bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_2502_orf1
Length=272
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_054370 adenylate and guanylate cyclase catalytic do... 472 7e-133
pfa:PF11_0395 guanylyl cyclase; K01769 guanylate cyclase, othe... 424 2e-118
bbo:BBOV_I000770 16.m00775; adenylate and guanylate cyclase ca... 343 3e-94
tpv:TP02_0848 guanylyl cyclase 323 4e-88
pfa:MAL13P1.301 gc-betA; guanylyl cyclase (EC:4.6.1.2); K01769... 211 3e-54
cpv:cgd3_1110 P-type ATpase fused to two adenyl cyclase domain... 159 8e-39
hsa:109 ADCY3, AC3, KIAA0511; adenylate cyclase 3 (EC:4.6.1.1)... 112 1e-24
mmu:104111 Adcy3, AC3, mKIAA0511; adenylate cyclase 3 (EC:4.6.... 112 1e-24
dre:557026 adcy1a, si:dkey-162m2.1; adenylate cyclase 1a (EC:4... 111 3e-24
dre:100333979 adenylate cyclase 1a-like 110 5e-24
dre:564719 adcy3, si:ch211-153j24.5; adenylate cyclase 3; K080... 108 2e-23
cel:T01C2.1 acy-4; Adenylyl CYclase family member (acy-4) 107 4e-23
dre:569499 adcy1b; adenylate cyclase 1b (EC:4.6.1.1); K08041 a... 107 4e-23
hsa:107 ADCY1, AC1; adenylate cyclase 1 (brain) (EC:4.6.1.1); ... 107 5e-23
mmu:432530 Adcy1, AC1, D11Bwg1392e, I-AC, KIAA4070, brl, mKIAA... 107 6e-23
cel:T03D8.5 gcy-22; Guanylyl CYclase family member (gcy-22); K... 105 2e-22
cel:T26C12.4 gcy-23; Guanylyl CYclase family member (gcy-23); ... 104 3e-22
dre:568137 atrial natriuretic peptide receptor A-like 104 4e-22
dre:100148976 adcy8, si:ch211-220f13.4; adenylate cyclase 8 (b... 103 6e-22
hsa:114 ADCY8, AC8, ADCY3, HBAC1; adenylate cyclase 8 (brain) ... 103 1e-21
mmu:11514 Adcy8, AC8, AW060868; adenylate cyclase 8 (EC:4.6.1.... 101 3e-21
cel:T01A4.1 gcy-28; Guanylyl CYclase family member (gcy-28); K... 100 5e-21
hsa:111 ADCY5, AC5; adenylate cyclase 5 (EC:4.6.1.1); K08045 a... 100 7e-21
mmu:224129 Adcy5, AW121902, Ac5; adenylate cyclase 5 (EC:4.6.1... 99.8 1e-20
dre:568726 adcy7, ADCY4a; adenylate cyclase 7 (EC:4.6.1.1); K0... 99.8 1e-20
cel:C10F3.3 acy-2; Adenylyl CYclase family member (acy-2) 99.4 1e-20
hsa:112 ADCY6, AC6, DKFZp779F075, KIAA0422; adenylate cyclase ... 98.2 3e-20
dre:570652 adcy6a, adcy6; adenylate cyclase 6a; K08046 adenyla... 98.2 3e-20
dre:100333350 guanylate cyclase 2G-like 97.8 3e-20
cel:F08B1.2 gcy-12; Guanylyl CYclase family member (gcy-12); K... 97.4 5e-20
dre:560807 adcy6b, si:ch211-190a18.1; adenylate cyclase 6b; K0... 97.4 5e-20
dre:796669 si:dkey-37g12.1 97.1 6e-20
dre:562619 adcy5; adenylate cyclase 5 (EC:4.6.1.1); K08045 ade... 97.1 6e-20
mmu:210044 Adcy2, MGC47193, mKIAA1060; adenylate cyclase 2 (EC... 97.1 6e-20
dre:100332957 adenylate cyclase type 5-like 97.1 6e-20
hsa:108 ADCY2, AC2, FLJ16822, FLJ45092, HBAC2, KIAA1060, MGC13... 97.1 7e-20
dre:560719 si:dkey-206f10.1; K08048 adenylate cyclase 8 [EC:4.... 96.7 8e-20
dre:560653 npr1a, sGC, si:dkey-27c15.1; natriuretic peptide re... 95.1 2e-19
dre:560410 adenylate cyclase 8-like; K08048 adenylate cyclase ... 94.7 3e-19
dre:140424 gucy2f, RETGC-1, gc1; guanylate cyclase 2F, retinal... 94.7 3e-19
hsa:113 ADCY7, AC7, FLJ36387, KIAA0037; adenylate cyclase 7 (E... 94.7 3e-19
mmu:230103 Npr2, GC-B, GC-B2, GC-B3, cn, mNPR-B; natriuretic p... 94.7 3e-19
cel:F23H12.6 gcy-13; Guanylyl CYclase family member (gcy-13); ... 94.7 4e-19
dre:140425 gc2, RETGC-2; guanylyl cyclase 2; K12321 guanylate ... 94.4 4e-19
hsa:4882 NPR2, AMDM, ANPRB, ANPb, GUC2B, GUCY2B, NPRB, NPRBi; ... 94.4 4e-19
xla:399350 npr2, addm, guc2b, gucy2b, npr-b, nprb, xgc-2; natr... 94.0 5e-19
cel:F52E1.4 gcy-7; Guanylyl CYclase family member (gcy-7) 94.0 6e-19
dre:557902 adcy2b, si:dkey-266i6.1; adenylate cyclase 2b (brai... 94.0 6e-19
mmu:11512 Adcy6, mKIAA0422; adenylate cyclase 6 (EC:4.6.1.1); ... 93.6 6e-19
cel:ZC412.2 gcy-14; Guanylyl CYclase family member (gcy-14); K... 93.6 7e-19
> tgo:TGME49_054370 adenylate and guanylate cyclase catalytic
domain-containing protein (EC:4.6.1.1 3.6.3.1 1.15.1.1 4.6.1.2
3.1.3.48 2.8.3.8)
Length=4368
Score = 472 bits (1214), Expect = 7e-133, Method: Compositional matrix adjust.
Identities = 217/270 (80%), Positives = 243/270 (90%), Gaps = 0/270 (0%)
Query 3 SFWLVADSVELFFYVVILHHNTGLLFQNCILFDILLLTTCLTFILTAAVSTSNTIGMVVN 62
++WL++D++ELFFY+VILHHNTGLLFQNCIL D+LL+T LTFI+T A T++T+ +
Sbjct 3900 TYWLLSDTIELFFYIVILHHNTGLLFQNCILVDVLLMTMSLTFIITTARETASTVSTIAT 3959
Query 63 FPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLA 122
FPCYVFFNLVSAY KEYIDRLTFYVNEHAKTTE RATQLLNDMLPKQVLEEFQQDKL+LA
Sbjct 3960 FPCYVFFNLVSAYCKEYIDRLTFYVNEHAKTTESRATQLLNDMLPKQVLEEFQQDKLKLA 4019
Query 123 YTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVA 182
Y H+ +TFLFADICGFTSWAK VDACEVVTMLQKLFAKFD+DSTK+ LYKLCTIGDAYVA
Sbjct 4020 YLHENVTFLFADICGFTSWAKGVDACEVVTMLQKLFAKFDKDSTKFGLYKLCTIGDAYVA 4079
Query 183 VSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVI 242
VSEPVT +N+D DP EG LV MA++MI NI EVRERL IP+LNMRIGLHYG+CVGGVI
Sbjct 4080 VSEPVTAENQDTDPREGMWLVYEMAKAMIGNITEVRERLCIPNLNMRIGLHYGSCVGGVI 4139
Query 243 GSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
GSGRLRYDLWGMDVLTGNMMESNG PGK+N
Sbjct 4140 GSGRLRYDLWGMDVLTGNMMESNGVPGKIN 4169
Score = 43.5 bits (101), Expect = 9e-04, Method: Compositional matrix adjust.
Identities = 17/47 (36%), Positives = 32/47 (68%), Gaps = 0/47 (0%)
Query 226 LNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++IG+H G + GV+G+ + +Y L+G V T + M++ GQPG ++
Sbjct 3115 IRVKIGIHSGRVISGVVGAKKPQYALFGDTVNTASRMKTTGQPGYIH 3161
Score = 43.1 bits (100), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 43/182 (23%), Positives = 81/182 (44%), Gaps = 18/182 (9%)
Query 15 FYVVILHHNTGLLFQNCILFDIL-LLTTCLTFILTAAVSTSNTIGMVVNFPCYVFFNLVS 73
F VIL + F ++++IL L+ T F+L + V P ++ ++
Sbjct 2824 FTFVILR----ISFLQAVVWNILFLIVTVARFMLDKKYLP--PLNFVHYIPLFIGIDVFV 2877
Query 74 A---YWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLA------YT 124
A Y EY R +F ++ + + ++LN MLP V+++ +L
Sbjct 2878 AFVGYRLEYNQRKSFLLDYSVDASRRKQREILNTMLPSFVVDQMINSELNEEGIPTSLKA 2937
Query 125 HDRMTF--LFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVA 182
DR T +F D+ F +++ +V +L LF FDR + ++ K+ T+ + Y+A
Sbjct 2938 EDRGTVSVIFCDVYEFQHVVASIEPTRLVEVLDSLFLCFDRSAEQFGCTKIETVFETYLA 2997
Query 183 VS 184
+
Sbjct 2998 AA 2999
> pfa:PF11_0395 guanylyl cyclase; K01769 guanylate cyclase, other
[EC:4.6.1.2]
Length=4226
Score = 424 bits (1090), Expect = 2e-118, Method: Composition-based stats.
Identities = 200/270 (74%), Positives = 227/270 (84%), Gaps = 0/270 (0%)
Query 3 SFWLVADSVELFFYVVILHHNTGLLFQNCILFDILLLTTCLTFILTAAVSTSNTIGMVVN 62
+ W+ D++E FFY+VILHHNTG+LFQ CIL D+L +T LTFI T+ V T T V+
Sbjct 3844 TIWMTNDTIEFFFYLVILHHNTGMLFQTCILVDLLFITMSLTFIATSVVKTITTDSTVLL 3903
Query 63 FPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLA 122
P YV FNL+S Y KE IDR TFY NE AK TE RAT+LLNDMLPK VLEEFQQDKL+LA
Sbjct 3904 IPWYVAFNLISTYCKESIDRRTFYANESAKKTENRATELLNDMLPKHVLEEFQQDKLKLA 3963
Query 123 YTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVA 182
YTHDR+TFLFADICGFTSWA VDA EV+T+LQKLFAKFD DSTKY LYKLCTIGDAYVA
Sbjct 3964 YTHDRLTFLFADICGFTSWANGVDASEVLTLLQKLFAKFDNDSTKYGLYKLCTIGDAYVA 4023
Query 183 VSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVI 242
+SEPVTEDN+DYDPV+GT VL MA SMI I+E+RE+L IP+LNMRIGLHYG+CVGGVI
Sbjct 4024 ISEPVTEDNKDYDPVDGTERVLEMAYSMIRIIKEIREKLYIPNLNMRIGLHYGSCVGGVI 4083
Query 243 GSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
GSGRLRYDLWG+DVLTGN+MESNG PGK+N
Sbjct 4084 GSGRLRYDLWGIDVLTGNLMESNGIPGKIN 4113
Score = 45.8 bits (107), Expect = 2e-04, Method: Composition-based stats.
Identities = 36/140 (25%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query 67 VFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLR------ 120
VF V Y EY R F + +++ + ++LN MLP V++E +L
Sbjct 2944 VFVGFV-GYRLEYNQRKNFLLEYSVESSRRKQREILNTMLPPFVVDEMIYSELNEEGIPI 3002
Query 121 --LAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGD 178
A +T +F DI F + +++ +V +L +LF FD+ + ++ K+ T+ +
Sbjct 3003 SLKAEDISTVTIIFCDIYDFQNIVASIEPTRLVEVLDRLFLCFDKCTEQFNCTKIETVFE 3062
Query 179 AYVAVSEPVTEDNEDYDPVE 198
Y+A V + +D D +E
Sbjct 3063 TYLAACGLVKRE-KDEDELE 3081
Score = 38.1 bits (87), Expect = 0.031, Method: Composition-based stats.
Identities = 15/43 (34%), Positives = 29/43 (67%), Gaps = 0/43 (0%)
Query 226 LNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQP 268
+ +++G+H G + GV+GS + +Y L+G V T + M++ G+P
Sbjct 3233 IRVKVGIHSGRIIAGVVGSKKPQYALFGDTVNTASRMKTTGKP 3275
> bbo:BBOV_I000770 16.m00775; adenylate and guanylate cyclase
catalytic domain containing protein
Length=2446
Score = 343 bits (881), Expect = 3e-94, Method: Compositional matrix adjust.
Identities = 156/271 (57%), Positives = 201/271 (74%), Gaps = 0/271 (0%)
Query 2 ASFWLVADSVELFFYVVILHHNTGLLFQNCILFDILLLTTCLTFILTAAVSTSNTIGMVV 61
A+ WL +D+ + + Y+V++HHN G+LFQ C+L D L + ++FI + + + G
Sbjct 2129 ANIWLPSDNFKFYTYIVVIHHNNGMLFQTCLLVDSLFMVISMSFINFSVAHSIVSAGARF 2188
Query 62 NFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRL 121
PCY+ FNLVSA+ KE IDR TFY NE A+ E R Q+LNDMLPK VLEEF+ DKL++
Sbjct 2189 TIPCYILFNLVSAHCKESIDRATFYSNEKARMIEARVGQMLNDMLPKSVLEEFKHDKLKM 2248
Query 122 AYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYV 181
+Y H++M+FLF+DI GFT WA +VDA +V+T+LQ+LFA+FDR STK+ LYKLCTIGDAYV
Sbjct 2249 SYCHEKMSFLFSDIVGFTLWANSVDAGQVITLLQRLFARFDRSSTKHGLYKLCTIGDAYV 2308
Query 182 AVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGV 241
AVSEP E + + + +L MAQSMI I++VRE +IP LNMRIGLHYG VGGV
Sbjct 2309 AVSEPAIEVPTEQEAIANIDGILQMAQSMIRTIRDVRESFDIPGLNMRIGLHYGHAVGGV 2368
Query 242 IGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
IGSGRLRYDLWGMD+ T N MES+G PGK+N
Sbjct 2369 IGSGRLRYDLWGMDIHTANAMESHGIPGKIN 2399
Score = 70.5 bits (171), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 62/260 (23%), Positives = 113/260 (43%), Gaps = 29/260 (11%)
Query 36 ILLLTTCLTFILTAAVSTSNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTE 95
I L + + F+L A +I ++ F F Y EY R F A
Sbjct 1496 IYALVSNVIFLLAAIGKLGTSIHVLPLFIAINVFVAFVGYRLEYNSRKNFLFEFSANNAR 1555
Query 96 GRATQLLNDMLP-----KQVLEEFQQDKLRLAYT---HDRMTFLFADICGFTSWAKNVDA 147
+ ++LLN MLP K + +D + + + H ++ +F D+C F + V+
Sbjct 1556 KKQSELLNTMLPTFVVTKMINARLNEDGIPIGFEAEEHTLVSVVFCDVCNFQNLVATVEP 1615
Query 148 CEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMA 207
+V +L LF FDR + ++ K+ T+ + Y+A + ++ N P E + MA
Sbjct 1616 TILVELLDSLFLAFDRCAEQFGATKIETVFETYLA-ALGLSRGN-IICPYEAAANSIDMA 1673
Query 208 QSMITNIQEVRERLNIPSLNMR---------------IGLHYGTCVGGVIGSGRLRYDLW 252
+MI EV + S+ R +G++ G + G++G + +Y L+
Sbjct 1674 LAMI----EVARSIRYTSMQERDDGTFAEQDDVAVVKVGINSGKIISGLVGFKKPQYALF 1729
Query 253 GMDVLTGNMMESNGQPGKVN 272
G V T + M++ G+ G ++
Sbjct 1730 GDTVNTASRMKTTGESGYIH 1749
> tpv:TP02_0848 guanylyl cyclase
Length=2664
Score = 323 bits (828), Expect = 4e-88, Method: Compositional matrix adjust.
Identities = 149/271 (54%), Positives = 198/271 (73%), Gaps = 1/271 (0%)
Query 1 DASFWLVADSVELFFYVVILHHNTGLLFQNCILFDILLLTTCLTFILTAAVSTSNTIGMV 60
D + WL +DSVE +FY+++LHH+TG+LFQNC+L D L L +TFI ++ + NT+ +
Sbjct 2333 DYNLWLNSDSVEFYFYLILLHHSTGMLFQNCLLIDSLFLVLSMTFISSSVQNNENTVTAL 2392
Query 61 VNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLR 120
P V FNL+SA+ KE IDR +Y NE A E R Q+L++MLPK +LEEF+ ++L+
Sbjct 2393 FTIPICVLFNLLSAHCKESIDRKKYYTNEKAYMIETRINQILSEMLPKSILEEFKLERLK 2452
Query 121 LAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAY 180
+ Y H+ M+FLF+DI GFT WA++VD EV+ +LQKLFA FDR++T + LYKLCTIGDAY
Sbjct 2453 MCYIHENMSFLFSDIVGFTKWAESVDPSEVIALLQKLFANFDRNTTNFNLYKLCTIGDAY 2512
Query 181 VAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGG 240
VA+SEP DN+D ++ +L MA SMI I E + +IP L MRIGLHYG+C+GG
Sbjct 2513 VAISEPKVIDNKDMR-IQDLENILLMAYSMIHIIDETSKIFSIPDLKMRIGLHYGSCIGG 2571
Query 241 VIGSGRLRYDLWGMDVLTGNMMESNGQPGKV 271
VIGSGRLRYD+WG DV T NM+ESNG PG+V
Sbjct 2572 VIGSGRLRYDVWGTDVYTANMIESNGVPGEV 2602
Score = 67.0 bits (162), Expect = 8e-11, Method: Compositional matrix adjust.
Identities = 61/274 (22%), Positives = 116/274 (42%), Gaps = 53/274 (19%)
Query 50 AVSTSNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQ 109
+++++N + + F +F V Y EY R F + + ++LLN MLPK
Sbjct 1615 SINSTNIHILPLFFGINIFVGFV-GYDLEYKSRSNFIMEFSVLNYRQKQSELLNTMLPKI 1673
Query 110 VLEEFQQDKLRL--------AYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKF 161
V+ + KL A H+ +T +FAD+ F ++ +V +L LF F
Sbjct 1674 VVSKMINAKLNENGIPIGFEAERHENVTVIFADVYNFQELIATIEPHRLVEILDTLFLSF 1733
Query 162 DRDSTKYKLYKLCTIGDAYV--------AVSEPVT---EDNEDYDP-------------- 196
DR S ++ K+ T+ + Y+ + S+ + D D+D
Sbjct 1734 DRCSKEFNAIKIETVSETYLTSMGLNTSSTSQTKSLGMTDGHDHDQSRNKKSGSSLGRRS 1793
Query 197 ------------------VEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCV 238
V+ L M+ +M+ ++ N S+ ++IG++ G +
Sbjct 1794 RRSKDIAIDTAVNKLDAYVQAASSSLDMSIAMLQVATTIKLNTN-ESIGVKIGINSGYVI 1852
Query 239 GGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
G++GS + +Y L+G V T + M+ G+ G+++
Sbjct 1853 SGLVGSKKPQYALFGDTVNTASRMKMTGEVGRIH 1886
> pfa:MAL13P1.301 gc-betA; guanylyl cyclase (EC:4.6.1.2); K01769
guanylate cyclase, other [EC:4.6.1.2]
Length=3179
Score = 211 bits (537), Expect = 3e-54, Method: Composition-based stats.
Identities = 97/206 (47%), Positives = 141/206 (68%), Gaps = 0/206 (0%)
Query 66 YVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTH 125
++ N++ ++ EY+DR+ F V E + L +LP+QVLEE+Q D L+L Y H
Sbjct 2905 FISINILYFWYSEYLDRIQFLVKRKRNRMEKISQDFLTKILPRQVLEEYQNDNLQLTYKH 2964
Query 126 DRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSE 185
+++ FLFADI GFT W+K V EV+ +LQKL +K D+D+ K LYKL TIGDAYVA S+
Sbjct 2965 EKIAFLFADIVGFTKWSKTVSPKEVLKLLQKLISKIDKDTIKLGLYKLFTIGDAYVATSQ 3024
Query 186 PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSG 245
P + ++ + +EG +L +A+ ++ NI ++ + N NMRIGLHYG+CVGG+IGS
Sbjct 3025 PNSSITDESEALEGILNILKLAKLILHNINTIKIQFNKHDFNMRIGLHYGSCVGGIIGSV 3084
Query 246 RLRYDLWGMDVLTGNMMESNGQPGKV 271
R+RYD+WG+DVL N +ESNG PG++
Sbjct 3085 RIRYDMWGLDVLIANKIESNGIPGEI 3110
Score = 50.1 bits (118), Expect = 1e-05, Method: Composition-based stats.
Identities = 50/241 (20%), Positives = 104/241 (43%), Gaps = 28/241 (11%)
Query 60 VVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEF----- 114
+++ + L Y++ + + F K + ++L+ MLP ++E
Sbjct 1469 LISLLSFTLICLSMKYYEIFYLKKKFLFRYKQKVNLAKQIEILHTMLPNFLVEYLLISDP 1528
Query 115 QQDKLRLAYT---HDR--MTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYK 169
+ D + + DR ++ +F DI F + + +V L L+ FD+ +
Sbjct 1529 KNDGIMVGKNISGEDRGIISVIFCDIDDFQNMVSTLQPHVLVETLDNLYLYFDKCIKYFN 1588
Query 170 LYKLCTIGDAYVAVSEPVTEDNEDYDPVE-GTGLVLTMAQSMIT-------NIQEVRERL 221
K+ T+ ++Y+A S + N D + T + +A + ++ + + RE
Sbjct 1589 CIKIETVFESYLAASGLSEKKNNALDKIMYDTKCAIKLAIAQLSAKYYISYKVLDTREHF 1648
Query 222 NIPS----------LNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKV 271
+ S ++++IG+H G + GVIGS + +Y L+G V T + M+S P +
Sbjct 1649 SDNSTSYDKYINKNISLKIGIHTGKAISGVIGSVKPQYALFGDTVNTASRMKSTSLPDHI 1708
Query 272 N 272
+
Sbjct 1709 H 1709
> cpv:cgd3_1110 P-type ATpase fused to two adenyl cyclase domains
and 21 predicted transmembrane regions
Length=3848
Score = 159 bits (403), Expect = 8e-39, Method: Composition-based stats.
Identities = 95/232 (40%), Positives = 139/232 (59%), Gaps = 22/232 (9%)
Query 20 LHHNTGLLFQNCILFDILLLTTCLTFILTAAVSTSNTIGMVVNFPCYVFFNLVSAYWKEY 79
+HHN GLLF+ +LFD+L++ LT I + ++ N G+VV + + N+++AY +E
Sbjct 3424 VHHNAGLLFKYIVLFDLLIMFLILT-IFSVGINV-NLEGIVV-YCVALLVNIIAAYSRER 3480
Query 80 IDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFT 139
R FY A E +A +LL MLP++VL +FQ+DKL+LAY H +TFLF+DICGFT
Sbjct 3481 TGRAIFYGTLVAGNCEKKAEELLVAMLPRKVLVDFQEDKLKLAYIHKNVTFLFSDICGFT 3540
Query 140 SWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEG 199
WA V+A VV ML L+A+FD +K+ L+KL TIGDAYVA+SEP + DP E
Sbjct 3541 QWAMTVEAESVVYMLSSLYAQFDDSLSKFGLFKLFTIGDAYVAMSEP------EIDPYE- 3593
Query 200 TGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDL 251
+S+ + Q+++++ N+ G VGG IGS + + L
Sbjct 3594 -------QKSLNVSSQKIKKKNKDNQANISFG-----TVGGGIGSLGMNFGL 3633
Score = 104 bits (259), Expect = 4e-22, Method: Composition-based stats.
Identities = 44/80 (55%), Positives = 57/80 (71%), Gaps = 0/80 (0%)
Query 192 EDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDL 251
E Y P EG + MA M+ I VRE+L++P L+MRIGLHYG C+GG++GS RLRY++
Sbjct 3694 EGYTPAEGARRSIAMAHDMLEKIAFVREKLSLPELSMRIGLHYGGCIGGIVGSSRLRYEV 3753
Query 252 WGMDVLTGNMMESNGQPGKV 271
WG DV+ GN MES G PG +
Sbjct 3754 WGHDVIIGNRMESCGTPGNI 3773
Score = 41.6 bits (96), Expect = 0.003, Method: Composition-based stats.
Identities = 17/53 (32%), Positives = 34/53 (64%), Gaps = 0/53 (0%)
Query 219 ERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKV 271
+ + + L ++IG+H G + GV+G+ + +Y L+G V T + M+S+ + GK+
Sbjct 2858 QEMALKQLKLKIGIHSGRVISGVVGTNKPQYALFGDTVNTASRMKSSCETGKI 2910
Score = 40.4 bits (93), Expect = 0.007, Method: Composition-based stats.
Identities = 32/131 (24%), Positives = 58/131 (44%), Gaps = 9/131 (6%)
Query 74 AYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEF---QQDKLRLAY--THDR- 127
Y E + R F + H R Q+L+ MLP ++E Q++ R + DR
Sbjct 2633 GYRSELLYRAQFLLETHTNDLRQRQRQILDTMLPSFIVERLLIDQKNNPRFSSENVEDRG 2692
Query 128 -MTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS-- 184
++ LF DI F S + +++++L F D Y K+ T+ + Y+ S
Sbjct 2693 TVSILFCDIYDFHSIVALLQPKKLISLLDCFFLTLDCLIDSYNCTKIETVFETYLVASCL 2752
Query 185 EPVTEDNEDYD 195
+P E + +++
Sbjct 2753 DPYDEASANFE 2763
> hsa:109 ADCY3, AC3, KIAA0511; adenylate cyclase 3 (EC:4.6.1.1);
K08043 adenylate cyclase 3 [EC:4.6.1.1]
Length=1144
Score = 112 bits (281), Expect = 1e-24, Method: Compositional matrix adjust.
Identities = 61/175 (34%), Positives = 98/175 (56%), Gaps = 7/175 (4%)
Query 98 ATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKL 157
A ++L DM + ++ QQ Y H+ ++ LFADI GFT + A E+V +L +L
Sbjct 288 ADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNEL 347
Query 158 FAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEV 217
FA+FD+ + KY ++ +GD Y + + + ED+ + M +M+ I V
Sbjct 348 FARFDKLAAKYHQLRIKILGDCYYCICG-LPDYREDHAVCS-----ILMGLAMVEAISYV 401
Query 218 RERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
RE+ ++MR+G+H GT +GGV+G R +YD+W DV N ME+ G PG+V+
Sbjct 402 REKTKT-GVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVH 455
Score = 62.4 bits (150), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 57/217 (26%), Positives = 98/217 (45%), Gaps = 22/217 (10%)
Query 76 WKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADI 135
WK + V E + E T +L + + + L ++D+ + T+D + +FA +
Sbjct 870 WKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASL 929
Query 136 CGF----TSWAKNVDACEVVTMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVT 188
F T + N E + L ++ + FD D+ K++ + K+ TIG Y+A S VT
Sbjct 930 PNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASG-VT 988
Query 189 ED----------NEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLN---MRIGLHYG 235
D ED E + +A + +++ +N S N +RIG++ G
Sbjct 989 PDVNTNGFASSNKEDKSERERWQHLADLADFALA-MKDTLTNINNQSFNNFMLRIGMNKG 1047
Query 236 TCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ GVIG+ + YD+WG V + MES G G +
Sbjct 1048 GVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQ 1084
> mmu:104111 Adcy3, AC3, mKIAA0511; adenylate cyclase 3 (EC:4.6.1.1);
K08043 adenylate cyclase 3 [EC:4.6.1.1]
Length=1144
Score = 112 bits (281), Expect = 1e-24, Method: Compositional matrix adjust.
Identities = 61/175 (34%), Positives = 98/175 (56%), Gaps = 7/175 (4%)
Query 98 ATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKL 157
A ++L DM + ++ QQ Y H+ ++ LFADI GFT + A E+V +L +L
Sbjct 288 ADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNEL 347
Query 158 FAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEV 217
FA+FD+ + KY ++ +GD Y + + + ED+ + M +M+ I V
Sbjct 348 FARFDKLAAKYHQLRIKILGDCYYCICG-LPDYREDHAVCS-----ILMGLAMVEAISYV 401
Query 218 RERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
RE+ ++MR+G+H GT +GGV+G R +YD+W DV N ME+ G PG+V+
Sbjct 402 REKTKT-GVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVH 455
Score = 60.1 bits (144), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 50/216 (23%), Positives = 95/216 (43%), Gaps = 20/216 (9%)
Query 76 WKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADI 135
WK + V E + E T +L + + + L ++D+ + ++D + +FA +
Sbjct 870 WKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASL 929
Query 136 CGF----TSWAKNVDACEVVTMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVS---- 184
F T + N E + L ++ + FD D+ K++ + K+ TIG Y+A S
Sbjct 930 PNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTP 989
Query 185 --------EPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGT 236
E+ D + + + A +M + + + + + +RIG++ G
Sbjct 990 DVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQ-SFNNFMLRIGMNKGG 1048
Query 237 CVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ GVIG+ + YD+WG V + MES G G +
Sbjct 1049 VLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQ 1084
> dre:557026 adcy1a, si:dkey-162m2.1; adenylate cyclase 1a (EC:4.6.1.1);
K08041 adenylate cyclase 1 [EC:4.6.1.1]
Length=1114
Score = 111 bits (278), Expect = 3e-24, Method: Compositional matrix adjust.
Identities = 68/185 (36%), Positives = 98/185 (52%), Gaps = 16/185 (8%)
Query 97 RATQLLNDMLPKQVLEEFQQDKLRLA---------YTHDRMTFLFADICGFTSWAKNVDA 147
+ +LL +LP+ V E ++D L+ HD ++ LFADI GFTS A A
Sbjct 255 KQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTA 314
Query 148 CEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMA 207
E+V +L +LF KFD +T+ ++ +GD Y VS +T+ D+ + M
Sbjct 315 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSG-LTQPKADH-----AHCCVEMG 368
Query 208 QSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQ 267
MI I V E + LNMR+GLH G + GV+G + +YD+W DV NMME+ G
Sbjct 369 LDMIDTITSVAEATEV-DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGL 427
Query 268 PGKVN 272
PGKV+
Sbjct 428 PGKVH 432
Score = 64.3 bits (155), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 55/193 (28%), Positives = 94/193 (48%), Gaps = 28/193 (14%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAY-THDRMTFLFADICGFTSWAKNVDA----CEVV 151
++L ++LP V + F R L Y ++ ++ LFA I F + +D E +
Sbjct 828 RILFNLLPAHVAQHFLLSNPRNMDLYYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECL 887
Query 152 TMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD D Y+ + K+ TIG Y+A V P EG+ + +++
Sbjct 888 RLLNEIIADFDALMDKECYRDIEKIKTIGSTYMAAVGLV--------PTEGSKVKKSISA 939
Query 209 SMIT------NIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTG 259
+ T + +V + +N S N +R+G++ G V GVIG+ R +YD+WG V
Sbjct 940 HLCTVADYAIEMFDVLDAINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVA 999
Query 260 NMMESNGQPGKVN 272
+ M+S G GK+
Sbjct 1000 SRMDSTGVQGKIQ 1012
> dre:100333979 adenylate cyclase 1a-like
Length=829
Score = 110 bits (275), Expect = 5e-24, Method: Compositional matrix adjust.
Identities = 68/182 (37%), Positives = 97/182 (53%), Gaps = 16/182 (8%)
Query 100 QLLNDMLPKQVLEEFQQDKLRLA---------YTHDRMTFLFADICGFTSWAKNVDACEV 150
+LL +LP+ V E ++D L+ HD ++ LFADI GFTS A A E+
Sbjct 5 RLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQEL 64
Query 151 VTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSM 210
V +L +LF KFD +T+ ++ +GD Y VS +T+ D+ + M M
Sbjct 65 VKLLNELFGKFDELATENHCRRIKILGDCYYCVSG-LTQPKADH-----AHCCVEMGLDM 118
Query 211 ITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGK 270
I I V E + LNMR+GLH G + GV+G + +YD+W DV NMME+ G PGK
Sbjct 119 IDTITSVAEATEV-DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGK 177
Query 271 VN 272
V+
Sbjct 178 VH 179
Score = 64.7 bits (156), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 55/193 (28%), Positives = 94/193 (48%), Gaps = 28/193 (14%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAY-THDRMTFLFADICGFTSWAKNVDA----CEVV 151
++L ++LP V + F R L Y ++ ++ LFA I F + +D E +
Sbjct 543 RILFNLLPAHVAQHFLLSNPRNMDLYYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECL 602
Query 152 TMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD D Y+ + K+ TIG Y+A V P EG+ + +++
Sbjct 603 RLLNEIIADFDALMDKECYRDIEKIKTIGSTYMAAVGLV--------PTEGSKVKKSISA 654
Query 209 SMIT------NIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTG 259
+ T + +V + +N S N +R+G++ G V GVIG+ R +YD+WG V
Sbjct 655 HLCTVADYAIEMFDVLDAINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVA 714
Query 260 NMMESNGQPGKVN 272
+ M+S G GK+
Sbjct 715 SRMDSTGVQGKIQ 727
> dre:564719 adcy3, si:ch211-153j24.5; adenylate cyclase 3; K08043
adenylate cyclase 3 [EC:4.6.1.1]
Length=1071
Score = 108 bits (271), Expect = 2e-23, Method: Compositional matrix adjust.
Identities = 63/195 (32%), Positives = 102/195 (52%), Gaps = 21/195 (10%)
Query 92 KTTEGRATQLLNDMLPKQVLEEFQQDKLRLA--------------YTHDRMTFLFADICG 137
K + +LL +LPK + +E Q + A Y H+ ++ LFADI G
Sbjct 256 KEQSQQQEELLLSILPKHIADEMLQGMKKGANQKTDAQQFNTMYMYRHEDVSILFADIVG 315
Query 138 FTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPV 197
FT + V E+V +L +LFA+FD+ + ++ ++ +GD Y + + + ED+
Sbjct 316 FTQLSSAVTPKELVKVLNELFARFDKLAAQHHQLRIKILGDCYYCIC-GLPDYREDH--- 371
Query 198 EGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVL 257
+ M SM+ I VRE+ ++MR+G+H GT +GGV+G R ++D+W DV
Sbjct 372 --AACSIMMGLSMVEAISYVREKTQT-GVDMRVGVHSGTVLGGVLGQKRWQFDVWSTDVT 428
Query 258 TGNMMESNGQPGKVN 272
N MES G PG+V+
Sbjct 429 VANKMESGGIPGRVH 443
Score = 65.1 bits (157), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 55/199 (27%), Positives = 92/199 (46%), Gaps = 32/199 (16%)
Query 101 LLNDMLPKQVLEEFQQDKLR----LAYTHDRMTFLFADICGFTSW----AKNVDACEVVT 152
L+ +MLP+ V + F K R + ++D + +FA I F+ + + N E +
Sbjct 821 LVTNMLPEHVAKHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGLECLR 880
Query 153 MLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQS 209
+L ++ + FD D T+++ + K+ TIG Y+A S E N + G QS
Sbjct 881 ILNEIISDFDSLLDRTEFRHITKIKTIGSTYMAASGVTPESNTN-----GYADRKIEDQS 935
Query 210 MITNIQEVRE-------------RLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWG 253
++ Q + LN S N +RIGL+ G+ + GVIG+ + +D+WG
Sbjct 936 LLDRWQHFADLADFALAMKVMLGNLNKQSFNNFMLRIGLNKGSVLAGVIGARKPHFDIWG 995
Query 254 MDVLTGNMMESNGQPGKVN 272
V + MES G G +
Sbjct 996 NTVNVASRMESTGVMGNIQ 1014
> cel:T01C2.1 acy-4; Adenylyl CYclase family member (acy-4)
Length=1013
Score = 107 bits (268), Expect = 4e-23, Method: Compositional matrix adjust.
Identities = 80/269 (29%), Positives = 130/269 (48%), Gaps = 51/269 (18%)
Query 25 GLLFQNCILFDILLLTTCLTFILTAAVSTSNTIGMVVNFPCYVFFNLVSAYWKEYIDRLT 84
G+L + FDI+L T + IL N +G +V +P E++ R T
Sbjct 200 GVLMDYNVGFDIIL-TRVMMVILV------NVVGSLVYYP------------TEFVQRKT 240
Query 85 FYVNEHAKTTE-------GRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTF------- 130
F+ + R ++L +LPK + E ++D + TH+ F
Sbjct 241 FHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKD---MQETHEERMFHKIYIRK 297
Query 131 ------LFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAV- 183
LFADICGFT+ A + ++V ML +LFA+FD+ ++ ++ ++ +GD Y V
Sbjct 298 YEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVC 357
Query 184 SEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIG 243
P + N + VE M + MI I+ VRE + + ++NMR+G+H G GV+G
Sbjct 358 GVPEYQKNHAINTVE-------MGRDMIEAIRLVRE-MTLVNVNMRVGIHTGKAHCGVLG 409
Query 244 SGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++D+W DV N MES G G+V+
Sbjct 410 LKKWQFDVWSNDVTLANQMESGGLAGRVH 438
Score = 66.6 bits (161), Expect = 9e-11, Method: Compositional matrix adjust.
Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 25/199 (12%)
Query 92 KTTEGRATQLLNDMLPKQVLEEFQQDKLRLAY----THDRMTFLFADICGFTSW----AK 143
K + +L ++LP V + F +D ++ + D +FA + F +
Sbjct 775 KRKHEQNRSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFDKFYIECDG 834
Query 144 NVDACEVVTMLQKLFAKFDR------DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDP 196
N + E + +L ++ + FD+ D ++K + K+ TI Y+ S + D
Sbjct 835 NNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECGDNSH 894
Query 197 VEGTGLVLTMAQSMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWG 253
VE L A+ ++ + E NI S N +RIG++ G V GVIGS + YD+WG
Sbjct 895 VEAIAL---FARELLVKL----ESTNIHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWG 947
Query 254 MDVLTGNMMESNGQPGKVN 272
V + M+S G G++
Sbjct 948 NSVNVASRMDSGGVAGRIQ 966
> dre:569499 adcy1b; adenylate cyclase 1b (EC:4.6.1.1); K08041
adenylate cyclase 1 [EC:4.6.1.1]
Length=1114
Score = 107 bits (268), Expect = 4e-23, Method: Compositional matrix adjust.
Identities = 67/185 (36%), Positives = 97/185 (52%), Gaps = 16/185 (8%)
Query 97 RATQLLNDMLPKQVLEEFQQDKLRLA---------YTHDRMTFLFADICGFTSWAKNVDA 147
+ +LL +LP+ V E ++D L+ HD ++ LFADI G TS A A
Sbjct 240 KQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGSTSLASQCTA 299
Query 148 CEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMA 207
E+V +L +LF KFD +T+ ++ +GD Y VS +T+ D+ + M
Sbjct 300 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSG-LTQPKTDH-----AHCCVEMG 353
Query 208 QSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQ 267
MI I V E + LNMR+GLH G + GV+G + +YD+W DV NMME+ G
Sbjct 354 LDMIDTITSVAEATEV-DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGL 412
Query 268 PGKVN 272
PGKV+
Sbjct 413 PGKVH 417
Score = 63.5 bits (153), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 54/187 (28%), Positives = 89/187 (47%), Gaps = 16/187 (8%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAY-THDRMTFLFADICGFTSWAKNVDA----CEVV 151
++L ++LP V + F R L Y ++ ++ LFA I F + +D E +
Sbjct 815 RILFNLLPVHVAQHFLLSNPRNMDLYYQSYAQVGVLFASIPNFNDFYIELDGNNMGVECL 874
Query 152 TMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD D YK + K+ TIG Y++ V + T L+
Sbjct 875 RLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGLVPTIGTKAK--KSTATHLSTIA 932
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ +V + +N S N +R+G++ G V GVIG+ R +YD+WG V + M+S
Sbjct 933 DFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDST 992
Query 266 GQPGKVN 272
G PGK+
Sbjct 993 GVPGKIQ 999
> hsa:107 ADCY1, AC1; adenylate cyclase 1 (brain) (EC:4.6.1.1);
K08041 adenylate cyclase 1 [EC:4.6.1.1]
Length=1119
Score = 107 bits (266), Expect = 5e-23, Method: Compositional matrix adjust.
Identities = 66/185 (35%), Positives = 97/185 (52%), Gaps = 16/185 (8%)
Query 97 RATQLLNDMLPKQVLEEFQQDKLRLA---------YTHDRMTFLFADICGFTSWAKNVDA 147
+ +LL +LP+ V E ++D L+ HD ++ LFADI GFT A A
Sbjct 262 KQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTA 321
Query 148 CEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMA 207
E+V +L +LF KFD +T+ ++ +GD Y VS +T+ D+ + M
Sbjct 322 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSG-LTQPKTDH-----AHCCVEMG 375
Query 208 QSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQ 267
MI I V E + LNMR+GLH G + GV+G + +YD+W DV N+ME+ G
Sbjct 376 LDMIDTITSVAEATEV-DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGL 434
Query 268 PGKVN 272
PGKV+
Sbjct 435 PGKVH 439
Score = 60.5 bits (145), Expect = 6e-09, Method: Compositional matrix adjust.
Identities = 53/193 (27%), Positives = 91/193 (47%), Gaps = 28/193 (14%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAY-THDRMTFLFADICGFTSWAKNVDA----CEVV 151
++L ++LP V + F R L Y ++ ++ +FA I F + +D E +
Sbjct 835 RILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECL 894
Query 152 TMLQKLFAKFDRDSTK--YK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD K YK + K+ TIG Y+A P GT +++
Sbjct 895 RLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAV--------GLAPTSGTKAKKSISS 946
Query 209 SMIT------NIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTG 259
+ T + +V + +N S N +R+G++ G V GVIG+ R +YD+WG V
Sbjct 947 HLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVA 1006
Query 260 NMMESNGQPGKVN 272
+ M+S G G++
Sbjct 1007 SRMDSTGVQGRIQ 1019
> mmu:432530 Adcy1, AC1, D11Bwg1392e, I-AC, KIAA4070, brl, mKIAA4070;
adenylate cyclase 1 (EC:4.6.1.1); K08041 adenylate cyclase
1 [EC:4.6.1.1]
Length=1118
Score = 107 bits (266), Expect = 6e-23, Method: Compositional matrix adjust.
Identities = 66/185 (35%), Positives = 97/185 (52%), Gaps = 16/185 (8%)
Query 97 RATQLLNDMLPKQVLEEFQQDKLRLA---------YTHDRMTFLFADICGFTSWAKNVDA 147
+ +LL +LP+ V E ++D L+ HD ++ LFADI GFT A A
Sbjct 261 KQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTA 320
Query 148 CEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMA 207
E+V +L +LF KFD +T+ ++ +GD Y VS +T+ D+ + M
Sbjct 321 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSG-LTQPKTDH-----AHCCVEMG 374
Query 208 QSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQ 267
MI I V E + LNMR+GLH G + GV+G + +YD+W DV N+ME+ G
Sbjct 375 LDMIDTITSVAEATEV-DLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGL 433
Query 268 PGKVN 272
PGKV+
Sbjct 434 PGKVH 438
Score = 62.8 bits (151), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 54/193 (27%), Positives = 92/193 (47%), Gaps = 28/193 (14%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAY-THDRMTFLFADICGFTSWAKNVDA----CEVV 151
++L ++LP V + F R L Y ++ ++ +FA I F + +D E +
Sbjct 834 RILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECL 893
Query 152 TMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD D YK L K+ TIG Y+A P GT +++
Sbjct 894 RLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAV--------GLAPTAGTRAKKSISS 945
Query 209 SMIT------NIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTG 259
+ T ++ +V + +N S N +R+G++ G V GVIG+ R +YD+WG V
Sbjct 946 HLCTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVA 1005
Query 260 NMMESNGQPGKVN 272
+ M+S G G++
Sbjct 1006 SRMDSTGVQGRIQ 1018
> cel:T03D8.5 gcy-22; Guanylyl CYclase family member (gcy-22);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1012
Score = 105 bits (262), Expect = 2e-22, Method: Compositional matrix adjust.
Identities = 70/205 (34%), Positives = 102/205 (49%), Gaps = 7/205 (3%)
Query 69 FNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRM 128
FN++ Y D + + E + + R+ LL MLPKQV E+ + + T D +
Sbjct 762 FNVLEQYASNLEDEVQARMKELTEEKK-RSDVLLYRMLPKQVAEKLKLGQSVEPETFDCV 820
Query 129 TFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSE-PV 187
T F+D+ FT+ A +VV +L L+ FD ++ +YK+ TIGD Y+ VS P
Sbjct 821 TIFFSDVVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPH 880
Query 188 TEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRL 247
NE + L A +ER+NI R+GLH G V GV+G
Sbjct 881 RNGNEHAKEISSMSFSLLKAIKTFRVPHLPKERINI-----RVGLHTGPVVTGVVGMTMP 935
Query 248 RYDLWGMDVLTGNMMESNGQPGKVN 272
RY L+G V T + MESNG+PG+V+
Sbjct 936 RYCLFGDSVNTASRMESNGKPGRVH 960
> cel:T26C12.4 gcy-23; Guanylyl CYclase family member (gcy-23);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1073
Score = 104 bits (260), Expect = 3e-22, Method: Compositional matrix adjust.
Identities = 71/199 (35%), Positives = 102/199 (51%), Gaps = 9/199 (4%)
Query 77 KEYIDRLTFYVNEHAKTTEG---RATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFA 133
++Y + L V E E RA +LL +LPK V E + + A T D T +F+
Sbjct 823 EQYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFS 882
Query 134 DICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSE-PVTEDNE 192
DI GFT+ + EVV+ML +++KFD K+ YK+ TIGDAY+ VS P NE
Sbjct 883 DIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNE 942
Query 193 DYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLW 252
+ T L L ++ E+ R N+ L +R+G+H GT GV+G RY L+
Sbjct 943 HIRNICNTALELM----LLLKTYEIPHRRNV-KLRIRLGIHTGTVAAGVVGLTAPRYCLF 997
Query 253 GMDVLTGNMMESNGQPGKV 271
G V + MES +P K+
Sbjct 998 GDTVNVASRMESTSEPEKI 1016
> dre:568137 atrial natriuretic peptide receptor A-like
Length=584
Score = 104 bits (259), Expect = 4e-22, Method: Compositional matrix adjust.
Identities = 70/218 (32%), Positives = 113/218 (51%), Gaps = 7/218 (3%)
Query 56 TIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQ 115
TI ++ + F ++ + ++Y L E K A LL+ MLPK V ++ +
Sbjct 254 TIACLIYPIVLLSFKQMTEWIQDYAQSLREKT-EDLKRERRLAEDLLHQMLPKSVAKQLR 312
Query 116 QDKLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCT 175
Q+K A +++++T F+DI GFT+ + + +VV ML L+ FD Y +YK+ T
Sbjct 313 QNKHFEAESYEKVTIFFSDIVGFTAISASCTPLQVVEMLNNLYMCFDTRIDSYDVYKVET 372
Query 176 IGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVR-ERLNIPSLNMRIGLHY 234
IGDAY+ VS + E N D E + M+ ++ +++V + L +R G+H
Sbjct 373 IGDAYMVVS-GLPERNGDRHADE----IAKMSLDLVAAVRQVPIPHMPTKRLQLRAGIHT 427
Query 235 GTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
G CV GV+G RY L+G V T + MES P K++
Sbjct 428 GPCVAGVVGYKMPRYCLFGDTVNTASRMESTSLPQKIH 465
> dre:100148976 adcy8, si:ch211-220f13.4; adenylate cyclase 8
(brain) (EC:4.6.1.1); K08048 adenylate cyclase 8 [EC:4.6.1.1]
Length=1225
Score = 103 bits (257), Expect = 6e-22, Method: Compositional matrix adjust.
Identities = 76/261 (29%), Positives = 125/261 (47%), Gaps = 33/261 (12%)
Query 38 LLTTCLTFILT------AAVSTSNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHA 91
LLT+ L L A +ST+ + V+ F C + +Y + R F
Sbjct 271 LLTSALHIALQLLVPPRAQISTNQLLAQVLLFLCINTAGMFISYLSDRAQRQAFLETRRC 330
Query 92 -------KTTEGRATQLLNDMLPK-----------QVLEEFQQDKLRLAYTH--DRMTFL 131
+T R +L+ +LP+ V +E Q + Y H + ++ L
Sbjct 331 IEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDETLQHQFHRIYIHRYENVSIL 390
Query 132 FADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDN 191
FAD+ GFT+ + + A E+V ML +LFA+FDR + ++ ++ +GD Y VS + E
Sbjct 391 FADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVS-GLPEPR 449
Query 192 EDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDL 251
D+ + M SMI I+ VR R ++MRIG+H G+ + GV+G + ++D+
Sbjct 450 PDH-----AHCCVEMGLSMIKTIRYVRSRTK-HDIDMRIGIHSGSVLCGVLGLRKWQFDV 503
Query 252 WGMDVLTGNMMESNGQPGKVN 272
W DV N +ES G PG+++
Sbjct 504 WSWDVDIANKLESGGIPGRIH 524
Score = 75.5 bits (184), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 59/213 (27%), Positives = 100/213 (46%), Gaps = 19/213 (8%)
Query 78 EYIDRLTFYVNEHAKTTEGRATQL-------LNDMLPKQV----LEEFQQDKLRLAYTHD 126
EY RL F AK +L L ++LP V LE+ + ++ + ++D
Sbjct 895 EYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 954
Query 127 RMTFLFADICGFTSWAK----NVDACEVVTMLQKLFAKFDR---DSTKYKLYKLCTIGDA 179
+ +FA I GF + N E + +L ++ A FD + + K+ TIG
Sbjct 955 TVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIKTIGST 1014
Query 180 YVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVG 239
Y+AVS E + D + A ++ +IQE+ + + + +RIG+ +G+ V
Sbjct 1015 YMAVSGLSPEKQQCEDKWGHLCALADFAIALNESIQEINKH-SFNNFQLRIGMAHGSVVA 1073
Query 240 GVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
GVIG+ + +YD+WG V + M+S G GK+
Sbjct 1074 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQ 1106
> hsa:114 ADCY8, AC8, ADCY3, HBAC1; adenylate cyclase 8 (brain)
(EC:4.6.1.1); K08048 adenylate cyclase 8 [EC:4.6.1.1]
Length=1251
Score = 103 bits (256), Expect = 1e-21, Method: Compositional matrix adjust.
Identities = 70/244 (28%), Positives = 118/244 (48%), Gaps = 27/244 (11%)
Query 49 AAVSTSNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHA-------KTTEGRATQL 101
A +S + + V F C + +Y + R F +T R +L
Sbjct 314 AVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERL 373
Query 102 LNDMLPK-----------QVLEEFQQDKLRLAYTH--DRMTFLFADICGFTSWAKNVDAC 148
+ +LP+ V +E Q + Y H + ++ LFAD+ GFT+ + + A
Sbjct 374 VLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQ 433
Query 149 EVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
E+V ML +LFA+FDR + ++ ++ +GD Y VS + E +D+ + M
Sbjct 434 ELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSG-LPEPRQDH-----AHCCVEMGL 487
Query 209 SMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQP 268
SMI I+ VR R ++MRIG+H G+ + GV+G + ++D+W DV N +ES G P
Sbjct 488 SMIKTIRYVRSRTK-HDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIP 546
Query 269 GKVN 272
G+++
Sbjct 547 GRIH 550
Score = 74.3 bits (181), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 19/213 (8%)
Query 78 EYIDRLTFYVNEHAKTTEGRATQL-------LNDMLPKQV----LEEFQQDKLRLAYTHD 126
EY RL F AK +L L ++LP V LE+ + ++ + ++D
Sbjct 920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 979
Query 127 RMTFLFADICGFTSWAK----NVDACEVVTMLQKLFAKFDR---DSTKYKLYKLCTIGDA 179
+ +FA I GF + N E + +L ++ A FD + + K+ TIG
Sbjct 980 AVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGST 1039
Query 180 YVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVG 239
Y+AVS E + D + + ++ +IQE+ + + + +RIG+ +G+ V
Sbjct 1040 YMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH-SFNNFELRIGISHGSVVA 1098
Query 240 GVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
GVIG+ + +YD+WG V + M+S G G++
Sbjct 1099 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQ 1131
> mmu:11514 Adcy8, AC8, AW060868; adenylate cyclase 8 (EC:4.6.1.1);
K08048 adenylate cyclase 8 [EC:4.6.1.1]
Length=1249
Score = 101 bits (251), Expect = 3e-21, Method: Compositional matrix adjust.
Identities = 71/244 (29%), Positives = 117/244 (47%), Gaps = 27/244 (11%)
Query 49 AAVSTSNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHA-------KTTEGRATQL 101
A S + + VV F C + +Y + R F +T R +L
Sbjct 312 AVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERL 371
Query 102 LNDMLPK-----------QVLEEFQQDKLRLAYTH--DRMTFLFADICGFTSWAKNVDAC 148
+ +LP+ V +E Q + Y H + ++ LFAD+ GFT+ + + A
Sbjct 372 VLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQ 431
Query 149 EVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
E+V ML +LFA+FDR + ++ ++ +GD Y VS + E D+ + M
Sbjct 432 ELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSG-LPEPRRDH-----AHCCVEMGL 485
Query 209 SMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQP 268
SMI I+ VR R ++MRIG+H G+ + GV+G + ++D+W DV N +ES G P
Sbjct 486 SMIKTIRFVRSRTK-HDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIP 544
Query 269 GKVN 272
G+++
Sbjct 545 GRIH 548
Score = 74.3 bits (181), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 19/213 (8%)
Query 78 EYIDRLTFYVNEHAKTTEGRATQL-------LNDMLPKQV----LEEFQQDKLRLAYTHD 126
EY RL F AK +L L ++LP V LE+ + ++ + ++D
Sbjct 918 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 977
Query 127 RMTFLFADICGFTSWAK----NVDACEVVTMLQKLFAKFDR---DSTKYKLYKLCTIGDA 179
+ +FA I GF + N E + +L ++ A FD + + K+ TIG
Sbjct 978 AVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGST 1037
Query 180 YVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVG 239
Y+AVS E + D + + ++ +IQE+ + + + +RIG+ +G+ V
Sbjct 1038 YMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH-SFNNFELRIGISHGSVVA 1096
Query 240 GVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
GVIG+ + +YD+WG V + M+S G G++
Sbjct 1097 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQ 1129
> cel:T01A4.1 gcy-28; Guanylyl CYclase family member (gcy-28);
K12323 atrial natriuretic peptide receptor A [EC:4.6.1.2]
Length=1276
Score = 100 bits (249), Expect = 5e-21, Method: Compositional matrix adjust.
Identities = 67/194 (34%), Positives = 105/194 (54%), Gaps = 14/194 (7%)
Query 81 DRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTS 140
+R Y+ E K E LL+ +LP + + + A ++D +T F+DI GFTS
Sbjct 1043 ERTQEYLAEKKKVEE-----LLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTS 1097
Query 141 WAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGT 200
+ +VVT+L L+ FD +K+YK+ TIGDAY+ VS + E +D+
Sbjct 1098 LSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSG-LPERRDDH-----A 1151
Query 201 GLVLTMAQSMITNIQE--VRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLT 258
+ M+ S++ ++ +R R + L +RIG+H G+ V GV+GS RY L+G V T
Sbjct 1152 NQIAQMSLSLLHKVKNFVIRHRPH-EQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNT 1210
Query 259 GNMMESNGQPGKVN 272
+ MESNG P K++
Sbjct 1211 SSRMESNGLPLKIH 1224
> hsa:111 ADCY5, AC5; adenylate cyclase 5 (EC:4.6.1.1); K08045
adenylate cyclase 5 [EC:4.6.1.1]
Length=911
Score = 100 bits (248), Expect = 7e-21, Method: Compositional matrix adjust.
Identities = 71/233 (30%), Positives = 115/233 (49%), Gaps = 26/233 (11%)
Query 52 STSNTIGMVVNFPCYVFFNLVSAYWKEYID-RLTFYVNEHAKTTEGRATQLLNDMLPKQV 110
S +N +G+ ++P V +E I RL H++ + +LL +LP+ V
Sbjct 37 SCTNIVGVCTHYPAEVSQRQAFQETRECIQARL------HSQRENQQQERLLLSVLPRHV 90
Query 111 LEEFQQD-----------KLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFA 159
E + D K+ + HD ++ LFADI GFTS A A E+V L +LFA
Sbjct 91 AMEMKADINAKQEDMMFHKIYIQ-KHDNVSILFADIEGFTSLASQCTAQELVMTLNELFA 149
Query 160 KFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRE 219
+FD+ + + ++ +GD Y VS + E D+ + M MI I VRE
Sbjct 150 RFDKLAAENHCLRIKILGDCYYCVS-GLPEARADH-----AHCCVEMGMDMIEAISLVRE 203
Query 220 RLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 204 VTGV-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIH 255
Score = 69.3 bits (168), Expect = 2e-11, Method: Compositional matrix adjust.
Identities = 53/186 (28%), Positives = 93/186 (50%), Gaps = 17/186 (9%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 688 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 747
Query 152 TMLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGL--VLTM 206
+L ++ A FD + +L K+ TIG Y+A S ++ YD V T + +
Sbjct 748 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAAS---GLNDSTYDKVGKTHIKALADF 804
Query 207 AQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNG 266
A ++ ++ + E + + M+IGL+ G V GVIG+ + +YD+WG V + M+S G
Sbjct 805 AMKLMDQMKYINEH-SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 863
Query 267 QPGKVN 272
P ++
Sbjct 864 VPDRIQ 869
> mmu:224129 Adcy5, AW121902, Ac5; adenylate cyclase 5 (EC:4.6.1.1);
K08045 adenylate cyclase 5 [EC:4.6.1.1]
Length=1262
Score = 99.8 bits (247), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 75/250 (30%), Positives = 122/250 (48%), Gaps = 28/250 (11%)
Query 35 DILLLTTCLTFILTAAVSTSNTIGMVVNFPCYVFFNLVSAYWKEYID-RLTFYVNEHAKT 93
D LL ++ +L S +N +G+ ++P V +E I RL H++
Sbjct 373 DQFLLKQLVSNVLI--FSCTNIVGVCTHYPAEVSQRQAFQETRECIQARL------HSQR 424
Query 94 TEGRATQLLNDMLPKQVLEEFQQD-----------KLRLAYTHDRMTFLFADICGFTSWA 142
+ +LL +LP+ V E + D K+ + HD ++ LFADI GFTS A
Sbjct 425 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQ-KHDNVSILFADIEGFTSLA 483
Query 143 KNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGL 202
A E+V L +LFA+FD+ + + ++ +GD Y VS + E D+
Sbjct 484 SQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG-LPEARADH-----AHC 537
Query 203 VLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMM 262
+ M MI I VRE + ++NMR+G+H G GV+G + ++D+W DV N M
Sbjct 538 CVEMGMDMIEAISLVREVTGV-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 596
Query 263 ESNGQPGKVN 272
E+ G+ G+++
Sbjct 597 EAGGKAGRIH 606
Score = 68.2 bits (165), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 52/186 (27%), Positives = 92/186 (49%), Gaps = 17/186 (9%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 1039 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1098
Query 152 TMLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGL--VLTM 206
+L ++ A FD + +L K+ TIG Y+A S ++ YD T + +
Sbjct 1099 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAAS---GLNDSTYDKAGKTHIKAIADF 1155
Query 207 AQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNG 266
A ++ ++ + E + + M+IGL+ G V GVIG+ + +YD+WG V + M+S G
Sbjct 1156 AMKLMDQMKYINEH-SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 1214
Query 267 QPGKVN 272
P ++
Sbjct 1215 VPDRIQ 1220
> dre:568726 adcy7, ADCY4a; adenylate cyclase 7 (EC:4.6.1.1);
K08047 adenylate cyclase 7 [EC:4.6.1.1]
Length=1043
Score = 99.8 bits (247), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 55/149 (36%), Positives = 85/149 (57%), Gaps = 9/149 (6%)
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
H+ ++ L+ADI GFT A + E+V ML +LF KFD+ + + + ++ +GD Y VS
Sbjct 277 HENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKENECMRIKILGDCYYCVS 336
Query 185 E-PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIG 243
PV+ N + V+ M M I++VRE + +NMR+G+H G + GVIG
Sbjct 337 GLPVSLPNHAKNCVK-------MGLDMCEAIKQVREATGV-DINMRVGVHSGNVLCGVIG 388
Query 244 SGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++D+W DV N MES G PG+V+
Sbjct 389 LRKWQFDVWSHDVTLANHMESGGLPGRVH 417
Score = 72.4 bits (176), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 71/285 (24%), Positives = 126/285 (44%), Gaps = 36/285 (12%)
Query 11 VELFFYVVILHHNTGLLFQ-NCILFDILLLTTCLTFILTAAVSTSNTIGMVVNFPCYVFF 69
V L Y +IL+ L NC+L+ + I + ++F
Sbjct 724 VSLVSYTIILYSQENLFSNYNCLLYT------------NPGLMKHPKIMSCIYITLFLFT 771
Query 70 NLVSAYWKEYIDRLTFYVN-------EHAKTTEGRATQLLNDMLPKQVLEEFQQDKLR-- 120
L+ + EY R F + E + E LL ++LP V F + +
Sbjct 772 MLLISRQNEYCCRQDFLLKNKNLADKEEVELCENLNRLLLENVLPAHVAALFVGENKKNE 831
Query 121 -LAY-THDRMTFLFADICGF----TSWAKNVDACEVVTMLQKLFAKFDRDSTKYK---LY 171
L Y ++D + +FA + F T N + E + +L ++ A FD +K K +
Sbjct 832 DLYYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVE 891
Query 172 KLCTIGDAYVA---VSEPVTEDNEDYDPVEGT-GLVLTMAQSMITNIQEVRERLNIPSLN 227
K+ TIG Y+A +S P + N+D + G ++ A ++I + + R + +
Sbjct 892 KIKTIGSTYMAAAGLSGPPEQSNQDRERQNAQIGNMVEFAIALIGKLDGI-NRHSFNTFR 950
Query 228 MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+R+G+++G + GVIG+ + +YD+WG V + MES G+ GK+
Sbjct 951 LRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQ 995
> cel:C10F3.3 acy-2; Adenylyl CYclase family member (acy-2)
Length=1080
Score = 99.4 bits (246), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 54/149 (36%), Positives = 84/149 (56%), Gaps = 9/149 (6%)
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
HD ++ LFADI FT A + A ++V L +L++KFDRD+ + + ++ +GD Y VS
Sbjct 310 HDNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRDAQRLQCMRIKFLGDCYYCVS 369
Query 185 E-PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIG 243
PV N + + M MI I++VR + +NMRIG+H G+ + G++G
Sbjct 370 GMPVNRPNH-------ADMCVVMGLEMINTIKQVRIATGV-DVNMRIGVHTGSVLCGIMG 421
Query 244 SGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++D+W DV N MES G PG V+
Sbjct 422 LRKWQFDIWSDDVTLANHMESAGVPGAVH 450
Score = 67.4 bits (163), Expect = 6e-11, Method: Compositional matrix adjust.
Identities = 51/204 (25%), Positives = 94/204 (46%), Gaps = 35/204 (17%)
Query 101 LLNDMLPKQVLEEFQQDKLRL----AYTHDRMTFLFADICGF----TSWAKNVDACEVVT 152
L+ ++LP V +F + A H+ + +FA I F + W N E +
Sbjct 817 LIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKDFWSEWDTN-RKLECLR 875
Query 153 MLQKLFAKFDRDSTKYK---LYKLCTIGDAYVAVSEPVTEDNEDYDPV------------ 197
+L ++ +FD+ +K K + K+ T+G Y+A + + E DYD +
Sbjct 876 LLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAG-LNESEADYDDIYLEKQNSGKYNN 934
Query 198 ---------EGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLR 248
L++ A +M + I + R + + +RIG+ G V GVIG+ + +
Sbjct 935 NIRHGNMAFRNANLMIEFALAM-SQILDALNRDSFQNFELRIGMSVGPLVAGVIGAQKPQ 993
Query 249 YDLWGMDVLTGNMMESNGQPGKVN 272
YD+WG V + M+++G+P K++
Sbjct 994 YDIWGNTVNLASRMDTHGEPRKIH 1017
> hsa:112 ADCY6, AC6, DKFZp779F075, KIAA0422; adenylate cyclase
6 (EC:4.6.1.1); K08046 adenylate cyclase 6 [EC:4.6.1.1]
Length=1168
Score = 98.2 bits (243), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 69/229 (30%), Positives = 112/229 (48%), Gaps = 22/229 (9%)
Query 54 SNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEE 113
+N IG+ ++P V + YI H + + +LL +LP+ V E
Sbjct 299 TNVIGICTHYPAEVSQRQAFQETRGYIQ-----ARLHLQHENRQQERLLLSVLPQHVAME 353
Query 114 FQQD----KLRLAY------THDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDR 163
++D K + + HD ++ LFADI GFTS A A E+V L +LFA+FD+
Sbjct 354 MKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDK 413
Query 164 DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNI 223
+ + ++ +GD Y VS + E D+ + M MI I VRE +
Sbjct 414 LAAENHCLRIKILGDCYYCVSG-LPEARADH-----AHCCVEMGVDMIEAISLVREVTGV 467
Query 224 PSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 468 -NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 515
Score = 67.8 bits (164), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 55/187 (29%), Positives = 94/187 (50%), Gaps = 19/187 (10%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 946 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1005
Query 152 TMLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD + +L K+ TIG Y+A S + YD V G + +A
Sbjct 1006 RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAAS---GLNASTYDQV-GRSHITALAD 1061
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ +++++ +N S N M+IGL+ G V GVIG+ + +YD+WG V + M+S
Sbjct 1062 YAMRLMEQMKH-INEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST 1120
Query 266 GQPGKVN 272
G P ++
Sbjct 1121 GVPDRIQ 1127
> dre:570652 adcy6a, adcy6; adenylate cyclase 6a; K08046 adenylate
cyclase 6 [EC:4.6.1.1]
Length=1174
Score = 98.2 bits (243), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 71/230 (30%), Positives = 114/230 (49%), Gaps = 24/230 (10%)
Query 54 SNTIGMVVNFPCYVFFNLVSAYWKEYID-RLTFYVNEHAKTTEGRATQLLNDMLPKQVLE 112
+N IG+ ++P V + YI RL H + + +LL +LP+ V
Sbjct 297 TNIIGICTHYPAEVSQRQAFQETRGYIQARL------HLQRENQQQERLLLSVLPRHVAM 350
Query 113 EFQQD----KLRLAY------THDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFD 162
E + D K + + HD ++ LFADI GFTS A A E+V L +LFA+FD
Sbjct 351 EMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFD 410
Query 163 RDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLN 222
+ +++ ++ +GD Y VS + E D+ + M MI I VRE
Sbjct 411 KLASENHCLRIKILGDCYYCVS-GLPEPRADH-----AHCCVEMGVDMIEAISLVREVTG 464
Query 223 IPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 465 V-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIH 513
Score = 71.2 bits (173), Expect = 3e-12, Method: Compositional matrix adjust.
Identities = 58/187 (31%), Positives = 96/187 (51%), Gaps = 19/187 (10%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 951 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECL 1010
Query 152 TMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD KY+ L K+ TIG Y+A S ++ YD EG + +A
Sbjct 1011 RLLNEIIADFDEIISEEKYRQLEKIKTIGSTYMAAS---GLNDSTYDK-EGRSHITALAD 1066
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ +++E + +N S N M+IGL+ G V GVIG+ + +YD+WG V + M+S
Sbjct 1067 YAM-HLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDST 1125
Query 266 GQPGKVN 272
G P ++
Sbjct 1126 GVPDRIQ 1132
> dre:100333350 guanylate cyclase 2G-like
Length=1060
Score = 97.8 bits (242), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 68/202 (33%), Positives = 109/202 (53%), Gaps = 13/202 (6%)
Query 77 KEYIDRLTFYVNEHAK---TTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFA 133
++Y + L V E + RA +LL+ MLP+ + ++ K +++ +T F+
Sbjct 763 EKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIADQLMAGKSVEPRSYEMVTIFFS 822
Query 134 DICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAY-VAVSEPVTEDNE 192
DI GFT+ A EVVT+L L++ FD Y +YK+ TIGDAY VA P++
Sbjct 823 DIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVYKVETIGDAYMVASGLPISNGTL 882
Query 193 DYDPVEGTGLVLTMAQSMITNIQEVRERLNIPS--LNMRIGLHYGTCVGGVIGSGRLRYD 250
+ + TMA +++I+ + R ++P+ L +RIG++ G V GV+GS RY
Sbjct 883 HAEEIS------TMALHFLSSIKRFKIR-HLPNERLALRIGINSGPVVAGVVGSTMPRYC 935
Query 251 LWGMDVLTGNMMESNGQPGKVN 272
L+G V T + MESN P K++
Sbjct 936 LFGDTVNTASRMESNSLPLKIH 957
> cel:F08B1.2 gcy-12; Guanylyl CYclase family member (gcy-12);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1280
Score = 97.4 bits (241), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 65/186 (34%), Positives = 92/186 (49%), Gaps = 13/186 (6%)
Query 92 KTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDACEVV 151
K + R+ LL MLP V E+ + + +T F+DI GFT+ + EVV
Sbjct 990 KDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVV 1049
Query 152 TMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMI 211
T L KL+ FD +Y +YK+ TIGDAY+ VS Y +E + M M
Sbjct 1050 TFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVS-----GVPQYKTMEYHAEQIAM---MA 1101
Query 212 TNIQEVRERLNIP-----SLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNG 266
+I +IP L +RIG+H G CV GV+G RY L+G V T + MESNG
Sbjct 1102 IHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNG 1161
Query 267 QPGKVN 272
+ +++
Sbjct 1162 EALRIH 1167
> dre:560807 adcy6b, si:ch211-190a18.1; adenylate cyclase 6b;
K08046 adenylate cyclase 6 [EC:4.6.1.1]
Length=1123
Score = 97.4 bits (241), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 69/229 (30%), Positives = 111/229 (48%), Gaps = 22/229 (9%)
Query 54 SNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEE 113
+N IG+ ++P V + YI H + + +LL +LP+ V E
Sbjct 307 TNIIGICTHYPAEVSQRQAFKETRGYIQ-----ARIHLQRENQQQERLLLSVLPRHVAME 361
Query 114 FQQD----KLRLAY------THDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDR 163
+ D K + + HD ++ LFADI GFTS A A E+V L +LFA+FD+
Sbjct 362 MKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDK 421
Query 164 DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNI 223
+ + ++ +GD Y VS + E D+ + M MI I VRE +
Sbjct 422 LAWENHCLRIKILGDCYYCVS-GLPEPRADH-----AHCCVEMGVDMIEAISLVREVTGV 475
Query 224 PSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 476 -NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGKAGRIH 523
Score = 74.3 bits (181), Expect = 5e-13, Method: Compositional matrix adjust.
Identities = 61/187 (32%), Positives = 95/187 (50%), Gaps = 19/187 (10%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGF----TSWAKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F T N + E +
Sbjct 900 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECL 959
Query 152 TMLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD KYK L K+ TIG Y+A S ++ YD EG +L +A
Sbjct 960 RLLNEIIADFDEIISEEKYKQLEKIKTIGSTYMAAS---GLNDSTYDK-EGRTHILALAD 1015
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ ++E + +N S N M+IGL+ G V GVIG+ + +YD+WG V + M+S
Sbjct 1016 YAM-RLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDST 1074
Query 266 GQPGKVN 272
G P ++
Sbjct 1075 GVPDRIQ 1081
> dre:796669 si:dkey-37g12.1
Length=1102
Score = 97.1 bits (240), Expect = 6e-20, Method: Compositional matrix adjust.
Identities = 68/197 (34%), Positives = 103/197 (52%), Gaps = 10/197 (5%)
Query 77 KEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADIC 136
+E + T + E K EG LL MLP+ V + K A T+D +T F+DI
Sbjct 874 EEIVSERTAELQEEKKRAEG----LLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIE 929
Query 137 GFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDP 196
GFT+ + ++ +VV +L L+ FD + +YK+ TIGDAY+ VS + +D+
Sbjct 930 GFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAK 989
Query 197 VEGTGLVLTMAQSMIT-NIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMD 255
E + L + Q + + + V E+ L +RIG+H G CV GV+G RY L+G
Sbjct 990 -EIARMSLAIVQGLRSFHSPHVPEQ----QLRVRIGVHSGPCVAGVVGLKMPRYCLFGDT 1044
Query 256 VLTGNMMESNGQPGKVN 272
V T + MES G P K++
Sbjct 1045 VNTASRMESYGLPLKIH 1061
> dre:562619 adcy5; adenylate cyclase 5 (EC:4.6.1.1); K08045 adenylate
cyclase 5 [EC:4.6.1.1]
Length=1186
Score = 97.1 bits (240), Expect = 6e-20, Method: Compositional matrix adjust.
Identities = 71/233 (30%), Positives = 114/233 (48%), Gaps = 26/233 (11%)
Query 52 STSNTIGMVVNFPCYVFFNLVSAYWKEYID-RLTFYVNEHAKTTEGRATQLLNDMLPKQV 110
S SN +G+ ++P +E I RL H++ + +LL +LP+ V
Sbjct 317 SCSNIVGVCTHYPAEGSQRQAFQETRECIQARL------HSQRENQQQERLLLSVLPRHV 370
Query 111 LEEFQQD-----------KLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFA 159
E + D K+ + HD ++ LFADI GFTS A A E+V L +LFA
Sbjct 371 ALEMKADINAKQEDMMFHKIYIQ-KHDNVSILFADIEGFTSLASQCTAQELVMTLNELFA 429
Query 160 KFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRE 219
+FD+ + + ++ +GD Y VS + E D+ + M MI I VRE
Sbjct 430 RFDKLAAENHCLRIKILGDCYYCVS-GLPEARADH-----AHCCVEMGVDMIEAISLVRE 483
Query 220 RLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 484 VTGV-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIH 535
Score = 66.2 bits (160), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 54/186 (29%), Positives = 93/186 (50%), Gaps = 19/186 (10%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 963 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECL 1022
Query 152 TMLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD + +L K+ TIG Y+A S ++ YD G + +A
Sbjct 1023 RLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAAS---GLNDSTYDKA-GRSHIRALAD 1078
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ + +++ +N S N M+IGL+ G V GVIG+ + +YD+WG V + M+S
Sbjct 1079 YAMRLMDQMK-YINEHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDST 1137
Query 266 GQPGKV 271
G P ++
Sbjct 1138 GVPERI 1143
> mmu:210044 Adcy2, MGC47193, mKIAA1060; adenylate cyclase 2 (EC:4.6.1.1);
K08042 adenylate cyclase 2 [EC:4.6.1.1]
Length=1095
Score = 97.1 bits (240), Expect = 6e-20, Method: Compositional matrix adjust.
Identities = 53/149 (35%), Positives = 84/149 (56%), Gaps = 9/149 (6%)
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
H ++ L+ADI GFT A + E+V ML +LF KFD+ + + + ++ +GD Y VS
Sbjct 290 HTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVS 349
Query 185 E-PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIG 243
P++ N + V+ M M I++VR+ + +NMR+G+H G + GVIG
Sbjct 350 GLPISLPNHAKNCVK-------MGLDMCEAIKKVRDATGV-DINMRVGVHSGNVLCGVIG 401
Query 244 SGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ +YD+W DV N ME+ G PG+V+
Sbjct 402 LQKWQYDVWSHDVTLANHMEAGGVPGRVH 430
Score = 66.2 bits (160), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 57/225 (25%), Positives = 99/225 (44%), Gaps = 24/225 (10%)
Query 71 LVSAYWKEYIDRLTFY-------VNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLR--- 120
LV EY RL F E +T E LL ++LP V E F L+
Sbjct 822 LVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEE 881
Query 121 -LAYTHDRMTFLFADICGFTSWAK----NVDACEVVTMLQKLFAKFDRDSTKYK---LYK 172
++D + +FA I F + N + E + +L ++ A FD +K K + K
Sbjct 882 LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEK 941
Query 173 LCTIGDAYVAVS--EPVTEDNEDYDPVEG---TGLVLTMAQSMITNIQEVRERLNIPSLN 227
+ TIG Y+A + V +P G ++ A +++ + + + +
Sbjct 942 IKTIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKH-SFNDFK 1000
Query 228 MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+R+G+++G + GVIG+ + +YD+WG V + M+S G K+
Sbjct 1001 LRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQ 1045
> dre:100332957 adenylate cyclase type 5-like
Length=1397
Score = 97.1 bits (240), Expect = 6e-20, Method: Compositional matrix adjust.
Identities = 71/233 (30%), Positives = 114/233 (48%), Gaps = 26/233 (11%)
Query 52 STSNTIGMVVNFPCYVFFNLVSAYWKEYID-RLTFYVNEHAKTTEGRATQLLNDMLPKQV 110
S SN +G+ ++P +E I RL H++ + +LL +LP+ V
Sbjct 317 SCSNIVGVCTHYPAEGSQRQAFQETRECIQARL------HSQRENQQQERLLLSVLPRHV 370
Query 111 LEEFQQD-----------KLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFA 159
E + D K+ + HD ++ LFADI GFTS A A E+V L +LFA
Sbjct 371 ALEMKADINAKQEDMMFHKIYIQ-KHDNVSILFADIEGFTSLASQCTAQELVMTLNELFA 429
Query 160 KFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRE 219
+FD+ + + ++ +GD Y VS + E D+ + M MI I VRE
Sbjct 430 RFDKLAAENHCLRIKILGDCYYCVS-GLPEARADH-----AHCCVEMGVDMIEAISLVRE 483
Query 220 RLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 484 VTGV-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIH 535
Score = 65.9 bits (159), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 54/186 (29%), Positives = 93/186 (50%), Gaps = 19/186 (10%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 1174 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECL 1233
Query 152 TMLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD + +L K+ TIG Y+A S ++ YD G + +A
Sbjct 1234 RLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAAS---GLNDSTYDKA-GRSHIRALAD 1289
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ + +++ +N S N M+IGL+ G V GVIG+ + +YD+WG V + M+S
Sbjct 1290 YAMRLMDQMK-YINEHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDST 1348
Query 266 GQPGKV 271
G P ++
Sbjct 1349 GVPERI 1354
Score = 47.8 bits (112), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 21/56 (37%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query 217 VRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
VRE + ++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 765 VREVTGV-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIH 819
> hsa:108 ADCY2, AC2, FLJ16822, FLJ45092, HBAC2, KIAA1060, MGC133314;
adenylate cyclase 2 (brain) (EC:4.6.1.1); K08042 adenylate
cyclase 2 [EC:4.6.1.1]
Length=1091
Score = 97.1 bits (240), Expect = 7e-20, Method: Compositional matrix adjust.
Identities = 53/149 (35%), Positives = 84/149 (56%), Gaps = 9/149 (6%)
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
H ++ L+ADI GFT A + E+V ML +LF KFD+ + + + ++ +GD Y VS
Sbjct 286 HTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVS 345
Query 185 E-PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIG 243
P++ N + V+ M M I++VR+ + +NMR+G+H G + GVIG
Sbjct 346 GLPISLPNHAKNCVK-------MGLDMCEAIKKVRDATGV-DINMRVGVHSGNVLCGVIG 397
Query 244 SGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ +YD+W DV N ME+ G PG+V+
Sbjct 398 LQKWQYDVWSHDVTLANHMEAGGVPGRVH 426
Score = 66.2 bits (160), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 60/225 (26%), Positives = 100/225 (44%), Gaps = 24/225 (10%)
Query 71 LVSAYWKEYIDRLTFY-------VNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLR--- 120
LV EY RL F E +T E LL ++LP V E F L+
Sbjct 818 LVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEE 877
Query 121 -LAYTHDRMTFLFADICGFTSWAK----NVDACEVVTMLQKLFAKFDRDSTKYK---LYK 172
++D + +FA I F + N + E + +L ++ A FD +K K + K
Sbjct 878 LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEK 937
Query 173 LCTIGDAYVAVS--EPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLN--- 227
+ TIG Y+A + V +P + TM + + ++ + +N S N
Sbjct 938 IKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKL-DAINKHSFNDFK 996
Query 228 MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+R+G+++G + GVIG+ + +YD+WG V + M+S G K+
Sbjct 997 LRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQ 1041
> dre:560719 si:dkey-206f10.1; K08048 adenylate cyclase 8 [EC:4.6.1.1]
Length=1199
Score = 96.7 bits (239), Expect = 8e-20, Method: Compositional matrix adjust.
Identities = 56/177 (31%), Positives = 99/177 (55%), Gaps = 11/177 (6%)
Query 98 ATQLLNDMLPKQVLEEFQQDKLRLAYTHD--RMTFLFADICGFTSWAKNVDACEVVTMLQ 155
A ++++DM +E + Y H ++ LFADI GFT + N+ A E+V +L
Sbjct 360 ALEMISDMTSMD--DELDPQQFHKVYIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLN 417
Query 156 KLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQ 215
+LF +FDR + +Y ++ +GD Y VS V E + + M +MI+ ++
Sbjct 418 ELFGRFDRLAEEYDCLRIKILGDCYYCVS-GVPEPQRAH-----ARCCVEMGLAMISTMR 471
Query 216 EVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+R++ N ++MRIG+H G+ + GV+G + ++D+W DV NM+E+ G PG+++
Sbjct 472 SLRKQQNF-DMDMRIGIHTGSVLCGVLGLQKWQFDVWSWDVGIANMLEAGGIPGRIH 527
Score = 77.0 bits (188), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 49/183 (26%), Positives = 94/183 (51%), Gaps = 12/183 (6%)
Query 101 LLNDMLPKQV----LEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVD----ACEVVT 152
LL+++LP V LE + D+ + ++D + +FA I GF + + + E +
Sbjct 918 LLHNILPAHVARHFLERNRNDQELYSQSYDEVGVMFASIAGFNDYYEQKEIKHEGVECLK 977
Query 153 MLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQS 209
+L ++ A FD +S + K+ TIG Y+A S + + D ++ A +
Sbjct 978 LLNEIIADFDELLEESYFLDIEKIKTIGSCYMAASGLSPDKQVNRDDWHHLSELVLFALA 1037
Query 210 MITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPG 269
M ++E+ + ++ + +R+G+ +G V GVIG+ + +YD+WGM V + M+S G G
Sbjct 1038 MQETLREINKH-SMNNFQLRVGIAHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGVSG 1096
Query 270 KVN 272
++
Sbjct 1097 RIQ 1099
> dre:560653 npr1a, sGC, si:dkey-27c15.1; natriuretic peptide
receptor 1a (EC:4.6.1.2); K12323 atrial natriuretic peptide
receptor A [EC:4.6.1.2]
Length=1067
Score = 95.1 bits (235), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 70/207 (33%), Positives = 104/207 (50%), Gaps = 10/207 (4%)
Query 70 NLVSAYWKEYIDRLTFYVNEHAKT---TEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHD 126
NL+S ++Y + L V E + + +A LL +LP V E+ ++ ++ A D
Sbjct 822 NLLSRM-EQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFD 880
Query 127 RMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSE- 185
+T F+DI GFT+ + EVVT+L L+ FD + +YK+ TIGDAY+ VS
Sbjct 881 SVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL 940
Query 186 PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSG 245
PV + L L A +R R N+ L +RIG+H G GV+G
Sbjct 941 PVRNGKLHAREIARMSLALLEAVHSF----RIRHRPNL-QLRLRIGIHSGPVCAGVVGLK 995
Query 246 RLRYDLWGMDVLTGNMMESNGQPGKVN 272
RY L+G V T + MESNG+ K++
Sbjct 996 MPRYCLFGDTVNTASRMESNGEALKIH 1022
> dre:560410 adenylate cyclase 8-like; K08048 adenylate cyclase
8 [EC:4.6.1.1]
Length=1183
Score = 94.7 bits (234), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 58/180 (32%), Positives = 97/180 (53%), Gaps = 20/180 (11%)
Query 96 GRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDACEVVTMLQ 155
G T L +++LP+Q + + + + ++ LFADI GFTS + + A E+V L
Sbjct 360 GDMTALDDELLPQQFHKTY-------FHQYKDVSILFADIKGFTSLSMTMPAQELVRTLN 412
Query 156 KLFAKFDRDSTKYKLYKLCTIGDAYVAVS---EPVTEDNEDYDPVEGTGLVLTMAQSMIT 212
+LF +FDR + + ++ +GD Y VS EP T + M +MI
Sbjct 413 ELFGRFDRLAEENHCMRIKILGDCYYCVSGVPEPQTAHAR---------CCVEMGLAMIN 463
Query 213 NIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
I+ VR+ L ++MRIG+H G+ + GV+G + ++D+W DV NM+E+ G PG+++
Sbjct 464 TIRYVRKELK-RDMDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVDVANMLEAGGIPGRIH 522
Score = 73.2 bits (178), Expect = 9e-13, Method: Compositional matrix adjust.
Identities = 50/183 (27%), Positives = 94/183 (51%), Gaps = 12/183 (6%)
Query 101 LLNDMLPKQV----LEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDA----CEVVT 152
LL ++LP V LE + ++ + +++R+ +FA I GF+ + + + E +
Sbjct 909 LLYNILPAHVARHFLERDRNNEDLFSESYERVGVMFASIPGFSDYYEKKELIHQDVECLR 968
Query 153 MLQKLFAKFDR--DSTKYK-LYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQS 209
+L ++ A FD D ++ + K+ TIG Y+A S E D ++ A +
Sbjct 969 LLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQVSMDEWAHLSTLVLFALA 1028
Query 210 MITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPG 269
M ++E+ +R + +R+G+ +G V GVIG+ + +YD+WGM V + M+S G G
Sbjct 1029 MQETLKEINKRTS-NDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGLSG 1087
Query 270 KVN 272
++
Sbjct 1088 RIQ 1090
> dre:140424 gucy2f, RETGC-1, gc1; guanylate cyclase 2F, retinal
(EC:4.6.1.2); K12321 guanylate cyclase 2D/E/F [EC:4.6.1.2]
Length=1107
Score = 94.7 bits (234), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 61/184 (33%), Positives = 99/184 (53%), Gaps = 4/184 (2%)
Query 89 EHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDAC 148
E + + R +LL++MLP V E + D++T F+DI GFT+ + D
Sbjct 845 EELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVTIYFSDIVGFTTISSLSDPI 904
Query 149 EVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
EVV +L L++ FD + +YK+ TIGDAY+ V+ + + N + E + L +
Sbjct 905 EVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYM-VASGLPKKNGNKHAAEIANMSLNILS 963
Query 209 SMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQP 268
S+ + ++R +P + +RIG+H G CV GV+G RY L+G V T + MES G P
Sbjct 964 SVGSF--KMRHMPEVP-VRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLP 1020
Query 269 GKVN 272
+++
Sbjct 1021 YRIH 1024
> hsa:113 ADCY7, AC7, FLJ36387, KIAA0037; adenylate cyclase 7
(EC:4.6.1.1); K08047 adenylate cyclase 7 [EC:4.6.1.1]
Length=1080
Score = 94.7 bits (234), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 9/149 (6%)
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
H ++ L+ADI GFT A + E+V +L +LF KFD+ + + ++ +GD Y VS
Sbjct 275 HQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVS 334
Query 185 E-PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIG 243
PV+ + V+ M M I++VRE + +NMR+G+H G + GVIG
Sbjct 335 GLPVSLPTHARNCVK-------MGLDMCQAIKQVREATGV-DINMRVGIHSGNVLCGVIG 386
Query 244 SGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ +YD+W DV N ME+ G PG+V+
Sbjct 387 LRKWQYDVWSHDVSLANRMEAAGVPGRVH 415
Score = 72.4 bits (176), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 54/194 (27%), Positives = 97/194 (50%), Gaps = 15/194 (7%)
Query 93 TTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTH---DRMTFLFADICGF----TSWAKNV 145
T E LL ++LP V F DKL + H D + +FA + F T N
Sbjct 840 TMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNK 899
Query 146 DACEVVTMLQKLFAKFDRDSTKYK---LYKLCTIGDAYVA---VSEPVTEDNEDYDPVEG 199
+ E + +L ++ A FD K K + K+ TIG Y+A +S +N++ +
Sbjct 900 EGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHA 959
Query 200 -TGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLT 258
G+++ + ++++ + + R + S +R+G+++G + GVIG+ + +YD+WG V
Sbjct 960 HIGVMVEFSIALMSKLDGI-NRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNV 1018
Query 259 GNMMESNGQPGKVN 272
+ MES G+ GK+
Sbjct 1019 ASRMESTGELGKIQ 1032
> mmu:230103 Npr2, GC-B, GC-B2, GC-B3, cn, mNPR-B; natriuretic
peptide receptor 2 (EC:4.6.1.2); K12324 atrial natriuretic
peptide receptor B [EC:4.6.1.2]
Length=1047
Score = 94.7 bits (234), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 65/201 (32%), Positives = 103/201 (51%), Gaps = 11/201 (5%)
Query 77 KEYIDRLTFYVNEHAKT---TEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFA 133
++Y + L V E + + +A LL +LP V E+ ++ + A D +T F+
Sbjct 806 EQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 865
Query 134 DICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNED 193
DI GFT+ + +VVT+L L+ FD + +YK+ TIGDAY+ VS + +
Sbjct 866 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQR 925
Query 194 YDPVEGTGLVLTMAQSMITNIQEVRERLNIP--SLNMRIGLHYGTCVGGVIGSGRLRYDL 251
+ P + MA +++ + R R + P L +RIG+H G GV+G RY L
Sbjct 926 HAPE-----IARMALALLDAVSSFRIR-HRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCL 979
Query 252 WGMDVLTGNMMESNGQPGKVN 272
+G V T + MESNGQ K++
Sbjct 980 FGDTVNTASRMESNGQALKIH 1000
> cel:F23H12.6 gcy-13; Guanylyl CYclase family member (gcy-13);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1035
Score = 94.7 bits (234), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 65/199 (32%), Positives = 97/199 (48%), Gaps = 11/199 (5%)
Query 72 VSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFL 131
S+ E +R+ V E K+ LL MLP+QV E + + + +T
Sbjct 799 ASSLEDEVQERMKELVEEKKKSD-----ILLYRMLPQQVAERLKLGQSVEPEAFESVTIF 853
Query 132 FADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDN 191
F+D+ GFT A +VV +L L+ FD K YK+ TIGDAY+ VS +
Sbjct 854 FSDVVGFTVLANKSTPLQVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNG 913
Query 192 EDYDPVEGTGLVLTMAQSMITNIQEVR-ERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYD 250
E + M+ ++ ++Q + L + +RIG+H G+CV GV+G RY
Sbjct 914 -----TEHVANIANMSLELMDSLQAFKIPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYC 968
Query 251 LWGMDVLTGNMMESNGQPG 269
L+G V T + MESNG+PG
Sbjct 969 LFGDTVNTASRMESNGKPG 987
> dre:140425 gc2, RETGC-2; guanylyl cyclase 2; K12321 guanylate
cyclase 2D/E/F [EC:4.6.1.2]
Length=1107
Score = 94.4 bits (233), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 62/187 (33%), Positives = 94/187 (50%), Gaps = 10/187 (5%)
Query 89 EHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFADICGFTSWAKNVDAC 148
E + + + +LL MLP V E + + ++ F+DI GFT+ + N +
Sbjct 844 EELEIEKQKTEKLLTQMLPPSVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANSEPI 903
Query 149 EVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAY-VAVSEPVTEDNEDYDPVEGTGLVLTMA 207
EVV +L L+ FD + +YK+ TIGDAY VA PV N + MA
Sbjct 904 EVVDLLNDLYTTFDAVIGNHDVYKVETIGDAYMVASGVPVPNGNRH------AAEIANMA 957
Query 208 QSMITNIQEVRER--LNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+++ + R R ++P + +RIGLH G CV GV+G RY L+G V T + MES
Sbjct 958 LDILSAVGTFRMRHMPDVP-VRIRIGLHTGPCVAGVVGLTMPRYCLFGDTVTTASRMEST 1016
Query 266 GQPGKVN 272
G P +++
Sbjct 1017 GLPYRIH 1023
> hsa:4882 NPR2, AMDM, ANPRB, ANPb, GUC2B, GUCY2B, NPRB, NPRBi;
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic
peptide receptor B) (EC:4.6.1.2); K12324 atrial natriuretic
peptide receptor B [EC:4.6.1.2]
Length=1047
Score = 94.4 bits (233), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 65/201 (32%), Positives = 103/201 (51%), Gaps = 11/201 (5%)
Query 77 KEYIDRLTFYVNEHAKT---TEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRMTFLFA 133
++Y + L V E + + +A LL +LP V E+ ++ + A D +T F+
Sbjct 806 EQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 865
Query 134 DICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEPVTEDNED 193
DI GFT+ + +VVT+L L+ FD + +YK+ TIGDAY+ VS + +
Sbjct 866 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQR 925
Query 194 YDPVEGTGLVLTMAQSMITNIQEVRERLNIP--SLNMRIGLHYGTCVGGVIGSGRLRYDL 251
+ P + MA +++ + R R + P L +RIG+H G GV+G RY L
Sbjct 926 HAPE-----IARMALALLDAVSSFRIR-HRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCL 979
Query 252 WGMDVLTGNMMESNGQPGKVN 272
+G V T + MESNGQ K++
Sbjct 980 FGDTVNTASRMESNGQALKIH 1000
> xla:399350 npr2, addm, guc2b, gucy2b, npr-b, nprb, xgc-2; natriuretic
peptide receptor B/guanylate cyclase B (atrionatriuretic
peptide receptor B); K12324 atrial natriuretic peptide
receptor B [EC:4.6.1.2]
Length=1082
Score = 94.0 bits (232), Expect = 5e-19, Method: Compositional matrix adjust.
Identities = 66/208 (31%), Positives = 109/208 (52%), Gaps = 12/208 (5%)
Query 70 NLVSAYWKEYIDRLTFYVNEHAKT---TEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHD 126
NL+S ++Y + L V E + + +A LL +LP V E+ ++ + A D
Sbjct 836 NLLSRM-EQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFD 894
Query 127 RMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSEP 186
+T F+DI GFTS + +VVT+L L+ FD + +YK+ TIGDAY+ VS
Sbjct 895 SVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL 954
Query 187 VTEDNEDYDPVEGTGLVLTMAQSMITNIQ--EVRERLNIPSLNMRIGLHYGTCVGGVIGS 244
+ + + T + M+ +++ ++ ++R R N L +RIG+H G GV+G
Sbjct 955 PVRNGKLH-----TREIARMSLALLETVKTFKIRHRPNT-QLRLRIGIHTGPVCAGVVGL 1008
Query 245 GRLRYDLWGMDVLTGNMMESNGQPGKVN 272
RY L+G V T + MESNG+ +++
Sbjct 1009 KMPRYCLFGDTVNTASRMESNGEALRIH 1036
> cel:F52E1.4 gcy-7; Guanylyl CYclase family member (gcy-7)
Length=1111
Score = 94.0 bits (232), Expect = 6e-19, Method: Compositional matrix adjust.
Identities = 63/206 (30%), Positives = 109/206 (52%), Gaps = 9/206 (4%)
Query 69 FNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYTHDRM 128
FN++ +Y + ++ E + + ++ LL MLPK V ++ + + T +++
Sbjct 837 FNMLESYASSLEEEVSERTKELVEEKK-KSDVLLYRMLPKTVADKLKLGQTVEPETFEQV 895
Query 129 TFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVSE-PV 187
T F+D+ FT+ A +VV +L L+ FD K+ +YK+ TIGD Y+ VS P
Sbjct 896 TIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLPH 955
Query 188 TEDNEDYDPVEGTGLVLTMAQSMITNIQEVR-ERLNIPSLNMRIGLHYGTCVGGVIGSGR 246
NE + M+ + ++++Q R L +N+RIG++ G+ V GV+G
Sbjct 956 RNGNEHVRQIA------LMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTM 1009
Query 247 LRYDLWGMDVLTGNMMESNGQPGKVN 272
R+ L+G V T + MESNG+PGK++
Sbjct 1010 PRFCLFGDAVNTASRMESNGKPGKIH 1035
> dre:557902 adcy2b, si:dkey-266i6.1; adenylate cyclase 2b (brain)
(EC:4.6.1.1); K08042 adenylate cyclase 2 [EC:4.6.1.1]
Length=1139
Score = 94.0 bits (232), Expect = 6e-19, Method: Compositional matrix adjust.
Identities = 52/151 (34%), Positives = 82/151 (54%), Gaps = 13/151 (8%)
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
H ++ L+ADI GFT A + E+V ML +LF KFD+ + ++ +GD Y VS
Sbjct 333 HTNVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVS 392
Query 185 ---EPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERLNIPSLNMRIGLHYGTCVGGV 241
+P+ + ++ + M M I++VRE + +NMR+G+H G + GV
Sbjct 393 GLPDPLLDHAKN---------CVKMGLDMCEAIEKVREATGV-DINMRVGVHSGNVLCGV 442
Query 242 IGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
IG + +YD+W DV N ME+ G PG+V+
Sbjct 443 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVH 473
Score = 70.5 bits (171), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 67/234 (28%), Positives = 108/234 (46%), Gaps = 30/234 (12%)
Query 66 YVFFN--LVSAYWKEYIDRLTFYVN-------EHAKTTEGRATQLLNDMLPKQVLEEF-- 114
++FF LV A EY RL F E +T E LL ++LP V E F
Sbjct 859 FIFFVTLLVLARQNEYYCRLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLG 918
Query 115 ----QQDKLRLAYTHDRMTFLFADICGF----TSWAKNVDACEVVTMLQKLFAKFDRDST 166
+D +Y D + +FA I F T N + E + +L ++ A FD +
Sbjct 919 RNWKNEDLYHQSY--DTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLS 976
Query 167 KYK---LYKLCTIGDAYVAVS----EPVTEDNEDYD-PVEGTGLVLTMAQSMITNIQEVR 218
K K + K+ TIG Y+A + P E + +D G ++ A +++ + +V
Sbjct 977 KPKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKL-DVI 1035
Query 219 ERLNIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ + MR+G+++G + GVIG+ + +YD+WG V + MES G GK+
Sbjct 1036 NKHSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQ 1089
> mmu:11512 Adcy6, mKIAA0422; adenylate cyclase 6 (EC:4.6.1.1);
K08046 adenylate cyclase 6 [EC:4.6.1.1]
Length=1168
Score = 93.6 bits (231), Expect = 6e-19, Method: Compositional matrix adjust.
Identities = 69/231 (29%), Positives = 112/231 (48%), Gaps = 24/231 (10%)
Query 54 SNTIGMVVNFPCYVFFNLVSAYWKEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEE 113
+N IG+ ++P V + YI H + + +LL +LP+ V E
Sbjct 297 TNAIGVCTHYPAEVSQRQAFQETRGYIQ-----ARLHLQHENRQQERLLLSVLPQHVAME 351
Query 114 FQQD----KLRLAY------THDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDR 163
++D K + + HD ++ LFADI GFTS A A E+V L +LFA+FD+
Sbjct 352 MKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDK 411
Query 164 DST--KYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVRERL 221
+ + ++ +GD Y VS + E D+ + M MI I VRE
Sbjct 412 LAAVRENHCLRIKILGDCYYCVSG-LPEARADH-----AHCCVEMGVDMIEAISLVREVT 465
Query 222 NIPSLNMRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
+ ++NMR+G+H G GV+G + ++D+W DV N ME+ G+ G+++
Sbjct 466 GV-NVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 515
Score = 68.2 bits (165), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 55/187 (29%), Positives = 94/187 (50%), Gaps = 19/187 (10%)
Query 100 QLLNDMLPKQVLEEFQQDKLR---LAYTH-DRMTFLFADICGFTSW----AKNVDACEVV 151
+LL+++LPK V F + R L Y + + +FA I F+ + N + E +
Sbjct 946 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1005
Query 152 TMLQKLFAKFDR---DSTKYKLYKLCTIGDAYVAVSEPVTEDNEDYDPVEGTGLVLTMAQ 208
+L ++ A FD + +L K+ TIG Y+A S + YD V G + +A
Sbjct 1006 RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAAS---GLNASTYDQV-GRSHITALAD 1061
Query 209 SMITNIQEVRERLNIPSLN---MRIGLHYGTCVGGVIGSGRLRYDLWGMDVLTGNMMESN 265
+ +++++ +N S N M+IGL+ G V GVIG+ + +YD+WG V + M+S
Sbjct 1062 YAMRLMEQMKH-INEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST 1120
Query 266 GQPGKVN 272
G P ++
Sbjct 1121 GVPDRIQ 1127
> cel:ZC412.2 gcy-14; Guanylyl CYclase family member (gcy-14);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1170
Score = 93.6 bits (231), Expect = 7e-19, Method: Compositional matrix adjust.
Identities = 68/210 (32%), Positives = 108/210 (51%), Gaps = 17/210 (8%)
Query 69 FNLVSAYW----KEYIDRLTFYVNEHAKTTEGRATQLLNDMLPKQVLEEFQQDKLRLAYT 124
FN++ Y +E DR V E K+ LL MLPK V ++ + + T
Sbjct 875 FNMLETYASTLEEEVSDRTKELVEEKKKSD-----VLLYRMLPKMVADKLKLGQTVEPET 929
Query 125 HDRMTFLFADICGFTSWAKNVDACEVVTMLQKLFAKFDRDSTKYKLYKLCTIGDAYVAVS 184
+++T F+D+ FT+ A +VVT+L L+ FD + +YK+ TIGD Y+ VS
Sbjct 930 FEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVS 989
Query 185 E-PVTEDNEDYDPVEGTGLVLTMAQSMITNIQEVR-ERLNIPSLNMRIGLHYGTCVGGVI 242
P NE + M+ +++++ R + L +N+RIG++ G+ V GV+
Sbjct 990 GLPHRNGNEHIRHIA------RMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVV 1043
Query 243 GSGRLRYDLWGMDVLTGNMMESNGQPGKVN 272
G RY L+G V T + MESNG+PGK++
Sbjct 1044 GLTMPRYCLFGDAVNTASRMESNGKPGKIH 1073
Lambda K H
0.324 0.139 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 10273785452
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40