
Query 310 YKPAFKGLDDTSNFDNYPE 328
P GL DT+N+ YP+
Sbjct 377 IVPRVSGLSDTTNYMQYPD 395
> dre:326020 fd58b04, wu:fd58b04; si:dkey-121j17.5
Length=663
Score = 261 bits (666), Expect = 3e-69, Method: Compositional matrix adjust.
Identities = 129/307 (42%), Positives = 183/307 (59%), Gaps = 10/307 (3%)
Query 42 TLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVN 101
TLG G FG+V L + A+KR+ K V+ +KQ HIL EK+ILQ I F V
Sbjct 361 TLGIGGFGKVELVTTLEH--RKYFAMKRISKQHVVAKKQEAHILLEKKILQAIRCDFIVR 418
Query 102 MLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYR 161
+ FKD Y+Y++ME+ GGE +T L++ RFE + F A V + YLH + I+YR
Sbjct 419 LHAAFKDSRYVYMIMEFCPGGEIWTKLKEAGRFEEKIAVFITACVVEAYAYLHNKGILYR 478
Query 162 DLKPENLLVDSEGYLKLTDFGFAKVIE--HRTYTLCGTPEYIAPEVLLNKGHGKPVDWWT 219
DLKPENL++DS+GY+KL DFGFAK + +TY+ CGTPEYI+PE++ N+GH D+W+
Sbjct 479 DLKPENLMLDSKGYVKLVDFGFAKELSRGEKTYSFCGTPEYISPEIIQNQGHDIAADFWS 538
Query 220 MGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGN 279
+G+LIYE++VG PPF EP +Y KIL G + FP + AK ++ +L +R GN
Sbjct 539 LGVLIYELLVGSPPFSSSEPQKIYAKILDGVLNFPSYMGEGAKSIISKLCRLRPGQRLGN 598
Query 280 LKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPESTEQPPPITGT 339
KNG+ D++ H+WF + +W+ L QL P + NFD +P Q
Sbjct 599 TKNGIKDVRHHRWFNSINWHKLRMGQLEAPTVRLIRKGPCYINFDRFPYDKTQAE----- 653
Query 340 LDPFTSW 346
+ F+ W
Sbjct 654 -EEFSGW 659
> cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=780
Score = 260 bits (665), Expect = 4e-69, Method: Compositional matrix adjust.
Identities = 132/322 (40%), Positives = 189/322 (58%), Gaps = 12/322 (3%)
Query 30 SKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKR 89
++ T N TLG G FGRV L D + A+K LKK ++ +Q +HI +E+
Sbjct 462 AQVTLKNVKRLATLGVGGFGRVELVCVNGDK-AKTFALKALKKKHIVDTRQQEHIFAERN 520
Query 90 ILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTI 149
I+ + + V + TF+D ++Y+++E +GGE +T LR F++ ++FY A V
Sbjct 521 IMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEG 580
Query 150 FEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKVIE--HRTYTLCGTPEYIAPEVLL 207
EYLH +NI+YRDLKPEN L+ + GYLKL DFGFAK + +T+T CGTPEY++PE++L
Sbjct 581 LEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIIL 640
Query 208 NKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFP-KSFDKNAKML 264
NKGH + D+W +GI I E+++G PPF +PM Y IL G + P + K A L
Sbjct 641 NKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATAL 700
Query 265 VKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFD 324
VK+L + +R G+ GV DI++H+WF FDW L + L PP P D +NFD
Sbjct 701 VKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFD 760
Query 325 NYPESTEQPPPITGTLDPFTSW 346
NYP + PP D F+ W
Sbjct 761 NYPPDNDVPP------DEFSGW 776
> cel:F57F5.5 pkc-1; Protein Kinase C family member (pkc-1); K06068
novel protein kinase C [EC:2.7.11.13]
Length=707
Score = 251 bits (640), Expect = 4e-66, Method: Compositional matrix adjust.
Identities = 128/332 (38%), Positives = 197/332 (59%), Gaps = 10/332 (3%)
Query 12 SQKDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLK 71
S+ D+ SS+ ++P + +F F LG GSFG+V LA RK T AIK LK
Sbjct 353 SEDDSGTTSSRSASKVPGGTLSIHDFTFMKVLGKGSFGKVMLAERK--GTDEVYAIKILK 410
Query 72 KFAVIRQKQVDHILSEKRILQLI-NHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRK 130
K +++ V+ + EKRIL L HPF + +F+ L+ VMEYV GG+ +++
Sbjct 411 KDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQR 470
Query 131 NRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV---I 187
R+F+ ++FYAA+VT ++LH ++IYRDLK +N+L+D+EG+ +L DFG K
Sbjct 471 ARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINK 530
Query 188 EHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKIL 247
++ T T CGTP+YIAPE+L +G VDWW +G+L+YEM+ G PPF D +++ IL
Sbjct 531 DNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAIL 590
Query 248 GGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNL--KNGVADIKEHKWFAAFDWNALIHKQ 305
+++P K A ++K +T + KR G + + G I+ H +F DW+AL +Q
Sbjct 591 NDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGGEDAIRAHPFFREIDWDALESRQ 650
Query 306 LPPPYKPAFKGLDDTSNFDNYPESTEQPPPIT 337
+ PP+KP K D +NFD+ + T++ P +T
Sbjct 651 VKPPFKPKIKSKRDANNFDS--DFTKEEPVLT 680
> sce:YKL126W YPK1, SLI2; Serine/threonine protein kinase that
phosphorylates and downregulates flippase activator Fpk1p;
mutations affect receptor-mediated endocytosis and sphingolipid-mediated
and cell integrity signaling pathways; homolog
of mammalian kinase SGK (EC:2.7.11.1); K08282 non-specific serine/threonine
protein kinase [EC:2.7.11.1]
Length=680
Score = 249 bits (636), Expect = 1e-65, Method: Compositional matrix adjust.
Identities = 125/313 (39%), Positives = 193/313 (61%), Gaps = 10/313 (3%)
Query 36 NFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLIN 95
+F +G GSFG+V R+KD T A+K ++K ++ + +V H L+E+ +L ++
Sbjct 346 DFDLLKVIGKGSFGKVMQVRKKD--TQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVD 403
Query 96 HPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHG 155
PF V + +F+ LY V+ ++ GGE F L+K RF+ ++FY A++ + LH
Sbjct 404 CPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHK 463
Query 156 RNIIYRDLKPENLLVDSEGYLKLTDFGFAKV---IEHRTYTLCGTPEYIAPEVLLNKGHG 212
+++YRDLKPEN+L+D +G++ L DFG K+ + +T T CGTPEY+APE+LL G+
Sbjct 464 LDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYT 523
Query 213 KPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKRLLTPD 272
K VDWWT+G+L+YEM+ G PP++D++ +Y+KIL ++FP FD++AK L+ LL+ D
Sbjct 524 KAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRD 583
Query 273 LAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYPESTEQ 332
+R G NG +I+ H +F+ W L+ K PPYKPA DTSNFD E +
Sbjct 584 PTRRLG--YNGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFD---EEFTR 638
Query 333 PPPITGTLDPFTS 345
PI +D + S
Sbjct 639 EKPIDSVVDEYLS 651
> hsa:6446 SGK1, SGK; serum/glucocorticoid regulated kinase 1
(EC:2.7.11.1); K13302 serum/glucocorticoid-regulated kinase
1 [EC:2.7.11.1]
Length=526
Score = 248 bits (634), Expect = 2e-65, Method: Compositional matrix adjust.
Identities = 132/320 (41%), Positives = 198/320 (61%), Gaps = 12/320 (3%)
Query 23 RQIRIPPSK---CTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQK 79
+QI + PS S+F F +G GSFG+V LAR K + A+K L+K A++++K
Sbjct 176 QQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF--YAVKVLQKKAILKKK 233
Query 80 QVDHILSEKRIL-QLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDA 138
+ HI+SE+ +L + + HPF V + +F+ LY V++Y+ GGE F L++ R F
Sbjct 234 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 293
Query 139 SKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV-IEHR--TYTLC 195
++FYAA++ + YLH NI+YRDLKPEN+L+DS+G++ LTDFG K IEH T T C
Sbjct 294 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 353
Query 196 GTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPK 255
GTPEY+APEVL + + + VDWW +G ++YEM+ G PPF+ +Y IL +
Sbjct 354 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 413
Query 256 SFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFK 315
+ +A+ L++ LL D KR G K+ +IK H +F+ +W+ LI+K++ PP+ P
Sbjct 414 NITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 472
Query 316 GLDDTSNFDNYPESTEQPPP 335
G +D +FD PE TE+P P
Sbjct 473 GPNDLRHFD--PEFTEEPVP 490
> mmu:20393 Sgk1, Sgk; serum/glucocorticoid regulated kinase 1
(EC:2.7.11.1); K13302 serum/glucocorticoid-regulated kinase
1 [EC:2.7.11.1]
Length=524
Score = 248 bits (632), Expect = 3e-65, Method: Compositional matrix adjust.
Identities = 132/320 (41%), Positives = 197/320 (61%), Gaps = 12/320 (3%)
Query 23 RQIRIPPSK---CTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQK 79
+QI + PS S+F F +G GSFG+V LAR K + A+K L+K A++++K
Sbjct 174 QQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF--YAVKVLQKKAILKKK 231
Query 80 QVDHILSEKRIL-QLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDA 138
+ HI+SE+ +L + + HPF V + +F+ LY V++Y+ GGE F L++ R F
Sbjct 232 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 291
Query 139 SKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV-IEHR--TYTLC 195
++FYAA++ + YLH NI+YRDLKPEN+L+DS+G++ LTDFG K IEH T T C
Sbjct 292 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFC 351
Query 196 GTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPK 255
GTPEY+APEVL + + + VDWW +G ++YEM+ G PPF+ +Y IL +
Sbjct 352 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 411
Query 256 SFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFK 315
+ +A+ L++ LL D KR G K+ +IK H +F+ +W+ LI+K++ PP+ P
Sbjct 412 NITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHIFFSLINWDDLINKKITPPFNPNVS 470
Query 316 GLDDTSNFDNYPESTEQPPP 335
G D +FD PE TE+P P
Sbjct 471 GPSDLRHFD--PEFTEEPVP 488
> xla:399130 sgk1-a, Sgk, sgk-A, sgk1; serum/glucocorticoid regulated
kinase 1 (EC:2.7.11.1); K13302 serum/glucocorticoid-regulated
kinase 1 [EC:2.7.11.1]
Length=434
Score = 246 bits (629), Expect = 7e-65, Method: Compositional matrix adjust.
Identities = 131/320 (40%), Positives = 196/320 (61%), Gaps = 12/320 (3%)
Query 23 RQIRIPPSK---CTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQK 79
+QI + PS S+F F +G GSFG+V LAR + D A+K L+K A++++K
Sbjct 84 QQINLGPSSNPHAKPSDFQFLKIIGKGSFGKVLLARHQADEKF--YAVKVLQKKAILKKK 141
Query 80 QVDHILSEKRIL-QLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDA 138
+ HI+SE+ +L + + HPF V + +F+ LY +++Y+ GGE F L++ R F
Sbjct 142 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTTSRLYFILDYINGGELFYHLQRERCFLEPR 201
Query 139 SKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV-IE--HRTYTLC 195
++FYAA++ + YLH NI+YRDLKPEN+L+DS+G++ LTDFG K IE T T C
Sbjct 202 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEPNGTTSTFC 261
Query 196 GTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPK 255
GTPEY+APEVL + + + VDWW +G ++YEM+ G PPF+ +Y IL +
Sbjct 262 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 321
Query 256 SFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFK 315
+ +A+ L++ LL D KR G KN +IK H +F+ +W+ LI+K++ PP+ P
Sbjct 322 NITNSARNLLEGLLQKDRTKRIG-AKNDFMEIKNHIFFSPINWDDLINKKITPPFNPNVS 380
Query 316 GLDDTSNFDNYPESTEQPPP 335
G D +FD PE TE+P P
Sbjct 381 GPSDLQHFD--PEFTEEPVP 398
> cel:C12D8.10 akt-1; AKT kinase family member (akt-1); K04456
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Length=541
Score = 245 bits (626), Expect = 2e-64, Method: Compositional matrix adjust.
Identities = 130/335 (38%), Positives = 191/335 (57%), Gaps = 14/335 (4%)
Query 6 FRKLLPSQKDAAAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPV 65
FR + S D + E+++R K T +F F LG G+FG+V L + K T
Sbjct 169 FRASMISIADTS-EAAKR------DKITMEDFDFLKVLGKGTFGKVILCKEK--RTQKLY 219
Query 66 AIKRLKKFAVIRQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFF 125
AIK LKK +I +++V H L+E R+LQ HPF + +F++ HYL VM++ GGE F
Sbjct 220 AIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELF 279
Query 126 TVLRKNRRFENDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAK 185
T +RK F ++FY A++ YLH +I+YRD+K ENLL+D +G++K+ DFG K
Sbjct 280 THVRKCGTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCK 339
Query 186 ---VIEHRTYTLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGV 242
+T T CGTPEY+APEVL + +G+ VDWW +G+++YEM+ G PF+ + +
Sbjct 340 EEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPFYSKDHNKL 399
Query 243 YQKILGGRIMFPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALI 302
++ I+ G + FP + A+ L+ LL D +R G +I +F DW A
Sbjct 400 FELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFFRTVDWEATY 459
Query 303 HKQLPPPYKPAFKGLDDTSNFDNYPESTEQPPPIT 337
K++ PPYKP + DTS FDN E T QP +T
Sbjct 460 RKEIEPPYKPNVQSETDTSYFDN--EFTSQPVQLT 492
> xla:444618 sgk1-b, MGC84110, Sgk, sgk-B, sgk2; serum/glucocorticoid
regulated kinase 1 (EC:2.7.11.1); K13302 serum/glucocorticoid-regulated
kinase 1 [EC:2.7.11.1]
Length=434
Score = 244 bits (624), Expect = 3e-64, Method: Compositional matrix adjust.
Identities = 131/323 (40%), Positives = 195/323 (60%), Gaps = 12/323 (3%)
Query 20 SSQRQIRIPPSK---CTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVI 76
S +QI + PS S+F F +G GSFG+V LAR K D A+K L+K A++
Sbjct 81 SHSQQINLGPSSNPHAKPSDFQFLKIIGKGSFGKVLLARHKADEKF--YAVKVLQKKAIL 138
Query 77 RQKQVDHILSEKRIL-QLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFE 135
++K+ HI+SE+ +L + + HPF V + + + LY +++Y+ GGE F L++ R F
Sbjct 139 KKKEEKHIMSERNVLLKNVKHPFLVGLHFSIQTTSRLYFILDYINGGELFYHLQRERCFL 198
Query 136 NDASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV-IEHR--TY 192
++FYAA++ + YLH NI+YRDLKPEN+L+DS+G++ LTDFG K IE T
Sbjct 199 EPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEPNGITS 258
Query 193 TLCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIM 252
T CGTPEY+APEVL + + + VDWW +G ++YEM+ G PPF+ +Y IL +
Sbjct 259 TFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQ 318
Query 253 FPKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKP 312
+ +A+ L++ LL D KR G K +IK H +F+ DW+ LI+K++ PP+ P
Sbjct 319 LKPNITNSARNLLEGLLQKDRTKRTG-AKTDFMEIKNHIFFSPIDWDDLINKKITPPFNP 377
Query 313 AFKGLDDTSNFDNYPESTEQPPP 335
G D +FD PE T++P P
Sbjct 378 NVSGPSDLQHFD--PEFTDEPVP 398
> tgo:TGME49_067540 protein kinase, putative (EC:4.1.1.70 2.7.11.13)
Length=951
Score = 243 bits (621), Expect = 5e-64, Method: Compositional matrix adjust.
Identities = 119/298 (39%), Positives = 177/298 (59%), Gaps = 5/298 (1%)
Query 31 KCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRI 90
+ + +F +G GS+G+V L + D A+K L+K AV+R+ QV+H +E+ +
Sbjct 453 RLSPEDFQLLRVIGKGSYGKVMLVQFHQDGGV--YAMKMLRKEAVVRRNQVEHTRTERDV 510
Query 91 LQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIF 150
L ++HPF V M F+ LY V+EY GGE F L + RF+ A+ FYAA+V
Sbjct 511 LAWVSHPFIVQMHYAFQTRKKLYFVLEYCPGGELFFHLSRAGRFKEYAACFYAAEVLLAL 570
Query 151 EYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV-IEHRTY--TLCGTPEYIAPEVLL 207
E+LH N++YRDLKPEN+L+D G+++LTDFG +K +E +LCGTPEY+APE+L
Sbjct 571 EHLHKYNVVYRDLKPENVLLDEHGHVRLTDFGLSKEGVEDNCSARSLCGTPEYLAPEILS 630
Query 208 NKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAKMLVKR 267
+GHGK VDWW++G LIYEM+ G PPF+ + +++ I + +P + A L++
Sbjct 631 QQGHGKAVDWWSLGALIYEMLTGLPPFYTGDRERLFENIRSSELQYPSYMSRAAVHLLRG 690
Query 268 LLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDN 325
L D +R G +IK H +F DW AL K++ PP++P + D FDN
Sbjct 691 LFQRDPNRRLGGGPGDAEEIKRHPFFGRIDWEALQAKRMRPPFRPRLQSPTDVQYFDN 748
> sce:YMR104C YPK2, YKR2; Protein kinase with similarity to serine/threonine
protein kinase Ypk1p; functionally redundant
with YPK1 at the genetic level; participates in a signaling
pathway required for optimal cell wall integrity; homolog of
mammalian kinase SGK (EC:2.7.11.1); K08282 non-specific serine/threonine
protein kinase [EC:2.7.11.1]
Length=677
Score = 242 bits (618), Expect = 1e-63, Method: Compositional matrix adjust.
Identities = 131/323 (40%), Positives = 195/323 (60%), Gaps = 13/323 (4%)
Query 29 PSK---CTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHIL 85
PSK + +F +G GSFG+V R+KD T A+K L+K ++ + +V H L
Sbjct 333 PSKNKPLSIDDFDLLKVIGKGSFGKVMQVRKKD--TQKIYALKALRKAYIVSKCEVTHTL 390
Query 86 SEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQ 145
+E+ +L ++ PF V + +F+ LY+V+ ++ GGE F L+ RF S+FY A+
Sbjct 391 AERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAE 450
Query 146 VTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAKV---IEHRTYTLCGTPEYIA 202
+ + LH ++IYRDLKPEN+L+D +G++ L DFG K+ +T T CGTPEY+A
Sbjct 451 LLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLA 510
Query 203 PEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMFPKSFDKNAK 262
PE+LL +G+ K VDWWT+GIL+YEM+ G PP++D+ +Y+KIL ++FP FD AK
Sbjct 511 PEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAK 570
Query 263 MLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSN 322
L+ LL+ D ++R G NG +I+ H +F W L+ K PPYKP K DT+N
Sbjct 571 DLLIGLLSRDPSRRLG--VNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTAN 628
Query 323 FDNYPESTEQPPPITGTLDPFTS 345
FD E T++ PI +D + S
Sbjct 629 FDQ--EFTKE-KPIDSVVDEYLS 648
> cel:C09G4.2 hypothetical protein
Length=617
Score = 241 bits (616), Expect = 2e-63, Method: Compositional matrix adjust.
Identities = 122/292 (41%), Positives = 178/292 (60%), Gaps = 9/292 (3%)
Query 40 ANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVIRQKQVDHILSEKRILQLINHPFT 99
+TLG G FGRV L R +S A+K + K ++ KQ H++SE+RIL ++ +
Sbjct 313 VSTLGMGGFGRVELVR---SASSRTYALKIMNKAHIVETKQESHVVSERRILMQCDNDYI 369
Query 100 VNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFENDASKFYAAQVTTIFEYLHGRNII 159
V M T++D +Y++ME +GGE +T+LRK RF+ND ++FY A EYLH +NI+
Sbjct 370 VRMYKTYRDSEKIYMLMEPCLGGEIWTILRKKGRFDNDLTRFYCAGAMEALEYLHRKNIV 429
Query 160 YRDLKPENLLVDSEGYLKLTDFGFAKVIEH--RTYTLCGTPEYIAPEVLLNKGHGKPVDW 217
YRDLKPEN+L+D G+ KL DFGFAK +++ RT+T CGT EY+APE++LNKGH VD
Sbjct 430 YRDLKPENMLLDRNGWPKLVDFGFAKKLKNGGRTWTFCGTAEYVAPEIVLNKGHDLSVDI 489
Query 218 WTMGILIYEMIVGYPPFFDDEPMGVYQKILGG--RIMFPKSFDKNAKMLVKRLLTPDLAK 275
W +GI + E++ G PPF +PM Y IL G + +P+ K A ++ L + +
Sbjct 490 WALGIFMCELLTGSPPFSSTDPMVTYNAILKGLEKWAWPRFVTKEAIDMMLSLCKYEPTE 549
Query 276 RYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPAFKGLDDTSNFDNYP 327
R G + +I+ H WF FD+ ++ PP+ P+ DTSNFD +P
Sbjct 550 RLGF--GDIGEIRHHIWFDNFDFVGFRAHRIRPPFIPSVANDIDTSNFDTFP 599
> dre:403146 akt2l; v-akt murine thymoma viral oncogene homolog
2, like (EC:2.7.11.1); K04456 RAC serine/threonine-protein
kinase [EC:2.7.11.1]
Length=478
Score = 241 bits (615), Expect = 3e-63, Method: Compositional matrix adjust.
Identities = 120/324 (37%), Positives = 189/324 (58%), Gaps = 7/324 (2%)
Query 17 AAESSQRQIRIPPSKCTASNFVFANTLGTGSFGRVFLARRKDDPTSPPVAIKRLKKFAVI 76
A E + + S+ T ++F + LG G+FG+V L R K + A+K L+K +I
Sbjct 129 ALEDMEMCLSKSSSRVTMNDFDYLKLLGKGTFGKVILVREK--ASGMYYAMKILRKEVII 186
Query 77 RQKQVDHILSEKRILQLINHPFTVNMLGTFKDDHYLYIVMEYVIGGEFFTVLRKNRRFEN 136
+ +V H ++E R+LQ HPF + F+ L VMEY GGE F L + R F
Sbjct 187 AKDEVAHTVTESRVLQNTRHPFLTTLKYAFQTHDRLCFVMEYANGGELFFHLSRERVFSE 246
Query 137 DASKFYAAQVTTIFEYLHGRNIIYRDLKPENLLVDSEGYLKLTDFGFAK---VIEHRTYT 193
D ++FY A++ + +YLH +N++YRDLK ENL++D++G++K+TDFG K E T
Sbjct 247 DRARFYGAEIVSALDYLHSQNVVYRDLKLENLMLDNDGHIKITDFGLCKEGITDEATMRT 306
Query 194 LCGTPEYIAPEVLLNKGHGKPVDWWTMGILIYEMIVGYPPFFDDEPMGVYQKILGGRIMF 253
CGTPEY+APEVL + +G+ VDWW +G+++YEM+ G PF+ + ++++I+ I F
Sbjct 307 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYSQDHERLFEQIVMEEIRF 366
Query 254 PKSFDKNAKMLVKRLLTPDLAKRYGNLKNGVADIKEHKWFAAFDWNALIHKQLPPPYKPA 313
P+S +A+ L+ LL + +R G + D+ HK+F+ W+ ++ K+L PP+KP
Sbjct 367 PRSLSTHARALLTGLLRKEPKQRLGGGPDDARDVMMHKFFSGVQWDDVLQKKLLPPFKPQ 426
Query 314 FKGLDDTSNFDNYPESTEQPPPIT 337
DT FD+ E T Q +T
Sbjct 427 VTSETDTRYFDD--EFTAQSITVT 448
Lambda K H
0.322 0.140 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 14791618220
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40