bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
164,496 sequences; 82,071,388 total letters
Query= Eten_1118_orf2
Length=553
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_113140 isocitrate dehydrogenase, putative (EC:1.1.1... 703 0.0
pfa:PF13_0242 isocitrate dehydrogenase (NADP), mitochondrial p... 657 0.0
tgo:TGME49_066760 isocitrate dehydrogenase, putative (EC:1.1.1... 594 3e-169
xla:494713 idh1; isocitrate dehydrogenase 1 (NADP+), soluble (... 583 7e-166
ath:AT5G14590 isocitrate dehydrogenase, putative / NADP+ isoci... 581 3e-165
mmu:269951 Idh2, E430004F23, IDPm, Idh-2; isocitrate dehydroge... 572 9e-163
dre:100006589 idh1, MGC171441, MGC174090, MGC55806, cb876, fm9... 570 5e-162
hsa:3418 IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH;... 569 8e-162
mmu:15926 Idh1, AI314845, AI788952, E030024J03Rik, Id-1, Idh-1... 568 3e-161
ath:AT1G54340 ICDH; ICDH (ISOCITRATE DEHYDROGENASE); isocitrat... 566 5e-161
cel:F59B8.2 hypothetical protein; K00031 isocitrate dehydrogen... 565 2e-160
hsa:3417 IDH1, IDCD, IDH, IDP, IDPC, PICD; isocitrate dehydrog... 564 3e-160
dre:386951 idh2, wu:fb33c06, wu:fk31e05, wu:fq43b01, zgc:55485... 559 8e-159
xla:380013 idh2; isocitrate dehydrogenase 2 (NADP+), mitochond... 557 4e-158
ath:AT1G65930 isocitrate dehydrogenase, putative / NADP+ isoci... 556 7e-158
cel:C34F6.8 hypothetical protein; K00031 isocitrate dehydrogen... 550 8e-156
sce:YDL066W IDP1; Idp1p (EC:1.1.1.42); K00031 isocitrate dehyd... 546 1e-154
bbo:BBOV_III007260 17.m07637; isocitrate dehydrogenase, NADP-d... 541 2e-153
tpv:TP04_0620 isocitrate dehydrogenase (NADP+) (EC:1.1.1.42); ... 540 5e-153
sce:YLR174W IDP2; Cytosolic NADP-specific isocitrate dehydroge... 509 1e-143
sce:YNL009W IDP3; Idp3p (EC:1.1.1.42); K00031 isocitrate dehyd... 489 1e-137
sce:YIL094C LYS12, LYS10, LYS11; Homo-isocitrate dehydrogenase... 53.1 3e-06
ath:AT3G09810 isocitrate dehydrogenase, putative / NAD+ isocit... 44.3 0.001
eco:b0073 leuB, ECK0075, JW5807; 3-isopropylmalate dehydrogena... 43.5 0.002
ath:AT5G03290 isocitrate dehydrogenase, putative / NAD+ isocit... 42.0 0.006
xla:444419 idh3a, MGC82998; isocitrate dehydrogenase 3 (NAD+) ... 40.0 0.025
hsa:3419 IDH3A; isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.... 38.9 0.050
mmu:67834 Idh3a, 1110003P10Rik, 1500012E04Rik, AA407078, AI316... 36.6 0.26
eco:b1136 icd, ECK1122, icdA, icdE, JW1122; e14 prophage; isoc... 34.7 0.90
sce:YCL018W LEU2; Beta-isopropylmalate dehydrogenase (IMDH), c... 34.3 1.2
tgo:TGME49_021320 acetyl-CoA carboxylase, putative (EC:6.3.4.1... 34.3 1.4
sce:YAL029C MYO4, FUN22, SHE1; Myo4p 34.3 1.5
tgo:TGME49_015670 protein kinase, putative (EC:2.7.12.1 2.7.11... 33.1 3.0
pfa:PF13_0043 CCAAT-binding transcription factor, putative 31.6 9.4
hsa:91607 SLFN11, FLJ34922, SLFN8/9; schlafen family member 11 31.2
> tgo:TGME49_113140 isocitrate dehydrogenase, putative (EC:1.1.1.42);
K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=517
Score = 703 bits (1815), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 350/500 (70%), Positives = 400/500 (80%), Gaps = 15/500 (3%)
Query 24 PMNSLLRNAASIGRRSLYTAVACSRP-----SNCNLVKTNGGCSVEGVLSSSGAQHTLHQ 78
P SL +S R+L T AC RP + CN V + + G+ S Q + +
Sbjct 18 PFTSL---QSSTFARALSTKSACVRPQLLSSALCNTVSSTSSSASSGLAVSP-VQKSGNP 73
Query 79 RQQWRHFSSAEKQTEGAGSVPAFDIEGKIKVENPVVELDGDEMTRILWAWIKEKLILPYL 138
R F+SA G AF++EGKI V NPVVE+DGDEMTRILWAWIKEKL+ PY+
Sbjct 74 DASPRFFASAASVATGG----AFNLEGKIHVANPVVEMDGDEMTRILWAWIKEKLLFPYV 129
Query 139 DVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNVGIKCATITPDAARVKEFGLKQMWKSP 198
++ L+Y+DLS+ NRD T+D++TL+AAEAIKK +VGIKCATITPD RVKEF LK+MWKSP
Sbjct 130 EIPLEYYDLSVTNRDQTEDKVTLEAAEAIKKCHVGIKCATITPDEGRVKEFNLKKMWKSP 189
Query 199 NGTIRNILDGTVFRAPILISNVPRLVPGWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMV 258
NGTIRNILDGTVFRAPILISNVPRLVPGW+KPIVIGRHAYGDQYK+++L+C+GPG F +
Sbjct 190 NGTIRNILDGTVFRAPILISNVPRLVPGWKKPIVIGRHAYGDQYKAESLVCDGPGDFTIS 249
Query 259 FTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTI 318
FTPA S+ ++ V F GPG+ML MYNT SIRGFALSSF FAL Q MPLYLSTKNTI
Sbjct 250 FTPAGGSRVEKK--VFSFSGPGVMLGMYNTEDSIRGFALSSFKFALQQNMPLYLSTKNTI 307
Query 319 LKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGD 378
LK+YDG+FKDIF+ Y QFK FE+ I+YEHRLIDDMVAQALKSEGGFVWACKNYDGD
Sbjct 308 LKQYDGMFKDIFQSYYDEQFKPLFEKQGIWYEHRLIDDMVAQALKSEGGFVWACKNYDGD 367
Query 379 VQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFA 438
VQSDIVAQGYGSLGLMTS+LVCPDGKT VSEAAHGTVTRHYRQHQ+GQKTSTNPIASIFA
Sbjct 368 VQSDIVAQGYGSLGLMTSILVCPDGKTVVSEAAHGTVTRHYRQHQKGQKTSTNPIASIFA 427
Query 439 WSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAGLMPKDLAICVKGAENVKPSDYLITE 498
W+RGL HRAKLD N RL QFCLALE AC+QTVE G MPKDLA+CVKGA+ V SDYL TE
Sbjct 428 WTRGLAHRAKLDGNDRLGQFCLALEHACIQTVENGAMPKDLALCVKGADKVTASDYLTTE 487
Query 499 DFIDAIADTLKMNLITHQLP 518
+F+DAI+DTLKMNLIT Q P
Sbjct 488 EFMDAISDTLKMNLITRQAP 507
> pfa:PF13_0242 isocitrate dehydrogenase (NADP), mitochondrial
precursor (EC:1.1.1.42); K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=468
Score = 657 bits (1696), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 308/447 (68%), Positives = 369/447 (82%), Gaps = 1/447 (0%)
Query 97 SVPAFDIEGKIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATD 156
S AF+I GKI VENP+VELDGDEMTRI+W IKEKLILPY+++ +KYFDLS+ NRD T+
Sbjct 23 SKAAFNICGKINVENPIVELDGDEMTRIIWKDIKEKLILPYVNLKIKYFDLSIENRDKTN 82
Query 157 DQITLDAAEAIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPIL 216
DQ+T++AAE IKK +VGIKCATITPDAARVKEF LK+MWKSPNGTIRNILDGTVFR PIL
Sbjct 83 DQVTIEAAEEIKKTSVGIKCATITPDAARVKEFNLKEMWKSPNGTIRNILDGTVFRTPIL 142
Query 217 ISNVPRLVPGWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKF 276
I N+P+LVP W+KPIVIGRHAY DQYK K+L E G FE+VFTP D+S+ RE V F
Sbjct 143 IKNIPKLVPNWKKPIVIGRHAYADQYKQKSLKIEKSGKFEIVFTPDDNSQV-LRETVFHF 201
Query 277 EGPGLMLSMYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLT 336
+ PG+ L MYNT +SIR FALS F +AL KMP+Y+STK+TILK YDG+FKDIF+EIY
Sbjct 202 KSPGVCLGMYNTEESIRNFALSCFQYALDLKMPVYMSTKSTILKIYDGLFKDIFDEIYEK 261
Query 337 QFKSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTS 396
QFK FEQ+N++YEH+LIDDMVAQ LKSEGGF+WACKNYDGD+QSD VAQGYGSLGLM+S
Sbjct 262 QFKKSFEQHNLWYEHKLIDDMVAQVLKSEGGFLWACKNYDGDIQSDAVAQGYGSLGLMSS 321
Query 397 VLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQ 456
VL+CPDG T VSEAAHGTVTRHYR +Q+G+KTSTNPIASIFAW++GL HRAKLDKN L+
Sbjct 322 VLLCPDGVTCVSEAAHGTVTRHYRAYQKGEKTSTNPIASIFAWTKGLEHRAKLDKNDNLK 381
Query 457 QFCLALERACVQTVEAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNLITHQ 516
QFC ALE+AC++TVE GLM KDLA C+KG +NV DY+ T+D I+AI + LK+ ++ +Q
Sbjct 382 QFCYALEKACIETVEDGLMSKDLAGCIKGIKNVTEKDYIFTQDLINAINEKLKLKILQNQ 441
Query 517 LPIHHSNNKHKLSNPNWDHYAPSEHNS 543
+KL N NW+ YAP EH++
Sbjct 442 SKNDPQATSYKLKNDNWNFYAPQEHST 468
> tgo:TGME49_066760 isocitrate dehydrogenase, putative (EC:1.1.1.42);
K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=594
Score = 594 bits (1531), Expect = 3e-169, Method: Compositional matrix adjust.
Identities = 289/456 (63%), Positives = 351/456 (76%), Gaps = 9/456 (1%)
Query 62 SVEGVLSSSGAQHTLHQRQQWRHFSSAEKQTEGAGSVPAFDIEGKIKVENPVVELDGDEM 121
+ GV SS + T+ + ++ S+A QT + F +IKV+ PVVE+DGDEM
Sbjct 144 TASGVQPSSASCKTVKKEER----SNALSQTGIMNKMSGFQ---RIKVDQPVVEMDGDEM 196
Query 122 TRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNVGIKCATITP 181
R++WA IKEKLILPYLD+ L Y+DLS+ +RD TDDQ+T+DAA AIK++ VG+KCATITP
Sbjct 197 ARVIWAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTIDAALAIKRHGVGVKCATITP 256
Query 182 DAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIVIGRHAYGDQ 241
D RVKEF LK+MWKSPN TIRN LDGT+FRAPIL+ NVPRLVP W KPI+IGRHA+ DQ
Sbjct 257 DEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPILMKNVPRLVPSWTKPIIIGRHAHADQ 316
Query 242 YKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSIRGFALSSFN 301
YK+ + PG F M F PAD S P E V +F+G G+ L MYNT SI+GFA S F
Sbjct 317 YKALDFTVDKPGRFVMSFIPADKSNPEVHE-VYEFKGGGVALGMYNTDASIKGFAHSCFQ 375
Query 302 FALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQA 361
+AL QKMPLYLSTKNT+LK+YDG FKDIF+ IY ++K KFE+ ++YEHRLIDDMVAQA
Sbjct 376 YALDQKMPLYLSTKNTVLKKYDGRFKDIFQTIYEKEYKQKFEEAGLWYEHRLIDDMVAQA 435
Query 362 LKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQ 421
+KS GGFVWACKNYDGDVQSD+VAQGYGSLGLMTSVLVCPDGKT +EAAHGTVTRHYRQ
Sbjct 436 IKSSGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQ 495
Query 422 HQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAGLMPKDLAI 481
+Q+G KTSTNPIASI+AW+R L HRAKLD N +L++F ALE ACV+TVEAG M KDLA+
Sbjct 496 YQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLAL 555
Query 482 CVKGAENVKPSDYLITEDFIDAIADTLKMNLITHQL 517
+KG + + DYL TEDF+D +A + L+ Q+
Sbjct 556 AIKG-DKLTDRDYLCTEDFMDKLARVAERKLLERQI 590
> xla:494713 idh1; isocitrate dehydrogenase 1 (NADP+), soluble
(EC:1.1.1.42); K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=415
Score = 583 bits (1502), Expect = 7e-166, Method: Compositional matrix adjust.
Identities = 274/404 (67%), Positives = 324/404 (80%), Gaps = 2/404 (0%)
Query 113 VVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNV 172
VVE+ GDEMTR++W IKEKLILPY++++L +DL + NRDATDDQ+T+DAAEAIKKYNV
Sbjct 10 VVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDAAEAIKKYNV 69
Query 173 GIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIV 232
GIKCATITPD RV+EF LKQMWKSPNGTIRNIL GTVFR I+ N+PRLV GW KPI+
Sbjct 70 GIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWIKPII 129
Query 233 IGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEG-PGLMLSMYNTVQS 291
IGRHAYGDQY++ + GPG E+ FTP D + + + FE G+ L MYNT QS
Sbjct 130 IGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAI-KYVIHNFEDCGGVALGMYNTDQS 188
Query 292 IRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEH 351
IR FA SSF ALS+ PLY+STKNTILK YDG FKDIF+EIY ++KS+FE+N I+YEH
Sbjct 189 IRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFEENKIWYEH 248
Query 352 RLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAA 411
RLIDDMVAQA+KSEGGF+WACKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT +EAA
Sbjct 249 RLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAA 308
Query 412 HGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVE 471
HGTVTRHYR HQ+GQ+TSTNPIASIFAWSRGL HRAKLD N L+ F ALE C++T+E
Sbjct 309 HGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALEEVCIETIE 368
Query 472 AGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNLITH 515
AG M KDLA C+KG NV+ DYL T +F+D + + L++ L H
Sbjct 369 AGFMTKDLAACIKGLPNVQRGDYLSTFEFMDKLGENLQLKLAAH 412
> ath:AT5G14590 isocitrate dehydrogenase, putative / NADP+ isocitrate
dehydrogenase, putative; K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=485
Score = 581 bits (1497), Expect = 3e-165, Method: Compositional matrix adjust.
Identities = 280/455 (61%), Positives = 350/455 (76%), Gaps = 11/455 (2%)
Query 65 GVLSSSGAQHTLHQRQQWRHFSSAEKQTEGAGSVPAFDIEGKIKVENPVVELDGDEMTRI 124
G+ SS +++ + Q+ S+ GS +I+V+NP+VE+DGDEMTR+
Sbjct 41 GIFSSGASRNRVTFPVQFHRASAVRCFASSGGS-------DRIQVQNPIVEMDGDEMTRV 93
Query 125 LWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNVGIKCATITPDAA 184
+W+ IKEKLILPYLD+++KYFDL + NRDATDD++T+++AEA KYNV IKCATITPD
Sbjct 94 IWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAEAALKYNVAIKCATITPDEG 153
Query 185 RVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIVIGRHAYGDQYKS 244
RVKEFGLK MW+SPNGTIRNILDGTVFR PI+ SN+PRLVPGW KPI IGRHA+GDQY++
Sbjct 154 RVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVPGWEKPICIGRHAFGDQYRA 213
Query 245 KALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSIRGFALSSFNFAL 304
+ +GPG +MVF P D + P + + V F+GPG+ L+MYN +SIR FA SS AL
Sbjct 214 TDTVIKGPGKLKMVFVPEDGNAPVELD-VYDFKGPGVALAMYNVDESIRAFAESSMAMAL 272
Query 305 SQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKS 364
++K PLYLSTKNTILK+YDG FKDIF+E+Y +K KFE+++I+YEHRLIDDMVA A+KS
Sbjct 273 TKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQKFEEHSIWYEHRLIDDMVAYAVKS 332
Query 365 EGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQ 424
EGG+VWACKNYDGDVQSD++AQG+GSLGLMTSVL+ DGKT SEAAHGTVTRH+R HQ+
Sbjct 333 EGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSADGKTLESEAAHGTVTRHFRLHQK 392
Query 425 GQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAGLMPKDLAICVK 484
GQ+TSTN IASIFAW+RGL HRAKLDKN +L F LE +CV TVE G M KDLA+ +
Sbjct 393 GQETSTNSIASIFAWTRGLEHRAKLDKNEKLMDFVKKLESSCVNTVETGKMTKDLALLIH 452
Query 485 GAENVKPSDYLITEDFIDAIADTLKMNLITHQLPI 519
G + V +L TE+FIDA+A LK +LP+
Sbjct 453 GPK-VSRDLFLNTEEFIDAVASKLKTQF--KELPL 484
> mmu:269951 Idh2, E430004F23, IDPm, Idh-2; isocitrate dehydrogenase
2 (NADP+), mitochondrial (EC:1.1.1.42); K00031 isocitrate
dehydrogenase [EC:1.1.1.42]
Length=452
Score = 572 bits (1475), Expect = 9e-163, Method: Compositional matrix adjust.
Identities = 278/438 (63%), Positives = 335/438 (76%), Gaps = 9/438 (2%)
Query 83 RHFSSAEKQTEGAGSVPAFD-------IEGKIKVENPVVELDGDEMTRILWAWIKEKLIL 135
R SA A +VP++ E +IKVE PVVE+DGDEMTRI+W +IKEKLIL
Sbjct 13 RASGSARTWAPAALTVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLIL 72
Query 136 PYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNVGIKCATITPDAARVKEFGLKQMW 195
P++DV LKYFDL LPNRD T+DQ+T+D+A A +KY+V +KCATITPD ARV+EF LK+MW
Sbjct 73 PHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMW 132
Query 196 KSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIVIGRHAYGDQYKSKALLCEGPGLF 255
KSPNGTIRNIL GTVFR PI+ N+PRLVPGW KPI IGRHA+GDQYK+ + + G F
Sbjct 133 KSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTF 192
Query 256 EMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSIRGFALSSFNFALSQKMPLYLSTK 315
++VFTP D S + E V F G+ + MYNT +SI GFA S F +++ +K PLYLSTK
Sbjct 193 KLVFTPKDGSSAKEWE-VYNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTK 251
Query 316 NTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACKNY 375
NTILK YDG FKDIF+EI+ +K+ F++N I+YEHRLIDDMVAQ LKS GGFVWACKNY
Sbjct 252 NTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNY 311
Query 376 DGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIAS 435
DGDVQSDI+AQG+GSLGLMTSVLVCPDGKT +EAAHGTVTRHYR+HQ+G+ TSTNPIAS
Sbjct 312 DGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIAS 371
Query 436 IFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAGLMPKDLAICVKGAENVKPSDYL 495
IFAW+RGL HR KLD N L +F LE+ CVQTVE+G M KDLA C+ G NVK +++
Sbjct 372 IFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHF 431
Query 496 I-TEDFIDAIADTLKMNL 512
+ T DF+D I L L
Sbjct 432 LNTTDFLDTIKSNLDRAL 449
> dre:100006589 idh1, MGC171441, MGC174090, MGC55806, cb876, fm90e09,
im:7143416, wu:fm90e09; isocitrate dehydrogenase 1 (NADP+),
soluble (EC:1.1.1.42); K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=429
Score = 570 bits (1469), Expect = 5e-162, Method: Compositional matrix adjust.
Identities = 269/414 (64%), Positives = 329/414 (79%), Gaps = 3/414 (0%)
Query 100 AFDIEGKIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQI 159
F + K+K VVE+ GDEMTR++W IKEKLI PYL+++L +DL + NRDATDD++
Sbjct 12 GFKMSQKVKA-GSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKV 70
Query 160 TLDAAEAIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISN 219
T++AAEA+++YNVGIKCATITPD RV+EF LKQMW+SPNGTIRNIL GTVFR I+ N
Sbjct 71 TVEAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKN 130
Query 220 VPRLVPGWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGP 279
+PRLVPGW KPI+IGRHA+GDQYK+ + GPG EM + P + + + V FEG
Sbjct 131 IPRLVPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGET-LKFVVHDFEGT 189
Query 280 G-LMLSMYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQF 338
G + L MYNT +SIR FA SSF L++ P+YLSTKNTILK+YDG FKDIF+EIY ++
Sbjct 190 GGVALGMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEY 249
Query 339 KSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVL 398
K+K+E I+YEHRLIDDMVAQA+KSEGGF+WACKNYDGDVQSD VAQGYGSLG+MTSVL
Sbjct 250 KAKYEAMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVL 309
Query 399 VCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQF 458
VCPDG+T +EAAHGTVTRHYR HQQG++TSTNPIASIFAW+RGL HRA+LDKN+ L+ F
Sbjct 310 VCPDGRTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVF 369
Query 459 CLALERACVQTVEAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNL 512
ALE CV+T+EAG M KDLAIC+KG V SDYL T +F+D +A+ LK+ L
Sbjct 370 AEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLKIKL 423
> hsa:3418 IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH;
isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42);
K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=452
Score = 569 bits (1467), Expect = 8e-162, Method: Compositional matrix adjust.
Identities = 270/408 (66%), Positives = 324/408 (79%), Gaps = 2/408 (0%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
+IKV PVVE+DGDEMTRI+W +IKEKLILP++D+ LKYFDL LPNRD TDDQ+T+D+A
Sbjct 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A +KY+V +KCATITPD ARV+EF LK+MWKSPNGTIRNIL GTVFR PI+ N+PRLVP
Sbjct 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSM 285
GW KPI IGRHA+GDQYK+ + + G F+MVFTP D S + E V F G+ + M
Sbjct 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWE-VYNFPAGGVGMGM 221
Query 286 YNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQN 345
YNT +SI GFA S F +A+ +K PLY+STKNTILK YDG FKDIF+EI+ +K+ F++N
Sbjct 222 YNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKN 281
Query 346 NIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKT 405
I+YEHRLIDDMVAQ LKS GGFVWACKNYDGDVQSDI+AQG+GSLGLMTSVLVCPDGKT
Sbjct 282 KIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKT 341
Query 406 EVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERA 465
+EAAHGTVTRHYR+HQ+G+ TSTNPIASIFAW+RGL HR KLD N L +F LE+
Sbjct 342 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKV 401
Query 466 CVQTVEAGLMPKDLAICVKGAENVKPSDYLI-TEDFIDAIADTLKMNL 512
CV+TVE+G M KDLA C+ G NVK +++ + T DF+D I L L
Sbjct 402 CVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
> mmu:15926 Idh1, AI314845, AI788952, E030024J03Rik, Id-1, Idh-1,
Idpc, MGC115782; isocitrate dehydrogenase 1 (NADP+), soluble
(EC:1.1.1.42); K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=414
Score = 568 bits (1463), Expect = 3e-161, Method: Compositional matrix adjust.
Identities = 269/405 (66%), Positives = 319/405 (78%), Gaps = 0/405 (0%)
Query 113 VVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNV 172
VVE+ GDEMTRI+W IKEKLILPY++++L +DL + NRDAT+DQ+T DAAEAIKKYNV
Sbjct 10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV 69
Query 173 GIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIV 232
G+KCATITPD RV+EF LKQMWKSPNGTIRNIL GTVFR I+ N+PRLV GW KPI+
Sbjct 70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129
Query 233 IGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSI 292
IGRHAYGDQY++ + GPG E+ +TP D ++ EG G+ + MYN +SI
Sbjct 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSI 189
Query 293 RGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHR 352
FA SSF ALS+ PLYLSTKNTILK+YDG FKDIF+EIY ++KS+FE I YEHR
Sbjct 190 EDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHR 249
Query 353 LIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAH 412
LIDDMVAQA+KSEGGF+WACKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT +EAAH
Sbjct 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAH 309
Query 413 GTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEA 472
GTVTRHYR +Q+GQ+TSTNPIASIFAWSRGL HRAKLD N+ L F ALE C++T+EA
Sbjct 310 GTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEA 369
Query 473 GLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNLITHQL 517
G M KDLA C+KG NV+ SDYL T +F+D + + LK L +L
Sbjct 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL 414
> ath:AT1G54340 ICDH; ICDH (ISOCITRATE DEHYDROGENASE); isocitrate
dehydrogenase (NADP+)/ oxidoreductase, acting on the CH-OH
group of donors, NAD or NADP as acceptor; K00031 isocitrate
dehydrogenase [EC:1.1.1.42]
Length=416
Score = 566 bits (1460), Expect = 5e-161, Method: Compositional matrix adjust.
Identities = 270/408 (66%), Positives = 328/408 (80%), Gaps = 2/408 (0%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
KIKV NPVVE+DGDEMTR++W +IK+KLI P+L++++KYFDL LPNRD TDD++T++ AE
Sbjct 5 KIKVINPVVEMDGDEMTRVIWKFIKDKLIFPFLELDIKYFDLGLPNRDFTDDKVTIETAE 64
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A KYNV IKCATITPD ARV+EFGLK+MW+SPNGTIRNIL+GTVFR PI+ N+PRLVP
Sbjct 65 ATLKYNVAIKCATITPDEARVREFGLKKMWRSPNGTIRNILNGTVFREPIICRNIPRLVP 124
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSM 285
GW KPI IGRHA+GDQY++ L+ PG ++VF P+ SS+ + E V F G G+ L+M
Sbjct 125 GWTKPICIGRHAFGDQYRATDLIVNEPGKLKLVFEPSGSSQKTEFE-VFNFTGGGVALAM 183
Query 286 YNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQN 345
YNT +SIR FA SS A +K PLYLSTKNTILK YDG FKDIF+E+Y ++SK+E
Sbjct 184 YNTDESIRAFAESSMYTAYQKKWPLYLSTKNTILKIYDGRFKDIFQEVYEANWRSKYEAA 243
Query 346 NIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKT 405
I+YEHRLIDDMVA A+KSEGG+VWACKNYDGDVQSD +AQGYGSLG+MTSVLVCPDGKT
Sbjct 244 GIWYEHRLIDDMVAYAMKSEGGYVWACKNYDGDVQSDFLAQGYGSLGMMTSVLVCPDGKT 303
Query 406 EVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERA 465
+EAAHGTVTRHYR HQ+G +TSTN IASIFAWSRGL HRAKLD N+ L + LE A
Sbjct 304 IEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDSNAALLSYTEKLEAA 363
Query 466 CVQTVEAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNLI 513
C+ TVE+G M KDLA+ + GA+ V+ Y+ TE+FIDA+A LK L+
Sbjct 364 CMGTVESGKMTKDLALLIHGAK-VRRDQYVNTEEFIDAVAWELKRRLL 410
> cel:F59B8.2 hypothetical protein; K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=412
Score = 565 bits (1456), Expect = 2e-160, Method: Compositional matrix adjust.
Identities = 270/398 (67%), Positives = 321/398 (80%), Gaps = 4/398 (1%)
Query 113 VVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNV 172
+VE+ GDEMTRI+W IKEKLILPY+D+N+ +FDL + +RDATDDQ+T+DAA A KYNV
Sbjct 11 IVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLKYNV 70
Query 173 GIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIV 232
+KCATITPD ARV+EF LK+MWKSPNGTIRNIL GTVFR PI++ NVPRLV W KPI+
Sbjct 71 AVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPII 130
Query 233 IGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSI 292
IGRHA+ DQYK+ + G G E+ F AD ++ Q E V F+GPG+ LSMYNT SI
Sbjct 131 IGRHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQ-ETVFDFKGPGVSLSMYNTDDSI 189
Query 293 RGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHR 352
R FA +SF +AL +K PLYLSTKNTILK+YDG FKDIF EIY +++++F+ I+YEHR
Sbjct 190 RDFAHASFKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIY-PEYEAEFKAAGIWYEHR 248
Query 353 LIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAH 412
LIDDMVAQA+KS+GGFVWACKNYDGDVQSD VAQGYGSLGLMTSVLVCPDGKT +EAAH
Sbjct 249 LIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAEAAH 308
Query 413 GTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEA 472
GTVTRHYR HQ+GQ+TSTNPIASIFAWSRGL HRA LDKNS L+ F LE C++T+EA
Sbjct 309 GTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIETMEA 368
Query 473 GLMPKDLAICVKG--AENVKPSDYLITEDFIDAIADTL 508
G + KDLAICVKG A V +DYL T +F+D +A+ L
Sbjct 369 GFLTKDLAICVKGGNASAVTRTDYLNTFEFLDKLAENL 406
> hsa:3417 IDH1, IDCD, IDH, IDP, IDPC, PICD; isocitrate dehydrogenase
1 (NADP+), soluble (EC:1.1.1.42); K00031 isocitrate
dehydrogenase [EC:1.1.1.42]
Length=414
Score = 564 bits (1454), Expect = 3e-160, Method: Compositional matrix adjust.
Identities = 267/405 (65%), Positives = 319/405 (78%), Gaps = 0/405 (0%)
Query 113 VVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNV 172
VVE+ GDEMTRI+W IKEKLI PY++++L +DL + NRDAT+DQ+T DAAEAIKK+NV
Sbjct 10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV 69
Query 173 GIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIV 232
G+KCATITPD RV+EF LKQMWKSPNGTIRNIL GTVFR I+ N+PRLV GW KPI+
Sbjct 70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129
Query 233 IGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSI 292
IGRHAYGDQY++ + GPG E+ +TP+D ++ EG G+ + MYN +SI
Sbjct 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189
Query 293 RGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHR 352
FA SSF ALS+ PLYLSTKNTILK+YDG FKDIF+EIY Q+KS+FE I+YEHR
Sbjct 190 EDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHR 249
Query 353 LIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAH 412
LIDDMVAQA+KSEGGF+WACKNYDGDVQSD VAQGYGSLG+MTSVLVCPDGKT +EAAH
Sbjct 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAH 309
Query 413 GTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEA 472
GTVTRHYR +Q+GQ+TSTNPIASIFAW+RGL HRAKLD N L F ALE ++T+EA
Sbjct 310 GTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEA 369
Query 473 GLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNLITHQL 517
G M KDLA C+KG NV+ SDYL T +F+D + + LK+ L +L
Sbjct 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 414
> dre:386951 idh2, wu:fb33c06, wu:fk31e05, wu:fq43b01, zgc:55485;
isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42);
K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=449
Score = 559 bits (1441), Expect = 8e-159, Method: Compositional matrix adjust.
Identities = 269/408 (65%), Positives = 322/408 (78%), Gaps = 2/408 (0%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
+I+V PVVE+DGDEMTRI+W +IKEKLIL ++V+LKY+DL LP RD TDDQ+T+D+A
Sbjct 41 RIQVAQPVVEMDGDEMTRIIWEFIKEKLILTNVNVDLKYYDLGLPYRDQTDDQVTIDSAI 100
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A KKYNV +KCATITPD ARV+EF LK+MWKSPNGTIRNIL GTVFR PI+ N+PRLVP
Sbjct 101 ATKKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 160
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSM 285
GW + I IGRHA+GDQYK+ + PG F+MVFTPAD SK + E V F G G + M
Sbjct 161 GWTQAITIGRHAFGDQYKATDFVVNQPGKFKMVFTPADGSKNKEWE-VYDFPGGGCGMGM 219
Query 286 YNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQN 345
YNT +SI GFA S F +A+ +K PLY+STKNTILK YDG FKDIF++I+ +K +F++
Sbjct 220 YNTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKL 279
Query 346 NIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKT 405
I+YEHRLIDDMVAQ LKS G FVWACKNYDGDVQSDI+AQG+GSLGLMTSVLVCPDGKT
Sbjct 280 KIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKT 339
Query 406 EVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERA 465
+EAAHGTVTRHYR+HQ+G+ TSTNPIASIFAW+RGL HR KLD N L +F LER
Sbjct 340 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFSQTLERV 399
Query 466 CVQTVEAGLMPKDLAICVKGAENVKPSD-YLITEDFIDAIADTLKMNL 512
CV+TVE+G+M KDLA C+ G N K ++ Y+ T DF+DAI L L
Sbjct 400 CVETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLDKAL 447
> xla:380013 idh2; isocitrate dehydrogenase 2 (NADP+), mitochondrial
(EC:1.1.1.42); K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=454
Score = 557 bits (1436), Expect = 4e-158, Method: Compositional matrix adjust.
Identities = 267/409 (65%), Positives = 323/409 (78%), Gaps = 3/409 (0%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
+IKV NPVVE+DGDEMTRI+W +IKEKLIL +DV LKYFDL LP RD TDDQ+T+D+A
Sbjct 44 RIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTDDQVTIDSAL 103
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A KYNV +KCATITPD ARV+EF LK+MWKSPNGT+RNIL GTVFR PI+ N+PRLVP
Sbjct 104 ATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTVRNILGGTVFREPIICKNIPRLVP 163
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSM 285
GW + I IGRHA+GDQYK+ + + G F+MVFTPA+ + + E V KF G+ + M
Sbjct 164 GWTQAITIGRHAHGDQYKATDFVVDQAGTFKMVFTPANGTATKEWE-VFKFPAGGVGMGM 222
Query 286 YNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQN 345
YNT +SI GFA S F +A+ +K PLY+STKNTILK YDG FKDIF++I+ +K F++
Sbjct 223 YNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYKPDFDKV 282
Query 346 NIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKT 405
I+YEHRLIDDMVAQ LKS GGFVWACKNYDGDVQSDI+AQG+GSLGLM+SVLVCPDGKT
Sbjct 283 KIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMSSVLVCPDGKT 342
Query 406 EVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERA 465
+EAAHGTVTRHYR+HQ+G+ TSTNPIASIFAW+RGL HR KLD N L F L LE+
Sbjct 343 IEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLKLEKV 402
Query 466 CVQTVEAGLMPKDLAICVKGA-ENVKPSD-YLITEDFIDAIADTLKMNL 512
CV+TVE+G+M KDLA C+ G NV+ ++ Y+ T DF+DAI + L L
Sbjct 403 CVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLDKAL 451
> ath:AT1G65930 isocitrate dehydrogenase, putative / NADP+ isocitrate
dehydrogenase, putative; K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=410
Score = 556 bits (1433), Expect = 7e-158, Method: Compositional matrix adjust.
Identities = 265/408 (64%), Positives = 324/408 (79%), Gaps = 5/408 (1%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
KIKV NP+VE+DGDEMTR++W IK+KLI P++++++KYFDL LP+RDATDD++T+++AE
Sbjct 5 KIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAE 64
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A KKYNV IKCATITPD RV EFGLKQMW+SPNGTIRNIL+GTVFR PI+ NVP+LVP
Sbjct 65 ATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVP 124
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPG-LMLS 284
GW KPI IGRHA+GDQY++ + +GPG M F D + V F G G + ++
Sbjct 125 GWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETE---VFTFTGEGGVAMA 181
Query 285 MYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQ 344
MYNT +SIR FA +S N A +K PLYLSTKNTILK+YDG FKDIF+E+Y +KSK++
Sbjct 182 MYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDA 241
Query 345 NNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGK 404
I+YEHRLIDDMVA ALKSEGG+VWACKNYDGDVQSD +AQG+GSLGLMTSVLVCPDGK
Sbjct 242 AGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGK 301
Query 405 TEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALER 464
T +EAAHGTVTRH+R HQ+G +TSTN IASIFAW+RGL HRAKLD N++L F LE
Sbjct 302 TIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFTEKLEA 361
Query 465 ACVQTVEAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNL 512
ACV TVE+G M KDLA+ + G++ + + YL TE+FIDA+A LK L
Sbjct 362 ACVGTVESGKMTKDLALIIHGSKLSRDT-YLNTEEFIDAVAAELKERL 408
> cel:C34F6.8 hypothetical protein; K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=435
Score = 550 bits (1416), Expect = 8e-156, Method: Compositional matrix adjust.
Identities = 263/400 (65%), Positives = 315/400 (78%), Gaps = 2/400 (0%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
KIKV+NPVV+LDGDEMTRI+W IK KLILPYLD+++KY+DL L RD T+DQ+T+DAA
Sbjct 26 KIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAH 85
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
AI +++VGIKCATITPD AR+KEF LK+MW SPNGTIRNIL GTVFR PIL N+PRLVP
Sbjct 86 AILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVP 145
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLSM 285
GW +PI IGRHA+GDQYK L+ +++ D SK K G G+ L+M
Sbjct 146 GWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDGSKDVHNVYDFKKSG-GVGLAM 204
Query 286 YNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQN 345
YNT +SI+GFA S F +AL ++ PLYLSTKNTILK+YDG FKDIF++IY ++++ F+ N
Sbjct 205 YNTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADFKNN 264
Query 346 NIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKT 405
I+YEHRLIDD VAQALKS GGFVWACKNYDGDVQSDIVAQGYGSLGLM+SVL+CPDGKT
Sbjct 265 KIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPDGKT 324
Query 406 EVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERA 465
+EAAHGTVTRHYR+HQ+G TSTNPIASIFAW+RGL HR LD N L+ F L LE+A
Sbjct 325 IEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTLEKA 384
Query 466 CVQTVEAGLMPKDLAICVKGA-ENVKPSDYLITEDFIDAI 504
C+ TVE G M KDL+IC+ G + + YLITEDF+ AI
Sbjct 385 CIDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLSAI 424
> sce:YDL066W IDP1; Idp1p (EC:1.1.1.42); K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=428
Score = 546 bits (1406), Expect = 1e-154, Method: Compositional matrix adjust.
Identities = 267/409 (65%), Positives = 322/409 (78%), Gaps = 5/409 (1%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
KIKV+ PVVELDGDEMTRI+W IK+KLILPYLDV+LKY+DLS+ +RDAT D+IT DAAE
Sbjct 19 KIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAE 78
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
AIKKY VGIKCATITPD ARVKEF L +MWKSPNGTIRNIL GTVFR PI+I +PRLVP
Sbjct 79 AIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVP 138
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPAD-SSKPPQREAVLKFEGPGLMLS 284
W KPI+IGRHA+GDQYK+ L GPG E+V+ P+D ++ PQ V ++G G+ ++
Sbjct 139 RWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMA 198
Query 285 MYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQ 344
MYNT +SI GFA SSF A+ +K+ L+LSTKNTILK+YDG FKDIF+E+Y Q+KSKFEQ
Sbjct 199 MYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQ 258
Query 345 NNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGK 404
I YEHRLIDDMVAQ +KS+GGF+ A KNYDGDVQSDIVAQG+GSLGLMTS+LV PDGK
Sbjct 259 LGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGK 318
Query 405 TEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALER 464
T SEAAHGTVTRHYR++Q+G++TSTN IASIFAWSRGL R +LD L +F LE
Sbjct 319 TFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILES 378
Query 465 ACVQTVEA-GLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNL 512
A + TV+ G+M KDLA+ E S Y+ TE+F+DA+ L+ +
Sbjct 379 ATLNTVQQDGIMTKDLALACGNNER---SAYVTTEEFLDAVEKRLQKEI 424
> bbo:BBOV_III007260 17.m07637; isocitrate dehydrogenase, NADP-dependent
family protein (EC:1.1.1.42); K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=446
Score = 541 bits (1395), Expect = 2e-153, Method: Compositional matrix adjust.
Identities = 256/405 (63%), Positives = 314/405 (77%), Gaps = 4/405 (0%)
Query 105 GKIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAA 164
KI+V+NP+VELDGDEMTR++W+ +KEKLILPY+D+ L Y+DLSLPNRDATDD++T +AA
Sbjct 45 AKIQVKNPIVELDGDEMTRVMWSSVKEKLILPYVDIPLLYYDLSLPNRDATDDKVTFEAA 104
Query 165 EAIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLV 224
EAIK+ +G+KCATITPD AR+KEFGLK+M++SPNGTIRNILDGTVFR+PIL VP +
Sbjct 105 EAIKQVGIGVKCATITPDEARLKEFGLKRMYRSPNGTIRNILDGTVFRSPILTKTVPAYI 164
Query 225 PGWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLMLS 284
PGW+KPI+IGRHA+GDQY + + G G E+VFTPAD P Q V F+GPG+ LS
Sbjct 165 PGWKKPIIIGRHAFGDQYNATDIKIPGAGTLELVFTPADGG-PTQAYKVTDFKGPGVALS 223
Query 285 MYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQ 344
M+N QSIRGFA + F +AL KMPLY+STKNTILK YDG FKDIF+++Y +F+ FE
Sbjct 224 MFNVDQSIRGFARACFTYALDVKMPLYMSTKNTILKSYDGRFKDIFQQMYDDEFRPLFEA 283
Query 345 NNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGK 404
IFYEHRLIDDMVA A KSEGGFVWACKNYDGDVQSDIV+Q YGSL LM+SVL DGK
Sbjct 284 AGIFYEHRLIDDMVAYACKSEGGFVWACKNYDGDVQSDIVSQAYGSLALMSSVLYSSDGK 343
Query 405 TEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALER 464
+ ++EAAHGTVTRH+R HQ+G TSTN IA+I AW+R L R D N L +F LER
Sbjct 344 SFLAEAAHGTVTRHFRVHQKGGSTSTNSIATIVAWARALEKRGLADGNDALVEFGRKLER 403
Query 465 ACVQTVEAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLK 509
A V+ V+AG KDLAI + G + +DYL TE F+D + + L+
Sbjct 404 APVEAVDAGYYTKDLAIAIHGPQ---ATDYLDTESFMDKVKEFLE 445
> tpv:TP04_0620 isocitrate dehydrogenase (NADP+) (EC:1.1.1.42);
K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=459
Score = 540 bits (1392), Expect = 5e-153, Method: Compositional matrix adjust.
Identities = 263/437 (60%), Positives = 325/437 (74%), Gaps = 16/437 (3%)
Query 74 HTLHQRQQWRHFSSAEKQTEGAGSVPAFDIEGKIKVENPVVELDGDEMTRILWAWIKEKL 133
+ LH HFSS +++ KI V+NPVVE+DGDEMTRI+W +K KL
Sbjct 35 NILHALTSKNHFSSFASNK--------MNLKNKIVVKNPVVEIDGDEMTRIMWDKVKNKL 86
Query 134 ILPYLDVNLKYFDLSLPNRDATDDQITLDAAEAIKKYNVGIKCATITPDAARVKEFGLKQ 193
I P+LD++LKYFDLS+ RD+TDD++TLDAA AI+KY VG+KCATITPD AR+KEF LK+
Sbjct 87 IFPHLDLDLKYFDLSIQQRDSTDDKVTLDAAAAIQKYGVGVKCATITPDEARLKEFNLKR 146
Query 194 MWKSPNGTIRNILDGTVFRAPILISNVPRLVPGWRKPIVIGRHAYGDQYKSKALLCEGPG 253
M+KSPNGTIRNILDGTVFR PI+ +VP LVPGW+KPIVIGRHA+GDQY + + PG
Sbjct 147 MYKSPNGTIRNILDGTVFRVPIITKSVPLLVPGWKKPIVIGRHAFGDQYNCQDFVVTEPG 206
Query 254 LFEMVFTPADSSKPPQREAVLKFEGPGLMLSMYNTVQSIRGFALSSFNFALSQKMPLYLS 313
E+ FTP P+ V +F+GPG+ + M+N +SI GFA +SFN+ALSQ +PLY S
Sbjct 207 KLELRFTPEGGE--PKNVVVHEFKGPGVAIGMFNLDKSILGFARASFNYALSQNLPLYFS 264
Query 314 TKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACK 373
TKNTILK YDG FKD+F+++Y +FK+KFE+ + Y+HRLIDDMVA ALKSEGGFVWACK
Sbjct 265 TKNTILKYYDGRFKDLFQKVYDEEFKAKFEEKGLTYQHRLIDDMVAFALKSEGGFVWACK 324
Query 374 NYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPI 433
NYDGDVQSDIVAQ YGSLGLM+SVL DGK +SEAAHGTVTRHYRQ+Q+G TSTNP+
Sbjct 325 NYDGDVQSDIVAQAYGSLGLMSSVLFSSDGKCFLSEAAHGTVTRHYRQYQKGVVTSTNPV 384
Query 434 ASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAGLMPKDLAICV--KGAENVKP 491
A I AW++ L R KLD N L QF LER+CV+ ++AG M KDLA+ K EN
Sbjct 385 AIIVAWAKALERRGKLDANQELVQFAQKLERSCVEAIDAGFMTKDLALARNPKATEN--- 441
Query 492 SDYLITEDFIDAIADTL 508
DYL T+ +ID + + L
Sbjct 442 -DYLNTDQYIDKVLEFL 457
> sce:YLR174W IDP2; Cytosolic NADP-specific isocitrate dehydrogenase,
catalyzes oxidation of isocitrate to alpha-ketoglutarate;
levels are elevated during growth on non-fermentable carbon
sources and reduced during growth on glucose (EC:1.1.1.42);
K00031 isocitrate dehydrogenase [EC:1.1.1.42]
Length=412
Score = 509 bits (1310), Expect = 1e-143, Method: Compositional matrix adjust.
Identities = 250/409 (61%), Positives = 309/409 (75%), Gaps = 12/409 (2%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
KIKV NP+VE+DGDE TRI+W I++KL+LPYLDV+LKY+DLS+ RD T+DQ+T+D+A
Sbjct 3 KIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSAT 62
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A KY V +KCATITPD ARV+EF LK+MWKSPNGTIRNIL GTVFR PI+I +PRLVP
Sbjct 63 ATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLVP 122
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLK-FEGP---GL 281
W KPI+IGRHA+GDQYK+ ++ G +V+ SK + LK F+ P G+
Sbjct 123 QWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVY----KSKSGTHDVDLKVFDYPEHGGV 178
Query 282 MLSMYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSK 341
+ MYNT SI GFA +SF A+ +K+PLY +TKNTILK+YDG FKD+FE +Y +K K
Sbjct 179 AMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEK 238
Query 342 FEQNNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCP 401
FE I+YEHRLIDDMVAQ LKS+GG++ A KNYDGDV+SDIVAQG+GSLGLMTSVL+ P
Sbjct 239 FESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITP 298
Query 402 DGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLA 461
DGKT SEAAHGTVTRH+RQHQQG++TSTN IASIFAW+RG+ R KLD + +F
Sbjct 299 DGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQI 358
Query 462 LERACVQTV-EAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLK 509
LE A V TV E G+M KDLA+ + +E S Y+ TE+FIDA+ LK
Sbjct 359 LESATVNTVQEDGIMTKDLALILGKSER---SAYVTTEEFIDAVESRLK 404
> sce:YNL009W IDP3; Idp3p (EC:1.1.1.42); K00031 isocitrate dehydrogenase
[EC:1.1.1.42]
Length=420
Score = 489 bits (1258), Expect = 1e-137, Method: Compositional matrix adjust.
Identities = 238/411 (57%), Positives = 308/411 (74%), Gaps = 6/411 (1%)
Query 106 KIKVENPVVELDGDEMTRILWAWIKEKLILPYLDVNLKYFDLSLPNRDATDDQITLDAAE 165
KIKV +P+VE+DGDE TR++W IKEKLILPYLDV+LKY+DLS+ RD T+DQ+T D++
Sbjct 3 KIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSSY 62
Query 166 AIKKYNVGIKCATITPDAARVKEFGLKQMWKSPNGTIRNILDGTVFRAPILISNVPRLVP 225
A KY V +KCATITPD AR+KEF LK+MWKSPNGTIRNIL GTVFR PI+I +PRLVP
Sbjct 63 ATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLVP 122
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKF-EGPGLMLS 284
W KPI+IGRHA+GDQY++ + + G + F+ +D K V +F + G+ ++
Sbjct 123 HWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFS-SDDGKENIDLKVYEFPKSGGIAMA 181
Query 285 MYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQ 344
M+NT SI+GFA +SF AL +K+PL+ +TKNTILK YD FK IF+ ++ ++K KF+
Sbjct 182 MFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEKFQA 241
Query 345 NNIFYEHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGK 404
I YEHRLIDDMVAQ LKS+GGF+ A KNYDGDVQSDIVAQG+GSLGLMTS+L+ PDGK
Sbjct 242 LKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILITPDGK 301
Query 405 TEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALER 464
T SEAAHGTVTRH+R+HQ+G++TSTN IASIFAW+R + R KLD + +F LE+
Sbjct 302 TFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGNLLEK 361
Query 465 ACVQTVE-AGLMPKDLAICVKGAENVKPSDYLITEDFIDAIADTLKMNLIT 514
A + TV+ G M KDLA+ + G N S Y+ TE+FID +A L+ +++
Sbjct 362 ATLDTVQVGGKMTKDLALML-GKTN--RSSYVTTEEFIDEVAKRLQNMMLS 409
> sce:YIL094C LYS12, LYS10, LYS11; Homo-isocitrate dehydrogenase,
an NAD-linked mitochondrial enzyme required for the fourth
step in the biosynthesis of lysine, in which homo-isocitrate
is oxidatively decarboxylated to alpha-ketoadipate (EC:1.1.1.87);
K05824 homoisocitrate dehydrogenase [EC:1.1.1.87]
Length=371
Score = 53.1 bits (126), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 17/152 (11%)
Query 291 SIRGFALSSFNFALSQ-----KMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQN 345
+ R A + + AL + + L ++ K+ +L + DG+F++I +E+Y + K K+ Q
Sbjct 177 ATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESN-KDKYGQ- 234
Query 346 NIFYEHRLIDDMVAQALKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGK 404
I Y +++D MV + + F V N GD+ SD A GSLG++ S V P+
Sbjct 235 -IKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-- 291
Query 405 TEVSEAAHGTVTRHYRQHQQGQKTSTNPIASI 436
+ E HG+ K NPIA+I
Sbjct 292 IVIGEPCHGSAP------DIAGKGIANPIATI 317
> ath:AT3G09810 isocitrate dehydrogenase, putative / NAD+ isocitrate
dehydrogenase, putative (EC:1.1.1.41); K00030 isocitrate
dehydrogenase (NAD+) [EC:1.1.1.41]
Length=374
Score = 44.3 bits (103), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 32/101 (31%), Positives = 53/101 (52%), Gaps = 9/101 (8%)
Query 315 KNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGF-VWACK 373
K I+++ DG+F +E+ +K+ + I+YE +ID+ +K+ F V
Sbjct 212 KANIMQKTDGLFLQCCDEV-----AAKYPE--IYYEKVVIDNCCMMLVKNPALFDVLVMP 264
Query 374 NYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGT 414
N GD+ SD+ A G LGL S+ + DG ++EA HG+
Sbjct 265 NLYGDIISDLCAGLVGGLGLTPSMNIGEDG-IALAEAVHGS 304
> eco:b0073 leuB, ECK0075, JW5807; 3-isopropylmalate dehydrogenase,
NAD(+)-dependent (EC:1.1.1.85); K00052 3-isopropylmalate
dehydrogenase [EC:1.1.1.85]
Length=363
Score = 43.5 bits (101), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 50/164 (30%), Positives = 69/164 (42%), Gaps = 23/164 (14%)
Query 343 EQNNIFYEHRLIDDMVAQALKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCP 401
E ++ H ID+ Q +K F V C N GD+ SD A GS+G++ S +
Sbjct 215 EYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE 274
Query 402 DGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLA 461
G + E A G+ K NPIA I S L R LD + A
Sbjct 275 QG-FGLYEPAGGSAP------DIAGKNIANPIAQIL--SLALLLRYSLDADDA----ACA 321
Query 462 LERACVQTVEAGLMPKDLAICVKGAENVKPSDYLITEDFIDAIA 505
+ERA + +E G+ DLA +GA V T++ D IA
Sbjct 322 IERAINRALEEGIRTGDLA---RGAAAVS------TDEMGDIIA 356
> ath:AT5G03290 isocitrate dehydrogenase, putative / NAD+ isocitrate
dehydrogenase, putative (EC:1.1.1.41); K00030 isocitrate
dehydrogenase (NAD+) [EC:1.1.1.41]
Length=374
Score = 42.0 bits (97), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 44/160 (27%), Positives = 68/160 (42%), Gaps = 22/160 (13%)
Query 315 KNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGF-VWACK 373
K I+++ DG+F E+ K+ + I YE +ID+ +K+ F V
Sbjct 212 KANIMQKTDGLFLKCCREV-----AEKYPE--ITYEEVVIDNCCMMLVKNPALFDVLVMP 264
Query 374 NYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPI 433
N GD+ SD+ A G LGL S + DG ++EA HG+ K NP
Sbjct 265 NLYGDIISDLCAGLVGGLGLTPSCNIGEDG-VALAEAVHGSAP------DIAGKNLANPT 317
Query 434 ASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAG 473
A + + L H L N + +Q + A + T+ G
Sbjct 318 ALLLSGVMMLRH---LKFNEQAEQ----IHSAIINTIAEG 350
> xla:444419 idh3a, MGC82998; isocitrate dehydrogenase 3 (NAD+)
alpha (EC:1.1.1.41); K00030 isocitrate dehydrogenase (NAD+)
[EC:1.1.1.41]
Length=368
Score = 40.0 bits (92), Expect = 0.025, Method: Compositional matrix adjust.
Identities = 46/184 (25%), Positives = 78/184 (42%), Gaps = 22/184 (11%)
Query 299 SFNFALS-QKMPLYLSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDM 357
+F +A + Q+ + K I++ DG+F E+ KF N Y + +M
Sbjct 185 AFEYARNNQRSTVTAVHKANIMRMSDGLFLKKCREVAENFKDIKF---NEMYLDTVCLNM 241
Query 358 VAQALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTR 417
V ++ + V N GD+ SD+ A G LG+ S + +G + E+ HGT
Sbjct 242 VQDPIQFD---VLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANG-VAIFESVHGTAP- 296
Query 418 HYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAG-LMP 476
K NP A + + L H L ++ +E AC +T+++G ++
Sbjct 297 -----DIAGKDFANPTALLLSAVMMLRHMG-------LHEYGRKIESACFETIKSGKVLT 344
Query 477 KDLA 480
KDL
Sbjct 345 KDLG 348
> hsa:3419 IDH3A; isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41);
K00030 isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
Length=366
Score = 38.9 bits (89), Expect = 0.050, Method: Compositional matrix adjust.
Identities = 51/193 (26%), Positives = 77/193 (39%), Gaps = 29/193 (15%)
Query 315 KNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACKN 374
K I++ DG+F E+ + KF N Y + +MV + + V N
Sbjct 200 KANIMRMSDGLFLQKCREVAESCKDIKF---NEMYLDTVCLNMVQDPSQFD---VLVMPN 253
Query 375 YDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIA 434
GD+ SD+ A G LG+ S + +G + E+ HGT K NP A
Sbjct 254 LYGDILSDLCAGLIGGLGVTPSGNIGANG-VAIFESVHGTAP------DIAGKDMANPTA 306
Query 435 SIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAG-LMPKDLAICVKGAENVKPSD 493
+ + L H D +R +E AC T++ G + KDL N K SD
Sbjct 307 LLLSAVMMLRHMGLFDHAAR-------IEAACFATIKDGKSLTKDL------GGNAKCSD 353
Query 494 YLITEDFIDAIAD 506
+ TE+ + D
Sbjct 354 F--TEEICRRVKD 364
> mmu:67834 Idh3a, 1110003P10Rik, 1500012E04Rik, AA407078, AI316514;
isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41);
K00030 isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
Length=366
Score = 36.6 bits (83), Expect = 0.26, Method: Compositional matrix adjust.
Identities = 50/193 (25%), Positives = 76/193 (39%), Gaps = 29/193 (15%)
Query 315 KNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHRLIDDMVAQALKSEGGFVWACKN 374
K I++ DG+F E+ KF N Y + +MV + + V N
Sbjct 200 KANIMRMSDGLFLQKCREVAENCKDIKF---NEMYLDTVCLNMVQDPSQFD---VLVMPN 253
Query 375 YDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTRHYRQHQQGQKTSTNPIA 434
GD+ SD+ A G LG+ S + +G + E+ HGT K NP A
Sbjct 254 LYGDILSDLCAGLIGGLGVTPSGNIGANG-VAIFESVHGTAP------DIAGKDMANPTA 306
Query 435 SIFAWSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAG-LMPKDLAICVKGAENVKPSD 493
+ + L H D ++ +E AC T++ G + KDL N K SD
Sbjct 307 LLLSAVMMLRHMGLFDHAAK-------IEAACFATIKDGKSLTKDL------GGNAKCSD 353
Query 494 YLITEDFIDAIAD 506
+ TE+ + D
Sbjct 354 F--TEEICRRVKD 364
> eco:b1136 icd, ECK1122, icdA, icdE, JW1122; e14 prophage; isocitrate
dehydrogenase, specific for NADP+ (EC:1.1.1.42); K00031
isocitrate dehydrogenase [EC:1.1.1.42]
Length=416
Score = 34.7 bits (78), Expect = 0.90, Method: Compositional matrix adjust.
Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 22/148 (14%)
Query 312 LSTKNTILKEYDGVFKDIFEEIYLTQFKSKFEQNNIFYEHR--------LIDDMVAQA-- 361
L K I+K +G FKD ++ +F + + + + +I D++A A
Sbjct 227 LVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFL 286
Query 362 ----LKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTEVSEAAHGTVTR 417
L+ V AC N +GD SD +A G +G+ + + + EA HGT +
Sbjct 287 QQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDE--CALFEATHGTAPK 344
Query 418 HYRQHQQGQKTSTNPIASIFAWSRGLTH 445
+ Q + NP + I + L H
Sbjct 345 YAGQDK------VNPGSIILSAEMMLRH 366
> sce:YCL018W LEU2; Beta-isopropylmalate dehydrogenase (IMDH),
catalyzes the third step in the leucine biosynthesis pathway
(EC:1.1.1.85); K00052 3-isopropylmalate dehydrogenase [EC:1.1.1.85]
Length=364
Score = 34.3 bits (77), Expect = 1.2, Method: Compositional matrix adjust.
Identities = 39/146 (26%), Positives = 61/146 (41%), Gaps = 19/146 (13%)
Query 341 KFEQNNIFYEHRLIDDMVAQALKSEGGF--VWACKNYDGDVQSDIVAQGYGSLGLMTSVL 398
K E + +H+LID +K+ + N GD+ SD + GSLGL+ S
Sbjct 211 KNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSAS 270
Query 399 VC--PDGKTE--VSEAAHGTVTRHYRQHQQGQKTSTNPIASIFAWSRGLTHRAKLDKNSR 454
+ PD T + E HG+ K NPIA+I + + L L + +
Sbjct 271 LASLPDKNTAFGLYEPCHGSAPDL-------PKNKVNPIATILSAAMMLKLSLNLPEEGK 323
Query 455 LQQFCLALERACVQTVEAGLMPKDLA 480
A+E A + ++AG+ DL
Sbjct 324 ------AIEDAVKKVLDAGIRTGDLG 343
> tgo:TGME49_021320 acetyl-CoA carboxylase, putative (EC:6.3.4.14
2.3.1.12 6.4.1.3); K11262 acetyl-CoA carboxylase / biotin
carboxylase [EC:6.4.1.2 6.3.4.14]
Length=2599
Score = 34.3 bits (77), Expect = 1.4, Method: Compositional matrix adjust.
Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 14/109 (12%)
Query 226 GWRKPIVIGRHAYGDQYKSKALLCEGPGLFEMVFTPADSSKPPQREAVLKFEGPGLML-S 284
GW K +V+GR G A+ E V PAD S P RE+V+ G S
Sbjct 2260 GWGKSVVVGRARLGG-IPFGAIAVETRTTEARV--PADPSSPDSRESVVMHAGQVWFPDS 2316
Query 285 MYNTVQSIRGFALSSFNFALSQKMPLYLSTKNTILKEYDGVFKDIFEEI 333
Y T Q+I +F + +PL + + + G +D+FEEI
Sbjct 2317 AYKTAQAIN-------DFNRGENLPLIIFAN---WRGFSGGTRDMFEEI 2355
> sce:YAL029C MYO4, FUN22, SHE1; Myo4p
Length=1471
Score = 34.3 bits (77), Expect = 1.5, Method: Compositional matrix adjust.
Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 3/67 (4%)
Query 56 KTNGGCSVEGVLSSSGAQHTLHQRQQWRHFSSAEKQTEGAGSVPAFDIEGKIKVENPVVE 115
K N V G SGA T+ + R+F+S ++ G V IE +I NP++E
Sbjct 156 KANQTVVVSG---ESGAGKTVSAKYIMRYFASVQESNNREGEVEMSQIESQILATNPIME 212
Query 116 LDGDEMT 122
G+ T
Sbjct 213 AFGNAKT 219
> tgo:TGME49_015670 protein kinase, putative (EC:2.7.12.1 2.7.11.13
3.2.1.17)
Length=1745
Score = 33.1 bits (74), Expect = 3.0, Method: Compositional matrix adjust.
Identities = 22/53 (41%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query 28 LLRNAASIGRRSLYTAVACSRPSNCNLVKTNGGCSVEGVLS-SSGAQHTLHQR 79
LLRNA + +L T ACS P NC V+T G + + V +S HT H+R
Sbjct 40 LLRNATTEAEPTLETLSACS-PKNCLRVQTEQGSTSDTVKRFASEVLHTCHKR 91
> pfa:PF13_0043 CCAAT-binding transcription factor, putative
Length=152
Score = 31.6 bits (70), Expect = 9.4, Method: Composition-based stats.
Identities = 33/138 (23%), Positives = 65/138 (47%), Gaps = 13/138 (9%)
Query 424 QGQKTSTNPIA-SIFAWSRGLTHRA---KLD-KNSRLQQFCLALERACVQTVEAGLMPKD 478
Q + TN I ++F S G+ +A +D +N R+++ L C+ +
Sbjct 4 QNNEEQTNKIKETLFGLSTGIIQKAINNNVDLRNYRMRKEALETLGKCLSMFILYITDGA 63
Query 479 LAICVKGAENVKPSDYLITEDFIDAIADTLKMNL---ITHQLPIHHSNNKHKLSNPNWDH 535
+ C EN K S L+ D ++++ D+L +++ + QL I NNK ++S + +
Sbjct 64 MEYC----ENEKRSTILV-RDILNSLDDSLFLDIHDELKRQLTIQEENNKTEISKVSENV 118
Query 536 YAPSEHNSEVDDHDGHTK 553
A N+E++++ K
Sbjct 119 QAQYASNNELNNNQKEGK 136
> hsa:91607 SLFN11, FLJ34922, SLFN8/9; schlafen family member
11
Length=901
Score = 31.2 bits (69), Expect = 9.8, Method: Compositional matrix adjust.
Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 0/56 (0%)
Query 439 WSRGLTHRAKLDKNSRLQQFCLALERACVQTVEAGLMPKDLAICVKGAENVKPSDY 494
WS+G+ ++ K ++Q + C + + G PKD+A+ V A+ V+ Y
Sbjct 769 WSQGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKY 824
Lambda K H
0.318 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 27257474100
Database: egene_temp_file_orthology_annotation_similarity_blast_database_866
Posted date: Sep 17, 2011 2:57 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40