bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_865
164,496 sequences; 82,071,388 total letters
Query= Emax_2398_orf1
Length=100
Score E
Sequences producing significant alignments: (Bits) Value
tpv:TP01_0390 serine hydroxymethyltransferase; K00600 glycine ... 124 7e-29
tgo:TGME49_034190 glycine hydroxymethyltransferase, putative (... 123 2e-28
bbo:BBOV_IV005840 23.m06426; serine hydroxymethyltransferase (... 112 4e-25
pfa:PFL1720w serine hydroxymethyltransferase (EC:2.1.2.1); K00... 109 2e-24
ath:AT1G22020 SHM6; SHM6 (serine hydroxymethyltransferase 6); ... 108 3e-24
dre:394021 shmt1, MGC66171, zgc:66171, zgc:77524; serine hydro... 106 2e-23
hsa:6472 SHMT2, GLYA, SHMT; serine hydroxymethyltransferase 2 ... 104 7e-23
ath:AT4G37930 SHM1; SHM1 (SERINE TRANSHYDROXYMETHYLTRANSFERASE... 103 2e-22
mmu:20425 Shmt1, AI324848, AI385541, C81125, Shmt, mshmt, mshm... 103 2e-22
ath:AT4G13890 EDA36; EDA36 (EMBRYO SAC DEVELOPMENT ARREST 37);... 102 3e-22
ath:AT4G13930 SHM4; SHM4 (serine hydroxymethyltransferase 4); ... 101 5e-22
hsa:6470 SHMT1, CSHMT, MGC15229, MGC24556, SHMT; serine hydrox... 101 6e-22
xla:447193 shmt2, MGC79128; serine hydroxymethyltransferase 2 ... 101 6e-22
ath:AT4G32520 SHM3; SHM3 (SERINE HYDROXYMETHYLTRANSFERASE 3); ... 101 7e-22
mmu:108037 Shmt2, 2700043D08Rik, AA408223, AA986903; serine hy... 100 9e-22
ath:AT1G36370 SHM7; SHM7 (serine hydroxymethyltransferase 7); ... 100 1e-21
xla:380048 shmt1, MGC53442; serine hydroxymethyltransferase 1 ... 100 1e-21
sce:YLR058C SHM2, SHMT2; Cytosolic serine hydroxymethyltransfe... 99.0 3e-21
dre:100144628 shmt2; serine hydroxymethyltransferase 2 (mitoch... 98.6 4e-21
cel:C05D11.11 mel-32; Maternal Effect Lethal family member (me... 98.6 5e-21
sce:YBR263W SHM1, SHMT1, TMP3; Mitochondrial serine hydroxymet... 95.9 3e-20
ath:AT5G26780 SHM2; SHM2 (SERINE HYDROXYMETHYLTRANSFERASE 2); ... 90.5 1e-18
eco:b2551 glyA, ECK2548, JW2535; serine hydroxymethyltransfera... 77.0 1e-14
cpv:cgd8_2610 cytosolic serine hydroxymethyl transferase ; K00... 65.9 3e-11
cpv:cgd8_2580 mitochondrial serine hydroxymethyl transferase 63.9 1e-10
eco:b0771 ybhJ, ECK0760, JW5103; predicted hydratase; K01681 a... 30.0 2.0
ath:AT4G11810 SPX (SYG1/Pho81/XPR1) domain-containing protein 30.0 2.1
dre:322327 cb1032, fb57h11, wu:fb57h11; zgc:193613 29.6 2.3
cel:C54G7.1 hypothetical protein 29.6 2.6
hsa:9701 PPP6R2, KIAA0685, PP6R2, SAP190, SAPS2, dJ579N16.1; p... 28.9 4.1
hsa:23043 TNIK; TRAF2 and NCK interacting kinase (EC:2.7.11.1)... 28.9 4.5
dre:556959 tnikb, MGC123033, MGC152783, MGC192776, im:6898857,... 28.9 4.6
mmu:665113 Tnik, 1500031A17Rik, 4831440I19Rik, AI451411, C5300... 28.9 4.6
dre:325042 tnika, fc52d11, msn, tnikl, wu:fc52d11, zgc:63535; ... 28.9 4.6
dre:798737 G protein-coupled receptor 151-like; K04231 galanin... 28.5 4.9
mmu:71474 Ppp6r2, 1110033O10Rik, 8430411H09Rik, B230107H12Rik,... 28.5 5.0
hsa:79705 LRRK1, FLJ23119, FLJ27465, KIAA1790, RIPK6, Roco1; l... 28.5 5.2
xla:446555 mink1, MGC81192, mink; misshapen-like kinase 1 (EC:... 28.5 5.6
mmu:50932 Mink1, B55, MINK, Map4k6, RP23-122P1.6, Ysk2; missha... 28.5 5.9
hsa:50488 MINK1, B55, MAP4K6, MGC21111, MINK, YSK2, ZC3, hMINK... 28.1 6.3
> tpv:TP01_0390 serine hydroxymethyltransferase; K00600 glycine
hydroxymethyltransferase [EC:2.1.2.1]
Length=503
Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats.
Identities = 54/100 (54%), Positives = 76/100 (76%), Gaps = 0/100 (0%)
Query 1 KRVPNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAEL 60
K +P+ ++ +VFP LQGGPH N+IAA+A QLKQ PEWK Y+Q+++DN ++LAAEL
Sbjct 312 KLLPDFGECINQSVFPTLQGGPHNNNIAALAVQLKQLSKPEWKTYAQRIVDNARVLAAEL 371
Query 61 QSYGLQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+ + +VTGGTDNH +++ L+P G+TG K +LVCD VNI
Sbjct 372 EKRDMPVVTGGTDNHTVIVSLRPFGVTGSKAELVCDLVNI 411
> tgo:TGME49_034190 glycine hydroxymethyltransferase, putative
(EC:2.1.2.1); K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=595
Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats.
Identities = 54/100 (54%), Positives = 72/100 (72%), Gaps = 0/100 (0%)
Query 1 KRVPNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAEL 60
+RVP+G +++ VFP LQGGPH + IAA+A QLK+ +P W Y+ QV+ N LAA L
Sbjct 400 RRVPDGEGLINSGVFPSLQGGPHNHQIAALACQLKEVMSPSWATYASQVIRNSNALAARL 459
Query 61 QSYGLQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
Q +G +L T GTDNHLLL+DL+P G+TG K+QL CD +I
Sbjct 460 QHHGHRLTTDGTDNHLLLMDLRPDGITGTKMQLCCDEASI 499
> bbo:BBOV_IV005840 23.m06426; serine hydroxymethyltransferase
(EC:2.1.2.1); K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=453
Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats.
Identities = 47/97 (48%), Positives = 71/97 (73%), Gaps = 0/97 (0%)
Query 4 PNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSY 63
P K++ AVFP +QGGPH N IA++A QLK +PEWKVY++ +++N + LA E +S
Sbjct 265 PTIEDKINNAVFPTVQGGPHNNAIASLAVQLKTVMSPEWKVYAKNIVENARRLAIECESR 324
Query 64 GLQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
G +VTGGTDNH ++++LKP G+ G K + +C+A+N+
Sbjct 325 GFLVVTGGTDNHTVVINLKPFGVNGNKAEHICNAINV 361
> pfa:PFL1720w serine hydroxymethyltransferase (EC:2.1.2.1); K00600
glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=442
Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats.
Identities = 54/100 (54%), Positives = 69/100 (69%), Gaps = 0/100 (0%)
Query 1 KRVPNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAEL 60
KR P K++++VFP QGGPH N IAAVA QLK+ TP +K Y++QVL N K LA L
Sbjct 252 KRNPGIDQKINSSVFPSFQGGPHNNKIAAVACQLKEVNTPFFKEYTKQVLLNSKALAECL 311
Query 61 QSYGLQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
L LVT GTDNHL+++DL+ +TG KLQ C+A+NI
Sbjct 312 LKRNLDLVTNGTDNHLIVVDLRKYNITGSKLQETCNAINI 351
> ath:AT1G22020 SHM6; SHM6 (serine hydroxymethyltransferase 6);
catalytic/ glycine hydroxymethyltransferase/ pyridoxal phosphate
binding (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=599
Score = 108 bits (271), Expect = 3e-24, Method: Composition-based stats.
Identities = 52/92 (56%), Positives = 66/92 (71%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K++ +VFP LQGGPH NHIAA+A LKQ +PE+K+Y +QV N K LA+ L S +L+
Sbjct 413 KINFSVFPSLQGGPHNNHIAALAIALKQAASPEYKLYMRQVKKNAKALASALISRKCKLI 472
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
TGGTDNHLLL DL P GLTG + VC+ +I
Sbjct 473 TGGTDNHLLLWDLTPLGLTGKVYEKVCEMCHI 504
> dre:394021 shmt1, MGC66171, zgc:66171, zgc:77524; serine hydroxymethyltransferase
1 (soluble) (EC:2.1.2.1); K00600 glycine
hydroxymethyltransferase [EC:2.1.2.1]
Length=481
Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats.
Identities = 52/96 (54%), Positives = 66/96 (68%), Gaps = 0/96 (0%)
Query 5 NGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYG 64
N S ++ AVFPGLQGGPH + IA VA LKQ TPE+K Y QVL NCK LA+ L G
Sbjct 284 NLESLINQAVFPGLQGGPHNHAIAGVAVALKQALTPEFKTYQLQVLANCKALASALMDKG 343
Query 65 LQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
++VTGG+DNHL+L+DL+ G GG+ + V +A I
Sbjct 344 YKVVTGGSDNHLILVDLRSNGTDGGRAEKVLEACAI 379
> hsa:6472 SHMT2, GLYA, SHMT; serine hydroxymethyltransferase
2 (mitochondrial) (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=494
Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats.
Identities = 49/92 (53%), Positives = 66/92 (71%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
+++ AVFP LQGGPH + IAAVA LKQ CTP ++ YS QVL N + +A L G LV
Sbjct 304 RINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLV 363
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+GGTDNHL+L+DL+P+GL G + + V + V+I
Sbjct 364 SGGTDNHLVLVDLRPKGLDGARAERVLELVSI 395
> ath:AT4G37930 SHM1; SHM1 (SERINE TRANSHYDROXYMETHYLTRANSFERASE
1); glycine hydroxymethyltransferase/ poly(U) binding (EC:2.1.2.1);
K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=517
Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats.
Identities = 47/92 (51%), Positives = 65/92 (70%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K++ AVFPGLQGGPH + I +A LKQ T E+K Y +QVL N A L G +LV
Sbjct 319 KINQAVFPGLQGGPHNHTITGLAVALKQATTSEYKAYQEQVLSNSAKFAQTLMERGYELV 378
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+GGTDNHL+L++LKP+G+ G +++ V +AV+I
Sbjct 379 SGGTDNHLVLVNLKPKGIDGSRVEKVLEAVHI 410
> mmu:20425 Shmt1, AI324848, AI385541, C81125, Shmt, mshmt, mshmt1,
mshmt2; serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1);
K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=478
Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats.
Identities = 48/93 (51%), Positives = 67/93 (72%), Gaps = 0/93 (0%)
Query 8 SKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQL 67
S +++AVFPGLQGGPH + IA VA LKQ T E+K+Y QVL NC+ L+ L G ++
Sbjct 284 SLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQVLANCRALSDALTELGYKI 343
Query 68 VTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
VTGG+DNHL+L+DL+ +G GG+ + V +A +I
Sbjct 344 VTGGSDNHLILMDLRSKGTDGGRAEKVLEACSI 376
> ath:AT4G13890 EDA36; EDA36 (EMBRYO SAC DEVELOPMENT ARREST 37);
catalytic/ glycine hydroxymethyltransferase/ pyridoxal phosphate
binding (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=470
Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats.
Identities = 48/89 (53%), Positives = 63/89 (70%), Gaps = 0/89 (0%)
Query 8 SKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQL 67
+K+++AVFP LQ GPH N I A+A LKQ P +KVY++QV N LA+ L + G L
Sbjct 277 AKINSAVFPALQSGPHNNKIGALAVALKQVMAPSFKVYAKQVKANAACLASYLINKGYTL 336
Query 68 VTGGTDNHLLLLDLKPQGLTGGKLQLVCD 96
VT GTDNHL+L DL+P GLTG K++ VC+
Sbjct 337 VTDGTDNHLILWDLRPLGLTGNKVEKVCE 365
> ath:AT4G13930 SHM4; SHM4 (serine hydroxymethyltransferase 4);
catalytic/ glycine hydroxymethyltransferase/ pyridoxal phosphate
binding (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=471
Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats.
Identities = 52/102 (50%), Positives = 67/102 (65%), Gaps = 5/102 (4%)
Query 4 PNGA-----SKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAA 58
P GA K++ AVFP LQGGPH + I A+A LKQ TP +KVY++QV N L
Sbjct 268 PEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVYAKQVKANAVALGN 327
Query 59 ELQSYGLQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
L S G Q+VT GT+NHL+L DL+P GLTG K++ +CD +I
Sbjct 328 YLMSKGYQIVTNGTENHLVLWDLRPLGLTGNKVEKLCDLCSI 369
> hsa:6470 SHMT1, CSHMT, MGC15229, MGC24556, SHMT; serine hydroxymethyltransferase
1 (soluble) (EC:2.1.2.1); K00600 glycine
hydroxymethyltransferase [EC:2.1.2.1]
Length=483
Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust.
Identities = 49/96 (51%), Positives = 68/96 (70%), Gaps = 0/96 (0%)
Query 5 NGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYG 64
N S +++AVFPGLQGGPH + IA VA LKQ T E+KVY QV+ NC+ L+ L G
Sbjct 287 NLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELG 346
Query 65 LQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
++VTGG+DNHL+L+DL+ +G GG+ + V +A +I
Sbjct 347 YKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSI 382
> xla:447193 shmt2, MGC79128; serine hydroxymethyltransferase
2 (mitochondrial) (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=496
Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats.
Identities = 50/101 (49%), Positives = 71/101 (70%), Gaps = 1/101 (0%)
Query 1 KRVP-NGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAE 59
K +P N K++ +VFP +QGGPH + IAAVA LKQ +P ++ Y+ QVL N K +AA
Sbjct 297 KEIPYNLEDKINFSVFPSIQGGPHNHAIAAVAVALKQASSPMFREYAVQVLKNAKSMAAA 356
Query 60 LQSYGLQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
L S G LV+GGTDNHL+L+DL+P+G+ G + + V + V+I
Sbjct 357 LLSKGYTLVSGGTDNHLVLVDLRPKGIDGARAERVLELVSI 397
> ath:AT4G32520 SHM3; SHM3 (SERINE HYDROXYMETHYLTRANSFERASE 3);
catalytic/ glycine hydroxymethyltransferase/ pyridoxal phosphate
binding (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=529
Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats.
Identities = 44/93 (47%), Positives = 65/93 (69%), Gaps = 0/93 (0%)
Query 8 SKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQL 67
S V+ AVFPGLQGGPH + I +A LK +PE+K Y ++V+ NC+ LA L G +L
Sbjct 338 SAVNNAVFPGLQGGPHNHTIGGLAVCLKHAQSPEFKAYQKRVVSNCRALANRLVELGFKL 397
Query 68 VTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
V+GG+DNHL+L+DL+P G+ G +++ + D +I
Sbjct 398 VSGGSDNHLVLVDLRPMGMDGARVEKILDMASI 430
> mmu:108037 Shmt2, 2700043D08Rik, AA408223, AA986903; serine
hydroxymethyltransferase 2 (mitochondrial) (EC:2.1.2.1); K00600
glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=504
Score = 100 bits (250), Expect = 9e-22, Method: Composition-based stats.
Identities = 48/92 (52%), Positives = 65/92 (70%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
+++ AVFP LQGGPH + IAAVA LKQ CTP ++ YS QVL N + +A L G LV
Sbjct 314 RINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLRNAQAMADALLKRGYSLV 373
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+GGTD HL+L+DL+P+GL G + + V + V+I
Sbjct 374 SGGTDTHLVLVDLRPKGLDGARAERVLELVSI 405
> ath:AT1G36370 SHM7; SHM7 (serine hydroxymethyltransferase 7);
catalytic/ glycine hydroxymethyltransferase/ pyridoxal phosphate
binding (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=598
Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats.
Identities = 54/92 (58%), Positives = 64/92 (69%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K++ AVFP LQGGPH NHIAA+A LKQ TPE+K Y QQ+ N + LAA L +LV
Sbjct 409 KINFAVFPSLQGGPHNNHIAALAIALKQVATPEYKAYIQQMKKNAQALAAALLRRKCRLV 468
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
TGGTDNHLLL DL P GLTG + VC+ +I
Sbjct 469 TGGTDNHLLLWDLTPMGLTGKVYEKVCEMCHI 500
> xla:380048 shmt1, MGC53442; serine hydroxymethyltransferase
1 (soluble) (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=485
Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats.
Identities = 46/96 (47%), Positives = 68/96 (70%), Gaps = 0/96 (0%)
Query 5 NGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYG 64
N S ++ AVFPGLQGGPH + IA VA LKQ +PE+K+Y +QV+ NCK L+ ++ G
Sbjct 288 NYESLINQAVFPGLQGGPHNHAIAGVAVALKQALSPEFKLYQKQVVSNCKALSLAIEELG 347
Query 65 LQLVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+VTGG+DNHL+L++L+ + GG+ + V +A +I
Sbjct 348 YHVVTGGSDNHLILVNLRDKKTDGGRAEKVLEACSI 383
> sce:YLR058C SHM2, SHMT2; Cytosolic serine hydroxymethyltransferase,
converts serine to glycine plus 5,10 methylenetetrahydrofolate;
major isoform involved in generating precursors
for purine, pyrimidine, amino acid, and lipid biosynthesis (EC:2.1.2.1);
K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=469
Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats.
Identities = 42/91 (46%), Positives = 66/91 (72%), Gaps = 0/91 (0%)
Query 10 VDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLVT 69
++ +VFPG QGGPH + IAA+A LKQ TPE+K Y QVL N K L +E ++ G +LV+
Sbjct 283 INFSVFPGHQGGPHNHTIAALATALKQAATPEFKEYQTQVLKNAKALESEFKNLGYRLVS 342
Query 70 GGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
GTD+H++L+ L+ +G+ G +++ +C+ +NI
Sbjct 343 NGTDSHMVLVSLREKGVDGARVEYICEKINI 373
> dre:100144628 shmt2; serine hydroxymethyltransferase 2 (mitochondrial)
(EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=492
Score = 98.6 bits (244), Expect = 4e-21, Method: Composition-based stats.
Identities = 48/92 (52%), Positives = 64/92 (69%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
KV+ +VFP LQGGPH + IA VA LKQ +P ++ Y QVL N K +AA L G LV
Sbjct 302 KVNFSVFPSLQGGPHNHAIAGVAVALKQATSPMFREYIAQVLKNSKAMAAALLDKGYTLV 361
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+GGTDNHL+L+DL+PQG+ G + + V + V+I
Sbjct 362 SGGTDNHLVLVDLRPQGMDGARAERVLELVSI 393
> cel:C05D11.11 mel-32; Maternal Effect Lethal family member (mel-32);
K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=507
Score = 98.6 bits (244), Expect = 5e-21, Method: Composition-based stats.
Identities = 45/92 (48%), Positives = 64/92 (69%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K+++AVFPGLQGGPH + IA +A L+Q + ++ Y +QVL N K LA ++ +G L
Sbjct 316 KINSAVFPGLQGGPHNHTIAGIAVALRQCLSEDFVQYGEQVLKNAKTLAERMKKHGYALA 375
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
TGGTDNHLLL+DL+P G+ G + + V D +I
Sbjct 376 TGGTDNHLLLVDLRPIGVEGARAEHVLDLAHI 407
> sce:YBR263W SHM1, SHMT1, TMP3; Mitochondrial serine hydroxymethyltransferase,
converts serine to glycine plus 5,10 methylenetetrahydrofolate;
involved in generating precursors for
purine, pyrimidine, amino acid, and lipid biosynthesis; reverse
reaction generates serine (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=490
Score = 95.9 bits (237), Expect = 3e-20, Method: Composition-based stats.
Identities = 43/92 (46%), Positives = 64/92 (69%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K++ +VFPG QGGPH + I A+A LKQ +PE+K Y Q+++DN K A EL G +LV
Sbjct 298 KINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKEYQQKIVDNSKWFAQELTKMGYKLV 357
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+GGTDNHL+++DL + G +++ + A+NI
Sbjct 358 SGGTDNHLIVIDLSGTQVDGARVETILSALNI 389
> ath:AT5G26780 SHM2; SHM2 (SERINE HYDROXYMETHYLTRANSFERASE 2);
catalytic/ glycine hydroxymethyltransferase/ pyridoxal phosphate
binding (EC:2.1.2.1); K00600 glycine hydroxymethyltransferase
[EC:2.1.2.1]
Length=533
Score = 90.5 bits (223), Expect = 1e-18, Method: Composition-based stats.
Identities = 50/109 (45%), Positives = 67/109 (61%), Gaps = 18/109 (16%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQ------- 61
+++ AVFPGLQGGPH + I +A LKQ TPE+K Y QVL NC AEL
Sbjct 319 RINQAVFPGLQGGPHNHTITGLAVALKQARTPEYKAYQDQVLRNCSKF-AELDIRPTVII 377
Query 62 SYGLQ----------LVTGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
SYGL LV+GGTDNHL+L++LK +G+ G +++ V + V+I
Sbjct 378 SYGLSMQTLLAKGYDLVSGGTDNHLVLVNLKNKGIDGSRVEKVLELVHI 426
> eco:b2551 glyA, ECK2548, JW2535; serine hydroxymethyltransferase
(EC:2.1.2.1); K00600 glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=417
Score = 77.0 bits (188), Expect = 1e-14, Method: Composition-based stats.
Identities = 41/92 (44%), Positives = 54/92 (58%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K+++AVFPG QGGP + IA A LK+ PE+K Y QQV N K + G ++V
Sbjct 251 KLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVV 310
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
+GGTDNHL L+DL + LTG + NI
Sbjct 311 SGGTDNHLFLVDLVDKNLTGKEADAALGRANI 342
> cpv:cgd8_2610 cytosolic serine hydroxymethyl transferase ; K00600
glycine hydroxymethyltransferase [EC:2.1.2.1]
Length=445
Score = 65.9 bits (159), Expect = 3e-11, Method: Composition-based stats.
Identities = 30/92 (32%), Positives = 54/92 (58%), Gaps = 0/92 (0%)
Query 9 KVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLV 68
K+D +V +Q H N +AA+ QLKQ + W Y+ +VL++ +LL L+ G++++
Sbjct 258 KIDESVSKEIQSSIHFNQVAALCFQLKQVVSASWVKYASRVLESSQLLCKLLEESGIKIL 317
Query 69 TGGTDNHLLLLDLKPQGLTGGKLQLVCDAVNI 100
T GTD+H +L+D + ++G K + + I
Sbjct 318 TNGTDSHKILIDTRSLNISGAKAEKALEVCEI 349
> cpv:cgd8_2580 mitochondrial serine hydroxymethyl transferase
Length=438
Score = 63.9 bits (154), Expect = 1e-10, Method: Composition-based stats.
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 0/83 (0%)
Query 4 PNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSY 63
P KV++AVFPGLQGGPH + I + A Q++ T + LDN +LA +
Sbjct 246 PGLFQKVNSAVFPGLQGGPHNHQIGSFAVQIQGMLTSRTSEFVAAALDNSAVLAQTMLDS 305
Query 64 GLQLVTGGTDNHLLLLDLKPQGL 86
G+ L+ GTD HL+ +D + G+
Sbjct 306 GIPLLGDGTDTHLVSVDCERLGV 328
> eco:b0771 ybhJ, ECK0760, JW5103; predicted hydratase; K01681
aconitate hydratase 1 [EC:4.2.1.3]
Length=753
Score = 30.0 bits (66), Expect = 2.0, Method: Composition-based stats.
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 0/37 (0%)
Query 2 RVPNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTC 38
+V NG KV + G GG +EN IAA Q+C
Sbjct 344 KVENGRLKVQQGIIAGCSGGNYENVIAAANALRGQSC 380
> ath:AT4G11810 SPX (SYG1/Pho81/XPR1) domain-containing protein
Length=707
Score = 30.0 bits (66), Expect = 2.1, Method: Composition-based stats.
Identities = 22/82 (26%), Positives = 34/82 (41%), Gaps = 20/82 (24%)
Query 27 IAAVAHQLKQTCTPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLD------ 80
+ A +LK+ EW Q+ N KL+ +++ YG Q+ G D +L D
Sbjct 1 MVAFGKKLKERSIEEW----QEYYINYKLMKKKVKQYGPQIEVGSLDRRHVLKDFSRMLD 56
Query 81 ----------LKPQGLTGGKLQ 92
L+ QGL +LQ
Sbjct 57 HQIEKIALFMLEQQGLLSSRLQ 78
> dre:322327 cb1032, fb57h11, wu:fb57h11; zgc:193613
Length=141
Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust.
Identities = 13/37 (35%), Positives = 20/37 (54%), Gaps = 0/37 (0%)
Query 1 KRVPNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQT 37
KR+ N K+ AV P L+G P + V +LK++
Sbjct 42 KRLVNAWEKIKTAVEPALEGSPTAGSLKDVVEELKKS 78
> cel:C54G7.1 hypothetical protein
Length=259
Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust.
Identities = 13/32 (40%), Positives = 19/32 (59%), Gaps = 0/32 (0%)
Query 40 PEWKVYSQQVLDNCKLLAAELQSYGLQLVTGG 71
P W Y Q+ + C+ LA LQ+ +QL+ GG
Sbjct 119 PCWSDYGHQISERCESLATFLQAEVMQLLQGG 150
> hsa:9701 PPP6R2, KIAA0685, PP6R2, SAP190, SAPS2, dJ579N16.1;
protein phosphatase 6, regulatory subunit 2
Length=932
Score = 28.9 bits (63), Expect = 4.1, Method: Composition-based stats.
Identities = 12/43 (27%), Positives = 22/43 (51%), Gaps = 0/43 (0%)
Query 8 SKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVL 50
+++ AV L+ GP + HI+ V L C W+ + ++ L
Sbjct 481 TRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETL 523
> hsa:23043 TNIK; TRAF2 and NCK interacting kinase (EC:2.7.11.1);
K08840 TRAF2 and NCK interacting kinase [EC:2.7.11.1]
Length=1352
Score = 28.9 bits (63), Expect = 4.5, Method: Composition-based stats.
Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQG 85
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG
Sbjct 1028 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQG 1069
> dre:556959 tnikb, MGC123033, MGC152783, MGC192776, im:6898857,
zgc:123033, zgc:152783; TRAF2 and NCK interacting kinase
b; K08840 TRAF2 and NCK interacting kinase [EC:2.7.11.1]
Length=1329
Score = 28.9 bits (63), Expect = 4.6, Method: Composition-based stats.
Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQG 85
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG
Sbjct 1005 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQG 1046
> mmu:665113 Tnik, 1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik,
C630040K21Rik, KIAA0551, MGC189819, MGC189859; TRAF2
and NCK interacting kinase (EC:2.7.11.1); K08840 TRAF2
and NCK interacting kinase [EC:2.7.11.1]
Length=1352
Score = 28.9 bits (63), Expect = 4.6, Method: Composition-based stats.
Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQG 85
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG
Sbjct 1028 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQG 1069
> dre:325042 tnika, fc52d11, msn, tnikl, wu:fc52d11, zgc:63535;
TRAF2 and NCK interacting kinase a; K08840 TRAF2 and NCK interacting
kinase [EC:2.7.11.1]
Length=1303
Score = 28.9 bits (63), Expect = 4.6, Method: Composition-based stats.
Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQG 85
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG
Sbjct 979 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQG 1020
> dre:798737 G protein-coupled receptor 151-like; K04231 galanin
receptor 2
Length=378
Score = 28.5 bits (62), Expect = 4.9, Method: Composition-based stats.
Identities = 9/37 (24%), Positives = 20/37 (54%), Gaps = 0/37 (0%)
Query 20 GGPHENHIAAVAHQLKQTCTPEWKVYSQQVLDNCKLL 56
GP+ ++ + + C P W+ ++++VLD C +
Sbjct 159 AGPYLSYYDLIDFENSNVCVPGWEEHNRKVLDTCTFV 195
> mmu:71474 Ppp6r2, 1110033O10Rik, 8430411H09Rik, B230107H12Rik,
Pp6r2, Saps2; protein phosphatase 6, regulatory subunit 2
Length=923
Score = 28.5 bits (62), Expect = 5.0, Method: Compositional matrix adjust.
Identities = 12/43 (27%), Positives = 22/43 (51%), Gaps = 0/43 (0%)
Query 8 SKVDAAVFPGLQGGPHENHIAAVAHQLKQTCTPEWKVYSQQVL 50
+++ AV L+ GP + HI+ V L C W+ + ++ L
Sbjct 483 TRIANAVVQNLEQGPVQAHISEVIRGLPADCRGRWESFVEETL 525
> hsa:79705 LRRK1, FLJ23119, FLJ27465, KIAA1790, RIPK6, Roco1;
leucine-rich repeat kinase 1 (EC:2.7.11.1); K08843 leucine-rich
repeat kinase 1 [EC:2.7.11.1]
Length=2015
Score = 28.5 bits (62), Expect = 5.2, Method: Composition-based stats.
Identities = 17/38 (44%), Positives = 22/38 (57%), Gaps = 4/38 (10%)
Query 1 KRVPNGASKVDAAVFPGLQGGPHENHIAAVAHQLKQTC 38
K VP G ++DA +F LQG N +AA+ Q K TC
Sbjct 463 KEVPLGLFQLDALMFLRLQG----NQLAALPPQEKWTC 496
> xla:446555 mink1, MGC81192, mink; misshapen-like kinase 1 (EC:2.7.11.1);
K04413 misshapen/NIK-related kinase [EC:2.7.11.1]
Length=1270
Score = 28.5 bits (62), Expect = 5.6, Method: Composition-based stats.
Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQG 85
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG
Sbjct 946 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQG 987
> mmu:50932 Mink1, B55, MINK, Map4k6, RP23-122P1.6, Ysk2; misshapen-like
kinase 1 (zebrafish) (EC:2.7.11.1); K04413 misshapen/NIK-related
kinase [EC:2.7.11.1]
Length=1337
Score = 28.5 bits (62), Expect = 5.9, Method: Composition-based stats.
Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 5/47 (10%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQG 85
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG
Sbjct 1013 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQG 1054
> hsa:50488 MINK1, B55, MAP4K6, MGC21111, MINK, YSK2, ZC3, hMINK,
hMINKbeta; misshapen-like kinase 1 (EC:2.7.11.1); K04413
misshapen/NIK-related kinase [EC:2.7.11.1]
Length=1312
Score = 28.1 bits (61), Expect = 6.3, Method: Composition-based stats.
Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 5/51 (9%)
Query 39 TPEWKVYSQQVLDNCKLLAAELQSYGLQLVTGGTDNHLLLLDLKPQGLTGG 89
TPE + Y ++ N ++L A L +G+ L+ G T+N L+LLD QG G
Sbjct 988 TPEIRKYKKRF--NSEILCAAL--WGVNLLVG-TENGLMLLDRSGQGKVYG 1033
Lambda K H
0.317 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 2041372988
Database: egene_temp_file_orthology_annotation_similarity_blast_database_865
Posted date: Sep 17, 2011 11:19 AM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40