bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_1415_orf5
Length=366
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_042070 cAMP-dependent protein kinase regulatory sub... 426 1e-118
pfa:PFL1110c PKAr; CAMP-dependent protein kinase regulatory su... 325 2e-88
cpv:cgd7_120 cAMP-dependent protein kinase regulatory subunit ... 307 3e-83
bbo:BBOV_II005430 18.m06452; cAMP-dependent protein kinase reg... 285 3e-76
tgo:TGME49_111300 cAMP-dependent protein kinase regulatory sub... 269 1e-71
tpv:TP02_0494 cAMP-dependent protein kinase regulatory subunit... 224 3e-58
mmu:19087 Prkar2a, 1110061A24Rik, AI317181, AI836829, RII(alph... 220 9e-57
sce:YIL033C BCY1, SRA1; Bcy1p; K04739 cAMP-dependent protein k... 218 3e-56
hsa:5576 PRKAR2A, MGC3606, PKR2, PRKAR2; protein kinase, cAMP-... 213 1e-54
hsa:5575 PRKAR1B, PRKAR1; protein kinase, cAMP-dependent, regu... 203 7e-52
mmu:19085 Prkar1b, AI385716, RIbeta; protein kinase, cAMP depe... 203 8e-52
dre:556042 prkar2aa, MGC153742, wu:fb55f12, wu:fj29e12, wu:fj3... 202 1e-51
mmu:19084 Prkar1a, 1300018C22Rik, RIalpha, Tse-1, Tse1; protei... 201 4e-51
hsa:5573 PRKAR1A, CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR... 201 4e-51
dre:767685 prkar1b, MGC153624, zgc:153624; protein kinase, cAM... 199 1e-50
cel:R07E4.6 kin-2; protein KINase family member (kin-2); K0473... 199 2e-50
dre:494533 prkar1aa, im:7047729, prkar1a, zgc:92515; protein k... 198 2e-50
dre:100329979 protein kinase, cAMP-dependent, regulatory, type... 198 2e-50
hsa:5577 PRKAR2B, PRKAR2, RII-BETA; protein kinase, cAMP-depen... 197 4e-50
dre:100331387 cAMP-dependent protein kinase, regulatory subuni... 196 2e-49
xla:432155 prkar1a, pkr1; protein kinase, cAMP-dependent, regu... 195 2e-49
mmu:19088 Prkar2b, AI451071, AW061005, Pkarb2, RII(beta); prot... 195 2e-49
xla:444805 prkar1b, MGC82149, prkar1; protein kinase, cAMP-dep... 194 6e-49
dre:405894 prkar2ab, MGC85886, prkar2a, zgc:85886; protein kin... 192 2e-48
xla:414594 prkar2b, MGC83177; protein kinase, cAMP-dependent, ... 192 2e-48
dre:550427 prkar1ab, zgc:112145; protein kinase, cAMP-dependen... 190 7e-48
dre:100329437 protein kinase, cAMP-dependent, regulatory, type... 169 2e-41
tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:... 149 2e-35
xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent, ty... 145 3e-34
pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12... 140 9e-33
dre:326020 fd58b04, wu:fd58b04; si:dkey-121j17.5 138 3e-32
dre:100125912 prkg2; protein kinase, cGMP-dependent, type II (... 137 7e-32
mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b; p... 137 8e-32
hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK, P... 136 1e-31
dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,... 135 2e-31
hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,... 134 4e-31
cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);... 134 7e-31
mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II; p... 131 3e-30
dre:556339 protein kinase, cGMP-dependent, type II-like; K0737... 123 1e-27
dre:566430 cGMP dependent protein kinase I 120 9e-27
bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:... 115 3e-25
tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07... 114 5e-25
cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase... 114 6e-25
ath:AT2G20050 ATP binding / cAMP-dependent protein kinase regu... 104 5e-22
tgo:TGME49_019070 cAMP-dependent protein kinase regulatory sub... 102 3e-21
dre:100332846 acyl-CoA synthetase long-chain family member 6-like 75.9 2e-13
cel:C09G4.2 hypothetical protein 68.2 5e-11
dre:557285 hcn2, si:dkey-28h18.1, wu:fj61d07; hyperpolarizatio... 64.3 6e-10
cel:T20G5.5 epac-1; Exchange Protein Activated by Cyclic AMP f... 63.9 8e-10
dre:560986 novel protein similar to H.sapiens PNPLA6, patatin-... 63.5 1e-09
> tgo:TGME49_042070 cAMP-dependent protein kinase regulatory subunit,
putative (EC:2.7.10.2); K04739 cAMP-dependent protein
kinase regulator
Length=308
Score = 426 bits (1094), Expect = 1e-118, Method: Compositional matrix adjust.
Identities = 205/312 (65%), Positives = 255/312 (81%), Gaps = 6/312 (1%)
Query 57 LPVPSAK--AQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSL 114
+P PS ++AKNRQSVSAE YGEWNK+ FVAPV+PKT E KERI +++++SFLFSSL
Sbjct 1 MPQPSEAYMSRAKNRQSVSAEAYGEWNKRKKFVAPVYPKTAEQKERITKVIESSFLFSSL 60
Query 115 DVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKV 174
D+E+++ V+NAF+EV VKKG +I+QG DGD+LYLIE+GE DV K+ EKE +
Sbjct 61 DIEDLETVINAFQEVSVKKGTVIIRQGDDGDRLYLIETGEVDVMKKFP----GEKENKFL 116
Query 175 NTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLK 234
M PGD GELALMYNAPRAATV+AA D+ LW+LDR +FT+IVRDAAAKKRE++EESLK
Sbjct 117 CKMHPGDAFGELALMYNAPRAATVIAADDMLLWALDRDSFTNIVRDAAAKKREIFEESLK 176
Query 235 EVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMK 294
EV +L+D+D YERSK++DAL++ Y GD II+EGE GDTFY+LL+G AEA+K KVVM+
Sbjct 177 EVRILEDMDPYERSKLSDALRTATYEDGDVIIKEGETGDTFYILLEGAAEAIKNDKVVME 236
Query 295 YSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVM 354
Y +G +FGELALLK+QPRAATV AK+ +VAYMDR+SFKRLLGP+E +LMRN D+YR M
Sbjct 237 YKKGGFFGELALLKDQPRAATVVAKSHVQVAYMDRKSFKRLLGPVEQILMRNQDNYRKAM 296
Query 355 TQLGLDTKYLDK 366
QLGLDTKYLDK
Sbjct 297 KQLGLDTKYLDK 308
> pfa:PFL1110c PKAr; CAMP-dependent protein kinase regulatory
subunit, putative; K04739 cAMP-dependent protein kinase regulator
Length=441
Score = 325 bits (833), Expect = 2e-88, Method: Compositional matrix adjust.
Identities = 162/310 (52%), Positives = 225/310 (72%), Gaps = 6/310 (1%)
Query 57 LPVPSAKAQAKNRQSVSAEVYGEWNKKT-NFVAPVHPKTPEVKERIQEILDNSFLFSSLD 115
L + S K R SVSAE YG+WNKK NF+ V+ K + K +I+E L+ SFLF+ L+
Sbjct 135 LDLESIHFIQKKRLSVSAEAYGDWNKKIDNFIPKVYKKDEKEKAKIREALNESFLFNHLN 194
Query 116 VEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVN 175
+E ++++NAF + V+KG +I +G GD LY+I+ GE +++K TKE N+KE L V
Sbjct 195 KKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYK--TKE-NNKKEVLTV- 250
Query 176 TMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKE 235
+K D GELAL+YN+ RAAT A T LW+LDR++FT+I++D AKKR+MYE+ L
Sbjct 251 -LKSKDVFGELALLYNSKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSH 309
Query 236 VELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMKY 295
V +LKD+D YER KVAD LKS+ Y+ G+ II+EGE GDTF++L+DG A A K KV+ Y
Sbjct 310 VNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKVIKTY 369
Query 296 SRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
++G YFGELALLKN+PRAAT+ A+ C+V Y+DR+SFKRLLGP+E +L RN+++Y+ V+
Sbjct 370 TKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLN 429
Query 356 QLGLDTKYLD 365
+LGLDT +D
Sbjct 430 ELGLDTTCID 439
> cpv:cgd7_120 cAMP-dependent protein kinase regulatory subunit
; K04739 cAMP-dependent protein kinase regulator
Length=345
Score = 307 bits (787), Expect = 3e-83, Method: Compositional matrix adjust.
Identities = 153/306 (50%), Positives = 207/306 (67%), Gaps = 5/306 (1%)
Query 52 DVVDDLPVPSAKAQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLF 111
DV D++ +P R SVSAE YG WNK +F P +PKT E ++RI+E L SF+F
Sbjct 41 DVRDNIEIPKNFLARGPRTSVSAEAYGAWNKMKDFTPPSYPKTKEQEKRIREKLLESFMF 100
Query 112 SSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKET 171
+SLD +E+ V+ A E VKK +I QG +GDKLY+I+ G + +K+ + E
Sbjct 101 TSLDDDELKTVILACVETSVKKDTEIITQGDNGDKLYIIDQGVVECYKKTSTEPRKH--- 157
Query 172 LKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEE 231
+ + PGD GELAL+YN PRAA+VVA TD LW+LDR+TF HIV+ +A+K+ YE
Sbjct 158 --LCDLNPGDAFGELALLYNCPRAASVVAKTDCLLWALDRETFNHIVKGSASKRISTYET 215
Query 232 SLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV 291
LKEVE+LK +D YE +K+ LKS ++ G II++GE GDTFYL++ G A A+K
Sbjct 216 FLKEVEILKTMDVYELNKLTMVLKSSIFEDGQEIIKQGEQGDTFYLIITGNAVALKDNVE 275
Query 292 VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYR 351
VM Y RG YFGELALL+N PRAATV A+ CKVAY+DR++FKR+LGP+E +L RN D Y+
Sbjct 276 VMSYKRGDYFGELALLRNAPRAATVKARGRCKVAYLDRKAFKRVLGPIEDILKRNTDKYK 335
Query 352 AVMTQL 357
V+ ++
Sbjct 336 TVIKKI 341
> bbo:BBOV_II005430 18.m06452; cAMP-dependent protein kinase regulatory
subunit; K04739 cAMP-dependent protein kinase regulator
Length=317
Score = 285 bits (728), Expect = 3e-76, Method: Compositional matrix adjust.
Identities = 151/315 (47%), Positives = 203/315 (64%), Gaps = 9/315 (2%)
Query 55 DDLPVPSAKA----QAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFL 110
DD+ SA+A +A+NR S+SAEV+G +N FVAPVH KTPE RI+E + FL
Sbjct 4 DDIDAISAEAIRFARARNRVSISAEVFGAYNNPDLFVAPVHEKTPEQATRIKETVLKCFL 63
Query 111 FSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKE 170
FSS+D ++ID ++ AFE V G +I+QG GDKLYLIESG A TK ++
Sbjct 64 FSSVDAKDIDTLVKAFESSDVSAGTKVIQQGDPGDKLYLIESGTA----RFTKTSAATEQ 119
Query 171 TLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYE 230
+ T G GELALMYNAPRA +VVA TD+KLWSLDR TF HIVR+A KKRE Y+
Sbjct 120 VHDLGTAGEGGCFGELALMYNAPRACSVVAETDMKLWSLDRSTFNHIVRNAVIKKREKYD 179
Query 231 ESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK 290
L+ V LL ++D Y+R ++ADAL + + D I+ EG+ G + +++L+G AEA GK
Sbjct 180 SLLQSVALLSNLDPYDRCRLADALTEKTFVDEDIIV-EGDKGTSVFMILEGNAEAYCQGK 238
Query 291 VVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHY 350
+V YS G YFGE+AL+ PRA+TV AK C VA ++R S LLGP+E N+ Y
Sbjct 239 LVKSYSEGGYFGEIALIAQTPRASTVKAKGKCVVAELERESCVTLLGPMEECFRDNLKEY 298
Query 351 RAVMTQLGLDTKYLD 365
+ V+ +L ++ K L+
Sbjct 299 QKVLAELNIENKNLE 313
> tgo:TGME49_111300 cAMP-dependent protein kinase regulatory subunit,
putative (EC:2.7.11.12); K04739 cAMP-dependent protein
kinase regulator
Length=410
Score = 269 bits (688), Expect = 1e-71, Method: Compositional matrix adjust.
Identities = 141/291 (48%), Positives = 193/291 (66%), Gaps = 12/291 (4%)
Query 67 KNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAF 126
K R SVSAEVYGEWNKK NFVAPV+ K KE+++ IL SFLF+SLD ++++ V+ A
Sbjct 122 KMRCSVSAEVYGEWNKKKNFVAPVYEKDEGQKEQLERILRQSFLFNSLDEKDLNTVILAM 181
Query 127 EEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGEL 186
+E ++ LI++G DG+ LY+++SGE + K + + E V + PGD GEL
Sbjct 182 QEKKIEASTCLIREGDDGECLYIVQSGELNCSKLI------DGEERVVKVVGPGDAFGEL 235
Query 187 ALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYE 246
AL+YNAPRAATV + + LW L R TF IV+DAA K+R MY+ LK V +L +DAYE
Sbjct 236 ALLYNAPRAATVTSVSACDLWELGRDTFNAIVKDAATKRRSMYDSFLKSVHILDGMDAYE 295
Query 247 RSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKG---GKV---VMKYSRGSY 300
R KVADAL+++++ G I+R+GE GD FY++ +G A A K G+ V KY G Y
Sbjct 296 RGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGSAVATKSFGPGQPPIEVKKYQAGDY 355
Query 301 FGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYR 351
FGELAL+ +PRAA V A CKVA ++R+SFKRL+G ++ LL + Y+
Sbjct 356 FGELALINEEPRAANVIAHGICKVACLERKSFKRLMGSVQDLLSKKASEYK 406
> tpv:TP02_0494 cAMP-dependent protein kinase regulatory subunit;
K04739 cAMP-dependent protein kinase regulator
Length=285
Score = 224 bits (572), Expect = 3e-58, Method: Compositional matrix adjust.
Identities = 120/280 (42%), Positives = 182/280 (65%), Gaps = 19/280 (6%)
Query 91 HPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFE------EVVVKKGETLIKQGADG 144
+ KTP+ + +I E++ + FLFS + +D+++ AF+ ++ G+ LIKQG DG
Sbjct 13 YEKTPQEQAKIMEMIKSCFLFSGVTSSGLDLLVKAFDFKAAKIKLFSSAGDVLIKQGDDG 72
Query 145 DKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDL 204
DKLYLIESG EVTK+ + E + T+ GD GELALMYN+PRAATVVA T++
Sbjct 73 DKLYLIESGTV----EVTKKSASGAEEF-LCTLTDGDYFGELALMYNSPRAATVVAKTEM 127
Query 205 KLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDT 264
LW+LDR TF H+VR A KKRE Y+ L +++L K V Y+R ++ADAL + Y +T
Sbjct 128 HLWTLDRTTFNHVVRMAVIKKREKYDSILAKLDLFKKVGPYDRCRLADALVERTYE-DET 186
Query 265 IIREGEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKV 324
+I++GE G + +++L+G+AE+ K+V Y+ G YFGE+ + +PRA+TV AK
Sbjct 187 VIKQGEPGSSLFMVLEGQAESFVENKLVKSYNPGDYFGEIGFILKKPRASTVKAK----- 241
Query 325 AYMDRRSFKRLLGPLEGLLMRNMDHYRAVMTQLGLDTKYL 364
++R +F LLGP+E +L +N+ +Y+ V+ +L L+ K L
Sbjct 242 --LERENFINLLGPMEDVLNKNIKNYKKVLEELKLENKQL 279
> mmu:19087 Prkar2a, 1110061A24Rik, AI317181, AI836829, RII(alpha);
protein kinase, cAMP dependent regulatory, type II alpha
(EC:2.7.11.1); K04739 cAMP-dependent protein kinase regulator
Length=402
Score = 220 bits (560), Expect = 9e-57, Method: Compositional matrix adjust.
Identities = 129/340 (37%), Positives = 191/340 (56%), Gaps = 22/340 (6%)
Query 31 TAPTSVVQLTEDDLDSNEGDDDVVDDLPVPSAKAQAKNRQSVSAEVYG-EWNKKTNFVAP 89
T +S V + E+D +S+ +D ++PVPS + R SV AE + + ++ N
Sbjct 60 TQESSAVPVIEEDGESDSDSEDADLEVPVPS---KFTRRVSVCAETFNPDEEEEDNDPRV 116
Query 90 VHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYL 149
VHPKT E + R+QE + LF +LD E++ VL+A E +VK E +I QG DGD Y+
Sbjct 117 VHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYV 176
Query 150 IESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSL 209
IE G D+ VTK+ +T V + GELALMYN PRAAT++A ++ LW L
Sbjct 177 IERGTYDIL--VTKDN----QTRSVGQYDNRGSFGELALMYNTPRAATIIATSEGSLWGL 230
Query 210 DRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREG 269
DR TF I+ AKKR+M+E ++ V L K ++ ER K+ D + ++Y G+ II +G
Sbjct 231 DRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIIAQG 290
Query 270 EAGDTFYLLLDGEAEAVKGGKV------------VMKYSRGSYFGELALLKNQPRAATVT 317
E D+FY++ GE + K + +G YFGELAL+ N+PRAA+
Sbjct 291 EKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASAY 350
Query 318 AKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMTQL 357
A D K MD ++F+RLLGP ++ RN+ HY + ++
Sbjct 351 AVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 390
> sce:YIL033C BCY1, SRA1; Bcy1p; K04739 cAMP-dependent protein
kinase regulator
Length=416
Score = 218 bits (555), Expect = 3e-56, Method: Compositional matrix adjust.
Identities = 128/294 (43%), Positives = 180/294 (61%), Gaps = 20/294 (6%)
Query 58 PVPSAKAQAKNRQSVSAEVYGEWNKKTNF--VAPVH--PKTPEVKERIQEILDNSFLFSS 113
P+P A+ R SVS GE + NF P H K+ + +R+++ + N+FLF+
Sbjct 133 PLP-MHFNAQRRTSVS----GETLQPNNFDDWTPDHYKEKSEQQLQRLEKSIRNNFLFNK 187
Query 114 LDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLK 173
LD + +V+N EE V KG T+IKQG GD Y++E G D + N+ K
Sbjct 188 LDSDSKRLVINCLEEKSVPKGATIIKQGDQGDYFYVVEKGTVDFY-------VNDN---K 237
Query 174 VNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESL 233
VN+ PG + GELALMYN+PRAATVVA +D LW+LDR TF I+ ++ KKR MY++ L
Sbjct 238 VNSSGPGSSFGELALMYNSPRAATVVATSDCLLWALDRLTFRKILLGSSFKKRLMYDDLL 297
Query 234 KEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK-VV 292
K + +LK + Y+R+K+ADAL +++Y G+TIIREG+ G+ FYL+ G + K G+ V+
Sbjct 298 KSMPVLKSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIEYGAVDVSKKGQGVI 357
Query 293 MKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRN 346
K YFGE+ALL + PR ATVTA KVA + + F+RLLGP +L N
Sbjct 358 NKLKDHDYFGEVALLNDLPRQATVTATKRTKVATLGKSGFQRLLGPAVDVLKLN 411
> hsa:5576 PRKAR2A, MGC3606, PKR2, PRKAR2; protein kinase, cAMP-dependent,
regulatory, type II, alpha (EC:2.7.11.1); K04739
cAMP-dependent protein kinase regulator
Length=404
Score = 213 bits (542), Expect = 1e-54, Method: Compositional matrix adjust.
Identities = 126/315 (40%), Positives = 180/315 (57%), Gaps = 24/315 (7%)
Query 57 LPVPSAKAQAKNRQSVSAEVYG--EWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSL 114
+PVPS + R SV AE Y E + T+ +HPKT E + R+QE + LF +L
Sbjct 88 VPVPS---RFNRRVSVCAETYNPDEEEEDTDPRV-IHPKTDEQRCRLQEACKDILLFKNL 143
Query 115 DVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKV 174
D E++ VL+A E +VK E +I QG DGD Y+IE G D+ VTK+ +T V
Sbjct 144 DQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDIL--VTKD----NQTRSV 197
Query 175 NTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLK 234
+ GELALMYN PRAAT+VA ++ LW LDR TF I+ AKKR+M+E ++
Sbjct 198 GQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIE 257
Query 235 EVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAV-------- 286
V LLK ++ ER K+ D + ++Y G+ II +GE D+FY++ GE +
Sbjct 258 SVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSN 317
Query 287 -KGGKV---VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGL 342
GG + + +G YFGELAL+ N+PRAA+ A D K MD ++F+RLLGP +
Sbjct 318 KDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDI 377
Query 343 LMRNMDHYRAVMTQL 357
+ RN+ HY + ++
Sbjct 378 MKRNISHYEEQLVKM 392
> hsa:5575 PRKAR1B, PRKAR1; protein kinase, cAMP-dependent, regulatory,
type I, beta (EC:2.7.11.1); K04739 cAMP-dependent
protein kinase regulator
Length=381
Score = 203 bits (517), Expect = 7e-52, Method: Compositional matrix adjust.
Identities = 124/347 (35%), Positives = 192/347 (55%), Gaps = 20/347 (5%)
Query 17 ERPQRWLKA--DDAEATAPTSVVQLTEDDLDSNEGDDDVVDDLPVPSAKAQAKNRQSVSA 74
ERP ++L+ + E ++ + + S+ D++V P P KA+ + R VSA
Sbjct 44 ERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKAR-RRRGGVSA 102
Query 75 EVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKG 134
EVY E ++V V PK + + + + + LF+ LD E + +A V G
Sbjct 103 EVYTE-EDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAG 161
Query 135 ETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPR 194
ET+I+QG +GD Y+++ GE DV+ V E V + G + GELAL+Y PR
Sbjct 162 ETVIQQGNEGDNFYVVDQGEVDVY--VNGEW--------VTNISEGGSFGELALIYGTPR 211
Query 195 AATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADAL 254
AATV A TDLKLW +DR ++ I+ + +KR+MYEE L +V +L+ ++ +ER VADAL
Sbjct 212 AATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADAL 271
Query 255 KSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV------VMKYSRGSYFGELALLK 308
+ + G+ I+ +GE GD FY++ +G A ++ V + YFGE+ALL
Sbjct 272 EPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLL 331
Query 309 NQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
N+PRAATV A+ K +DR F+R+LGP +L RN+ Y + ++
Sbjct 332 NRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378
> mmu:19085 Prkar1b, AI385716, RIbeta; protein kinase, cAMP dependent
regulatory, type I beta (EC:2.7.11.1); K04739 cAMP-dependent
protein kinase regulator
Length=381
Score = 203 bits (517), Expect = 8e-52, Method: Compositional matrix adjust.
Identities = 125/351 (35%), Positives = 193/351 (54%), Gaps = 20/351 (5%)
Query 13 VCECERPQRWLKA--DDAEATAPTSVVQLTEDDLDSNEGDDDVVDDLPVPSAKAQAKNRQ 70
V + +RP R+L+ + E ++ + + + D+++ P P KA+ + R
Sbjct 40 VAKPDRPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKAR-RRRG 98
Query 71 SVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVV 130
VSAEVY E ++V V PK + + + + + LFS LD E + +A V
Sbjct 99 GVSAEVYTE-EDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVT 157
Query 131 VKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMY 190
GET+I+QG +GD Y+I+ GE DV+ V E V + G + GELAL+Y
Sbjct 158 HIGGETVIQQGNEGDNFYVIDQGEVDVY--VNGEW--------VTNISEGGSFGELALIY 207
Query 191 NAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKV 250
PRAATV A TDLKLW +DR ++ I+ + +KR+MYEE L +V +L+ ++ +ER V
Sbjct 208 GTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTV 267
Query 251 ADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV------VMKYSRGSYFGEL 304
ADAL+ + G+ I+ +GE GD FY++ +G A ++ V + YFGE+
Sbjct 268 ADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEI 327
Query 305 ALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
ALL N+PRAATV A+ K +DR F+R+LGP +L RN+ Y + ++
Sbjct 328 ALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 378
> dre:556042 prkar2aa, MGC153742, wu:fb55f12, wu:fj29e12, wu:fj33e06,
zgc:153742; protein kinase, cAMP-dependent, regulatory,
type II, alpha A; K04739 cAMP-dependent protein kinase regulator
Length=397
Score = 202 bits (515), Expect = 1e-51, Method: Compositional matrix adjust.
Identities = 117/310 (37%), Positives = 173/310 (55%), Gaps = 18/310 (5%)
Query 60 PSAKAQAKNRQSVSAEVYG-EWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEE 118
P ++ R SV AE + + +++ + VHPKT E + R+QE + LF +LD E+
Sbjct 85 PPPPSRFNRRVSVCAEAFNPDDDEEDSEPRVVHPKTDEQRCRLQEACKDILLFKALDQEQ 144
Query 119 IDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMK 178
VL+A EV+V+ + +I QG DGD Y+IE G D+ V K+G V
Sbjct 145 FSEVLDAMFEVLVQPQDHVIDQGDDGDNFYVIERGVYDIV--VQKDGVG----CCVGQYN 198
Query 179 PGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVEL 238
+ GELALMYN PRAAT++A + LW LDR TF ++ AKKR MYE ++ + L
Sbjct 199 NKGSFGELALMYNTPRAATIIAKDEGALWGLDRATFRRLIVKNNAKKRRMYECFIESIPL 258
Query 239 LKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV------- 291
LK ++ ER K+ D L + + G+ II +G+ D FY++ GE + + K
Sbjct 259 LKSLELSERMKIVDVLGVKTFQDGERIIMQGDKADCFYIVESGEVKIMMKSKTKADRQDN 318
Query 292 ----VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNM 347
+ + SRG YFGELAL+ N+PRAA+ A D K +D ++F+RLLGP + ++ RN+
Sbjct 319 AEVEIARCSRGQYFGELALVTNKPRAASAYAIGDVKCLVIDIQAFERLLGPCKEIMKRNI 378
Query 348 DHYRAVMTQL 357
HY + L
Sbjct 379 AHYEEQLVAL 388
> mmu:19084 Prkar1a, 1300018C22Rik, RIalpha, Tse-1, Tse1; protein
kinase, cAMP dependent regulatory, type I, alpha (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=381
Score = 201 bits (511), Expect = 4e-51, Method: Compositional matrix adjust.
Identities = 122/347 (35%), Positives = 193/347 (55%), Gaps = 20/347 (5%)
Query 17 ERPQRWLKA--DDAEATAPTSVVQLTEDDLDSNEGDDDVVDDLPVPSAKAQAKNRQSVSA 74
ERP +L+ + E + L + + ++ +D++ P P K + + R ++SA
Sbjct 44 ERPMAFLREYFERLEKEEARQIQCLQKTGIRTDSREDEISPPPPNPVVKGR-RRRGAISA 102
Query 75 EVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKG 134
EVY E ++V V PK + + + ++ + LFS LD E + +A V G
Sbjct 103 EVYTE-EDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAG 161
Query 135 ETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPR 194
ET+I+QG +GD Y+I+ GE DV+ NE T ++ G + GELAL+Y PR
Sbjct 162 ETVIQQGDEGDNFYVIDQGEMDVYV------NNEWAT----SVGEGGSFGELALIYGTPR 211
Query 195 AATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADAL 254
AATV A T++KLW +DR ++ I+ + +KR+MYEE L +V +L+ +D +ER VADAL
Sbjct 212 AATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADAL 271
Query 255 KSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VVMKYSRGSYFGELALLK 308
+ + G I+ +GE GD F+++L+G A ++ V + YFGE+ALL
Sbjct 272 EPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331
Query 309 NQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
N+PRAATV A+ K +DR F+R+LGP +L RN+ Y + ++
Sbjct 332 NRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378
> hsa:5573 PRKAR1A, CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR1,
PPNAD1, PRKAR1, TSE1; protein kinase, cAMP-dependent, regulatory,
type I, alpha (tissue specific extinguisher 1) (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=381
Score = 201 bits (511), Expect = 4e-51, Method: Compositional matrix adjust.
Identities = 122/347 (35%), Positives = 192/347 (55%), Gaps = 20/347 (5%)
Query 17 ERPQRWLKA--DDAEATAPTSVVQLTEDDLDSNEGDDDVVDDLPVPSAKAQAKNRQSVSA 74
ERP +L+ + E + L + ++ +D++ P P K + + R ++SA
Sbjct 44 ERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGR-RRRGAISA 102
Query 75 EVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKG 134
EVY E ++V V PK + + + ++ + LFS LD E + +A V G
Sbjct 103 EVYTE-EDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAG 161
Query 135 ETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPR 194
ET+I+QG +GD Y+I+ GE DV+ NE T ++ G + GELAL+Y PR
Sbjct 162 ETVIQQGDEGDNFYVIDQGETDVYV------NNEWAT----SVGEGGSFGELALIYGTPR 211
Query 195 AATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADAL 254
AATV A T++KLW +DR ++ I+ + +KR+MYEE L +V +L+ +D +ER VADAL
Sbjct 212 AATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADAL 271
Query 255 KSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VVMKYSRGSYFGELALLK 308
+ + G I+ +GE GD F+++L+G A ++ V + YFGE+ALL
Sbjct 272 EPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331
Query 309 NQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
N+PRAATV A+ K +DR F+R+LGP +L RN+ Y + ++
Sbjct 332 NRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 378
> dre:767685 prkar1b, MGC153624, zgc:153624; protein kinase, cAMP-dependent,
regulatory, type I, beta (EC:2.7.11.1); K04739
cAMP-dependent protein kinase regulator
Length=380
Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust.
Identities = 128/354 (36%), Positives = 197/354 (55%), Gaps = 22/354 (6%)
Query 12 NVC--ECERPQRWLKA--DDAEATAPTSVVQLTEDDLDSNEGDDDVVDDLPVPSAKAQAK 67
N+C + ERP ++L+ + E ++ + + S+ DD+V P P KA+ +
Sbjct 36 NLCIAKPERPMKFLREHFEKLEKEECKQIMARQKSNSQSDSHDDEVSPPPPNPVVKAR-R 94
Query 68 NRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFE 127
R VSAEVY E ++V V PK + + + + + LF+ LD E + +A
Sbjct 95 RRGGVSAEVYTE-EDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMF 153
Query 128 EVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELA 187
V GET+I+QG +GD Y+I+ GE DV+ V E V ++ G + GELA
Sbjct 154 PVTHIAGETVIQQGDEGDNFYVIDQGEVDVY--VNGEW--------VTSIGEGGSFGELA 203
Query 188 LMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYER 247
L+Y PRAATV A TDLKLW +DR ++ I+ + +KR+MYEE L +V +L+ +D +ER
Sbjct 204 LIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWER 263
Query 248 SKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VVMKYSRGSYF 301
VADAL+ + G+ I+ +GE GD F+++ +G A ++ V + YF
Sbjct 264 LTVADALEPVQFEDGEKIVVQGEPGDDFFIITEGTASVLQRRSDNEEYVEVGRLGPSDYF 323
Query 302 GELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
GE+ALL N+PRAATV A+ K +DR F+R+LGP +L RN+ Y + ++
Sbjct 324 GEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFIS 377
> cel:R07E4.6 kin-2; protein KINase family member (kin-2); K04739
cAMP-dependent protein kinase regulator
Length=376
Score = 199 bits (505), Expect = 2e-50, Method: Compositional matrix adjust.
Identities = 111/300 (37%), Positives = 173/300 (57%), Gaps = 18/300 (6%)
Query 59 VPSAKAQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEE 118
V K R +SAE E T + V PK + ++ + + LF+ L+ +E
Sbjct 83 VEPPKRSGGRRTGISAEPIKE--DDTEYKKVVIPKDDATRRSLESAMRKNLLFAHLEEDE 140
Query 119 IDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMK 178
+ +A V GET+I+QG +GD Y+I+ G DV+ N + L +N
Sbjct 141 QKTMYDAMFPVEKSAGETIIEQGEEGDNFYVIDKGTVDVY-------VNHEYVLTINE-- 191
Query 179 PGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVEL 238
G + GELAL+Y PRAATV+A TD+KLW++DR T+ I+ + KKR+MY+E L +V++
Sbjct 192 -GGSFGELALIYGTPRAATVIAKTDVKLWAIDRLTYRRILMGSVTKKRKMYDEFLSKVQI 250
Query 239 LKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VV 292
L D+D +ER+ VADAL+ + G ++ +G+ GD F+++L+GEA ++ VV
Sbjct 251 LADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANVLQKRSDDAPFDVV 310
Query 293 MKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRA 352
YFGE+ALL ++PRAATV AKT K +DR F+R++GP+ +L R++ +Y +
Sbjct 311 GHLGMSDYFGEIALLLDRPRAATVVAKTHLKCIKLDRNRFERVMGPVREILKRDVSNYNS 370
> dre:494533 prkar1aa, im:7047729, prkar1a, zgc:92515; protein
kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific
extinguisher 1) a
Length=379
Score = 198 bits (504), Expect = 2e-50, Method: Compositional matrix adjust.
Identities = 113/302 (37%), Positives = 177/302 (58%), Gaps = 18/302 (5%)
Query 60 PSAKAQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEI 119
P K + + R ++SAEVY E T++V V PK + + + ++ + LF+ LD E
Sbjct 87 PVVKGR-RRRGAISAEVYTE-EDATSYVRKVIPKDYKTMAALAKAIEKNVLFAHLDDNER 144
Query 120 DVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKP 179
+ +A V GET+I+QG +GD Y+I+ GE DV+ V E V ++
Sbjct 145 SDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDVY--VNNEW--------VTSIGE 194
Query 180 GDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELL 239
G + GELAL+Y PRAATV A T++KLW +DR ++ I+ + +KR+MYEE L +V +L
Sbjct 195 GGSFGELALIYGTPRAATVRAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSIL 254
Query 240 KDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VVM 293
+ +D +ER VADAL++ + G I+ +G+ GD F+++L+G A ++ V
Sbjct 255 ESLDKWERLTVADALETVQFEDGQKIVVQGQPGDEFFIILEGSAAVLQRRSENEEFVEVG 314
Query 294 KYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAV 353
+ + YFGE+ALL N+PRAATV A+ K +DR F+R+LGP +L RN+ Y +
Sbjct 315 RLAPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSF 374
Query 354 MT 355
++
Sbjct 375 VS 376
> dre:100329979 protein kinase, cAMP-dependent, regulatory, type
I, alpha (tissue specific extinguisher 1) a-like; K04739
cAMP-dependent protein kinase regulator
Length=379
Score = 198 bits (504), Expect = 2e-50, Method: Compositional matrix adjust.
Identities = 113/302 (37%), Positives = 177/302 (58%), Gaps = 18/302 (5%)
Query 60 PSAKAQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEI 119
P K + + R ++SAEVY E T++V V PK + + + ++ + LF+ LD E
Sbjct 87 PVVKGR-RRRGAISAEVYTE-EDATSYVRKVIPKDYKTMAALAKAIEKNVLFAHLDDNER 144
Query 120 DVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKP 179
+ +A V GET+I+QG +GD Y+I+ GE DV+ V E V ++
Sbjct 145 SDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDVY--VNNEW--------VTSIGE 194
Query 180 GDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELL 239
G + GELAL+Y PRAATV A T++KLW +DR ++ I+ + +KR+MYEE L +V +L
Sbjct 195 GGSFGELALIYGTPRAATVRAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSIL 254
Query 240 KDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VVM 293
+ +D +ER VADAL++ + G I+ +G+ GD F+++L+G A ++ V
Sbjct 255 ESLDKWERLTVADALETVQFEDGQKIVVQGQPGDEFFIILEGSAAVLQRRSENEEFVEVG 314
Query 294 KYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAV 353
+ + YFGE+ALL N+PRAATV A+ K +DR F+R+LGP +L RN+ Y +
Sbjct 315 RLAPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSF 374
Query 354 MT 355
++
Sbjct 375 VS 376
> hsa:5577 PRKAR2B, PRKAR2, RII-BETA; protein kinase, cAMP-dependent,
regulatory, type II, beta (EC:2.7.11.1); K04739 cAMP-dependent
protein kinase regulator
Length=418
Score = 197 bits (502), Expect = 4e-50, Method: Compositional matrix adjust.
Identities = 115/301 (38%), Positives = 172/301 (57%), Gaps = 18/301 (5%)
Query 69 RQSVSAEVYGEWNKKTNFVAPV-HPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFE 127
R SV AE Y ++ + + + HPKT + + R+QE + LF +LD E++ VL+A
Sbjct 112 RASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMF 171
Query 128 EVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELA 187
E +VK GE +I QG DGD Y+I+ G D++ + G V + GELA
Sbjct 172 EKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRC------VGNYDNRGSFGELA 225
Query 188 LMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYER 247
LMYN PRAAT+ A + LW LDR TF I+ AKKR+MYE ++ + LK ++ ER
Sbjct 226 LMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSER 285
Query 248 SKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGE----------AEAVKGGKV-VMKYS 296
KV D + +++Y+ G+ II +G++ D+F+++ GE +E + G V + + S
Sbjct 286 LKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCS 345
Query 297 RGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMTQ 356
RG YFGELAL+ N+PRAA+ A K MD ++F+RLLGP ++ RN+ Y +
Sbjct 346 RGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVA 405
Query 357 L 357
L
Sbjct 406 L 406
> dre:100331387 cAMP-dependent protein kinase, regulatory subunit
beta 2-like; K04739 cAMP-dependent protein kinase regulator
Length=403
Score = 196 bits (497), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 116/294 (39%), Positives = 164/294 (55%), Gaps = 18/294 (6%)
Query 69 RQSVSAEVYGEWNKKTNFVAPV-HPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFE 127
R SV AE Y + V +PKT E ++R+QE + LF +LD E++ VL+A
Sbjct 97 RASVCAEAYNPDEDEEEREPRVTYPKTDEQRQRLQEACKDILLFKNLDQEQMSQVLDAMF 156
Query 128 EVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELA 187
E VV GE +I Q DGD Y+IE G ++ + +GT T V + + GELA
Sbjct 157 EKVVVSGEHIIDQDDDGDNFYVIERGMFEIL--LKADGT----TRTVGSYDNRGSFGELA 210
Query 188 LMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYER 247
LMYN PRAAT++A + LW LDR TF I+ AKKR+MYE + + LL ++ ER
Sbjct 211 LMYNTPRAATIIATSPGALWCLDRLTFRRIIVKNNAKKRKMYEAFIGTLPLLTSLEVSER 270
Query 248 SKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAE-AVKGGKV----------VMKYS 296
KV D L +++Y+ G+ II +G+ D FY++ G +K K + S
Sbjct 271 MKVVDVLSTKVYNGGEQIIAQGDLADCFYIVESGHVRITMKRSKSKNDTEDEEVEIATCS 330
Query 297 RGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHY 350
RG YFGELAL+ N+PRAA+ A K MD ++F+RLLGP ++ RN+ +Y
Sbjct 331 RGQYFGELALVTNKPRAASAYAMDSVKCLVMDVQAFERLLGPCMDIMKRNIANY 384
> xla:432155 prkar1a, pkr1; protein kinase, cAMP-dependent, regulatory,
type I, alpha (tissue specific extinguisher 1) (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=381
Score = 195 bits (496), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 113/307 (36%), Positives = 175/307 (57%), Gaps = 20/307 (6%)
Query 58 PVPSAKAQAKNRQ---SVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSL 114
P P + K R+ ++SAEVY E ++V V PK + + + ++ + LF+ L
Sbjct 83 PPPHMNSVVKGRRRRGAISAEVYTE-EDAASYVRKVIPKDYKTMAALAKAIEKNVLFAHL 141
Query 115 DVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKV 174
D E + +A V GET+I+QG +GD Y+++ GE DV+ NE T
Sbjct 142 DDTERSDIFDAMFSVTYISGETVIQQGDEGDNFYVVDQGEMDVYV------NNEWMT--- 192
Query 175 NTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLK 234
++ G + GELAL+Y PRAATV A T++KLW +DR ++ I+ + +KR+MYEE L
Sbjct 193 -SIGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
Query 235 EVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK---- 290
+V +L+ +D +ER VADAL+ + G I+ +GE GD F+++L+G A ++
Sbjct 252 KVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEE 311
Query 291 --VVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMD 348
V + YFGE+ALL N+PRAATV A+ K +DR F+R+LGP +L RN+
Sbjct 312 FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQ 371
Query 349 HYRAVMT 355
Y + ++
Sbjct 372 QYNSFVS 378
> mmu:19088 Prkar2b, AI451071, AW061005, Pkarb2, RII(beta); protein
kinase, cAMP dependent regulatory, type II beta (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=416
Score = 195 bits (496), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 114/301 (37%), Positives = 171/301 (56%), Gaps = 18/301 (5%)
Query 69 RQSVSAEVYGEWNKKTNFVAPV-HPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFE 127
R SV AE Y ++ + + + HPKT + + R+QE + LF +LD E++ VL+A
Sbjct 110 RASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMF 169
Query 128 EVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELA 187
E +VK+GE +I QG DGD Y+I+ G D++ + G V + GELA
Sbjct 170 EKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRC------VGNYDNRGSFGELA 223
Query 188 LMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYER 247
LMYN PRAAT+ A + LW LDR TF I+ AKKR+MYE ++ + LK ++ ER
Sbjct 224 LMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSER 283
Query 248 SKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGE----------AEAVKGGKV-VMKYS 296
KV D + +++Y+ G+ II +G+ D+F+++ GE +E + G V + +
Sbjct 284 LKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCF 343
Query 297 RGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMTQ 356
RG YFGELAL+ N+PRAA+ A K MD ++F+RLLGP ++ RN+ Y +
Sbjct 344 RGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVA 403
Query 357 L 357
L
Sbjct 404 L 404
> xla:444805 prkar1b, MGC82149, prkar1; protein kinase, cAMP-dependent,
regulatory, type I,beta; K04739 cAMP-dependent protein
kinase regulator
Length=381
Score = 194 bits (492), Expect = 6e-49, Method: Compositional matrix adjust.
Identities = 112/307 (36%), Positives = 175/307 (57%), Gaps = 20/307 (6%)
Query 58 PVPSAKAQAKNRQ---SVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSL 114
P P + K R+ ++SAEVY E ++V V PK + + + ++ + LF+ L
Sbjct 83 PPPHMNSVVKGRRRRGAISAEVYTE-EDAASYVRKVIPKDYKTMAALAKAIEKNVLFAHL 141
Query 115 DVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKV 174
D E + +A V GET+I+QG +GD Y+++ GE DV+ N+ T
Sbjct 142 DDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVVDQGEMDVYV------NNDWMT--- 192
Query 175 NTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLK 234
++ G + GELAL+Y PRAATV A T++KLW +DR ++ I+ + +KR+MYEE L
Sbjct 193 -SIGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
Query 235 EVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK---- 290
+V +L+ +D +ER VADAL+ + G I+ +GE GD F+++L+G A ++
Sbjct 252 KVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEE 311
Query 291 --VVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMD 348
V + YFGE+ALL N+PRAATV A+ K +DR F+R+LGP +L RN+
Sbjct 312 FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQ 371
Query 349 HYRAVMT 355
Y + ++
Sbjct 372 QYNSFVS 378
> dre:405894 prkar2ab, MGC85886, prkar2a, zgc:85886; protein kinase,
cAMP-dependent, regulatory, type II, alpha, B; K04739
cAMP-dependent protein kinase regulator
Length=422
Score = 192 bits (488), Expect = 2e-48, Method: Compositional matrix adjust.
Identities = 114/309 (36%), Positives = 172/309 (55%), Gaps = 25/309 (8%)
Query 58 PVPSAKAQAKNRQSVSAEVYG-----EWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFS 112
P PS + R SV AE Y + + + + +H KT E ++R+Q+ + LF
Sbjct 107 PPPS---KCNRRVSVCAEPYNPDEDDDDGDEGSQLTVLHQKTDEQRQRLQDACKHILLFK 163
Query 113 SLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETL 172
+L+ +++ VL++ EV+VK GE +I QG DGD Y+IE G ++ + ++G
Sbjct 164 TLEEDQLAEVLDSMFEVLVKPGECIINQGDDGDNFYVIERGVYEIV--IQQDGLQHS--- 218
Query 173 KVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEES 232
V + GELALMYN PRAAT+ A + LW+LDR TF ++ AKKR MYE
Sbjct 219 -VGRYDHKGSFGELALMYNTPRAATIRALQEGALWALDRATFHRLIVKNNAKKRRMYESF 277
Query 233 LKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV- 291
++ V LLK + ER K+ D L + + G+ II++G++ D FY++ GE + K
Sbjct 278 IECVPLLKSLQLSERMKIVDVLGMRSFSDGERIIQQGDSADCFYIVESGEVRIMIRSKTR 337
Query 292 ----------VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEG 341
V + SRG YFGELAL+ +PRAA+V A D + +D ++F+RLLG +
Sbjct 338 ACQLLQEEVEVARCSRGQYFGELALVTKRPRAASVYAVGDTRCLVIDVQAFERLLGSCKQ 397
Query 342 LLMRNMDHY 350
+L RN+ HY
Sbjct 398 ILKRNITHY 406
> xla:414594 prkar2b, MGC83177; protein kinase, cAMP-dependent,
regulatory, type II, beta; K04739 cAMP-dependent protein kinase
regulator
Length=402
Score = 192 bits (487), Expect = 2e-48, Method: Compositional matrix adjust.
Identities = 120/326 (36%), Positives = 177/326 (54%), Gaps = 22/326 (6%)
Query 45 DSNEGDDDVVDDLPVPSAKAQAKNRQSVSAEVYG--EWNKKTNFVAPVHPKTPEVKERIQ 102
DS G++D +D P ++ R SV AE Y E + T V + PKT + + R+Q
Sbjct 74 DSENGEEDE-EDFVAPVINRFSR-RASVCAEAYNPDEEDDDTE-VKILFPKTDDQRNRLQ 130
Query 103 EILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVT 162
E + LF +LD E++ VL+A E +V+ GE +I QG DGD Y+I+ G D+F V
Sbjct 131 EACTDILLFKNLDQEQMSQVLDAMFEKLVQCGEHVIDQGDDGDNFYVIDRGTYDIF--VK 188
Query 163 KEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAA 222
+G V + GELALMYN PRAAT+VA + +W LDR TF I+
Sbjct 189 SDGVARC----VCAYDNRGSFGELALMYNTPRAATIVATSVGAIWGLDRATFRRIIVKNN 244
Query 223 AKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGE 282
AKKR +YE ++ + LK ++ ER KV D + ++ Y + II +G+ D+F+++ GE
Sbjct 245 AKKRRLYENFIESLPFLKSLEFSERLKVVDVIGTKTYCDEEQIIAQGDGADSFFIVESGE 304
Query 283 AEAVKGGKV-----------VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRS 331
K + +Y RG YFGELAL+ N+PRAA+ A + K MD ++
Sbjct 305 VRITMKSKSKPDAETNEAVEIARYIRGQYFGELALVTNKPRAASAYAVGNVKCLVMDVQA 364
Query 332 FKRLLGPLEGLLMRNMDHYRAVMTQL 357
F+RLLGP ++ RN+ +Y + L
Sbjct 365 FERLLGPCMEIMKRNIANYEEQLVAL 390
> dre:550427 prkar1ab, zgc:112145; protein kinase, cAMP-dependent,
regulatory, type I, alpha (tissue specific extinguisher
1) b (EC:2.7.11.1); K04739 cAMP-dependent protein kinase regulator
Length=379
Score = 190 bits (483), Expect = 7e-48, Method: Compositional matrix adjust.
Identities = 109/295 (36%), Positives = 168/295 (56%), Gaps = 17/295 (5%)
Query 67 KNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAF 126
+ R ++SAEVY E ++V V PK + + + ++ + LFS LD E + +A
Sbjct 93 RRRGAISAEVYTE-EDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAM 151
Query 127 EEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGEL 186
V GE +I+QG +GD Y+I+ GE DV+ V E ++ G + GEL
Sbjct 152 FPVTYIAGEIVIQQGDEGDNFYVIDQGEMDVY--VNSEWAT--------SIGEGGSFGEL 201
Query 187 ALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYE 246
AL+Y PRAATV A T++KLW +DR ++ I+ + +KR+MYEE L +V +L+ +D +E
Sbjct 202 ALIYGTPRAATVRAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWE 261
Query 247 RSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK------VVMKYSRGSY 300
R VADAL+ + I+ +GE GD F+++L+G A ++ V + Y
Sbjct 262 RLTVADALEPVQFEDSQKIVVQGEPGDEFFIILEGCAAVLQRRSENEEFVEVGRLGPSDY 321
Query 301 FGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMT 355
FGE+ALL N+PRAATV A+ K +DR F+R+LGP +L RN+ Y + ++
Sbjct 322 FGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 376
> dre:100329437 protein kinase, cAMP-dependent, regulatory, type
II, alpha-like
Length=385
Score = 169 bits (427), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 104/288 (36%), Positives = 156/288 (54%), Gaps = 25/288 (8%)
Query 58 PVPSAKAQAKNRQSVSAEVYG-----EWNKKTNFVAPVHPKTPEVKERIQEILDNSFLFS 112
P PS + R SV AE Y + + + + +H KT E ++R+Q+ + LF
Sbjct 107 PPPS---KCNRRVSVCAEPYNPDEDDDDGDEGSQLTVLHQKTDEQRQRLQDACKHILLFK 163
Query 113 SLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETL 172
+L+ +++ VL++ EV+VK GE +I QG DGD Y+IE G ++ + ++G
Sbjct 164 TLEEDQLAEVLDSMFEVLVKPGECIINQGDDGDNFYVIERGVYEIV--IQQDGLQHS--- 218
Query 173 KVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEES 232
V + GELALMYN PRAAT+ A + LW+LDR TF ++ AKKR MYE
Sbjct 219 -VGRYDHKGSFGELALMYNTPRAATIRALQEGALWALDRATFHRLIVKNNAKKRRMYESF 277
Query 233 LKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV- 291
++ V LLK + ER K+ D L + + G+ II++G++ D FY++ GE + K
Sbjct 278 IECVPLLKSLQLSERMKIVDVLGMRSFSDGERIIQQGDSADCFYIVESGEVRIMIRSKTR 337
Query 292 ----------VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDR 329
V + SRG YFGELAL+ +PRAA+V A D + +R
Sbjct 338 ACQLLQEEVEVARCSRGQYFGELALVTKRPRAASVYAVGDTRCLGKNR 385
Score = 65.1 bits (157), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 39/117 (33%), Positives = 67/117 (57%), Gaps = 4/117 (3%)
Query 224 KKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEA 283
++R+ +++ K + L K ++ + ++V D++ L G+ II +G+ GD FY++ G
Sbjct 147 EQRQRLQDACKHILLFKTLEEDQLAEVLDSMFEVLVKPGECIINQGDDGDNFYVIERGVY 206
Query 284 EAV--KGG--KVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLL 336
E V + G V +Y FGELAL+ N PRAAT+ A + + +DR +F RL+
Sbjct 207 EIVIQQDGLQHSVGRYDHKGSFGELALMYNTPRAATIRALQEGALWALDRATFHRLI 263
> tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=994
Score = 149 bits (375), Expect = 2e-35, Method: Compositional matrix adjust.
Identities = 102/319 (31%), Positives = 160/319 (50%), Gaps = 28/319 (8%)
Query 41 EDDLDSNEGDDDVVDDLP-----------VPSAKAQAKNRQSVSAEVYGEWNKKTNFVAP 89
EDDL + DV + P P+ KA K S + E +K N
Sbjct 115 EDDLKREAPNQDVPSEAPEGPKEKPGGDRKPAQKAILKQDDSHTEE------EKLNAHLA 168
Query 90 VHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYL 149
KTP IQ+ L + + SSL+ EID + A + KKG+ + KQG G ++
Sbjct 169 YREKTPADFALIQDSLKANLVCSSLNEGEIDALAVAMQFFTFKKGDVVTKQGEPGSYFFI 228
Query 150 IESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAA-TDLKLWS 208
I SG DV N+K +VN M G GE+AL++N R+ATVVA+ T+ LW
Sbjct 229 IHSGTFDVL-------VNDK---RVNAMDKGKAFGEIALIHNTERSATVVASSTEGALWG 278
Query 209 LDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIRE 268
+ R TF ++ +++ + L V+ + + +++ + +AL + + G I++E
Sbjct 279 VQRHTFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVENFKPGQPIVKE 338
Query 269 GEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMD 328
G+AGD Y+L G+A+ GG+ + +G YFGE ALL +PR+AT+TA+ +
Sbjct 339 GDAGDVLYILKSGKAKVSIGGREIRMLRKGDYFGERALLYKEPRSATITAEEFTVCVSIG 398
Query 329 RRSFKRLLGPLEGLLMRNM 347
R R+LG L+ +L RN+
Sbjct 399 RELLDRVLGNLQHVLFRNI 417
Score = 65.9 bits (159), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 54/210 (25%), Positives = 90/210 (42%), Gaps = 22/210 (10%)
Query 144 GDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGE-LALMYNAPRAATVVAAT 202
G + + + GE V+ T E+E T+K G GE L P V +
Sbjct 463 GIRFFFVLEGELSVYAYAQNPATKEEERKLAATLKRGQAFGEEYVLNPTRPFNHYVKSVG 522
Query 203 DLKLWSLDRQTFTHIV-----------RDAAAKKREMYEESLKEVELLKDVDAYERSKVA 251
KL T + + A R+MY + + + ++ + +
Sbjct 523 PCKLALFTSSVLTATLGGEDIDETLDFNNKRAIIRKMY--------IFRYLSDHQMTMLI 574
Query 252 DALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQP 311
A K+ Y +G+ II+EGE G F+++ GE +K K + R YFGE ALL ++P
Sbjct 575 KAFKTVRYMSGEYIIKEGERGTRFFIIKAGEVAILKNNKRLRTLGRHDYFGERALLYDEP 634
Query 312 RAATVTAKT-DCKVAYMDRRSFKRLL-GPL 339
R A+V A + + +D+ F ++ GP+
Sbjct 635 RTASVCANSAGVDLWVVDKSVFNEIIKGPM 664
Score = 65.1 bits (157), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 35/117 (29%), Positives = 64/117 (54%), Gaps = 11/117 (9%)
Query 104 ILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTK 163
I+ ++F L ++ +++ AF+ V GE +IK+G G + ++I++GE + K
Sbjct 555 IIRKMYIFRYLSDHQMTMLIKAFKTVRYMSGEYIIKEGERGTRFFIIKAGEVAILK---- 610
Query 164 EGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVA-ATDLKLWSLDRQTFTHIVR 219
N K ++ T+ D GE AL+Y+ PR A+V A + + LW +D+ F I++
Sbjct 611 ---NNK---RLRTLGRHDYFGERALLYDEPRTASVCANSAGVDLWVVDKSVFNEIIK 661
> xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent,
type II (EC:2.7.11.1); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=783
Score = 145 bits (365), Expect = 3e-34, Method: Compositional matrix adjust.
Identities = 86/264 (32%), Positives = 147/264 (55%), Gaps = 22/264 (8%)
Query 101 IQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKE 160
I + L+ + +D +I ++ E + +GE +I+QG G +++++ G+A+VF++
Sbjct 181 ISDALNKNQFTKRMDNHQIQDMVECMYERIYLQGEFIIRQGEPGSQIFVLADGKAEVFQD 240
Query 161 VTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRD 220
+ + ++ T GELA++YN R A+V A T+++ W+LDR+ F +I+R
Sbjct 241 ----------SKLLTSIPVWTTFGELAILYNCTRTASVKAITNVRTWALDREVFQNIMRK 290
Query 221 AAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLD 280
A K E Y LK V LLK + ++ K+AD L+ + Y GD IIREGE G TF+++
Sbjct 291 TAQSKHEEYLRFLKSVSLLKKLPDHKLMKIADCLELEYYETGDYIIREGEEGSTFFIIAK 350
Query 281 GE------AEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTA---KTDCKVAYMDRRS 331
G+ AE + + + +G YFGE AL+ + R+A + A + +C V MDR +
Sbjct 351 GKVKVTQSAEGYEEPQYIKLLEKGDYFGEKALISDDVRSANILAYGERVECLV--MDRET 408
Query 332 FKRLLGPLEGLLMRNMDHYRAVMT 355
F + +G E LM+ ++ Y A +T
Sbjct 409 FNKTVGTYEE-LMKCLEGYVANLT 431
> pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=853
Score = 140 bits (352), Expect = 9e-33, Method: Compositional matrix adjust.
Identities = 82/259 (31%), Positives = 141/259 (54%), Gaps = 17/259 (6%)
Query 96 EVKERIQEILD-------NSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLY 148
E++E++ E +D N+ + S+L+ EI + N + V K G +IKQG G +
Sbjct 37 ELREKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFF 96
Query 149 LIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWS 208
+I SG+ DV+ N+K KV TM G + GE AL++N R+AT++A TD LW
Sbjct 97 IINSGKFDVY-------VNDK---KVKTMGKGSSFGEAALIHNTQRSATIIAETDGTLWG 146
Query 209 LDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIRE 268
+ R TF ++ + + + V + + +++ + +A Q + +G+TI+++
Sbjct 147 VQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVKQ 206
Query 269 GEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMD 328
G+ GD Y+L +G+A + + +GSYFGE ALL ++PR+AT+ AK A +
Sbjct 207 GDYGDVLYILKEGKATVYINDEEIRVLEKGSYFGERALLYDEPRSATIIAKEPTACASIC 266
Query 329 RRSFKRLLGPLEGLLMRNM 347
R+ +LG L+ +L RN+
Sbjct 267 RKLLNIVLGNLQVVLFRNI 285
Score = 80.5 bits (197), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 62/237 (26%), Positives = 115/237 (48%), Gaps = 13/237 (5%)
Query 104 ILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTK 163
+D+ +F L + +++ NA K GET++KQG GD LY+++ G+A V+
Sbjct 170 FIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVY----- 224
Query 164 EGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRD-AA 222
N++E + ++ G GE AL+Y+ PR+AT++A S+ R+ ++ +
Sbjct 225 --INDEE---IRVLEKGSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQV 279
Query 223 AKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLL-LDG 281
R + E+L++ E+ K + + +AD + Y A I+ + + Y++ L+G
Sbjct 280 VLFRNIMTEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEG 339
Query 282 EAEAVKGGKVVMKYSRGSYFGELALL-KNQPRAATVTAKTDCKVAYMDRRSFKRLLG 337
+ E + SRG FG+ +L + QP T+ + CK+A + LG
Sbjct 340 KVELFLDDTSIGILSRGMSFGDQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLG 396
Score = 68.9 bits (167), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 34/92 (36%), Positives = 57/92 (61%), Gaps = 2/92 (2%)
Query 250 VADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKN 309
+ +A ++ Y GD II+EGE G FY++ +GE E VK K + + YFGE ALL +
Sbjct 430 LIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDYFGERALLYD 489
Query 310 QPRAATVTAKT-DCKVAYMDRRSFKRLL-GPL 339
+PR A+V +K + + ++D+ F +++ GP+
Sbjct 490 EPRTASVISKVNNVECWFVDKSVFLQIIQGPM 521
Score = 62.8 bits (151), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 31/119 (26%), Positives = 69/119 (57%), Gaps = 11/119 (9%)
Query 102 QEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEV 161
+ I+ ++F L ++ ++++ AF ++G+ +I++G G + Y+I++GE ++ K
Sbjct 410 KSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVK-- 467
Query 162 TKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVA-ATDLKLWSLDRQTFTHIVR 219
N+K ++ T+ D GE AL+Y+ PR A+V++ +++ W +D+ F I++
Sbjct 468 -----NKK---RLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQ 518
> dre:326020 fd58b04, wu:fd58b04; si:dkey-121j17.5
Length=663
Score = 138 bits (347), Expect = 3e-32, Method: Compositional matrix adjust.
Identities = 84/266 (31%), Positives = 140/266 (52%), Gaps = 28/266 (10%)
Query 70 QSVSAEVYGEWNKKTNFVAP-------------VHPKTPEVKERIQEILDNSFLFSSLDV 116
Q S E+ W + +AP V + E + ++ I N FL LD
Sbjct 55 QRTSNELPKVWQGRAAVMAPEQVPEVLDITANRVQKTSSETSQIVKAIGKNDFL-RRLDE 113
Query 117 EEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNT 176
E+I ++++ + + + G+ +IK+G +GD +Y++ +GE +VT+ G + +
Sbjct 114 EQISMMVDLMKVLDCRAGDEIIKEGTEGDSMYIVAAGEL----KVTQAGRD------LRI 163
Query 177 MKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKEV 236
+ PGD GELA++YN R A+V A + +KLW ++RQT+ I+ + + KRE LK
Sbjct 164 LSPGDMFGELAILYNCKRTASVKAISAVKLWCIERQTYRSIMTNKSKMKREQLMGFLKTA 223
Query 237 ELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKG----GKVV 292
LK ++ + SK+ D+++ + + I+REG G+TFY++L GE K K +
Sbjct 224 RTLKALNDVQLSKIIDSMEEVRFQDNEVIVREGAEGNTFYIILKGEVLVTKKVNGQQKTI 283
Query 293 MKYSRGSYFGELALLKNQPRAATVTA 318
K G +FGELAL++ R AT TA
Sbjct 284 RKMGEGEHFGELALIREILRTATCTA 309
Score = 63.5 bits (153), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 33/100 (33%), Positives = 59/100 (59%), Gaps = 0/100 (0%)
Query 237 ELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMKYS 296
+ L+ +D + S + D +K AGD II+EG GD+ Y++ GE + + G+ + S
Sbjct 106 DFLRRLDEEQISMMVDLMKVLDCRAGDEIIKEGTEGDSMYIVAAGELKVTQAGRDLRILS 165
Query 297 RGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLL 336
G FGELA+L N R A+V A + K+ ++R++++ ++
Sbjct 166 PGDMFGELAILYNCKRTASVKAISAVKLWCIERQTYRSIM 205
Score = 52.0 bits (123), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 31/114 (27%), Positives = 63/114 (55%), Gaps = 6/114 (5%)
Query 98 KERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADV 157
+E++ L + +L+ ++ ++++ EEV + E ++++GA+G+ Y+I GE
Sbjct 213 REQLMGFLKTARTLKALNDVQLSKIIDSMEEVRFQDNEVIVREGAEGNTFYIILKGEV-- 270
Query 158 FKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDR 211
VTK+ +++T++ M G+ GELAL+ R AT A + +S+D+
Sbjct 271 --LVTKKVNGQQKTIR--KMGEGEHFGELALIREILRTATCTAVGVVICFSIDK 320
> dre:100125912 prkg2; protein kinase, cGMP-dependent, type II
(EC:2.7.11.1); K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=768
Score = 137 bits (345), Expect = 7e-32, Method: Compositional matrix adjust.
Identities = 80/259 (30%), Positives = 144/259 (55%), Gaps = 22/259 (8%)
Query 93 KTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIES 152
K VK+ + + L+ + L+V+++ ++ E ++GE +IKQG G+ L+++
Sbjct 158 KEQSVKKLLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHLFVLAD 217
Query 153 GEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQ 212
G+ DV++ + ++ T GELA++YN R A+V AA+++K W+LDR+
Sbjct 218 GKLDVYQH----------NKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDRE 267
Query 213 TFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAG 272
F +I+R A + E Y L+ V LL + + +K+ D L+ + Y+ GD IIREGE G
Sbjct 268 VFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLE-EYYNKGDYIIREGEEG 326
Query 273 DTFYLLLDGEAEAVKGG------KVVMKYSRGSYFGELALLKNQPRAATVTAKTD---CK 323
+TFY++ +G+ + + +++ +G YFGE AL+ + R+A + A+ D C
Sbjct 327 NTFYIIANGKIKVTQSTQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECL 386
Query 324 VAYMDRRSFKRLLGPLEGL 342
V +DR +F + +G + L
Sbjct 387 V--IDRETFSQTVGTFDEL 403
> mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b;
protein kinase, cGMP-dependent, type I (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 137 bits (344), Expect = 8e-32, Method: Compositional matrix adjust.
Identities = 99/295 (33%), Positives = 146/295 (49%), Gaps = 23/295 (7%)
Query 57 LPVPSAKAQAKNR--QSVSAE--VYGEWNKKTNFVAPVHPKTPEVKERIQE-ILDNSFLF 111
LPVPS + Q +SAE Y ++ K+ K+ I+E ILDN F+
Sbjct 47 LPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKF-TKSERSKDLIKEAILDNDFM- 104
Query 112 SSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKET 171
+L++ +I +++ V K +IK+G G +Y++E G+ EVTKEG
Sbjct 105 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKV----EVTKEG------ 154
Query 172 LKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEE 231
+K+ TM PG GELA++YN R ATV ++KLW++DRQ F I+ K Y E
Sbjct 155 VKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYME 214
Query 232 SLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK- 290
LK V + + SK+AD L+ Y G+ IIR+G GDTF+++ G+ +
Sbjct 215 FLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSP 274
Query 291 -----VVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLE 340
+ +G +FGE AL R A V A +DR SFK L+G L+
Sbjct 275 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLD 329
> hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK,
PKG, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha; protein kinase,
cGMP-dependent, type I (EC:2.7.11.12); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 136 bits (343), Expect = 1e-31, Method: Compositional matrix adjust.
Identities = 99/295 (33%), Positives = 145/295 (49%), Gaps = 23/295 (7%)
Query 57 LPVPSAKAQAKNR--QSVSAE--VYGEWNKKTNFVAPVHPKTPEVKERIQE-ILDNSFLF 111
LPVPS + Q +SAE Y ++ K+ K+ I+E ILDN F+
Sbjct 47 LPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKF-TKSERSKDLIKEAILDNDFM- 104
Query 112 SSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKET 171
+L++ +I +++ V K +IK+G G +Y++E G+ EVTKEG
Sbjct 105 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKV----EVTKEG------ 154
Query 172 LKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEE 231
+K+ TM PG GELA++YN R ATV ++KLW++DRQ F I+ K Y E
Sbjct 155 VKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYME 214
Query 232 SLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK- 290
LK V + + SK+AD L+ Y G+ IIR+G GDTF+++ G +
Sbjct 215 FLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 274
Query 291 -----VVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLE 340
+ +G +FGE AL R A V A +DR SFK L+G L+
Sbjct 275 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLD 329
> dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,
cGMP-dependent, type Ia (EC:2.7.11.1); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=667
Score = 135 bits (341), Expect = 2e-31, Method: Compositional matrix adjust.
Identities = 101/291 (34%), Positives = 143/291 (49%), Gaps = 19/291 (6%)
Query 57 LPVPSAKAQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQE-ILDNSFLFSSLD 115
LP + Q +SAE + V K+ K+ I+ ILDN F+ +L+
Sbjct 47 LPSAQIGPRTHRAQGISAEPQTHQDLSNQSFRRV-AKSDRSKDLIKSAILDNDFM-KNLE 104
Query 116 VEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVN 175
+ +I +++ V K +IK+G G +Y++E G+ EVTKEG LK+
Sbjct 105 MSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKV----EVTKEG------LKLC 154
Query 176 TMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESLKE 235
TM PG GELA++YN R ATV + +KLW++DRQ F I+ K Y E LK
Sbjct 155 TMGPGKVFGELAILYNCTRTATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKS 214
Query 236 VELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEA----EAVKGGKV 291
V + + SK+AD L+ Y G+ IIR+G GDTF+++ G+ E G +
Sbjct 215 VLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCPGQEP 274
Query 292 VMKYS--RGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLE 340
V S RG FGE AL R A V A +DR S+K L+G LE
Sbjct 275 VYLRSMGRGDSFGEKALQGEDIRTANVIAAETVTCLVIDRDSYKHLIGGLE 325
> hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,
type II (EC:2.7.11.12); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=762
Score = 134 bits (338), Expect = 4e-31, Method: Compositional matrix adjust.
Identities = 79/252 (31%), Positives = 137/252 (54%), Gaps = 17/252 (6%)
Query 98 KERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADV 157
K+ I + L+ + LD ++I ++ ++G +IKQG G+ ++++ G +V
Sbjct 156 KKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEV 215
Query 158 FKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHI 217
F + E L ++++ T GELA++YN R A+V A T++K W+LDR+ F +I
Sbjct 216 F---------QGEKL-LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNI 265
Query 218 VRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYL 277
+R A + E Y L+ V LLK++ + +K+ D L+ + Y GD IIREGE G TF++
Sbjct 266 MRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFI 325
Query 278 LLDGEAEAVKGG------KVVMKYSRGSYFGELALLKNQPRAATVTA-KTDCKVAYMDRR 330
L G+ + + +++ +G YFGE AL+ + R+A + A + D +DR
Sbjct 326 LAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRE 385
Query 331 SFKRLLGPLEGL 342
+F + +G E L
Sbjct 386 TFNQTVGTFEEL 397
> cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=780
Score = 134 bits (336), Expect = 7e-31, Method: Compositional matrix adjust.
Identities = 88/299 (29%), Positives = 154/299 (51%), Gaps = 19/299 (6%)
Query 51 DDVVDDLPVPSAKAQAKNRQSVSAEVYGEWNKKTNFVAPVHPKTPEVKERIQEILDNSFL 110
+D+ +P+ Q + +VSAE NK + KT K+ I++ + +
Sbjct 144 NDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQH--YNKTVGAKQMIRDAVQKNDF 201
Query 111 FSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKE 170
L E+I ++N E+ + G+ +I++G GD+L+++ GE +V++EG
Sbjct 202 LKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGEL----QVSREGA---- 253
Query 171 TLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYE 230
+ M+ G +GELA++YN R A+V A TD++LW LDR F I + ++
Sbjct 254 --LLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLM 311
Query 231 ESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEA---EAVK 287
L +V + +++ SK+AD + Y G IIR+GE GD F+++ G+ + ++
Sbjct 312 NFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIE 371
Query 288 G---GKVVMKYSRGSYFGELALLKNQPRAATVTAKT-DCKVAYMDRRSFKRLLGPLEGL 342
G + + ++G +FGE ALL + R A + A+ +V +DR SF +L+G LE L
Sbjct 372 GETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESL 430
> mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II;
protein kinase, cGMP-dependent, type II (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=762
Score = 131 bits (330), Expect = 3e-30, Method: Compositional matrix adjust.
Identities = 80/266 (30%), Positives = 144/266 (54%), Gaps = 18/266 (6%)
Query 98 KERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADV 157
K+ I + L+ + LD ++I ++ ++G +IKQG G+ ++++ G +V
Sbjct 156 KKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEV 215
Query 158 FKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHI 217
F + E L ++++ T GELA++YN R A+V A T++K W+LDR+ F +I
Sbjct 216 F---------QGEKL-LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNI 265
Query 218 VRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYL 277
+R A + E Y L+ V LLK++ + +K+ D L+ + Y GD IIREGE G TF++
Sbjct 266 MRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFI 325
Query 278 LLDGEAEAVKGG------KVVMKYSRGSYFGELALLKNQPRAATVTA-KTDCKVAYMDRR 330
L G+ + + +++ +G YFGE AL+ + R+A + A + D +DR
Sbjct 326 LAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRE 385
Query 331 SFKRLLGPLEGLLMRNMDHYRAVMTQ 356
+F + +G + L + ++ Y A + +
Sbjct 386 TFNQTVGTFDE-LQKYLEGYVATLNR 410
> dre:556339 protein kinase, cGMP-dependent, type II-like; K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=730
Score = 123 bits (308), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 78/246 (31%), Positives = 126/246 (51%), Gaps = 18/246 (7%)
Query 104 ILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTK 163
++ N FL L+ + +++ E + + +I++G G+ LY++ G EV +
Sbjct 131 LMKNDFL-KKLEPQHTREMVDCMYEKIYGAEQLVIQEGEPGNFLYVLAEG----LLEVIQ 185
Query 164 EGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAA 223
G + M+PG GELA++YN R ATV A + +W+LDRQTF I+ +
Sbjct 186 NGKF------LGQMRPGTAFGELAILYNCKRTATVKAVSQSHIWALDRQTFQTIMMRSTQ 239
Query 224 KKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEA 283
+ E Y L+ V LLKD+ + +K+ D L+ + G+ IIREGE G+TF+++ GE
Sbjct 240 ARHEEYFSFLRSVSLLKDLPEEKLAKIIDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEV 299
Query 284 ------EAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAK-TDCKVAYMDRRSFKRLL 336
E + + G YFGE AL+ R+A + AK D + +DR +F ++
Sbjct 300 SVTQTTEGFTEPQEIKTLRVGDYFGEKALISEDVRSANIIAKENDTQCLVVDRDNFNEMV 359
Query 337 GPLEGL 342
G E L
Sbjct 360 GTYEEL 365
> dre:566430 cGMP dependent protein kinase I
Length=528
Score = 120 bits (301), Expect = 9e-27, Method: Compositional matrix adjust.
Identities = 74/195 (37%), Positives = 103/195 (52%), Gaps = 12/195 (6%)
Query 160 EVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVR 219
EVTKEG +K+ TM PG GELA++YN R ATV T++KLW++DRQ F I+
Sbjct 6 EVTKEG------MKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMM 59
Query 220 DAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLL 279
K Y E LK V + + SK+AD L+ Y G+ IIR+G GDTF+++
Sbjct 60 RTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIIS 119
Query 280 DGEA-----EAVKGGKVVMK-YSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFK 333
G+ +A G V ++ +G +FGE AL R A V A +DR SFK
Sbjct 120 KGKVNVTREDAPNGTPVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVTCLVIDRESFK 179
Query 334 RLLGPLEGLLMRNMD 348
L+G L+ + + D
Sbjct 180 HLIGGLDDVSNKGYD 194
Score = 58.9 bits (141), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 36/116 (31%), Positives = 57/116 (49%), Gaps = 4/116 (3%)
Query 103 EILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVT 162
E L + F L E + + + EE GE +I+QGA GD ++I G+ +V +E
Sbjct 71 EFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDA 130
Query 163 KEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIV 218
GT + + + GD GE AL R A V+AA + +DR++F H++
Sbjct 131 PNGT----PVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVTCLVIDRESFKHLI 182
Score = 45.4 bits (106), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 30/90 (33%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query 280 DGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPL 339
DG+ E K G + G FGELA+L N R ATV T+ K+ +DR+ F+ ++ +
Sbjct 2 DGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIM--M 59
Query 340 EGLLMRN---MDHYRAVMTQLGLDTKYLDK 366
L+++ M+ ++V T GL + L K
Sbjct 60 RTGLIKHAEYMEFLKSVPTFQGLQEEILSK 89
> bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:2.7.11.1);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=887
Score = 115 bits (288), Expect = 3e-25, Method: Compositional matrix adjust.
Identities = 71/251 (28%), Positives = 126/251 (50%), Gaps = 14/251 (5%)
Query 101 IQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKE 160
I+ L N+ + SL+ EID + + + G +++QG +G ++I G+ DV+
Sbjct 72 IRHALANNLVCESLNEYEIDAFIGSMSSFELPAGAPVVRQGDNGTYFFIISEGDFDVY-- 129
Query 161 VTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVV----AATDLKLWSLDRQTFTH 216
V E VN+M G GE++L++N PR+ATV A KLW + R F
Sbjct 130 VDGE--------HVNSMTRGTAFGEISLIHNTPRSATVKVKNKAGNCGKLWGVTRVVFRD 181
Query 217 IVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFY 276
++ + + E + V + +++ +S + +AL + G++I+++G+ GD Y
Sbjct 182 TLKRISLRNYTENREFIDCVTIFENLTEENKSCITNALVELRFSPGESIVKQGDPGDDLY 241
Query 277 LLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLL 336
L+ G A+ V ++G YFGE A+L ++PR+AT+ A + R + +L
Sbjct 242 LIKQGSADVYVNDIRVRTITKGQYFGERAILYSEPRSATIKAIDYVICVSITRDILQSVL 301
Query 337 GPLEGLLMRNM 347
G L +L RN+
Sbjct 302 GNLNNVLFRNI 312
Score = 65.1 bits (157), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 57/218 (26%), Positives = 99/218 (45%), Gaps = 23/218 (10%)
Query 130 VVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALM 189
V+ ETL+K G + +++ G V + + GT M+ GD+ GE +
Sbjct 348 VILDRETLLK----GIRYFIVLEGSVRVLYDGNELGT----------MQRGDSFGEEYIT 393
Query 190 Y-NAPRAATVVA----ATDLKLWSLDRQTFTHIVRDAAAKKREMYEE---SLKEVELLKD 241
+ N P TV+A KL + I+ ++ Y +L+++ +L+
Sbjct 394 HANLPFNHTVIADGGNVNVSKLAFFTKHAMQLILGGENLSEKLDYNNKMAALRKIYILRH 453
Query 242 VDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYF 301
+ + + ALK+ Y DTI EGE GD Y++ GE +K G + + YF
Sbjct 454 LSEKQIDMLIKALKTLRYKLNDTIFNEGEIGDMLYIIKSGEVAIIKNGVKIRTLGKHDYF 513
Query 302 GELALLKNQPRAATVTAK-TDCKVAYMDRRSFKRLLGP 338
GE ALL ++ R+A+V + T + +++ F L+ P
Sbjct 514 GERALLYDEQRSASVVSNATYVDLWVVEKPVFMELMEP 551
Score = 55.8 bits (133), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 0/102 (0%)
Query 219 RDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLL 278
RD K + +L + + ++ YE ++ S AG ++R+G+ G F+++
Sbjct 62 RDKTDKDITLIRHALANNLVCESLNEYEIDAFIGSMSSFELPAGAPVVRQGDNGTYFFII 121
Query 279 LDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKT 320
+G+ + G+ V +RG+ FGE++L+ N PR+ATV K
Sbjct 122 SEGDFDVYVDGEHVNSMTRGTAFGEISLIHNTPRSATVKVKN 163
> tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=892
Score = 114 bits (286), Expect = 5e-25, Method: Compositional matrix adjust.
Identities = 71/261 (27%), Positives = 132/261 (50%), Gaps = 21/261 (8%)
Query 98 KERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADV 157
K I++ L N+ +FS+L+ E+ +++ V G + +QG +G ++I G DV
Sbjct 68 KSFIKKSLANNVIFSALNDLEMSAFVDSMSYYVFSVGSKVTEQGTNGSYFFVINEGIFDV 127
Query 158 FKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVV---------AATDL--KL 206
+ + VNTM+ G GE++L+ + PR ATV A++D L
Sbjct 128 YIDGKL----------VNTMERGTAFGEISLINDTPRTATVKVRGVTENVKASSDTLGSL 177
Query 207 WSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTII 266
W ++R F +++ + + L V++ + + +++ V +A + GD I+
Sbjct 178 WGVNRTVFRETLKNISMEVYSQNRSFLDSVKIFEMLTENQKNMVTNAFVESKFVPGDRIV 237
Query 267 REGEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAY 326
+G+ GD Y++ +G+A+ + + V + G YFGE ALL ++PR+AT+ A D
Sbjct 238 TQGDFGDVLYIIKEGKADVLINDEKVRTLTNGQYFGERALLYDEPRSATIVATEDTVCVS 297
Query 327 MDRRSFKRLLGPLEGLLMRNM 347
+ R ++LG L+ +L RN+
Sbjct 298 LGREILNKVLGNLDNVLFRNV 318
Score = 59.7 bits (143), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/233 (24%), Positives = 103/233 (44%), Gaps = 23/233 (9%)
Query 101 IQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLI--KQGADGDKLYLIESGEADVF 158
+ E L NS +F +++ ++ + K G+ ++ ++ G + +++ G +
Sbjct 319 MMEYLQNSTVFRQFTPDQLAKLIESASVRDFKPGDVILHREEKIKGIRFFILLEGSVQIL 378
Query 159 KEVTKEGTNEKETLKVNTMKPGDTVGE-LALMYNAPRAATVVAATD-------LKLWSLD 210
E NE + M+ GD+ GE L P A TV + KL L
Sbjct 379 YE-----DNE-----IGIMERGDSFGEEYVLSPEIPFAHTVKCIINDKRAEGSCKLALLT 428
Query 211 RQTFTHIVRDAAAKKREMYEESL---KEVELLKDVDAYERSKVADALKSQLYHAGDTIIR 267
+ I+ ++ Y L K++ + + + + KS+ Y G+ IIR
Sbjct 429 KHAIQEILGTDLIDEKLDYNNKLSVIKKMYIFRYLSEAHLDMLIKKFKSKRYKKGEYIIR 488
Query 268 EGEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKT 320
EGE GD+FY++ G+ + +K G + + YFGE ALL ++PR A+V +
Sbjct 489 EGEVGDSFYIISKGDVDIIKSGTRLRTLGKNDYFGERALLYDEPRTASVVCSS 541
Score = 55.1 bits (131), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 1/111 (0%)
Query 210 DRQTFTHIV-RDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIRE 268
D + H+V R+ + + ++SL + ++ E S D++ ++ G + +
Sbjct 51 DTEIVKHLVKREKSESDKSFIKKSLANNVIFSALNDLEMSAFVDSMSYYVFSVGSKVTEQ 110
Query 269 GEAGDTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAK 319
G G F+++ +G + GK+V RG+ FGE++L+ + PR ATV +
Sbjct 111 GTNGSYFFVINEGIFDVYIDGKLVNTMERGTAFGEISLINDTPRTATVKVR 161
> cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase
with 3 cNMP binding domains and a Ser/Thr kinase domain ;
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=965
Score = 114 bits (285), Expect = 6e-25, Method: Compositional matrix adjust.
Identities = 72/255 (28%), Positives = 129/255 (50%), Gaps = 10/255 (3%)
Query 93 KTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIES 152
KT E + I + L + + +SL+ EI ++++ + GE +I+QGA G ++I +
Sbjct 92 KTEEDIKTISKALAGNVVGASLNESEIATLVSSMHYYEYEVGEVVIEQGASGFYFFVIST 151
Query 153 GEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQ 212
G V E +VNTM G GELAL++N PR+AT++ LW L R
Sbjct 152 GSFGV----------EINGNRVNTMSEGTAFGELALIHNTPRSATILVIEKGGLWGLGRS 201
Query 213 TFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAG 272
TF +R +++ E ++ + + + ++S +++AL +++ IIRE E G
Sbjct 202 TFRDTLRLISSRNYEENRAFIESLSIFSGLTDKQKSLLSEALVREIFVKDQVIIREKEIG 261
Query 273 DTFYLLLDGEAEAVKGGKVVMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSF 332
+ Y++ G K + + G FGE +L+ ++PR+ATV A + ++R
Sbjct 262 NVLYMIKSGIVGVFVEDKYIRSLNEGDAFGERSLMFDEPRSATVIANATTECLTLNRGIL 321
Query 333 KRLLGPLEGLLMRNM 347
++LG L +L +N+
Sbjct 322 TQILGNLGQVLSKNL 336
Score = 58.2 bits (139), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 33/120 (27%), Positives = 66/120 (55%), Gaps = 11/120 (9%)
Query 100 RIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFK 159
R ++ + + F+F + +++ +++ + V GE ++ QG G ++++SGE V++
Sbjct 489 RKRDAIKSCFVFQYVSEQQLSLLVKSLRLVKFTSGEKIVVQGDKGTAFFILQSGEVAVYR 548
Query 160 EVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAAT-DLKLWSLDRQTFTHIV 218
N K + + D GE AL+Y+ R+AT+ AAT ++ LW++D++ F IV
Sbjct 549 -------NNK---FIRYLGKNDYFGERALLYDELRSATIEAATPEVHLWTVDKEAFLKIV 598
Score = 54.3 bits (129), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 28/109 (25%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
Query 231 ESLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK 290
+++K + + V + S + +L+ + +G+ I+ +G+ G F++L GE + K
Sbjct 492 DAIKSCFVFQYVSEQQLSLLVKSLRLVKFTSGEKIVVQGDKGTAFFILQSGEVAVYRNNK 551
Query 291 VVMKYSRGSYFGELALLKNQPRAATVTAKT-DCKVAYMDRRSFKRLLGP 338
+ + YFGE ALL ++ R+AT+ A T + + +D+ +F +++ P
Sbjct 552 FIRYLGKNDYFGERALLYDELRSATIEAATPEVHLWTVDKEAFLKIVEP 600
> ath:AT2G20050 ATP binding / cAMP-dependent protein kinase regulator/
catalytic/ protein kinase/ protein serine/threonine
phosphatase; K04345 protein kinase A [EC:2.7.11.11]
Length=1094
Score = 104 bits (260), Expect = 5e-22, Method: Compositional matrix adjust.
Identities = 78/283 (27%), Positives = 135/283 (47%), Gaps = 32/283 (11%)
Query 88 APVHPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKL 147
+P H KT E + I+ +L + FLF L + V+L+ + + G+ ++KQG +GD
Sbjct 469 SPAHRKTWEEEAHIERVLRDHFLFRKLTDSQCQVLLDCMQRLEANPGDIVVKQGGEGDCF 528
Query 148 YLIESGEADVFKEVTKEGTNEK--ETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLK 205
Y++ SGE +V T++G N + L+ T + + GELALM+N P A+V A
Sbjct 529 YVVGSGEFEVL--ATQDGKNGEVPRILQRYTAEKQSSFGELALMHNKPLQASVRAVDHGT 586
Query 206 LWSLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTI 265
LW+L R+ F I+ + + + L+ V+LL + + S VA++L + G TI
Sbjct 587 LWALKREDFRGILMSEFSNLASL--KLLRSVDLLSRLTILQLSHVAESLSEACFSDGQTI 644
Query 266 IREGEAGDTFYLLLDG-----------EAEAVK---------------GGKVVMKYSRGS 299
+ + + Y++ G E++ V G +V ++ GS
Sbjct 645 VTKDQKLQGLYVIQKGRVKISFCTEVLESQNVSSLTTGITNEYDNLEIGTEVSIEKHEGS 704
Query 300 YFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGL 342
YFGE ALL + +V A + + + +F+ +GPL +
Sbjct 705 YFGEWALLGELKDSLSVVAVGEVVCVVLTKENFESAVGPLTNI 747
> tgo:TGME49_019070 cAMP-dependent protein kinase regulatory subunit,
putative (EC:3.6.3.14 2.7.10.2 2.7.11.12)
Length=2634
Score = 102 bits (253), Expect = 3e-21, Method: Compositional matrix adjust.
Identities = 77/264 (29%), Positives = 131/264 (49%), Gaps = 17/264 (6%)
Query 91 HPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLI 150
H P +R+ ++L+ F +L + ++ V + + KG +++ G D +
Sbjct 2234 HRTYPTCTKRLVDVLEKKEGFMNLQLLQLRYVASTMRRECLAKGVRVMEAG-DEACMVFC 2292
Query 151 ESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLK-LWSL 209
GE FK + E E V + P + G L+ ++P A++V D LW L
Sbjct 2293 AWGE---FKILQAGLFGESE---VGVVCPDECFGLSELINDSPLTASLVTEVDNSVLWVL 2346
Query 210 DRQTFTHIVRDAAAKKREM---YEESLKEVELLKDVDAYERSKVADALKSQLYHAGDTII 266
+R T+ ++RD +R + E LK V ++KD+ E VA A K + + T+
Sbjct 2347 ERDTYNDLIRDMLEARRAVVPVIENFLKSVPIVKDMSETEIQNVARACKIETFSPHQTVF 2406
Query 267 REGEAGDTFYLLLDGEAEAVK---GGKVVMKYSR---GSYFGELALLKNQPRAATVTAKT 320
R G AGD F + GE +K G+ ++ R G YFGE+A++KNQ R A++ A T
Sbjct 2407 RAGMAGDMFCFIFKGEITMLKPMGAGQEPIELGRLQAGVYFGEMAVIKNQRRTASIIAAT 2466
Query 321 DCKVAYMDRRSFKRLLGPLEGLLM 344
D + +D+ SF+R+LG ++G ++
Sbjct 2467 DLTLFCLDKGSFERVLGRVKGKMI 2490
Score = 67.8 bits (164), Expect = 6e-11, Method: Compositional matrix adjust.
Identities = 63/281 (22%), Positives = 116/281 (41%), Gaps = 46/281 (16%)
Query 104 ILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESG--EADVFKEV 161
+L+ + L +E ++ A +I QG + Y++++G A+++
Sbjct 1488 LLEGVPVLKELSLERRKEIVKAMSLECFYPNTPIILQGEESQNFYVLKTGTVAAELY--- 1544
Query 162 TKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDA 221
G K K+ GE++++ N PR + A + ++L+SL + F ++ D
Sbjct 1545 VGPG---KPFRKIKEYNSTCYFGEMSIIKNEPRGCYITAKSPVQLYSLTGEKFKELLEDC 1601
Query 222 AAKKRE----MYE-ESLK-----------------------------EVELLKDVDAYER 247
+E YE E+LK +V ++ +D
Sbjct 1602 YPAFQEYAQAQYEQETLKRQASSQLVSSEAVREEPTADYGEIMNLLVQVPVINMLDEDAL 1661
Query 248 SKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEA---VKGGKV-VMKYSRGSYFGE 303
++ A K + Y + II EG + F+++ G+ V G V ++ G Y GE
Sbjct 1662 QQLTRAFKVECYQEREVIIHEGTPAEHFFIIFSGDVSVQKIVDGAPVEIVVLHAGEYLGE 1721
Query 304 LALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLM 344
+A L QPR A+ AK+D K+ + R F+ LG L+ +
Sbjct 1722 IAFLNEQPRTASCVAKSDVKLLSLTRSDFQVHLGALQDAFL 1762
Score = 63.2 bits (152), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 46/170 (27%), Positives = 78/170 (45%), Gaps = 13/170 (7%)
Query 188 LMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMYEESL---KEVELLKDVDA 244
++ + P V A T K+++ R+ F V+ K+ ++ K V +L +
Sbjct 1242 MLEDKPNPFAVKALTATKVFAYSREDFVRSVKHEQIKRTRDVATNMALIKIVPVLSKLTE 1301
Query 245 YERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGK---------VVMK- 294
+ ++A + + G+ I +E + D FYL+ GEA VK K VV +
Sbjct 1302 VQARRLARTFGEETFEDGEAIFKEFDEPDNFYLVKKGEAAVVKYKKDPTTKEMEEVVFRI 1361
Query 295 YSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLM 344
Y G YFGE+++L++Q R ATV A+ C V + + F L E +
Sbjct 1362 YQPGEYFGEISILRDQTRTATVKARGICTVLSLPKEDFNSQLRRFEAAFI 1411
Score = 50.1 bits (118), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 31/114 (27%), Positives = 58/114 (50%), Gaps = 6/114 (5%)
Query 101 IQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKE 160
I +L + + LD + + + AF+ ++ E +I +G + ++I SG+ V K
Sbjct 1643 IMNLLVQVPVINMLDEDALQQLTRAFKVECYQEREVIIHEGTPAEHFFIIFSGDVSVQKI 1702
Query 161 VTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTF 214
V + +++ + G+ +GE+A + PR A+ VA +D+KL SL R F
Sbjct 1703 V------DGAPVEIVVLHAGEYLGEIAFLNEQPRTASCVAKSDVKLLSLTRSDF 1750
Score = 49.3 bits (116), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 0/94 (0%)
Query 126 FEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGE 185
F E + GE + K+ + D YL++ GEA V K T E E + +PG+ GE
Sbjct 1311 FGEETFEDGEAIFKEFDEPDNFYLVKKGEAAVVKYKKDPTTKEMEEVVFRIYQPGEYFGE 1370
Query 186 LALMYNAPRAATVVAATDLKLWSLDRQTFTHIVR 219
++++ + R ATV A + SL ++ F +R
Sbjct 1371 ISILRDQTRTATVKARGICTVLSLPKEDFNSQLR 1404
> dre:100332846 acyl-CoA synthetase long-chain family member 6-like
Length=1391
Score = 75.9 bits (185), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 58/268 (21%), Positives = 125/268 (46%), Gaps = 33/268 (12%)
Query 91 HPKTPEVKERIQEILDNSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLI 150
H K+ E + I+ L + LD +++ ++++ ++K+G L ++G G + Y++
Sbjct 101 HSKSQESQRLIESALAENECMKYLDRDQLQCLVDSAYPTMLKQGVCLFQEGEHGAQAYIV 160
Query 151 ESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLD 210
E G+ EV++ G +++ ++ G EL L++N + TV A + +LW ++
Sbjct 161 EEGKL----EVSRAGQ------RLHIIESGMMFEELGLIHNHTCSTTVTALANSRLWVME 210
Query 211 RQTFTHIVRDAAA----KKREMYEES----------LKEVELLKDVDAYERSKVADALKS 256
Q F +++ ++ + ++ S ++ + +++ + + K A S
Sbjct 211 AQVFQKLMQKSSVITITQSLQLLRRSGVTLIENKVHVRTLNMMRGIKPAFQDKCQSACSS 270
Query 257 QL---YHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV------VMKYSRGSYFGELALL 307
+ Y GD II++G D ++L G+ + ++ V V +RG FGE A
Sbjct 271 EQKVHYSDGDYIIQDGSPADKLFILSQGQVKVLEKQCVGEDSVMVCVLTRGDSFGESASQ 330
Query 308 KNQPRAATVTAKTDCKVAYMDRRSFKRL 335
+ R+ +V A D +DR F+++
Sbjct 331 GDDVRSISVLAAGDVTCLLIDREVFRKV 358
> cel:C09G4.2 hypothetical protein
Length=617
Score = 68.2 bits (165), Expect = 5e-11, Method: Compositional matrix adjust.
Identities = 42/128 (32%), Positives = 68/128 (53%), Gaps = 11/128 (8%)
Query 107 NSFLFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGT 166
NSFL +LD +I+ + +A V V G +I+QG G +Y+I+ G+ V K+
Sbjct 70 NSFL-RNLDATQIEKISSAMYPVEVPAGAIIIRQGDLGSIMYVIQEGKVQVVKD------ 122
Query 167 NEKETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKR 226
V TM+ G GELA++++ R ATV A LW+++R F I+ ++A +K
Sbjct 123 ----NRFVRTMEDGALFGELAILHHCERTATVRAIESCHLWAIERNVFHAIMMESAREKT 178
Query 227 EMYEESLK 234
++ LK
Sbjct 179 MSFKRHLK 186
Score = 64.3 bits (155), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 33/105 (31%), Positives = 58/105 (55%), Gaps = 0/105 (0%)
Query 232 SLKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKV 291
+L+ L+++DA + K++ A+ AG IIR+G+ G Y++ +G+ + VK +
Sbjct 66 ALRLNSFLRNLDATQIEKISSAMYPVEVPAGAIIIRQGDLGSIMYVIQEGKVQVVKDNRF 125
Query 292 VMKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLL 336
V G+ FGELA+L + R ATV A C + ++R F ++
Sbjct 126 VRTMEDGALFGELAILHHCERTATVRAIESCHLWAIERNVFHAIM 170
> dre:557285 hcn2, si:dkey-28h18.1, wu:fj61d07; hyperpolarization
activated cyclic nucleotide-gated potassium channel 2; K04955
hyperpolarization activated cyclic nucleotide-gated potassium
channel 2
Length=901
Score = 64.3 bits (155), Expect = 6e-10, Method: Compositional matrix adjust.
Identities = 33/104 (31%), Positives = 52/104 (50%), Gaps = 0/104 (0%)
Query 233 LKEVELLKDVDAYERSKVADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVV 292
+ + L + D + + L+ +++ GD IIREG G Y + G + G +
Sbjct 484 VASMPLFANADPNFVTAMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNIG 543
Query 293 MKYSRGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLL 336
MK S GSYFGE+ LL R A+V A T C++ + +F +L
Sbjct 544 MKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVL 587
Score = 49.3 bits (116), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 61/261 (23%), Positives = 110/261 (42%), Gaps = 25/261 (9%)
Query 110 LFSSLDVEEIDVVLNAFEEVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEK 169
LF++ D + +L V + G+ +I++G G K+Y I+ G V +TK K
Sbjct 489 LFANADPNFVTAMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSV---LTKGNIGMK 545
Query 170 ETLKVNTMKPGDTVGELALMYNAPRAATVVAATDLKLWSLDRQTFTHIVRDAAAKKREMY 229
+ G GE+ L+ R A+V A T +L+SL F ++ + +R
Sbjct 546 -------LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 598
Query 230 EESLKEVELLKDVDAYERSKVADALKSQLYHAGDT-IIREGEAGDTFYLLLDGEAEAVKG 288
++ ++ + ++ KV L S +++ + +I+E D + L + + +
Sbjct 599 TVAIDRLDRIGKKNSILMHKVQHDLNSGVFNNRENEMIQEIVKYDREMVKLVKQGDMQRP 658
Query 289 GKVVMKYS-RGSYFGELALLKNQPRAATVTAKTDCKVAYMDRRSFKRLLG-PLEG----L 342
+ M S GS FG +QP ++ A VA SF +G PL G
Sbjct 659 RAMSMTPSTHGSMFGP----SSQPSTSSAIATLQQAVAM----SFCPQMGNPLMGSGSVQ 710
Query 343 LMRNMDHYRAVMTQLGLDTKY 363
R + ++ V TQ ++Y
Sbjct 711 SPRMVRRFQVVQTQTPPGSQY 731
> cel:T20G5.5 epac-1; Exchange Protein Activated by Cyclic AMP
family member (epac-1); K04351 Rap guanine nucleotide exchange
factor (GEF) 4
Length=1234
Score = 63.9 bits (154), Expect = 8e-10, Method: Composition-based stats.
Identities = 39/127 (30%), Positives = 68/127 (53%), Gaps = 2/127 (1%)
Query 236 VELLKDVDAYERSKVADALKSQLY-HAGDTIIREGEAGDTFYLLLDGEAEAVKGGKVVMK 294
++ L + + ++++ +K + Y HAG + R+GE G +Y++L G E GK+V
Sbjct 569 IKALSHLSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGAVEVNVNGKIVCL 628
Query 295 YSRGSYFGELALLKNQPRAAT-VTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAV 353
G FG+LAL+ + PRAAT VT + D +D+ F ++L +E +R D+ V
Sbjct 629 LREGDDFGKLALVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEANTVRLKDYGEDV 688
Query 354 MTQLGLD 360
+ +D
Sbjct 689 LVLEKVD 695
Score = 40.0 bits (92), Expect = 0.016, Method: Composition-based stats.
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 12/117 (10%)
Query 128 EVVVKKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELA 187
E V G + +QG G Y++ G +V N K V ++ GD G+LA
Sbjct 590 EQYVHAGSVVFRQGEIGVYWYIVLKGAVEV-------NVNGK---IVCLLREGDDFGKLA 639
Query 188 LMYNAPRAATVVAATDLKLW-SLDRQTFTHIVRDAAAKKREMYEESLKEVELLKDVD 243
L+ + PRAAT+V D ++ +D+ F I+ A + + ++V +L+ VD
Sbjct 640 LVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEANTVRLKDYG-EDVLVLEKVD 695
> dre:560986 novel protein similar to H.sapiens PNPLA6, patatin-like
phospholipase domain containing 6 (PNPLA6); K14676 lysophospholipid
hydrolase [EC:3.1.1.5]
Length=1348
Score = 63.5 bits (153), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 29/232 (12%)
Query 132 KKGETLIKQGADGDKLYLIESGEADVFKEVTKEGTNEKETLKVNTMKPGDTVGELALMYN 191
K G L +QG L+ + SG V++++ +++E + + +PG+ VG+LA++
Sbjct 495 KAGSVLARQGDQDVSLHFVLSGCLHVYQKMI----DKQEAVCLFVTQPGEMVGQLAVLTG 550
Query 192 APRAATVVAATDLKLWSLDRQTFTHIVRD-AAAKKREMYEESLKEVELLKDVDAYERSKV 250
P T+ A D + + F I+R+ + + +++ ++ +D
Sbjct 551 EPLIFTIKAERDCTFLKISKSEFYEIMREQPSVVLSAAHTVAIRMSAFVRQMDF------ 604
Query 251 ADALKSQLYHAGDTIIREGEAGDTFYLLLDGEAEAV---KGGK--VVMKYSRGSYFGELA 305
A+ AG + R+ + D Y++L+G +V GK +V +Y RG G +
Sbjct 605 --AIDWMAVEAGRALYRQDDQSDCTYIVLNGRLRSVIRKANGKKELVGEYGRGDLIGVVE 662
Query 306 LLKNQPRAATVTAKTDCKVAYMDRRSFKRLLGPLEGLLMRNMDHYRAVMTQL 357
L QPRA TV A D ++ + EG L Y V+T+L
Sbjct 663 ALTRQPRATTVHAVRDTELVKLP-----------EGTLNNIKRRYPQVVTRL 703
Lambda K H
0.313 0.131 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 15956348688
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40