bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_3219_orf1
Length=244
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC... 275 1e-73
tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.1... 221 1e-57
tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, ... 220 5e-57
tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, p... 207 2e-53
pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:... 203 4e-52
tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nu... 191 2e-48
tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, ... 186 5e-47
tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesteras... 182 1e-45
tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic n... 177 4e-44
tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) 176 7e-44
cpv:cgd3_2320 cGMP phosphodiesterase A4 173 6e-43
pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.1... 164 3e-40
tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase... 159 1e-38
xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296... 158 1e-38
hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited ... 158 2e-38
mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A, ... 157 4e-38
bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodie... 152 8e-37
dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic ... 150 4e-36
dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiester... 149 9e-36
dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; ... 149 9e-36
hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase 1A... 149 1e-35
hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-in... 149 1e-35
dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296... 148 2e-35
mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiester... 148 2e-35
dre:566998 novel protein similar to vertebrate phosphodiestera... 147 2e-35
mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, ... 147 4e-35
tpv:TP01_1200 hypothetical protein 147 4e-35
hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4... 147 5e-35
cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K1... 146 7e-35
mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase 3B... 145 1e-34
bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodie... 144 2e-34
tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K0112... 144 2e-34
mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-cal... 144 4e-34
mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B, c... 143 7e-34
xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specifi... 142 1e-33
hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodul... 142 1e-33
dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-25... 141 2e-33
cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01... 141 2e-33
hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIV... 141 2e-33
hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP... 140 3e-33
mmu:18585 Pde9a, PDE9A1; phosphodiesterase 9A (EC:3.1.4.35); K... 140 4e-33
hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-s... 140 4e-33
mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 ca... 140 4e-33
mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP ... 140 4e-33
hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-depend... 139 7e-33
dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;... 139 8e-33
pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucl... 139 1e-32
hsa:5152 PDE9A, FLJ90181, HSPDE9A2; phosphodiesterase 9A (EC:3... 139 1e-32
xla:495146 hypothetical LOC495146; K01120 3',5'-cyclic-nucleot... 139 1e-32
dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 ... 138 2e-32
> tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17
1.6.5.3); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=1085
Score = 275 bits (702), Expect = 1e-73, Method: Compositional matrix adjust.
Identities = 127/240 (52%), Positives = 176/240 (73%), Gaps = 0/240 (0%)
Query 2 LLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALT 61
+LR+RE + DLE+ ++ IA+LCHD+ HPGRNNNFM+ ANTPLA+TYND SVLEN H++LT
Sbjct 831 MLRLRESLGDLEEASLIIAALCHDIAHPGRNNNFMVNANTPLALTYNDISVLENMHASLT 890
Query 62 FRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASN 121
F+ L + +L AYR+ R +IE I+STDMK HF+ I+ FR +R EF+ +N
Sbjct 891 FKLLLDRRLGLLNHLHREAYRSFRMTVIELIMSTDMKTHFEQIANFRVRRQKEEFDPINN 950
Query 122 EEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSL 181
+DR +V+SM +K+AD+GH W HE WC VV EFY+QGDEE+RLGLP SFLCDR
Sbjct 951 YDDRQKVMSMIIKSADIGHGTLPWADHERWCNLVVQEFYEQGDEEKRLGLPVSFLCDRDQ 1010
Query 182 HEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQKE 241
H++EF SQVGF++FVVKPLYEELK+++ L L+ + + +IC+ N++ N + W++ +E
Sbjct 1011 HDREFFKSQVGFLDFVVKPLYEELKALETQLNLNPQLPIENICLKNLQENISEWKKKNEE 1070
> tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.17
1.1.99.3)
Length=1324
Score = 221 bits (564), Expect = 1e-57, Method: Compositional matrix adjust.
Identities = 114/240 (47%), Positives = 151/240 (62%), Gaps = 7/240 (2%)
Query 1 RLLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSAL 60
R+L + M+ ++ + + +A+LCHDVGHPGRNN F I A PLA+ YND +VLEN HS L
Sbjct 761 RMLNAQRNMNSIDKVTLTVAALCHDVGHPGRNNQFFINAFDPLAVIYNDVAVLENFHSCL 820
Query 61 TFRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIAS 120
TFR L NI + ++R IR+Y+IE IL+TDMK HF+ +S FR +R + EFN
Sbjct 821 TFRTLENKDRNIFACLDESSFRYIRQYVIECILATDMKQHFESLSRFRIRRNSPEFNYVK 880
Query 121 NEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRS 180
N EDR V MCVK AD+GH+ W QH EW RVV EFY QGDEE +P S LCDR
Sbjct 881 NVEDRWFVARMCVKVADIGHSCVPWNQHFEWSSRVVEEFYLQGDEERSRNMPVSPLCDRD 940
Query 181 LHEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQK 240
H + SQ GF+ FVVKPL +E+ +D ++ R ++ +++IE N WQ Q+
Sbjct 941 KH-ADMAKSQGGFLEFVVKPLIKEIDEIDPFGRV--RSDI----LSHIEYNEKKWQELQE 993
> tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase,
putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=812
Score = 220 bits (560), Expect = 5e-57, Method: Compositional matrix adjust.
Identities = 110/236 (46%), Positives = 145/236 (61%), Gaps = 7/236 (2%)
Query 1 RLLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSAL 60
R L + M+ L A +A+LCHD+GHPGRNNNF +A+ PLA+ YND +VLEN HSAL
Sbjct 391 RGLGINREMNSLSTAACAVAALCHDIGHPGRNNNFFVASGAPLAVLYNDKAVLENFHSAL 450
Query 61 TFRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIAS 120
TFR L + CN+ +D ++ +R +I+ IL+TDMK HFD +S FR +R FN
Sbjct 451 TFRVLGRHDCNVFAYLSDEEFKHVRANMIDLILATDMKTHFDFLSRFRNRRQAPGFNFHK 510
Query 121 NEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRS 180
ED+ +C++A+DLGHA T W+QH EW RVVTEFY QG+EE RLGL S LCDR
Sbjct 511 VAEDQWLAAEICIRASDLGHAMTEWDQHFEWASRVVTEFYLQGEEERRLGLHVSPLCDRD 570
Query 181 LHEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQ 236
H F Q GF+ +VVKPL EL D + Q + + N++ N W+
Sbjct 571 DH-PSFSKCQHGFLGYVVKPLIAELGECDTL------QRIIPQLMQNLKENMERWE 619
> tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase,
putative (EC:3.1.4.17 1.6.99.5)
Length=1670
Score = 207 bits (528), Expect = 2e-53, Method: Composition-based stats.
Identities = 102/220 (46%), Positives = 139/220 (63%), Gaps = 8/220 (3%)
Query 17 VGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQCNILEKA 76
V +A LCHD+GHPGRNN I A P+A+ YND SVLEN+HS LTF+ L P C+I
Sbjct 1371 VVVAGLCHDIGHPGRNNALFINALDPVAVLYNDKSVLENYHSCLTFKTLELPDCDIFFSL 1430
Query 77 TDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRVISMCVKAA 136
Y +R II+ IL+TDMK HF+ +S FR +R +F+++S EED + + +K A
Sbjct 1431 RTKDYHMVRSLIIDLILATDMKNHFETVSRFRVRRNALDFDLSS-EEDFWFAVKIIMKCA 1489
Query 137 DLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSSQVGFINF 196
DL H + W QH +WC+R+ EFYDQGDEE LP S LCDR H E SQ+GF++F
Sbjct 1490 DLSHCSVPWSQHFQWCQRLSVEFYDQGDEEVARHLPMSPLCDREKHS-EVAKSQLGFMSF 1548
Query 197 VVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQ 236
V PL+EEL ++D + K C++ ++ NA+HW+
Sbjct 1549 VAVPLFEELMAIDGTGNIEK------YCISVMKTNASHWE 1582
> pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=1139
Score = 203 bits (517), Expect = 4e-52, Method: Composition-based stats.
Identities = 99/223 (44%), Positives = 141/223 (63%), Gaps = 7/223 (3%)
Query 19 IASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQCNILEKATD 78
I+ +CHD+GHPG NN F + + PL+I YND SVLEN+H+++TF+ L QCNIL+ ++
Sbjct 882 ISGICHDIGHPGYNNLFFVNSLHPLSIIYNDISVLENYHASITFKILQLNQCNILKNFSE 941
Query 79 CAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRVISMCVKAADL 138
+R +R YIIE ILSTDMK HF+ IS FR +R N +F+ N +D + M +K+AD+
Sbjct 942 KDFRMMRSYIIELILSTDMKHHFEIISKFRIRRENEDFDYIKNSDDLLILTKMIIKSADI 1001
Query 139 GHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSSQVGFINFVV 198
H + W +H WC+RV++EFY QGDEE + +P S LCDR+ H E SQ+ F+ FVV
Sbjct 1002 SHGSVSWSEHYCWCQRVLSEFYTQGDEELKNKMPLSPLCDRTKH-NEVCKSQITFLKFVV 1060
Query 199 KPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQKE 241
PL+EEL +D + + C+ + +N W KE
Sbjct 1061 MPLFEELSHID------NNKFIKSFCLKRLNSNCIMWDTLMKE 1097
> tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic
nucleotide phosphodiesterase, putative (EC:3.1.4.17)
Length=1320
Score = 191 bits (485), Expect = 2e-48, Method: Composition-based stats.
Identities = 96/228 (42%), Positives = 132/228 (57%), Gaps = 7/228 (3%)
Query 15 IAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQCNILE 74
+++ IA+L HD GHPGR+N F++ ++ L++ YND S+LEN+H+ LTF LS + NI
Sbjct 1094 LSLAIAALGHDAGHPGRSNAFLVQTSSTLSVVYNDRSILENYHACLTFYTLSHRKSNIFR 1153
Query 75 KATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRVISMCVK 134
T YR +RK IE ILSTDM +HF+ ++ +R N +FN EEDR V+S+ +K
Sbjct 1154 GKTVTQYRDVRKKAIELILSTDMSLHFEFLTRVAARRENPDFNFVDREEDRALVLSLAIK 1213
Query 135 AADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSSQVGFI 194
ADLGH A WE H W R+ EF QGDEE RLGLP S LCDR+ + + SQ FI
Sbjct 1214 VADLGHCALDWEAHTLWSARLKEEFLAQGDEELRLGLPVSPLCDRT-QQGQLARSQANFI 1272
Query 195 NFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQKEI 242
F+ PL + L +V + V N + W+ Q E+
Sbjct 1273 EFLFLPLAQHLAAV------APDDRFEATVVTRARQNISMWEGAQDEV 1314
> tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase,
putative (EC:2.1.1.43 3.1.4.17)
Length=1281
Score = 186 bits (473), Expect = 5e-47, Method: Compositional matrix adjust.
Identities = 92/239 (38%), Positives = 143/239 (59%), Gaps = 8/239 (3%)
Query 1 RLLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSAL 60
R L + ++ E +A+ +A+LCHD+GH G+NN F +A+ +PL I YND +VLEN H+ L
Sbjct 881 RKLELASSLTAPELVALIVAALCHDIGHQGKNNAFYVASRSPLGIIYNDIAVLENFHACL 940
Query 61 TFRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIAS 120
TF+ L++P+CNI ++ +R +I+ IL+TDMKMHF+ +S FR +R + +F +
Sbjct 941 TFKILARPECNIFTHLPPEDFQIVRNRMIDLILATDMKMHFEMVSKFRLRRNSPDF-CRT 999
Query 121 NEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRS 180
N++D ++ MC+K DL H W+ H W R +EFY+QGD E G + + DR
Sbjct 1000 NDDDVWMLLRMCIKGGDLSHGLLSWDSHVSWSYRAASEFYEQGDLELAQGRTITPMFDRR 1059
Query 181 LHEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQ 239
H +F Q GF+ F++ PLYEE+ +VD + C+ N AN+ W++ Q
Sbjct 1060 KH-ADFPKGQEGFLRFIIIPLYEEIAAVDTT------DVVQTCCLQNAVANSERWRQLQ 1111
> tgo:TGME49_026770 cGMP-inhibited 3',5'-cyclic phosphodiesterase,
putative (EC:3.1.4.17)
Length=995
Score = 182 bits (461), Expect = 1e-45, Method: Composition-based stats.
Identities = 97/213 (45%), Positives = 130/213 (61%), Gaps = 14/213 (6%)
Query 20 ASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLS-----------KP 68
A+L HDVGHPG NN F++A N P+A+ YND++VLEN+H+ +TFR L+
Sbjct 331 AALGHDVGHPGFNNAFLVATNQPIALVYNDHAVLENYHAYITFRTLTCYTSTTDTNGQGC 390
Query 69 QCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRV 128
+ ++L+ T YR RK++IE IL+TDM HF IS R +R + FN +NEEDR +
Sbjct 391 EGSVLKGITPAEYRYFRKHLIELILATDMSQHFSTISTVRVRRESRTFNFITNEEDRWMM 450
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+C+K D+GHAA W+QH +W RV EF QGD E + GLP S LCDR+ E E
Sbjct 451 KKLCMKIGDIGHAALDWDQHYKWSMRVTEEFLLQGDAELKAGLPVSPLCDRNAPEIELHK 510
Query 189 SQVGFINFVVKPLYEELKSVDEMLQLSKRQELA 221
SQ FIN++V PL EL L+ RQ +A
Sbjct 511 SQSSFINYLVVPLINELVGC---LEAHPRQSVA 540
> tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic
nucleotide phosphodiesterase, putative (EC:3.4.21.69 3.1.4.17)
Length=1531
Score = 177 bits (448), Expect = 4e-44, Method: Compositional matrix adjust.
Identities = 100/229 (43%), Positives = 129/229 (56%), Gaps = 3/229 (1%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSK-P 68
S ++ +A+ HDVGHP R N F+ PL+I YND S LEN HSAL FR LS+ P
Sbjct 1243 SAFANLCTLVAAAAHDVGHPARTNLFLQNLLHPLSIVYNDVSTLENFHSALLFRILSEIP 1302
Query 69 QCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRV 128
N+ +R R+ II IL+TD+K HF+ IS FR +R + EFN EED V
Sbjct 1303 DSNVFSGLPQETFRIARQNIITLILATDIKQHFETISRFRLRRNSPEFNFLKKEEDDWLV 1362
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
M K AD+ HA W+ H W +V EFY QGD E RLGLP S LCDR H E
Sbjct 1363 RKMIFKIADISHATVAWDAHFFWSCKVNAEFYAQGDAEVRLGLPVSPLCDREKH-FEMGK 1421
Query 189 SQVGFINFVVKPLYEELKSVDEM-LQLSKRQELAHICVANIEANAAHWQ 236
SQV F+NFVV+PL EL++++ + L L ++ + N N W+
Sbjct 1422 SQVAFLNFVVEPLLRELEAIEALVLPLGTCPIISTELLPNFAENVQQWK 1470
> tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17)
Length=1065
Score = 176 bits (446), Expect = 7e-44, Method: Compositional matrix adjust.
Identities = 90/190 (47%), Positives = 119/190 (62%), Gaps = 1/190 (0%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQCN 71
+E + +A+LCHD+GHPGR N F ++++ PLAI YND S LEN H L FR L K + N
Sbjct 642 VERATLYVAALCHDLGHPGRTNQFFVSSHDPLAIVYNDISCLENLHCCLCFRTLQKEENN 701
Query 72 ILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRVISM 131
+ + +R +R +IE IL+TDMK HF+ IS FR + +F++A + +DR V+ M
Sbjct 702 VFYYVDNEQFRFVRSKLIEAILATDMKQHFETISRFRLRTSADDFDVAKHVDDRWAVLKM 761
Query 132 CVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSSQV 191
VK AD+ H A W+ H +V EFY QGDEE R G+P S LCDRS H E SQ
Sbjct 762 FVKMADISHVALPWDMHFRLSCDIVEEFYQQGDEELRRGMPLSQLCDRSKH-NEMPKSQE 820
Query 192 GFINFVVKPL 201
GFI F+ KPL
Sbjct 821 GFIEFLAKPL 830
> cpv:cgd3_2320 cGMP phosphodiesterase A4
Length=997
Score = 173 bits (438), Expect = 6e-43, Method: Compositional matrix adjust.
Identities = 91/204 (44%), Positives = 126/204 (61%), Gaps = 5/204 (2%)
Query 9 MSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR---FL 65
+ +E +A IASL HDVGH GR +NF++ + LAI YND SVLE H++LTFR +
Sbjct 750 LDTVERLASVIASLGHDVGHIGRTSNFLVNSRHMLAINYNDRSVLEMFHASLTFRIIYYY 809
Query 66 SKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDR 125
+ L+ ++ R+ +IE IL TDM HF+ +S FR +R +++ + +DR
Sbjct 810 GGGAADFLQSWDAELHKEFRRIVIELILETDMHRHFECVSRFRVRRQAVDWDPYGDAQDR 869
Query 126 TRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKE 185
+ C+KAAD+GH A W QH +WCR VV EF+ QGDEE+ L LP S +CDR +
Sbjct 870 LMLARTCLKAADIGHGALKWNQHYKWCRSVVEEFFLQGDEEKALSLPISPICDR--ESTD 927
Query 186 FVSSQVGFINFVVKPLYEELKSVD 209
SQVGF+NFV PL++EL VD
Sbjct 928 VPKSQVGFLNFVCLPLFQELCYVD 951
> pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=954
Score = 164 bits (415), Expect = 3e-40, Method: Composition-based stats.
Identities = 90/235 (38%), Positives = 138/235 (58%), Gaps = 8/235 (3%)
Query 2 LLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALT 61
+L + +S +++ + I+SLCHD GHPG NN F+I + LA+TYNDNSVLEN+H +L
Sbjct 698 MLDMNHKISAIDEFCLHISSLCHDTGHPGLNNYFLINSENNLALTYNDNSVLENYHCSLL 757
Query 62 FRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASN 121
F+ L P NI E + + +K II+ ILSTDMK HF++IS FRT + +++ SN
Sbjct 758 FKTLKNPNYNIFEHYPYHIFISCKKNIIKAILSTDMKNHFEYISDFRTSKEFIDYDNLSN 817
Query 122 EEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSL 181
++ ++ + +KA+D+GH+ W +H EW ++ EFY QG E+ L + SFLCD +
Sbjct 818 DQ-IWQIFCLILKASDIGHSTLEWNKHLEWTLKINEEFYLQGLLEKSLNIQNSFLCDINT 876
Query 182 HEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQ 236
K SQ+ F+ + PL+ EL + K ++ C+ IE N W+
Sbjct 877 MNK-LALSQIDFLKHLCIPLFNELNYI------CKNNDVYTHCIQPIENNIERWE 924
> tgo:TGME49_057080 cAMP-specific 3',5'-cyclic phosphodiesterase,
putative (EC:3.1.4.17)
Length=1691
Score = 159 bits (401), Expect = 1e-38, Method: Compositional matrix adjust.
Identities = 89/244 (36%), Positives = 142/244 (58%), Gaps = 5/244 (2%)
Query 2 LLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALT 61
+L ++ ++ ++++ + IAS+ HDVGHPG NN ++I++ + LA TYND +VLEN+H+A
Sbjct 1365 VLPSKQALTYVDELCLIIASVAHDVGHPGLNNQYLISSQSLLATTYNDIAVLENYHAACC 1424
Query 62 FRFLS-KPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIAS 120
FR NI Y+ +R+ II ILSTDM H ++S R + +G F++ +
Sbjct 1425 FRTAGINEDHNIFSGLAKEVYQYMRQNIIGLILSTDMSKHISYVSRLRVRAESGNFDV-N 1483
Query 121 NEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRS 180
NE DR + C+KAADL H AT W+ H+ W + EF+ QGDEE R G+ + DR
Sbjct 1484 NEGDRWLLFQGCIKAADLAHTATFWDNHKRWAECLCEEFFKQGDEERRQGMNVMDIFDRR 1543
Query 181 LHEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQK 240
++ F SQ FI VV+PL+ + S++++L+ + IC + +N A W+ +
Sbjct 1544 QKDR-FPQSQYRFIELVVEPLFNSVCSIEDLLK-GRGGVRGKIC-KTLSSNLARWKEAAE 1600
Query 241 EIWK 244
+ K
Sbjct 1601 ALEK 1604
> xla:496104 pde3b; phosphodiesterase 3b, cGMP-inhibited; K13296
cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
Length=985
Score = 158 bits (400), Expect = 1e-38, Method: Composition-based stats.
Identities = 85/193 (44%), Positives = 112/193 (58%), Gaps = 5/193 (2%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLSKPQC 70
LE +A+ +A+ HD HPGR N F++A N P A+ YND SVLENHH+A + FLS+P+
Sbjct 678 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLFLSQPEY 737
Query 71 NILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTK--RINGEFNIASNEEDRTRV 128
N L ++ R +IE IL+TD+K HFD ++ F K +NG SNE DR V
Sbjct 738 NFLSYLDHVQFKRFRFLVIEAILATDLKKHFDFLAEFNAKVNDVNGLGIDWSNENDRLLV 797
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+C+K AD+ A E H +W +V EFY+QGDEE LGLP S DRS +
Sbjct 798 CQVCIKLADINGPAKTRELHLKWTEGIVNEFYEQGDEESSLGLPISPFMDRS--APQLAK 855
Query 189 SQVGFINFVVKPL 201
Q FI +V PL
Sbjct 856 LQESFITHIVGPL 868
> hsa:5139 PDE3A, CGI-PDE; phosphodiesterase 3A, cGMP-inhibited
(EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic phosphodiesterase
[EC:3.1.4.17]
Length=1141
Score = 158 bits (399), Expect = 2e-38, Method: Compositional matrix adjust.
Identities = 86/202 (42%), Positives = 118/202 (58%), Gaps = 5/202 (2%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLSKPQC 70
LE +A+ +A+ HD HPGR N F++A + P A+ YND SVLENHH+A + F+S+P+
Sbjct 824 LELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEY 883
Query 71 NILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIA-SNEEDRTRVI 129
N L ++ R +IE IL+TD+K HFD ++ F K +N + I +NE DR V
Sbjct 884 NFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK-VNDDVGIDWTNENDRLLVC 942
Query 130 SMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSS 189
MC+K AD+ A C E H +W +V EFY+QGDEE LGLP S DRS + +
Sbjct 943 QMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRS--APQLANL 1000
Query 190 QVGFINFVVKPLYEELKSVDEM 211
Q FI+ +V PL S M
Sbjct 1001 QESFISHIVGPLCNSYDSAGLM 1022
> mmu:54611 Pde3a, A930022O17Rik, C87899; phosphodiesterase 3A,
cGMP inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1141
Score = 157 bits (396), Expect = 4e-38, Method: Compositional matrix adjust.
Identities = 85/202 (42%), Positives = 117/202 (57%), Gaps = 5/202 (2%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLSKPQC 70
LE +A+ +A+ HD HPGR N F++A + P A+ YND SVLENHH+A + F+S+P+
Sbjct 824 LELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEY 883
Query 71 NILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIA-SNEEDRTRVI 129
N L ++ R +IE IL+TD+K HFD ++ F K +N + I +NE DR V
Sbjct 884 NFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAK-VNDDVGIDWTNENDRLLVC 942
Query 130 SMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSS 189
MC+K AD+ A C E H W + +EFY+QGDEE LGLP S DRS + +
Sbjct 943 QMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRS--APQLANL 1000
Query 190 QVGFINFVVKPLYEELKSVDEM 211
Q FI+ +V PL S M
Sbjct 1001 QESFISHIVGPLCHSYDSAGLM 1022
> bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodiesterase
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=777
Score = 152 bits (385), Expect = 8e-37, Method: Compositional matrix adjust.
Identities = 86/204 (42%), Positives = 114/204 (55%), Gaps = 9/204 (4%)
Query 7 EFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLS 66
E +S L++ + +A+L HDVGHPGRNN F + + P+A YND SVLEN+H+A R L
Sbjct 521 EHLSILDEALLMVAALSHDVGHPGRNNAFFVRTHHPVAQLYNDTSVLENYHAASALRVLC 580
Query 67 KPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRT 126
P CN+ DC Y +R IIE IL+TD F IS F +F EE +
Sbjct 581 TPGCNLFP---DCDYDYVRSQIIEHILATDTVDQFHMISQFVLSCKRDDFTF---EEYNS 634
Query 127 RVIS--MCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R+++ M +KAAD+ W EW R++ EFY QG EE +P S LCDR HE+
Sbjct 635 RILTSKMLMKAADVAAPTMQWANSLEWVSRLLGEFYAQGAEEVDYCIPISALCDRQHHEQ 694
Query 185 EFVSSQVGFINFVVKPLYEELKSV 208
SQ F+ VV PLYE + S+
Sbjct 695 S-AKSQAAFLRIVVAPLYEAIASL 717
> dre:567051 si:dkey-48h7.2; K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1117
Score = 150 bits (379), Expect = 4e-36, Method: Compositional matrix adjust.
Identities = 84/207 (40%), Positives = 115/207 (55%), Gaps = 5/207 (2%)
Query 8 FMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLS 66
+ LE +A+ +A+ HD HPGR N F++A + P A+ YND SVLENHH+A + F+S
Sbjct 746 LIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAASAWNLFMS 805
Query 67 KPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTK-RINGEFNIA-SNEED 124
+P+ N L ++ R +IE IL+TD+K HFD ++ F K +G I +NE D
Sbjct 806 RPEYNFLASLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKVGDDGCSGIDWTNEND 865
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R V MC+K AD+ C + H +W +V EFY+QGDEE LGLP S DRS
Sbjct 866 RLLVCQMCIKLADINGPLKCKDLHLQWTEGIVNEFYEQGDEESSLGLPISPFMDRS--AP 923
Query 185 EFVSSQVGFINFVVKPLYEELKSVDEM 211
+ Q FI +V PL S M
Sbjct 924 QLAKLQESFITHIVGPLCSSYDSAALM 950
> dre:565259 pde4c, im:7160317, si:dkey-149i17.5; phosphodiesterase
4C, cAMP-specific (phosphodiesterase E1 dunce homolog,
Drosophila)
Length=672
Score = 149 bits (376), Expect = 9e-36, Method: Compositional matrix adjust.
Identities = 76/199 (38%), Positives = 117/199 (58%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A AS HDV HPG +N F+I N+ LA+ YND+SVLENHH A+ F+ L +
Sbjct 400 TDLEILAAMFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN 459
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFR----TKRING-EFNIASNEED 124
C+I + T +++RK +I+ +L+TDM H + ++ + TK++ + N D
Sbjct 460 CDIFQNLTKKQRQSLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSD 519
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 520 RIQVLQNMVHCADLSNPTKPLELYRQWTDRIMVEFFTQGDRERDKGMEISPMCDK--HNA 577
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 578 SIEKSQVGFIDYIVHPLWE 596
> dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent;
K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=625
Score = 149 bits (376), Expect = 9e-36, Method: Compositional matrix adjust.
Identities = 77/208 (37%), Positives = 115/208 (55%), Gaps = 8/208 (3%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
V ++++LE +A+ A+ HD H G NNF I + +AI YND SVLENHH + +R
Sbjct 243 VMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRL 302
Query 65 LSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEED 124
+ + + NIL + +R +R +IE ++STDM HF I R E D
Sbjct 303 MQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGI------D 356
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
+ + +S+ + AAD+ H A W+ H W + ++ EF+ QGD+E LGLP S LCDR
Sbjct 357 KAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRK--AT 414
Query 185 EFVSSQVGFINFVVKPLYEELKSVDEML 212
SQ+GFI+F+V+P + L E +
Sbjct 415 MIAQSQIGFIDFIVEPTFSVLVDTTEKI 442
> hsa:5136 PDE1A, HCAM1, HSPDE1A, MGC26303; phosphodiesterase
1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=535
Score = 149 bits (376), Expect = 1e-35, Method: Compositional matrix adjust.
Identities = 78/206 (37%), Positives = 113/206 (54%), Gaps = 8/206 (3%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
+ ++++LE +A+ A+ HD H G NNF I + +AI YND SVLENHH + +R
Sbjct 240 IMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL 299
Query 65 LSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEED 124
+ + + NIL + +R +R +IE +LSTDM HF I R E D
Sbjct 300 MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE------GID 353
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R + +S+ + AAD+ H A W+ H W ++ EF+ QGD+E LGLP S LCDR
Sbjct 354 RAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRK--ST 411
Query 185 EFVSSQVGFINFVVKPLYEELKSVDE 210
SQ+GFI+F+V+P + L E
Sbjct 412 MVAQSQIGFIDFIVEPTFSLLTDSTE 437
> hsa:5140 PDE3B, HcGIP1, cGIPDE1; phosphodiesterase 3B, cGMP-inhibited
(EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1112
Score = 149 bits (376), Expect = 1e-35, Method: Compositional matrix adjust.
Identities = 82/193 (42%), Positives = 111/193 (57%), Gaps = 5/193 (2%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLSKPQC 70
LE +A+ +A+ HD HPGR N F++A N P A+ YND SVLENHH+A + +LS+P+
Sbjct 809 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEY 868
Query 71 NILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKR--INGEFNIASNEEDRTRV 128
N L ++ R +IE IL+TD+K HFD ++ F K +N SNE DR V
Sbjct 869 NFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLV 928
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+C+K AD+ A + H +W +V EFY+QGDEE LGLP S DRS +
Sbjct 929 CQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRS--SPQLAK 986
Query 189 SQVGFINFVVKPL 201
Q FI +V PL
Sbjct 987 LQESFITHIVGPL 999
> dre:563432 pde3b; phosphodiesterase 3B, cGMP-inhibited; K13296
cGMP-inhibited 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]
Length=1107
Score = 148 bits (373), Expect = 2e-35, Method: Compositional matrix adjust.
Identities = 82/193 (42%), Positives = 111/193 (57%), Gaps = 5/193 (2%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLSKPQC 70
LE +A+ +A+ HD HPGR N F++A N P A+ YND SVLENHH+A + FLS+P+
Sbjct 798 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWSLFLSRPEF 857
Query 71 NILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTK--RINGEFNIASNEEDRTRV 128
N L ++ R +IE IL+TD+K HFD ++ F +K +N +NE DR V
Sbjct 858 NFLCNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSPGIDWTNENDRLLV 917
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+C+K AD+ A H +W +V EFY+QGDEE LGLP S DRS +
Sbjct 918 CQVCIKLADINGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPISPFMDRS--APQLAK 975
Query 189 SQVGFINFVVKPL 201
Q FI +V PL
Sbjct 976 LQESFITHIVGPL 988
> mmu:18573 Pde1a, AI987702, AW125737, MGC116577; phosphodiesterase
1A, calmodulin-dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=545
Score = 148 bits (373), Expect = 2e-35, Method: Compositional matrix adjust.
Identities = 77/206 (37%), Positives = 113/206 (54%), Gaps = 8/206 (3%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
+ ++++LE +A+ A+ HD H G NNF I + +AI YND SVLENHH + +R
Sbjct 240 IMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL 299
Query 65 LSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEED 124
+ + + NIL + +R +R +IE +L+TDM HF I R E D
Sbjct 300 MQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPE------GID 353
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R + +S+ + AAD+ H A W+ H W ++ EF+ QGD+E LGLP S LCDR
Sbjct 354 RAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRK--ST 411
Query 185 EFVSSQVGFINFVVKPLYEELKSVDE 210
SQ+GFI+F+V+P + L E
Sbjct 412 MVAQSQIGFIDFIVEPTFSLLTDSTE 437
> dre:566998 novel protein similar to vertebrate phosphodiesterase
4D, cAMP-specific (phosphodiesterase E3 dunce homolog,
Drosophila) (PDE4D); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=745
Score = 147 bits (372), Expect = 2e-35, Method: Compositional matrix adjust.
Identities = 75/199 (37%), Positives = 116/199 (58%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A AS HDV HPG +N F+I N+ LA+ YND+SVLENHH A+ F+ L +
Sbjct 400 TDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN 459
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T +++RK +I+ +L+TDM H + ++ +T K + + N D
Sbjct 460 CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSD 519
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + + + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 520 RIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFSQGDRERERGMEISPMCDK--HNA 577
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 578 SVEKSQVGFIDYIVHPLWE 596
> mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D,
cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=747
Score = 147 bits (371), Expect = 4e-35, Method: Compositional matrix adjust.
Identities = 75/199 (37%), Positives = 116/199 (58%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A AS HDV HPG +N F+I N+ LA+ YND+SVLENHH A+ F+ L +
Sbjct 427 TDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN 486
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T +++RK +I+ +L+TDM H + ++ +T K + + N D
Sbjct 487 CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSD 546
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + + + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 547 RIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK--HNA 604
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 605 SVEKSQVGFIDYIVHPLWE 623
> tpv:TP01_1200 hypothetical protein
Length=840
Score = 147 bits (370), Expect = 4e-35, Method: Composition-based stats.
Identities = 81/205 (39%), Positives = 114/205 (55%), Gaps = 8/205 (3%)
Query 19 IASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQCNILEKATD 78
I+ LCHD+GHPG N F I + LA +ND SVLEN H LTF L Q N+
Sbjct 642 ISGLCHDIGHPGLTNAFFINSGHQLAHLFNDKSVLENFHCCLTFNVLR--QSNLFSFLDK 699
Query 79 CAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRVISMCVKAADL 138
+ +R+ II+ ILSTD++ HF I+ FR +R + EF++ E + + M +KA+D+
Sbjct 700 EEMKIVRRKIIQLILSTDLEDHFQTITQFRVRRASREFSV---EGEIDTICKMLIKASDI 756
Query 139 GHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVSSQVGFINFVV 198
G + W EW +R+V EFY QG EE LGLP + LCD + H +Q GF+ V
Sbjct 757 GSSCMEWRLTLEWSQRLVQEFYTQGLEELSLGLPITPLCDPNKH-NHLPKAQSGFLAIFV 815
Query 199 KPLYEELKSVDEMLQLSKRQELAHI 223
PLY E+ ++ + + Q HI
Sbjct 816 IPLYTEIANIPQ--HNTSSQPFTHI 838
> hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2,
STRK1; phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17);
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=809
Score = 147 bits (370), Expect = 5e-35, Method: Compositional matrix adjust.
Identities = 75/199 (37%), Positives = 116/199 (58%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A AS HDV HPG +N F+I N+ LA+ YND+SVLENHH A+ F+ L +
Sbjct 488 TDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN 547
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T +++RK +I+ +L+TDM H + ++ +T K + + N D
Sbjct 548 CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSD 607
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + + + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 608 RIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK--HNA 665
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 666 SVEKSQVGFIDYIVHPLWE 684
> cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1);
K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=664
Score = 146 bits (368), Expect = 7e-35, Method: Compositional matrix adjust.
Identities = 78/194 (40%), Positives = 107/194 (55%), Gaps = 12/194 (6%)
Query 9 MSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKP 68
+ DLE +AV +L HD H G NNF I + + A+ YND SVLENHH + FR + +
Sbjct 358 LGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKED 417
Query 69 QCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEE--DRT 126
NIL T Y+ +R +IE +L+TDM HF I ++ + S E D+
Sbjct 418 DKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKS--------MLSLPEGIDKN 469
Query 127 RVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEF 186
+ + + V A D+ H A W HE W V+ EF+ QGD E +GLP S LCDR H
Sbjct 470 KALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDR--HTVHV 527
Query 187 VSSQVGFINFVVKP 200
SQ+GFI+F+V+P
Sbjct 528 ADSQIGFIDFIVEP 541
> mmu:18576 Pde3b, 9830102A01Rik, AI847709; phosphodiesterase
3B, cGMP-inhibited (EC:3.1.4.17); K13296 cGMP-inhibited 3',5'-cyclic
phosphodiesterase [EC:3.1.4.17]
Length=1099
Score = 145 bits (366), Expect = 1e-34, Method: Compositional matrix adjust.
Identities = 81/193 (41%), Positives = 110/193 (56%), Gaps = 5/193 (2%)
Query 12 LEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFR-FLSKPQC 70
LE +A+ +A+ HD HPGR N F++A N P A+ YND SVLENHH+A + +LS+P+
Sbjct 785 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEY 844
Query 71 NILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKR--INGEFNIASNEEDRTRV 128
N L ++ R +IE IL+TD+K HFD ++ F K +N S+E DR V
Sbjct 845 NFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLV 904
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+C+K AD+ A + H W +V EFY+QGDEE LGLP S DRS +
Sbjct 905 CQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRS--SPQLAK 962
Query 189 SQVGFINFVVKPL 201
Q FI +V PL
Sbjct 963 LQESFITHIVGPL 975
> bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodiesterase
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=485
Score = 144 bits (364), Expect = 2e-34, Method: Compositional matrix adjust.
Identities = 84/247 (34%), Positives = 128/247 (51%), Gaps = 21/247 (8%)
Query 1 RLLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSAL 60
+ L + ++++ LE A IA+L HD GHPG+ N F+ + PLA+ YND S+LEN+H++L
Sbjct 228 KALSLEQYLTPLEQFAYLIAALGHDAGHPGKTNAFLRSTQNPLALIYNDASILENYHASL 287
Query 61 TFRFLSKPQCNILEKATDC-------AYRAIRKYIIEWILSTDMKMHFDHISAFRTKRIN 113
C+I+ D + IRK II+ +L+TDM HF H++ + +R++
Sbjct 288 V--------CHIIRAKEDFFGLFNQQDWEIIRKRIIQLVLATDMMTHFTHVNNVKERRLS 339
Query 114 GEFNIASNEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPK 173
G F+ +N ED + + VK AD+GH W +H W + EF+ QGDEE L LP
Sbjct 340 GTFDYVNNPEDLWFCLVLLVKTADIGHNFLPWCEHLPWTNALFDEFHMQGDEERLLSLPL 399
Query 174 SFLCDRSLHEKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAA 233
DR+ + SQ+GF PL +EL ++ + L AN N
Sbjct 400 LLFFDRT-RSADIPDSQLGFFQGFTSPLIDELTFIN-----TNSTYLNDFLNANAHDNLE 453
Query 234 HWQRGQK 240
HW++ K
Sbjct 454 HWKKNSK 460
> tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=450
Score = 144 bits (364), Expect = 2e-34, Method: Compositional matrix adjust.
Identities = 83/243 (34%), Positives = 128/243 (52%), Gaps = 15/243 (6%)
Query 1 RLLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSAL 60
++ + ++ E+ A I+SL HDVGHPG+ NN++ + L++ YNDNS LEN+H +L
Sbjct 187 NIVTTKRRLNPYEEFAFIISSLAHDVGHPGKTNNYLSNTSNVLSLIYNDNSTLENYHCSL 246
Query 61 TFRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIAS 120
F ++ K N + ++RK II+ ILSTDM HF HI + KR+ G+F+I
Sbjct 247 LF-YIIKNNTNFYSIIPKDIWPSLRKRIIQLILSTDMINHFLHIDNVKEKRLQGKFDIK- 304
Query 121 NEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRS 180
N++D ++ +C+KAAD+GH W H W + + EFY QGDEE+ + DR+
Sbjct 305 NDDDFWLLLVLCIKAADIGHNFLPWADHLPWTQVLFEEFYKQGDEEKMQSISPLMFFDRN 364
Query 181 LHEKEFVSSQVGFIN------FVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAH 234
+ Q+ F N + +PL EL DE + I N NA +
Sbjct 365 -ESRNIPILQLQFFNTMTQLLILSQPLLSELNYFDE------NNFINDILSKNSNDNANN 417
Query 235 WQR 237
W++
Sbjct 418 WKK 420
> mmu:18574 Pde1b, 63kDa, Pde1b1; phosphodiesterase 1B, Ca2+-calmodulin
dependent (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=535
Score = 144 bits (362), Expect = 4e-34, Method: Compositional matrix adjust.
Identities = 74/202 (36%), Positives = 110/202 (54%), Gaps = 8/202 (3%)
Query 9 MSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKP 68
+S++E +A+ A+ HD H G N+F I + AI YND SVLENHH + FR +
Sbjct 247 LSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDD 306
Query 69 QCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRV 128
+ NI T + +R +IE +L+TDM HF + +T E D+++
Sbjct 307 EMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLE------RIDKSKA 360
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+S+ + AAD+ H W H W + ++ EF+ QGD+E LGLP S LCDR+
Sbjct 361 LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRT--STLVAQ 418
Query 189 SQVGFINFVVKPLYEELKSVDE 210
SQ+GFI+F+V+P + L V E
Sbjct 419 SQIGFIDFIVEPTFSVLTDVAE 440
> mmu:18578 Pde4b, Dpde4, R74983, dunce; phosphodiesterase 4B,
cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=564
Score = 143 bits (360), Expect = 7e-34, Method: Compositional matrix adjust.
Identities = 75/199 (37%), Positives = 114/199 (57%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 260 TDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEH 319
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T + +RK +I+ +L+TDM H ++ +T K + + N D
Sbjct 320 CDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTD 379
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD+E G+ S +CD+ H
Sbjct 380 RIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK--HTA 437
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 438 SVEKSQVGFIDYIVHPLWE 456
> xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specific;
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=721
Score = 142 bits (358), Expect = 1e-33, Method: Compositional matrix adjust.
Identities = 75/199 (37%), Positives = 114/199 (57%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 418 TDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEH 477
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T +++RK +I+ +L+TDM H ++ +T K + + N D
Sbjct 478 CDIFQNLTKKQRQSLRKMVIDLVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTD 537
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 538 RIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDRERERGMEISPMCDK--HTA 595
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 596 SVEKSQVGFIDYIVHPLWE 614
> hsa:5153 PDE1B, PDE1B1, PDES1B; phosphodiesterase 1B, calmodulin-dependent
(EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=536
Score = 142 bits (358), Expect = 1e-33, Method: Compositional matrix adjust.
Identities = 74/202 (36%), Positives = 109/202 (53%), Gaps = 8/202 (3%)
Query 9 MSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKP 68
+S++E +A+ A+ HD H G N+F I + AI YND SVLENHH + FR +
Sbjct 248 LSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDD 307
Query 69 QCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEEDRTRV 128
+ NI T + +R +IE +L+TDM HF + +T E D+ +
Sbjct 308 EMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLE------RIDKPKA 361
Query 129 ISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEKEFVS 188
+S+ + AAD+ H W H W + ++ EF+ QGD+E LGLP S LCDR+
Sbjct 362 LSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRT--STLVAQ 419
Query 189 SQVGFINFVVKPLYEELKSVDE 210
SQ+GFI+F+V+P + L V E
Sbjct 420 SQIGFIDFIVEPTFSVLTDVAE 441
> dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-255d18.1
Length=709
Score = 141 bits (356), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 72/204 (35%), Positives = 117/204 (57%), Gaps = 7/204 (3%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
+ + +DLE +A AS HDV HPG N F+I N+ LA+ YND SVLENHH A+ F+
Sbjct 381 LEDVFTDLEIMAALFASAIHDVDHPGVTNQFLINTNSELALMYNDASVLENHHLAVGFKL 440
Query 65 LSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFR----TKRINGE-FNIA 119
L + C+I + +++R+ I+ +L+TDM H + ++ + TK++ + +
Sbjct 441 LQEENCDIFCNLSKKQRQSLRQMTIDMVLATDMSKHMNFLADLKTMVETKKVTSQGVLLL 500
Query 120 SNEEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDR 179
N DR +V+ V ADL + E + +W R++ EF+ QGD E G+ S +CD+
Sbjct 501 DNYSDRIQVLQNMVHCADLSNPTKPLELYRKWTDRIMVEFFSQGDRERDKGIDVSPMCDK 560
Query 180 SLHEKEFVSSQVGFINFVVKPLYE 203
H ++QVGFI++++ PL+E
Sbjct 561 --HTASMENTQVGFIDYIIHPLWE 582
> cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=673
Score = 141 bits (356), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 75/204 (36%), Positives = 115/204 (56%), Gaps = 7/204 (3%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
+ E +DLE +A A HDV HPG N ++I +N LAI YND SVLE HH A+ F+
Sbjct 427 LTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKL 486
Query 65 LSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT----KRINGEFNIAS 120
L C+ L + RK +I+ +L+TDM H ++ +T K++ G I
Sbjct 487 LQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVL 546
Query 121 NE-EDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDR 179
++ D+ +V+ + ADL + E +++W +R++ E++ QGD+E+ LGL S +CDR
Sbjct 547 DKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDR 606
Query 180 SLHEKEFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PLYE
Sbjct 607 G--NVTIEKSQVGFIDYIVHPLYE 628
> hsa:5142 PDE4B, DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB;
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17); K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=564
Score = 141 bits (356), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 75/199 (37%), Positives = 113/199 (56%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 260 TDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEH 319
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I T + +RK +I+ +L+TDM H ++ +T K + + N D
Sbjct 320 CDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTD 379
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD+E G+ S +CD+ H
Sbjct 380 RIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK--HTA 437
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 438 SVEKSQVGFIDYIVHPLWE 456
> hsa:5141 PDE4A, DPDE2, PDE4, PDE46; phosphodiesterase 4A, cAMP-specific
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=886
Score = 140 bits (354), Expect = 3e-33, Method: Compositional matrix adjust.
Identities = 74/199 (37%), Positives = 114/199 (57%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 459 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDN 518
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + + +++RK +I+ +L+TDM H ++ +T K + + N D
Sbjct 519 CDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSD 578
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 579 RIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDK--HTA 636
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 637 SVEKSQVGFIDYIVHPLWE 655
> mmu:18585 Pde9a, PDE9A1; phosphodiesterase 9A (EC:3.1.4.35);
K13761 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase
9 [EC:3.1.4.35]
Length=534
Score = 140 bits (354), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 74/207 (35%), Positives = 119/207 (57%), Gaps = 5/207 (2%)
Query 2 LLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALT 61
L ++E S ++ + + A++CHD+ HPG NN + I A T LA+ YND S LENHH A+
Sbjct 269 LCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIA 328
Query 62 FRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASN 121
F+ L++P+CNI +R IR+ +I IL+TDM H + + +F+ K N ++ SN
Sbjct 329 FQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDY---SN 385
Query 122 EEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSL 181
EE T + + +K D+ + E E W ++ E++ Q D E+ GLP + DR
Sbjct 386 EEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK 445
Query 182 HEKEFVSSQVGFINFVVKPLYEELKSV 208
K ++Q+GFI FV+ P++E + +
Sbjct 446 VTK--ATAQIGFIKFVLIPMFETVTKL 470
> hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-specific
(EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=712
Score = 140 bits (354), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 73/199 (36%), Positives = 112/199 (56%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A AS HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L
Sbjct 414 TDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN 473
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFR----TKRING-EFNIASNEED 124
C+I + + ++R+ +I+ +L+TDM H + ++ + TK++ + N D
Sbjct 474 CDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSD 533
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + + +W R++ EF+ QGD E GL S +CD+ H
Sbjct 534 RIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDK--HTA 591
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++ PL+E
Sbjct 592 SVEKSQVGFIDYIAHPLWE 610
> mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=631
Score = 140 bits (353), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 76/209 (36%), Positives = 112/209 (53%), Gaps = 9/209 (4%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
V ++++LE A+ ++ HD H G NNF I + AI YND SVLENHH + +R
Sbjct 249 VANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRL 308
Query 65 LSK-PQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEE 123
L + + NIL + +R R +IE +++TDM HF I A +T E
Sbjct 309 LQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI------ 362
Query 124 DRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHE 183
++ + +S+ + AD+ H A W+ H W ++ EF+ QGD E LGLP S LCDR
Sbjct 363 EKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK--S 420
Query 184 KEFVSSQVGFINFVVKPLYEELKSVDEML 212
SQVGFI+F+V+P + L + E +
Sbjct 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
> mmu:18577 Pde4a, D9Ertd60e, Dpde2; phosphodiesterase 4A, cAMP
specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase
[EC:3.1.4.17]
Length=610
Score = 140 bits (353), Expect = 4e-33, Method: Compositional matrix adjust.
Identities = 74/199 (37%), Positives = 114/199 (57%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 211 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEN 270
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + + +++RK +I+ +L+TDM H ++ +T K + + N D
Sbjct 271 CDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSD 330
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 331 RIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDK--HTA 388
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 389 SVEKSQVGFIDYIVHPLWE 407
> hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-dependent
70kDa (EC:3.1.4.17); K13755 calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]
Length=634
Score = 139 bits (351), Expect = 7e-33, Method: Compositional matrix adjust.
Identities = 76/209 (36%), Positives = 111/209 (53%), Gaps = 9/209 (4%)
Query 5 VREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRF 64
V ++++LE A+ ++ HD H G NNF I + AI YND SVLENHH + +R
Sbjct 249 VANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRL 308
Query 65 LSK-PQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNEE 123
L + NIL + +R R +IE +++TDM HF I A +T E
Sbjct 309 LQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE------AI 362
Query 124 DRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHE 183
++ + +S+ + AD+ H A W+ H W ++ EF+ QGD E LGLP S LCDR
Sbjct 363 EKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK--S 420
Query 184 KEFVSSQVGFINFVVKPLYEELKSVDEML 212
SQVGFI+F+V+P + L + E +
Sbjct 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
> dre:565706 cAMP-specific 3,5-cyclic phosphodiesterase 4B-like;
K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=713
Score = 139 bits (350), Expect = 8e-33, Method: Compositional matrix adjust.
Identities = 74/199 (37%), Positives = 113/199 (56%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 410 TDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDN 469
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T ++R+ +I+ +L+TDM H ++ +T K + + N D
Sbjct 470 CDIFQNLTKKQRTSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTD 529
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD E G+ S +CD+ H
Sbjct 530 RIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFHQGDRERERGMEISPMCDK--HTA 587
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 588 SVEKSQVGFIDYIVHPLWE 606
> pfa:MAL13P1.119 calcium/calmodulin-dependent 3',5'-cyclic nucleotide
phosphodiesterase 1b (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=769
Score = 139 bits (350), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 85/238 (35%), Positives = 128/238 (53%), Gaps = 11/238 (4%)
Query 3 LRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTF 62
L + D E A+ +ASL HD+GH GR N F+ L+I YND S+LEN+H + F
Sbjct 507 LNTANILRDNELGALFVASLGHDIGHFGRTNIFLKNCCNFLSIIYNDKSILENYHCSYLF 566
Query 63 RFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASNE 122
L K + NI + A+R+ IIE IL+TDM H ++ FR K I + I E
Sbjct 567 NILLKDENNIFKNEDPKCLLALRQQIIELILATDMSKHIKILAQFRIKSIKIKSYI---E 623
Query 123 EDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLH 182
++ + M +KAADL H W +H +W +R+V EFY +GDE ++G + L DR+ H
Sbjct 624 KNIILCLKMIIKAADLSHNCVDWSEHYQWVKRLVNEFYYEGDELFQMGYKINPLFDRNCH 683
Query 183 EKEFVSSQVGFINFVVKPLYEELKSVDEMLQLSKRQELAHICVANIEANAAHWQRGQK 240
F+ Q F+ +V PL LK++D S Q++ + N++ N + W + +K
Sbjct 684 N-NFIQIQRTFLKELVYPLIISLKTLDNT---SITQDM----INNVKRNYSKWTKIEK 733
> hsa:5152 PDE9A, FLJ90181, HSPDE9A2; phosphodiesterase 9A (EC:3.1.4.35);
K13761 high affinity cGMP-specific 3',5'-cyclic
phosphodiesterase 9 [EC:3.1.4.35]
Length=533
Score = 139 bits (349), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 74/212 (34%), Positives = 121/212 (57%), Gaps = 5/212 (2%)
Query 2 LLRVREFMSDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALT 61
L ++E S + + + A++CHD+ HPG NN + I A T LA+ YND S LENHH A+
Sbjct 270 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 329
Query 62 FRFLSKPQCNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRTKRINGEFNIASN 121
F+ L++P+CNI ++ IR+ +I IL+TDM H + + +F+ K N ++ SN
Sbjct 330 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDY---SN 386
Query 122 EEDRTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSL 181
EE T + + +K D+ + E E W ++ E++ Q D E+ GLP + DR
Sbjct 387 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK 446
Query 182 HEKEFVSSQVGFINFVVKPLYEELKSVDEMLQ 213
K ++Q+GFI FV+ P++E + + M++
Sbjct 447 VTK--ATAQIGFIKFVLIPMFETVTKLFPMVE 476
> xla:495146 hypothetical LOC495146; K01120 3',5'-cyclic-nucleotide
phosphodiesterase [EC:3.1.4.17]
Length=682
Score = 139 bits (349), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 74/199 (37%), Positives = 113/199 (56%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
+DLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 370 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEN 429
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + + +RK +I+ +L+TDM H ++ +T K + + N D
Sbjct 430 CDIFQNLPKRQRQMMRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTD 489
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + E + +W R++ EF+ QGD+E G+ S +CD+ H
Sbjct 490 RIQVLRNMVHCADLSNPTKPLELYRQWTDRILEEFFRQGDKERERGMEISPMCDK--HTA 547
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 548 SVEKSQVGFIDYIVHPLWE 566
> dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120
3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17]
Length=736
Score = 138 bits (347), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 74/199 (37%), Positives = 114/199 (57%), Gaps = 7/199 (3%)
Query 10 SDLEDIAVGIASLCHDVGHPGRNNNFMIAANTPLAITYNDNSVLENHHSALTFRFLSKPQ 69
SDLE +A A+ HDV HPG +N F+I N+ LA+ YND SVLENHH A+ F+ L +
Sbjct 418 SDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLHEEN 477
Query 70 CNILEKATDCAYRAIRKYIIEWILSTDMKMHFDHISAFRT-----KRINGEFNIASNEED 124
C+I + T +++RK +I+ +L+TDM H ++ +T K + + + D
Sbjct 478 CDIFQNLTKRQRQSLRKLVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLMLDHYND 537
Query 125 RTRVISMCVKAADLGHAATCWEQHEEWCRRVVTEFYDQGDEEERLGLPKSFLCDRSLHEK 184
R +V+ V ADL + + +W R++ EF+ QGD+E G+ S +CD+ H
Sbjct 538 RIQVLRNMVHCADLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEISPMCDK--HTA 595
Query 185 EFVSSQVGFINFVVKPLYE 203
SQVGFI+++V PL+E
Sbjct 596 SVEKSQVGFIDYIVHPLWE 614
Lambda K H
0.322 0.134 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 8572894952
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40