bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 164,496 sequences; 82,071,388 total letters Query= Eten_0516_orf6 Length=623 Score E Sequences producing significant alignments: (Bits) Value tgo:TGME49_057010 insulysin, putative (EC:3.4.24.56); K01408 i... 443 9e-124 tgo:TGME49_006510 peptidase M16 domain containing protein (EC:... 97.4 2e-19 cpv:cgd1_1680 insulinase like protease, signal peptide ; K0140... 92.0 7e-18 cpv:cgd2_4270 secreted insulinase-like peptidase 86.7 2e-16 dre:561390 ide, MGC162603, zgc:162603; insulin-degrading enzym... 79.3 4e-14 mmu:15925 Ide, 1300012G03Rik, 4833415K22Rik, AA675336, AI50753... 76.3 3e-13 hsa:3416 IDE, FLJ35968, INSULYSIN; insulin-degrading enzyme (E... 72.4 5e-12 cel:F44E7.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 72.0 6e-12 cel:Y70C5C.1 hypothetical protein; K01408 insulysin [EC:3.4.24... 70.5 2e-11 cel:C02G6.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 63.2 3e-09 sce:YLR389C STE23; Metalloprotease involved, with homolog Axl1... 58.5 7e-08 mmu:230598 Nrd1, 2600011I06Rik, AI875733, MGC25477, NRD-C; nar... 52.4 6e-06 hsa:4898 NRD1, hNRD1, hNRD2; nardilysin (N-arginine dibasic co... 52.4 6e-06 tgo:TGME49_044490 insulin-degrading enzyme, putative (EC:3.4.2... 52.0 7e-06 tgo:TGME49_069870 hypothetical protein 50.4 2e-05 cel:C28F5.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 48.1 1e-04 ath:AT2G41790 peptidase M16 family protein / insulinase family... 44.7 0.001 dre:557565 nrd1, si:dkey-171o17.4; nardilysin (N-arginine diba... 42.7 0.004 ath:AT1G06900 catalytic/ metal ion binding / metalloendopeptid... 42.4 0.006 ath:AT3G57470 peptidase M16 family protein / insulinase family... 41.2 0.011 dre:393572 traf3ip1, Elipsa, MGC63522, zgc:63522; TNF receptor... 41.2 0.014 eco:b2821 ptrA, ECK2817, JW2789, ptr; protease III (EC:3.4.24.... 38.5 0.072 cpv:cgd2_920 peptidase'insulinase-like peptidase' 37.7 0.14 mmu:209361 Taf3, 140kDa, 4933439M23Rik, AW539625, TAF140, TAFI... 36.6 0.31 pfa:PFE0230w conserved Plasmodium protein, unknown function 35.8 0.56 tgo:TGME49_016980 hypothetical protein 35.4 0.62 ath:AT5G67320 HOS15; HOS15 (high expression of osmotically res... 34.3 1.7 pfa:MAL7P1.129 conserved Plasmodium protein, unknown function 32.3 5.5 mmu:226562 Prrc2c, 1810043M20Rik, 9630039I18Rik, A630006J20, B... 32.3 6.5 > tgo:TGME49_057010 insulysin, putative (EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56] Length=953 Score = 443 bits (1140), Expect = 9e-124, Method: Compositional matrix adjust. Identities = 213/466 (45%), Positives = 315/466 (67%), Gaps = 3/466 (0%) Query 92 RERERERERERERPNAFRMPPPLLHIPKASELEILPGLLGLNEPELISEQGGNAGTAVWW 151 +E+ R E P A+++PP L H+P+ +L +LP L G++ PEL+ + + G AVWW Sbjct 485 KEQRRRLETVTPSPGAYKIPPALKHVPRPEDLHLLPALGGMSIPELLGDSNTSGGHAVWW 544 Query 152 QGQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGITHSLA 211 QGQG +PRV + + + ++ SRTQ ++ +AA+AE L EET D + CGI+HS+ Sbjct 545 QGQGTLPVPRVHANIKARTQRSRTNMASRTQATLLMAALAEQLDEETVDLKQCGISHSVG 604 Query 212 FKGTGFHMTFEGYTKTQLDKLMSHVASVLRDPSVVESERFERVKQKQIKLLADPATNMAF 271 G G + F YT QL ++M+ VAS ++DP V E +RF+R+KQ+ I+ L D A+ +A+ Sbjct 605 VSGDGLLLAFAAYTPKQLRQVMAVVASKIQDPQV-EQDRFDRIKQRMIEELEDSASQVAY 663 Query 272 EHALQAAAILTRNDAFSRMDLLNALEQ--TTYDDSIAKLSELKNVHVDAFVMGNIDRDQS 329 EHA+ AA++L RNDA SR DLL L+ T+ ++++ +LK VH DAF+MGNID+ + Sbjct 664 EHAIAAASVLLRNDANSRKDLLRLLKSSSTSLNETLKTFRDLKAVHADAFIMGNIDKADA 723 Query 330 LLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANPIKGDKDHASLVQFQLGVPSI 389 + +SFL+ +GFT I DA +SL ++Q+ IEA +ANPI D +HA++VQ+QLGVPSI Sbjct 724 NSVVQSFLQDSGFTQIPMKDAAQSLVVDQRAPIEALIANPIPKDVNHATVVQYQLGVPSI 783 Query 390 EERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGSKSHPDEVVK 449 EERVNLA+L Q LNRR++D LRTE QLGYI GA+ +S L+C +EGS+ HPDE+ Sbjct 784 EERVNLAVLGQMLNRRLFDRLRTEEQLGYIVGARSYIDSSVESLRCVLEGSRKHPDEIAD 843 Query 450 MIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADEIFSHANCFSKR 509 +ID EL K D++ ++ + EL WKE+A A+L K F E+F +S +I +H +CF+KR Sbjct 844 LIDKELWKMNDHLQSISDGELDHWKESARAELEKPTETFYEEFGRSWGQIANHGHCFNKR 903 Query 510 DLEVKYLDNDFSRKHLLRTFTKLSDPSRRMVVKLIADLEPAKEVTL 555 DLE+ YL+ +F+RK L RT+TKL +P+RR+V ++ + P +L Sbjct 904 DLELIYLNTEFNRKQLSRTYTKLLEPTRRLVGFVLNHVTPCLNKSL 949 > tgo:TGME49_006510 peptidase M16 domain containing protein (EC:4.1.1.70 3.4.24.13 3.4.24.56 3.4.21.10 3.4.24.35 3.2.1.91) Length=2435 Score = 97.4 bits (241), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 88/356 (24%), Positives = 170/356 (47%), Gaps = 13/356 (3%) Query 199 ADFQYCGITHSLAFKGTGFHMTFEGYTKTQLDKLMSHVASVLRDPS-VVESERFERVKQK 257 A FQ CG+ ++F + + +++ +++ + VL++ V+ F ++ Sbjct 1011 ASFQGCGVDLLMSFTNGALVLEIQAFSEL-FAPVLARLIEVLKESQDNVKQSDFNKIFNT 1069 Query 258 QIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTT--YDDSIAKLSEL--KN 313 L+D +T FE AL A + R + FS++DL +A+ + ++D L ++ KN Sbjct 1070 LKVQLSDFSTVTPFELALDVALSVVRRNRFSQLDLRSAVTDASSQFEDFKVFLEKVLTKN 1129 Query 314 VHVDAFVMGNIDRDQSLLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANPIKGD 373 +D F+MG+ID +++ L E F P+ ++ S + IE +NPI D Sbjct 1130 A-LDVFIMGDIDYEEARKLAEDFRAALSKQPLPFSESAGSEILNLADDIEIRFSNPIPED 1188 Query 374 KDHASLVQFQL-GVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTAL 432 +A + + P + E V +++ + ++ +D++RT GY+A A + Sbjct 1189 ATNAYVSLYVTHPPPDMMEMVVYSLIGEVISSPFFDTIRTHWMDGYVAAAAVREVPPAMT 1248 Query 433 LQCFVEGSKSHPDEVVKMIDAELAKAKDYI--SNMPEAELSRWKEAAHAKLTKVEANFSE 490 L V+GS+ PDE+ + + A LA+ ++ I S EA L R + + +K + +FS+ Sbjct 1249 LATIVQGSQRKPDELERHVCAFLAEMEENIGSSMTTEAFLERLRWLSSSKFHRSATSFSD 1308 Query 491 DFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTF-TKLSDPS--RRMVVKL 543 F + +I S CF + L + S +L+++ L D + +R+ VK+ Sbjct 1309 YFGEVTSQIASRNFCFIREQLARLATEKFLSCPAILKSYMNSLVDRANRKRITVKI 1364 > cpv:cgd1_1680 insulinase like protease, signal peptide ; K01408 insulysin [EC:3.4.24.56] Length=1033 Score = 92.0 bits (227), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 111/229 (48%), Gaps = 8/229 (3%) Query 316 VDAFVMGNIDRDQSLLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANPIKGDKD 375 + A++ GNI +++SL L E F+ + + +++ + + I+ L NP+ D + Sbjct 761 IIAYLQGNISKNKSLYLIEKFVLNSKILSLNDKYSMKKKIHKLTRPIDIALINPVFEDIN 820 Query 376 HASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQC 435 + L +Q GVPS EE+++L L + IYD+LRT QLGYI A +ST LL Sbjct 821 NTVLAFYQFGVPSFEEKLHLMALQPIIQGYIYDNLRTNKQLGYIIFANIVPISSTRLLVV 880 Query 436 FVEGSKSHPDE----VVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSED 491 VEG ++ E +++ E + K + NM K A + + +F++ Sbjct 881 GVEGDNNNSVEKIESIIRNTLYEFSTRK--LGNMESHMFEDIKSALIQEAKSIGNSFNQK 938 Query 492 FKKSADEIFSHANCFSKRDLE--VKYLDNDFSRKHLLRTFTKLSDPSRR 538 DEI + +L+ + Y++N + +HL TF+KL + R Sbjct 939 LNHYWDEIRYVGDLSESFNLQRAIDYINNKMTIEHLYNTFSKLINSKER 987 > cpv:cgd2_4270 secreted insulinase-like peptidase Length=1257 Score = 86.7 bits (213), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 102/429 (23%), Positives = 193/429 (44%), Gaps = 36/429 (8%) Query 146 GTAVWWQGQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHLQEETAD----- 200 G ++W+G +P + + L + D+ + + S+ +A + LQ D Sbjct 692 GLRIFWKGP-IHTVPTINLTLVQRLPN--KDVSNNVRVSL-IANLHAQLQNSKMDYILSS 747 Query 201 FQYCGITHSLAFKGTGFHMTFEGYTKT---QLDKLMSHVASVLRDPSVVESERFERVKQK 257 F+ CG+ +++ F + + Y+ ++KL +++ S R P+ E E + Sbjct 748 FKLCGLEADISYSRGRFVINVQSYSSNFEDIIEKLSNYLVSESRLPTKTEFETALTNLKS 807 Query 258 QIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQT--TYDDSIAKLSELKNV- 314 +I L+D MA++ A A + ++ +SR+ L +L++T T+D+ I K+ ++ +V Sbjct 808 EILNLSDL---MAYDVATDVAQSVYLSNYYSRLQLRESLQKTEITFDEYIEKIKDIFSVG 864 Query 315 HVDAFVMGNIDRDQSLLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANPIKGDK 374 + DA ++GNI ++S+ L + I + +A+ + I NPI DK Sbjct 865 YFDALIVGNIGYEKSIKLVSRMVGSLVTKKIPYSNAIHDGILNVSGDIHIKANNPISSDK 924 Query 375 DHASLVQFQLGVPSIEERVNLAILS---QFLNRRIYDSLRTEAQLGYIAGA-KESQAAST 430 ++A + F P + + ++++I S + LN YD+LRTE Q GY+A A + + Sbjct 925 NNAVVAHFL--TPPV-DLIDVSIYSSIGEILNSPFYDTLRTEWQDGYVAFATTKYETPII 981 Query 431 ALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELS------RWKEAAHAKLTKV 484 +L+ K V M A +KD ++ E S RW + K+ Sbjct 982 SLIGAVQSAEKLSETLVCHMFSALKKVSKDVEEDLKEISKSEFEDKIRWFGLSKYSSQKL 1041 Query 485 EANFSEDFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHL-LRTFTKLSDPS---RRMV 540 ++ F++ + + SH CF K L S ++ + KL PS R ++ Sbjct 1042 DS-FTKYIEHFGKLVVSHELCFEKNKLIENATQAFISEPNIYIEKLNKLIKPSSSRRLVI 1100 Query 541 VKLIADLEP 549 V+LI + P Sbjct 1101 VELIGNKSP 1109 > dre:561390 ide, MGC162603, zgc:162603; insulin-degrading enzyme (EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56] Length=978 Score = 79.3 bits (194), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 91/466 (19%), Positives = 194/466 (41%), Gaps = 21/466 (4%) Query 108 FRMPPPLLHIPKASELEILPGLLGLNEPELISEQGGNAGTAVWWQGQGFSALPRVAVQLS 167 F++P IP + EI P L + P + A + VW++ LP+ + Sbjct 481 FKLPMKNEFIP--TNFEIYP--LEKDSPSAPTLIKDTAMSKVWFKQDDKFFLPKACLNFE 536 Query 168 GSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGITHSLAFKGTGFHMTFEGYTKT 227 D L + L + + L E + G+++ L G +++ +GY Sbjct 537 FFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTVYGMYLSVKGYNDK 596 Query 228 Q---LDKLMSHVASVLRDPSVVESERFERVKQKQIKLLADPATNMAFEHALQAAAILTRN 284 Q L K++ +A+ ++ +RF+ +K+ ++ L + +HA+ +L Sbjct 597 QHILLKKIIEKMATF-----EIDEKRFDIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTE 651 Query 285 DAFSRMDLLNALEQTTYDDSIAKLSEL-KNVHVDAFVMGNIDRDQSL----LLTESFLEQ 339 A+++ +L +AL+ T A + +L +H++A + GNI + +L +L ++ +E Sbjct 652 VAWTKDELRDALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQSALEMMQMLEDTLIEH 711 Query 340 AGFTPIEHDDAVESLAMEQKQTIEATLANPIKGDKDHASLVQFQLGVPSIEERVNLAILS 399 A P+ + ++ + + + +Q + + E + L + Sbjct 712 AHTKPLLPSQLIRYREVQVPDGGWYVYQQRNEVHNNCGIEIYYQTDMQNTHENMLLELFC 771 Query 400 QFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGSKSHPDEVVKMIDAELAKAK 459 Q ++ +++LRT+ QLGYI + +A L+ ++ K+ P + ++A L + Sbjct 772 QIISEPCFNTLRTKEQLGYIVFSGPRRANGVQGLRFIIQSEKA-PHYLESRVEAFLKTME 830 Query 460 DYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADEIFSHANCFSKRDLEVKYLDND 519 + M + + +A + + + K EI S F + ++EV YL Sbjct 831 KSVEEMGDEAFQKHIQALAIRRLDKPKKLAAECAKYWGEIISQQYNFDRDNIEVAYLKT- 889 Query 520 FSRKHLLRTFTKL--SDPSRRMVVKLIADLEPAKEVTLIGEAKGQD 563 +++H+++ + L D RR V + L+GE Q+ Sbjct 890 LTKEHIMQFYRDLLAIDAPRRHKVSVHVLSREMDSCPLVGEFPAQN 935 > mmu:15925 Ide, 1300012G03Rik, 4833415K22Rik, AA675336, AI507533; insulin degrading enzyme (EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56] Length=1019 Score = 76.3 bits (186), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 86/439 (19%), Positives = 181/439 (41%), Gaps = 20/439 (4%) Query 135 PELISEQGGNAGTAVWWQGQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHL 194 P LI + A + +W++ LP+ + D L + L + + L Sbjct 548 PALIKD---TAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSL 604 Query 195 QEETADFQYCGITHSLAFKGTGFHMTFEGYTKTQ---LDKLMSHVASVLRDPSVVESERF 251 E + G+++ L G +++ +GY Q L K+ +A+ ++ +RF Sbjct 605 NEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATF-----EIDKKRF 659 Query 252 ERVKQKQIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAKLSEL 311 E +K+ ++ L + +HA+ +L A+++ +L AL+ T A + +L Sbjct 660 EIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQL 719 Query 312 -KNVHVDAFVMGNIDRDQSL----LLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATL 366 +H++A + GNI + +L ++ ++ +E A P+ V ++ Sbjct 720 LSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVY 779 Query 367 ANPIKGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQ 426 + + + +Q + S E + L + Q ++ +++LRT+ QLGYI + + Sbjct 780 QQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRR 839 Query 427 AASTALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEA 486 A L+ ++ K P + ++A L + I +M E + +A + Sbjct 840 ANGIQGLRFIIQSEKP-PHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPK 898 Query 487 NFSEDFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTFTKL--SDPSRRMVVKLI 544 S + K EI S + + ++EV YL ++ ++R + ++ D RR V + Sbjct 899 KLSAECAKYWGEIISQQYNYDRDNIEVAYLKT-LTKDDIIRFYQEMLAVDAPRRHKVSVH 957 Query 545 ADLEPAKEVTLIGEAKGQD 563 ++GE Q+ Sbjct 958 VLAREMDSCPVVGEFPSQN 976 > hsa:3416 IDE, FLJ35968, INSULYSIN; insulin-degrading enzyme (EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56] Length=464 Score = 72.4 bits (176), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 89/433 (20%), Positives = 182/433 (42%), Gaps = 29/433 (6%) Query 147 TAVWWQGQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGI 206 + +W++ LP+ + D L + L + + L E + G+ Sbjct 2 SKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGL 61 Query 207 THSLAFKGTGFHMTFEGYTKTQ---LDKLMSHVASVLRDPSVVESERFERVKQKQIKLLA 263 ++ L G +++ +GY Q L K++ +A+ ++ +RFE +K+ ++ L Sbjct 62 SYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF-----EIDEKRFEIIKEAYMRSLN 116 Query 264 DPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAKLSEL-KNVHVDAFVMG 322 + +HA+ +L A+++ +L AL+ T A + +L +H++A + G Sbjct 117 NFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHG 176 Query 323 NIDRDQSLLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANPIKG-------DKD 375 NI + +L ++ T IEH L + + E L P +G ++ Sbjct 177 NITKQAAL----GIMQMVEDTLIEHAHTKPLLPSQLVRYREVQL--PDRGWFVYQQRNEV 230 Query 376 HASL---VQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTAL 432 H + + +Q + S E + L + Q ++ +++LRT+ QLGYI + +A Sbjct 231 HNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQG 290 Query 433 LQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSEDF 492 L+ F+ S+ P + ++A L + I +M E + +A + S + Sbjct 291 LR-FIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAEC 349 Query 493 KKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTFTKL--SDPSRRMVVKLIADLEPA 550 K EI S F + + EV YL +++ +++ + ++ D RR V + Sbjct 350 AKYWGEIISQQYNFDRDNTEVAYLKT-LTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREM 408 Query 551 KEVTLIGEAKGQD 563 ++GE Q+ Sbjct 409 DSCPVVGEFPCQN 421 > cel:F44E7.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] Length=1051 Score = 72.0 bits (175), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 92/430 (21%), Positives = 177/430 (41%), Gaps = 18/430 (4%) Query 99 ERERERPNAFRMPPPLLHIPK-----ASELEILPGLLGLNE-PELISEQGGNAGTAVWWQ 152 E ++ NA + LH+P+ A+ + P NE P LIS+ G + VW++ Sbjct 531 ETMKKYENALKTSHHALHLPEKNEYIATNFDQKPRESVKNEHPRLISDDGW---SRVWFK 587 Query 153 GQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGITHSLAF 212 +P+ +L+ + + S+ L +++ L EET + G+ L Sbjct 588 QDDEYNMPKQETKLALTTPMVAQNPRMSLLSSLWLWCLSDTLAEETYNADLAGLKCQLES 647 Query 213 KGTGFHMTFEGYTKTQLDKLMSHVASVLRDPSVVESERFERVKQKQIKLLADPATNMAFE 272 G M GY + Q H+A+ + + + + RF+ + + + L + A + + Sbjct 648 SPFGVQMRVYGYDEKQA-LFAKHLANRMTNFKI-DKTRFDVLFESLKRALTNHAFSQPYL 705 Query 273 HALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAKLSE-LKNVHVDAFVMGNIDRDQSLL 331 +L + +S+ LL + T +D E L+ H++ FV GN +++ Sbjct 706 LTQHYNQLLIVDKVWSKEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQ 765 Query 332 LTESFLE-----QAGFTPIEHDDAVESLAMEQKQTIEATLANPIKGDKDHASLVQFQLGV 386 L++ ++ P+ ++ ++ E + K V +Q+GV Sbjct 766 LSKELMDVLKSAAPNSRPLYRNEHNPRRELQLNNGDEYVYRHLQKTHDVGCVEVTYQIGV 825 Query 387 PSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGSKSHPDE 446 + + + ++ Q + +++LRT LGYI T L V+G KS D Sbjct 826 QNTYDNAVVGLIDQLIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKS-VDH 884 Query 447 VVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADEIFSHANCF 506 V++ I+ L + I+ MP+ E A+L + S F++ +EI F Sbjct 885 VLERIEVFLESVRKEIAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNF 944 Query 507 SKRDLEVKYL 516 ++R+ EV L Sbjct 945 ARREEEVALL 954 > cel:Y70C5C.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56] Length=985 Score = 70.5 bits (171), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 100/483 (20%), Positives = 204/483 (42%), Gaps = 31/483 (6%) Query 47 LAVLVPSVARNPHLFLLLSTRRRNKTKNSRERERERERERERERERERERERERERERPN 106 L++L+PS + ++S + + + N+ E E + R ++ E + + Sbjct 431 LSMLIPSNMK----IQVVSQKFKGQEGNTNEPVYGTEIKVTRISSETMQKYEEALKTSHH 486 Query 107 AFRMPPPLLHIPKASELEILPG-LLGLNEPELISEQGGNAGTAVWWQGQGFSALPRVAVQ 165 A +P +I A++ + P L+ + P LI++ + + VW++ +P+ + Sbjct 487 ALHLPEKNQYI--ATKFDQKPRELVKSDHPRLIND---DEWSRVWFKQDDEYKMPKQETK 541 Query 166 LSGSI----AKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGITHSLAFKGTGFHMTF 221 L+ + + LLSR + L +++ L EE+ + G+ + L G M Sbjct 542 LALTTPIVSQSPRMTLLSR----LWLRCLSDSLAEESYSAKVAGLNYELESSFFGVQMRV 597 Query 222 EGYTKTQLDKLMS-HVASVLRDPSVVESERFERVKQKQIKLLADPATNMAFEHALQAAAI 280 GY + Q L S H+ L + + + RF+ + + L + A + + + + Sbjct 598 SGYAEKQ--ALFSKHLTKRLFNFKI-DQTRFDVLFDSLKRDLTNHAFSQPYVLSQHYTEL 654 Query 281 LTRNDAFSRMDLLNALEQTTYDDSIAKLSE--LKNVHVDAFVMGNIDRDQSLLLTESFLE 338 L + +S+ LL E +D + + + L+ H++ V GN +++ L++ ++ Sbjct 655 LVVDKEWSKQQLLAVCESVKLED-VQRFGKEMLQAFHLELLVYGNSTEKETIQLSKDLID 713 Query 339 -----QAGFTPIEHDDAVESLAMEQKQTIEATLANPIKGDKDHASLVQFQLGVPSIEERV 393 P+ ++ + ++ E + V +Q+GV + + Sbjct 714 ILKSAAPSSRPLFRNEHILRREIQLNNGDEYIYRHLQTTHDVGCVQVTYQIGVQNTYDNA 773 Query 394 NLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGSKSHPDEVVKMIDA 453 + ++ + +D+LRT+ LGYI + T LQ V+G KS D V++ I+A Sbjct 774 VIGLIKNLITEPAFDTLRTKESLGYIVWTRTHFNCGTVALQILVQGPKS-VDHVLERIEA 832 Query 454 ELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADEIFSHANCFSKRDLEV 513 L + I MP+ E A+L + S FKK DEI F++ + +V Sbjct 833 FLESVRKEIVEMPQEEFENRVSGLIAQLEEKPKTLSCRFKKFWDEIECRQYNFTRIEEDV 892 Query 514 KYL 516 + L Sbjct 893 ELL 895 > cel:C02G6.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56] Length=980 Score = 63.2 bits (152), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 91/446 (20%), Positives = 174/446 (39%), Gaps = 34/446 (7%) Query 99 ERERERPNAFRMPPPLLHIPKASELEIL-----PGLLGLNE-PELISEQGGNAGTAVWWQ 152 E+ ++ NA + LH+P+ +E P NE P+LIS+ G + VW++ Sbjct 445 EKMKKYENALKTSHHALHLPEKNEYIATNFGQKPRESVKNEHPKLISDDGW---SRVWFK 501 Query 153 GQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGITHSLAF 212 +P+ + + + + S+ L + L EET + G+ Sbjct 502 QDDEYNMPKQETKFALTTPIVSQNPRISLISSLWLWCFCDILSEETYNAALAGLGCQFEL 561 Query 213 KGTGFH----------------MTFEGYTKTQLDKLMSHVASVLRDPSVVESERFERVKQ 256 G + GY + Q + H+ S + + + + RFE + + Sbjct 562 SPFGVQKQSTDGREAERHASLTLHVYGYDEKQ-PLFVKHLTSCMINFKI-DRTRFEVLFE 619 Query 257 KQIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAKLSE-LKNVH 315 + L + A + + +L + +S+ LL + T ++ E L+ H Sbjct 620 SLKRTLTNHAFSQPYLLTQHYNQLLIVDKVWSKEQLLAVCDSVTLENVQGFAREMLQAFH 679 Query 316 VDAFVMGNIDRDQSLLLTESFLE-----QAGFTPIEHDDAVESLAMEQKQTIEATLANPI 370 ++ FV GN +++ L++ ++ P+ ++ + E + Sbjct 680 MELFVHGNSTEKEAIQLSKELMDILKSAAPNSRPLYRNEHNPRREFQLNNGDEYIYRHLQ 739 Query 371 KGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAAST 430 K V +Q+GV + + + ++ Q + ++D+LRT LGYI Sbjct 740 KTHDAGCVEVTYQIGVQNKYDNAVVGLIDQLIKEPVFDTLRTNEALGYIVWTGCRFNCGA 799 Query 431 ALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSE 490 L FV+G KS D V++ I+ L + I MP+ E + A+L + S Sbjct 800 VALNIFVQGPKS-VDYVLERIEVFLESVRKEIIEMPQDEFEKKVAGMIARLEEKPKTLSN 858 Query 491 DFKKSADEIFSHANCFSKRDLEVKYL 516 FK+ +I F++R+ EVK L Sbjct 859 RFKRFWYQIECRQYDFARREKEVKVL 884 > sce:YLR389C STE23; Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-A-factor to the mature form; member of the insulin-degrading enzyme family (EC:3.4.24.-); K01408 insulysin [EC:3.4.24.56] Length=1027 Score = 58.5 bits (140), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 83/452 (18%), Positives = 193/452 (42%), Gaps = 21/452 (4%) Query 107 AFRMPPPLLHIPKASELEILPGLLGLNEPELISEQGGNAGTAVWWQGQGFSALPRVAVQL 166 A +P P + +++ + G+ L+EP L+ + + +W++ PR + L Sbjct 530 ALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLL---SDDVSKLWYKKDDRFWQPRGYIYL 586 Query 167 SGSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCGITHSLAFKGTGFHMTFEGYTK 226 S + A +++ ++ + L++ D + S G +T G+ Sbjct 587 SFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGLAITASGFN- 645 Query 227 TQLDKLMSHVASVLRDPSVVE--SERFERVKQKQIKLLADPATNMAFEHALQAAAILTRN 284 +KL+ + L+ + E +RFE +K K I+ L + + + + Sbjct 646 ---EKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYNAIINE 702 Query 285 DAFSRMDLLNALEQTTYDDSIAKLSEL-KNVHVDAFVMGNIDRDQSL---LLTESFLEQA 340 ++S + L E+ T++ I + + + V+ + + GNI +++L L +S + Sbjct 703 RSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKSLIPNN 762 Query 341 GFTPIEHDDAVESLAMEQKQTIEATLANPIKGDKDHASLVQF--QLGVPSIEERVNLAIL 398 ++ + S + + +T A +K ++ S +Q QL V S + + Sbjct 763 IHNLQVSNNRLRSYLLPKGKTFRYETA--LKDSQNVNSCIQHVTQLDVYSEDLSALSGLF 820 Query 399 SQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGSKSHPDEVVKMIDAELAKA 458 +Q ++ +D+LRT+ QLGY+ + TA ++ ++ + P + I+ Sbjct 821 AQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTP-YLEWRINNFYETF 879 Query 459 KDYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADEIFSHANCFSKRDLEVKYLDN 518 + +MPE + + KEA L + N +E+ + I+ F+ R + K + N Sbjct 880 GQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLVAN 939 Query 519 DFSRKHLLRTFTK--LSDPSRRMVVKLIADLE 548 +++ ++ + +S+ + ++++ L + +E Sbjct 940 -ITKQQMIDFYENYIMSENASKLILHLKSQVE 970 > mmu:230598 Nrd1, 2600011I06Rik, AI875733, MGC25477, NRD-C; nardilysin, N-arginine dibasic convertase, NRD convertase 1 (EC:3.4.24.61); K01411 nardilysin [EC:3.4.24.61] Length=1161 Score = 52.4 bits (124), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 62/295 (21%), Positives = 126/295 (42%), Gaps = 13/295 (4%) Query 252 ERVKQKQIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAK-LSE 310 E++K+ +L P T A ++ +S +D AL DS+ + + Sbjct 807 EQLKKTYFNILIKPET-----LAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKD 861 Query 311 LKN-VHVDAFVMGNIDRDQSLLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANP 369 K+ + V+ V GN+ +S+ + +++ F P+E + V+ +E Sbjct 862 FKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFAPLEREMPVQFQVVELPSGHHLCKVRA 921 Query 370 I-KGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGY--IAGAKESQ 426 + KGD + V +Q G S+ E + +L + +D LRT+ LGY + + Sbjct 922 LNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTS 981 Query 427 AASTALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVE- 485 + + +K + + V K I+ L+ ++ I N+ E + + A KL + E Sbjct 982 GILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNT-QVTALIKLKECED 1040 Query 486 ANFSEDFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTFTKLSDPSRRMV 540 + E+ ++ +E+ + F + E++ L + FS+ L+ F P +M+ Sbjct 1041 THLGEEVDRNWNEVVTQQYLFDRLAHEIEALKS-FSKSDLVSWFKAHRGPGSKML 1094 > hsa:4898 NRD1, hNRD1, hNRD2; nardilysin (N-arginine dibasic convertase) (EC:3.4.24.61); K01411 nardilysin [EC:3.4.24.61] Length=1151 Score = 52.4 bits (124), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 61/295 (20%), Positives = 128/295 (43%), Gaps = 13/295 (4%) Query 252 ERVKQKQIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNAL-EQTTYDDSIAKLSE 310 E++K+ +L P T A ++ +S +D AL + + + ++ + E Sbjct 796 EQLKKTYFNILIKPET-----LAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKE 850 Query 311 LKN-VHVDAFVMGNIDRDQSLLLTESFLEQAGFTPIEHDDAVESLAMEQKQTIEATLANP 369 K+ + V+ V GN+ +S+ + +++ F P+E + V+ +E Sbjct 851 FKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKA 910 Query 370 I-KGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGY--IAGAKESQ 426 + KGD + V +Q G S+ E + +L + +D LRT+ LGY + + Sbjct 911 LNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTS 970 Query 427 AASTALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVE- 485 + + +K + + V K I+ L+ ++ I N+ E + + A KL + E Sbjct 971 GILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNT-QVTALIKLKECED 1029 Query 486 ANFSEDFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTFTKLSDPSRRMV 540 + E+ ++ +E+ + F + E++ L + FS+ L+ F P +M+ Sbjct 1030 THLGEEVDRNWNEVVTQQYLFDRLAHEIEALKS-FSKSDLVNWFKAHRGPGSKML 1083 > tgo:TGME49_044490 insulin-degrading enzyme, putative (EC:3.4.24.56) Length=592 Score = 52.0 bits (123), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 57/268 (21%), Positives = 106/268 (39%), Gaps = 44/268 (16%) Query 286 AFSRMDLLNALEQTTYDDSIAKLSELKNVHVDAFVMGNIDRDQSLLLTESFLEQAGFTPI 345 S DLL LEQTT D + + V+ V+GNI + ++ E L+ Sbjct 193 CLSYEDLLRVLEQTTLDVQEVPKTLFERACVEGLVVGNISSAEVCVMVEMALKNLNIETT 252 Query 346 EHDDAV-----------------------------------ESLAMEQKQTIEATLA--- 367 ++V +L E+ + E L Sbjct 253 LDSNSVPEKAVVDLASLDLARLRSSGSGVAGLDEEREAMQCRTLVCEELKASEVKLKTRS 312 Query 368 -NPIKGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQ 426 N D++ + ++FQLG ER L++ S +++ +D LRT+ QL Y+ A S Sbjct 313 ENSNTQDRNSVAFLRFQLGNLEDRERSMLSLFSHCISQAFFDDLRTQQQLDYVLHAHRSF 372 Query 427 AASTALLQCFVEGSKSHPD----EVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLT 482 + + FV GS + D + ++++ L+ + + +P+A + + A ++L Sbjct 373 QLRSQGMHFFVAGS-TFSDLMTLRIGRLVEKYLSSEQGLHAGLPDALCEKHRSALVSELR 431 Query 483 KVEANFSEDFKKSADEIFSHANCFSKRD 510 N E+ ++ EI + F++ D Sbjct 432 VRPQNAFEEAQRYTREISTWYFMFNRHD 459 > tgo:TGME49_069870 hypothetical protein Length=413 Score = 50.4 bits (119), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/149 (26%), Positives = 78/149 (52%), Gaps = 19/149 (12%) Query 358 QKQTIEATLANPIKGDKDHASLVQFQLG-VPSIEERVNLAILSQFLNRRIYDSLRTEAQL 416 Q ++I L NP DK + + + ++G +P+I +R L ++S+++++R ++ LRTE QL Sbjct 190 QLRSIRKNL-NP--NDKKNQAYLLIEVGALPNIHDRAVLYMVSRWMSQRFFNKLRTEQQL 246 Query 417 GYIAGAKESQAASTALLQCFVEGSKSHP----DEVVKMIDAELAK--AKDYISNMPEAEL 470 GY+ S+ + F+ S P D +V+ I+AE +K ++ + + +A + Sbjct 247 GYLTAMHSSRLEDRFYYRFFIT-STYDPAEVADRIVEFINAERSKIPTQEEFATLKQAAI 305 Query 471 SRWKEAAHAKLTKVEANFSEDFKKSADEI 499 WK+ N E+F+K+ ++ Sbjct 306 DVWKQKPK--------NIFEEFRKNRRQV 326 > cel:C28F5.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] Length=856 Score = 48.1 bits (113), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 86/410 (20%), Positives = 157/410 (38%), Gaps = 35/410 (8%) Query 135 PELISEQGGNAGTAVWWQGQGFSALPRVAVQLSGSIAKDKADLLSRTQGSVALAAIAEHL 194 P LISE + VW++ P+ + + + L+++ +V + + Sbjct 450 PRLISE---DEWIQVWFKQDNEYNSPKQGIMFALTTP-----LVAKKSKNVVAFKSLDTI 501 Query 195 QEETADFQYCGITHSLAFKGTGFHMTFEGYTKTQLDKLMSHVASVLRDPSV---VESERF 251 EET + + G+ +G + GY + Q H+ + + + V F Sbjct 502 IEETYNARLAGLECQFESSSSGVQIRVFGYDEKQ-SLFAKHLVNRMANFQVNRLCFDISF 560 Query 252 ERVKQKQIKLLADPATNMAFE--HALQAAAI--LTRNDAFSRMDLLNALEQTTYDDSIA- 306 E +K+ TN AF H L A I L ++ +S+ LL + T +D Sbjct 561 ESLKRT--------LTNHAFSQPHDLSAHFIDLLVVDNIWSKEQLLAVCDSVTLEDVHGF 612 Query 307 KLSELKNVHVDAFVMGNIDRDQSLLLTESFLE-----QAGFTPIEHDDAVESLAMEQKQT 361 + L+ H++ FV GN +L L++ + P++ D+ ++ Sbjct 613 AIKMLQAFHMELFVHGNSTEKDTLQLSKELSDILKSVAPNSRPLKRDEHNPHRELQLING 672 Query 362 IEATLANPIKGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAG 421 E + K V FQ+GV S +L++ + Y LRT LGY Sbjct 673 HEHVYRHFQKTHDVGCVEVAFQIGVQSTYNNSVNKLLNELIKNPAYTILRTNEALGYNVS 732 Query 422 AKESQAASTALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKL 481 + L V+G +S D V++ I+ L A++ I MP+ + A Sbjct 733 TESRLNDGNVYLHVIVQGPES-ADHVLERIEVFLESAREEIVAMPQEDFDY---QVWAMF 788 Query 482 TKVEANFSEDFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTFTK 531 + S+ F EI S F R+ EV+ + +++ ++ F + Sbjct 789 KENPPTLSQCFSMFWSEIHSRQYNFG-RNKEVRGISKRITKEEVINFFDR 837 > ath:AT2G41790 peptidase M16 family protein / insulinase family protein; K01408 insulysin [EC:3.4.24.56] Length=970 Score = 44.7 bits (104), Expect = 0.001, Method: Compositional matrix adjust. Identities = 67/347 (19%), Positives = 139/347 (40%), Gaps = 33/347 (9%) Query 190 IAEHLQEETADFQYCGITHSLAFKGTGFHMTFEGYT---KTQLDKLMSHVASVLRDPSVV 246 + ++L E Q G+ + ++ GF +T GY + L+ ++ +A+ P Sbjct 560 LMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRILLETVVGKIANFEVKP--- 616 Query 247 ESERFERVKQKQIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIA 306 +RF +K+ K + + A+ +++ ++ + + L+ L +D +A Sbjct 617 --DRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEELDVLSHLEAED-VA 673 Query 307 KLSE--LKNVHVDAFVMGNIDRDQSLLLTESFLEQAGFT----------PIEH-DDAVES 353 K L ++ ++ GN++ +++ + + +E F P +H + V Sbjct 674 KFVPMLLSRTFIECYIAGNVENNEAESMVKH-IEDVLFNDPKPICRPLFPSQHLTNRVVK 732 Query 354 LAMEQKQTIEATLANPIKGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTE 413 L K +NP D++ A + Q+ + L + + + LRT Sbjct 733 LGEGMKYFYHQDGSNP--SDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQLRTV 790 Query 414 AQLGYIAGAKESQAASTALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRW 473 QLGYI + + +Q ++ S P + +++ L K++ S + E + Sbjct 791 EQLGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLL---KNFESKLYEMSNEDF 847 Query 474 KEAAHA----KLTKVEANFSEDFKKSADEIFSHANCFSKRDLEVKYL 516 K A KL K N E+ + EI S F++++ EV L Sbjct 848 KSNVTALIDMKLEK-HKNLKEESRFYWREIQSGTLKFNRKEAEVSAL 893 > dre:557565 nrd1, si:dkey-171o17.4; nardilysin (N-arginine dibasic convertase) (EC:3.4.24.61) Length=1061 Score = 42.7 bits (99), Expect = 0.004, Method: Compositional matrix adjust. Identities = 33/136 (24%), Positives = 56/136 (41%), Gaps = 6/136 (4%) Query 289 RMDLLNALEQTTYDDSIAKLSELKN-----VHVDAFVMGNIDRDQSLLLTESFLEQAGFT 343 R ++ E D S+A L N + V+ V GN +S + F+E+ + Sbjct 733 RWSVMQKYEAIMADPSVADLMTFANRFKAELFVEGLVQGNFTSAESKEFLQCFIEKLKYA 792 Query 344 PIEHDDAVESLAMEQKQTIEATLANPI-KGDKDHASLVQFQLGVPSIEERVNLAILSQFL 402 P + V +E QT + K D + V +Q G+ ++ E + +L + Sbjct 793 PHPIEPPVLFRVVELPQTHHLCKVQSLNKADANSEVTVYYQTGLKNLREHTLMELLVMHM 852 Query 403 NRRIYDSLRTEAQLGY 418 +D LRT+ LGY Sbjct 853 EEPCFDFLRTKETLGY 868 > ath:AT1G06900 catalytic/ metal ion binding / metalloendopeptidase/ zinc ion binding; K01411 nardilysin [EC:3.4.24.61] Length=1024 Score = 42.4 bits (98), Expect = 0.006, Method: Compositional matrix adjust. Identities = 82/422 (19%), Positives = 172/422 (40%), Gaps = 50/422 (11%) Query 150 WWQGQGFSALPRVA----VQLSGSIAKDKADLLSRTQGSVALAAIAEHLQEETADFQYCG 205 W++ +PR + L G+ A K LL+ + + + + L E Sbjct 588 WYKLDETFKVPRANTYFRINLKGAYASVKNCLLTE----LYINLLKDELNEIIYQASIAK 643 Query 206 ITHSLAFKGTGFHMTFEGYTKTQLDKLMSHVASVLRD--PSVVESERFERVKQKQIKLLA 263 + SL+ G + G+ + ++ L+S + ++ + P++ ERF+ +K+ + Sbjct 644 LETSLSMYGDKLELKVYGFNE-KIPALLSKILAIAKSFMPNL---ERFKVIKENMERGFR 699 Query 264 DPATNMA-FEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAKLSELKN-VHVDAFVM 321 + TNM H+ L + + L+ L + DD + + EL++ + ++A Sbjct 700 N--TNMKPLNHSTYLRLQLLCKRIYDSDEKLSVLNDLSLDDLNSFIPELRSQIFIEALCH 757 Query 322 GNIDRDQSLLLTESFLEQAGFTPI----EHDDAVESLAMEQKQTIEATLANPIKGDKDHA 377 GN+ D+++ ++ F + P+ H + + M K + + N K + + Sbjct 758 GNLSEDEAVNISNIFKDSLTVEPLPSKCRHGEQITCFPMGAKLVRDVNVKN--KSETNSV 815 Query 378 SLVQFQLG---VPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQ 434 + +Q+ S + L + + + +++ LRT+ QLGY+ Sbjct 816 VELYYQIEPEEAQSTRTKAVLDLFHEIIEEPLFNQLRTKEQLGYVVECGPRLTYRVHGFC 875 Query 435 CFVEGSKSHP-------DEVVKMIDAELAK-----AKDYISNMPEAELSRWKEAAHAKLT 482 V+ SK P D +K I+ L + +DY S M ++R E + L+ Sbjct 876 FCVQSSKYGPVHLLGRVDNFIKDIEGLLEQLDDESYEDYRSGM----IARLLEKDPSLLS 931 Query 483 KVEANFSEDFKKSADEIFSHANCFSKRDLEVKYLDNDFSRKHLLRTFTKLSDP-SRRMVV 541 + +S+ K FSH R ++ K + + + +T+ + S P RR+ V Sbjct 932 ETNDLWSQIVDKRYMFDFSHKEAEELRSIQKKDVISWY------KTYFRESSPKCRRLAV 985 Query 542 KL 543 ++ Sbjct 986 RV 987 > ath:AT3G57470 peptidase M16 family protein / insulinase family protein; K01408 insulysin [EC:3.4.24.56] Length=891 Score = 41.2 bits (95), Expect = 0.011, Method: Compositional matrix adjust. Identities = 56/302 (18%), Positives = 116/302 (38%), Gaps = 25/302 (8%) Query 185 VALAAIAEHLQEETADFQYCGITHSLAFKGTGFHMTFEGYT---KTQLDKLMSHVASVLR 241 + + + ++L E Q G+ + L+ GF ++ G+ + L+ ++ +A Sbjct 482 IFVWLLVDYLNEYAYYAQAAGLDYGLSLSDNGFELSLAGFNHKLRILLEAVIQKIAKFEV 541 Query 242 DPSVVESERFERVKQKQIKLLADPATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTY 301 P +RF +K+ K + E A +++ ++ + + L+AL Sbjct 542 KP-----DRFSVIKETVTKAYQNNKFQQPHEQATNYCSLVLQDQIWPWTEELDALSHLEA 596 Query 302 DDSIAKLSE--LKNVHVDAFVMGNIDRDQSLLLTESFLEQAGFT---PIEH--------D 348 +D +A L V+ ++ GN+++D++ + + +E FT PI Sbjct 597 ED-LANFVPMLLSRTFVECYIAGNVEKDEAESMVKH-IEDVLFTDSKPICRPLFPSQFLT 654 Query 349 DAVESLAMEQKQTIEATLANPIKGDKDHASLVQFQLGVPSIEERVNLAILSQFLNRRIYD 408 + V L K +N D++ A + Q+ L + + + Sbjct 655 NRVTELGTGMKHFYYQEGSN--SSDENSALVHYIQVHKDEFSMNSKLQLFELIAKQDTFH 712 Query 409 SLRTEAQLGYIAGAKESQAASTALLQCFVEGSKSHPDEVVKMIDAELAKAKDYISNMPEA 468 LRT QLGYI S + +Q ++ S P + +++ L + NM + Sbjct 713 QLRTIEQLGYITSLSLSNDSGVYGVQFIIQSSVKGPGHIDSRVESLLKDLESKFYNMSDE 772 Query 469 EL 470 E Sbjct 773 EF 774 > dre:393572 traf3ip1, Elipsa, MGC63522, zgc:63522; TNF receptor-associated factor 3 interacting protein 1 Length=629 Score = 41.2 bits (95), Expect = 0.014, Method: Compositional matrix adjust. Identities = 21/39 (53%), Positives = 34/39 (87%), Gaps = 1/39 (2%) Query 66 TRRRNKTKNSRERERERERERERERERERERERERERER 104 +R R K K +RE+ERERE++R RE+ERER+++R++++ER Sbjct 219 SRDREKDK-TREKEREREKDRNREKERERDKDRDKKKER 256 Score = 40.0 bits (92), Expect = 0.028, Method: Compositional matrix adjust. Identities = 21/39 (53%), Positives = 33/39 (84%), Gaps = 1/39 (2%) Query 67 RRRNKTKN-SRERERERERERERERERERERERERERER 104 R R+K K+ RE+++ RE+ERERE++R RE+ERER+++R Sbjct 212 RDRDKDKSRDREKDKTREKEREREKDRNREKERERDKDR 250 Score = 38.9 bits (89), Expect = 0.056, Method: Compositional matrix adjust. Identities = 19/37 (51%), Positives = 33/37 (89%), Gaps = 1/37 (2%) Query 67 RRRNKTKNSRERERERERERERERERERERERERERE 103 R ++KT+ +ERERE++R RE+ERER+++R++++ERE Sbjct 222 REKDKTRE-KEREREKDRNREKERERDKDRDKKKERE 257 Score = 37.0 bits (84), Expect = 0.23, Method: Compositional matrix adjust. Identities = 19/41 (46%), Positives = 32/41 (78%), Gaps = 3/41 (7%) Query 67 RRRNKTKN---SRERERERERERERERERERERERERERER 104 R R +TK+ +++ R+RE+++ RE+ERERE++R RE+ER Sbjct 204 RERERTKDRDRDKDKSRDREKDKTREKEREREKDRNREKER 244 > eco:b2821 ptrA, ECK2817, JW2789, ptr; protease III (EC:3.4.24.55); K01407 protease III [EC:3.4.24.55] Length=962 Score = 38.5 bits (88), Expect = 0.072, Method: Compositional matrix adjust. Identities = 69/313 (22%), Positives = 125/313 (39%), Gaps = 19/313 (6%) Query 205 GITHSLAFKGTGFHMTFEGYTKTQLDKLMSHVASVLRDPSVVESERFERVKQKQIKLLAD 264 GI+ S G + GYT+ +L +L + + E ++ E+ K +++ Sbjct 591 GISFSTN-ANNGLMVNANGYTQ-RLPQLFQALLEGYFSYTATE-DQLEQAKSWYNQMMDS 647 Query 265 PATNMAFEHALQAAAILTRNDAFSRMDLLNALEQTTYDDSIAKLSELKNVHVDAF-VMGN 323 AFE A+ A +L++ FSR + L T + +A LK+ F V+GN Sbjct 648 AEKGKAFEQAIMPAQMLSQVPYFSRDERRKILPSITLKEVLAYRDALKSGARPEFMVIGN 707 Query 324 IDRDQSLLLTESFLEQAGFTPIE---HDDAVESLAMEQKQTIEATLANPIKGDKDHASL- 379 + Q+ L +Q G E + D V +++KQ++ A G+ ++L Sbjct 708 MTEAQATTLARDVQKQLGADGSEWCRNKDVV----VDKKQSVIFEKA----GNSTDSALA 759 Query 380 -VQFQLGVPSIEERVNLAILSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVE 438 V G ++L Q + Y+ LRTE QLGY A + ++ Sbjct 760 AVFVPTGYDEYTSSAYSSLLGQIVQPWFYNQLRTEEQLGYAVFAFPMSVGRQWGMGFLLQ 819 Query 439 GSKSHPDEVVKMIDAELAKAKDYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADE 498 + P + + A A+ + M E ++ ++A ++ + E+ K + + Sbjct 820 SNDKQPSFLWERYKAFFPTAEAKLRAMKPDEFAQIQQAVITQMLQAPQTLGEEASKLSKD 879 Query 499 IFSHANC-FSKRD 510 F N F RD Sbjct 880 -FDRGNMRFDSRD 891 > cpv:cgd2_920 peptidase'insulinase-like peptidase' Length=1028 Score = 37.7 bits (86), Expect = 0.14, Method: Compositional matrix adjust. Identities = 45/243 (18%), Positives = 111/243 (45%), Gaps = 11/243 (4%) Query 287 FSRMDLLNALEQTTYDDSIA-KLSELKNVHVDAFVMGNIDRDQSLLLT-ESFLEQAGF-T 343 F+R + LN LE T++ + + L N ++ +MGN + ++ + + F Sbjct 711 FNRQEKLNVLESFTFELFCSIRQHFLSNCRLEGLIMGNFSEPNAKCISIQHWKNLINFQN 770 Query 344 PIEHDDAVESLAMEQ------KQTIEATLANPIKGDKDHASLVQFQLGVPSIEERVNLAI 397 ++++ + +EQ K+ I P DK+ ++ F LG ++ ++V + Sbjct 771 SVKNEVKSCGIKVEQFSIVNLKKDIYTLNYIPNSSDKNGCWMLSFFLGEYNLRKQVLCDL 830 Query 398 LSQFLNRRIYDSLRTEAQLGYIAGAKESQAASTALLQCFVEGSK-SHPDEVVKMIDAELA 456 + F++ + LRT QL Y+ A + ++ ++ +++ S+ ++ + ++++ + Sbjct 831 ILPFVSSEAFADLRTNQQLAYVVRATQIFSSPAIIIGYYLQSSEYTNALTLERLLEFHIN 890 Query 457 KAK-DYISNMPEAELSRWKEAAHAKLTKVEANFSEDFKKSADEIFSHANCFSKRDLEVKY 515 K K + S + + + K++ L+ + +++K EI + F R ++ Sbjct 891 KTKVELKSKLNKEMFIKLKDSTIQTLSSNPKSIFDEYKTYLHEINERSYLFDIRQRKIDI 950 Query 516 LDN 518 L+N Sbjct 951 LNN 953 > mmu:209361 Taf3, 140kDa, 4933439M23Rik, AW539625, TAF140, TAFII-140, TAFII140, mTAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor; K14650 transcription initiation factor TFIID subunit 3 Length=932 Score = 36.6 bits (83), Expect = 0.31, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 32/47 (68%), Gaps = 4/47 (8%) Query 76 RERERERERERERERER----ERERERERERERPNAFRMPPPLLHIP 118 RERE+ ++++++RER + +RERER +E+ R + + PP L +P Sbjct 613 REREKHKDKKKDRERSKREKDKRERERLKEKNREDKIKAPPTQLVLP 659 Score = 32.7 bits (73), Expect = 5.1, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query 67 RRRNKTKNSRERERERERERERERERERERERERE---RERPNAFRMPPPLLHIPKASEL 123 RR + ++++RER + + +RERER +E+ RE + P +PP + +P S Sbjct 612 RREREKHKDKKKDRERSKREKDKRERERLKEKNREDKIKAPPTQLVLPPKEMALPLFSPS 671 Query 124 EI-LPGLLGLNEPEL 137 + +P +L P L Sbjct 672 AVRVPAMLPAFSPML 686 > pfa:PFE0230w conserved Plasmodium protein, unknown function Length=2349 Score = 35.8 bits (81), Expect = 0.56, Method: Composition-based stats. Identities = 17/33 (51%), Positives = 25/33 (75%), Gaps = 1/33 (3%) Query 76 RERERERERERERERERERERER-ERERERPNA 107 +E+ER +ERE RE+ER RE+ER ++ER + A Sbjct 1461 KEKERYKEREILREKERLREKERLKQERLKKEA 1493 > tgo:TGME49_016980 hypothetical protein Length=530 Score = 35.4 bits (80), Expect = 0.62, Method: Compositional matrix adjust. Identities = 16/31 (51%), Positives = 26/31 (83%), Gaps = 0/31 (0%) Query 74 NSRERERERERERERERERERERERERERER 104 N +ER+RE+E E+ER R R+RE +++R+RE+ Sbjct 411 NKKERKREQEGEKERTRRRDRENKKKRQREQ 441 > ath:AT5G67320 HOS15; HOS15 (high expression of osmotically responsive genes 15) Length=613 Score = 34.3 bits (77), Expect = 1.7, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 27/42 (64%), Gaps = 0/42 (0%) Query 63 LLSTRRRNKTKNSRERERERERERERERERERERERERERER 104 +L ++R + +ER+R +E ++ ERE E +R R +E++R Sbjct 97 MLREKKRKERDMEKERDRSKENDKGVEREHEGDRNRAKEKDR 138 Score = 31.6 bits (70), Expect = 9.9, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 22/32 (68%), Gaps = 0/32 (0%) Query 76 RERERERERERERERERERERERERERERPNA 107 + +ER+ E+ER+R +E ++ ERE E +R A Sbjct 102 KRKERDMEKERDRSKENDKGVEREHEGDRNRA 133 > pfa:MAL7P1.129 conserved Plasmodium protein, unknown function Length=1003 Score = 32.3 bits (72), Expect = 5.5, Method: Compositional matrix adjust. Identities = 17/29 (58%), Positives = 24/29 (82%), Gaps = 0/29 (0%) Query 75 SRERERERERERERERERERERERERERE 103 +RERE+E +RER+ +R RE+ER +RERE Sbjct 664 NREREKEMDRERDMDRNREKERNMDRERE 692 > mmu:226562 Prrc2c, 1810043M20Rik, 9630039I18Rik, A630006J20, Bat2d, Bat2d1, Bat2l2, E130112L15Rik, Prrc3, mKIAA1096; proline-rich coiled-coil 2C Length=2846 Score = 32.3 bits (72), Expect = 6.5, Method: Compositional matrix adjust. Identities = 15/29 (51%), Positives = 24/29 (82%), Gaps = 0/29 (0%) Query 76 RERERERERERERERERERERERERERER 104 RE ER R++E+E E++RE+E+E +R RE+ Sbjct 534 REMERARQQEKELEQQREKEQELQRLREQ 562 Lambda K H 0.316 0.132 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 31498167456 Database: egene_temp_file_orthology_annotation_similarity_blast_database_866 Posted date: Sep 17, 2011 2:57 PM Number of letters in database: 82,071,388 Number of sequences in database: 164,496 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40