bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_865
164,496 sequences; 82,071,388 total letters
Query= Emax_1232_orf2
Length=484
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_057010 insulysin, putative (EC:3.4.24.56); K01408 i... 665 0.0
cpv:cgd1_1680 insulinase like protease, signal peptide ; K0140... 274 5e-73
dre:561390 ide, MGC162603, zgc:162603; insulin-degrading enzym... 234 4e-61
mmu:15925 Ide, 1300012G03Rik, 4833415K22Rik, AA675336, AI50753... 233 1e-60
ath:AT2G41790 peptidase M16 family protein / insulinase family... 229 1e-59
dre:557565 nrd1, si:dkey-171o17.4; nardilysin (N-arginine diba... 227 1e-58
sce:YLR389C STE23; Metalloprotease involved, with homolog Axl1... 224 4e-58
cpv:cgd2_930 peptidase'insulinase-like peptidase' ; K01408 ins... 224 8e-58
cel:C02G6.2 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 220 8e-57
dre:565850 fk24c07; wu:fk24c07; K01411 nardilysin [EC:3.4.24.61] 217 1e-55
mmu:230598 Nrd1, 2600011I06Rik, AI875733, MGC25477, NRD-C; nar... 213 9e-55
hsa:4898 NRD1, hNRD1, hNRD2; nardilysin (N-arginine dibasic co... 213 1e-54
ath:AT1G06900 catalytic/ metal ion binding / metalloendopeptid... 204 5e-52
cel:Y70C5C.1 hypothetical protein; K01408 insulysin [EC:3.4.24... 204 9e-52
cel:F44E7.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 202 2e-51
tgo:TGME49_069890 M16 family peptidase, putative (EC:3.4.24.56) 202 3e-51
cel:C02G6.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 199 3e-50
cel:C28F5.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56] 190 8e-48
eco:b2821 ptrA, ECK2817, JW2789, ptr; protease III (EC:3.4.24.... 190 1e-47
cpv:cgd2_920 peptidase'insulinase-like peptidase' 188 5e-47
ath:AT3G57470 peptidase M16 family protein / insulinase family... 180 1e-44
cpv:cgd3_4260 peptidase'insulinase like peptidase' ; K01408 in... 172 2e-42
cpv:cgd3_4270 peptidase'insulinase like peptidase' ; K01408 in... 163 1e-39
tgo:TGME49_044480 insulin-degrading enzyme, putative (EC:3.4.2... 135 3e-31
cpv:cgd2_4270 secreted insulinase-like peptidase 132 4e-30
sce:YPR122W AXL1, FUS5, STE22; Axl1p (EC:3.4.24.-); K01422 [E... 130 1e-29
cpv:cgd6_5520 peptidase'insulinase like peptidase' ; K01408 in... 129 2e-29
cpv:cgd3_4240 insulinase like peptidase ; K01408 insulysin [EC... 124 6e-28
cpv:cgd3_4170 secreted insulinase like peptidase 113 2e-24
tgo:TGME49_006510 peptidase M16 domain containing protein (EC:... 94.7 8e-19
cpv:cgd3_4180 secreted insulinase like peptidase 82.4 4e-15
cpv:cgd3_4280 secreted insulinase like peptidase, signal peptide 77.8 1e-13
cpv:cgd3_4210 secreted insulinase like peptidase, signal peptide 75.5 4e-13
ath:AT3G02090 MPPBETA; mitochondrial processing peptidase beta... 70.9 1e-11
cpv:cgd3_4250 secreted insulinase like peptidase, signal peptide 67.4 1e-10
eco:b1494 pqqL, ECK1488, JW1489, pqqE, pqqM, yddC; predicted p... 67.0 2e-10
pfa:PF11_0226 petidase, M16 family 60.8 1e-08
ath:AT5G42390 metalloendopeptidase 58.2 7e-08
cpv:cgd3_4200 secreted insulinase like peptidase, signal peptide 57.8 8e-08
dre:503532 pmpcb, zgc:110738; peptidase (mitochondrial process... 55.8 4e-07
tgo:TGME49_036210 mitochondrial-processing peptidase beta subu... 55.1 6e-07
ath:AT5G56730 peptidase M16 family protein / insulinase family... 55.1 6e-07
sce:YLR163C MAS1, MIF1; Mas1p (EC:3.4.24.64); K01412 mitochond... 54.7 9e-07
hsa:9512 PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52; peptidase... 54.3 1e-06
mmu:73078 Pmpcb, 3110004O18Rik, MPP11, MPPB, MPPP52; peptidase... 54.3 1e-06
bbo:BBOV_IV001260 21.m02910; mitochondrial processing peptidas... 52.8 3e-06
dre:393793 uqcrc1, MGC73404, zgc:73404, zgc:85750; ubiquinol-c... 52.4 4e-06
tpv:TP01_0151 biquinol-cytochrome C reductase complex core pro... 51.2 9e-06
pfa:PFI1625c organelle processing peptidase, putative; K01412 ... 51.2 1e-05
cpv:cgd5_3400 mitochondrial processing peptidase beta subunit ... 50.8 1e-05
> tgo:TGME49_057010 insulysin, putative (EC:3.4.24.56); K01408
insulysin [EC:3.4.24.56]
Length=953
Score = 665 bits (1717), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 294/473 (62%), Positives = 382/473 (80%), Gaps = 0/473 (0%)
Query 12 AIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPG 71
A+G + ++LKP ADYRDF H+QL NGM +A+HHP++ E ++VA NTGSLYDPED+PG
Sbjct 15 AVGCVCGEVLKPGADYRDFHHFQLPNGMQCLAIHHPKTTEGAYSVAVNTGSLYDPEDLPG 74
Query 72 LAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRF 131
LAHFLEHMLFLGTSK+PEPESYD F+++ GG NNAYTDEEKTVFFN+V+D E+ALDRF
Sbjct 75 LAHFLEHMLFLGTSKHPEPESYDKFMSERGGQNNAYTDEEKTVFFNQVSDKYLEDALDRF 134
Query 132 AEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNSETLS 191
++FFKSPLF+ +YEE+E +A+D+EHQKN+PND+ER W+TIRSLAKGP+SRFATGN ETL+
Sbjct 135 SQFFKSPLFNPEYEEREAHAVDSEHQKNVPNDEERTWFTIRSLAKGPLSRFATGNLETLN 194
Query 192 TNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLG 251
T PK KGI++V RL+DFH KYYC SNM V +SPRSL EQE+L+R+ E +++G+ ++LG
Sbjct 195 TAPKRKGINVVSRLKDFHKKYYCASNMAVVIMSPRSLVEQETLLRKSFEDVTSGNPNFLG 254
Query 252 MVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLL 311
QCPG +D PFD +N+GKFIH+QS E SLWVAF LP T+TSYKKQPT +LTYL
Sbjct 255 FDQCPGVDYDRTPPFDLSNTGKFIHLQSVGGESSLWVAFSLPPTITSYKKQPTGILTYLF 314
Query 312 EYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYIN 371
EY+G+GSL+KRLR +GLAD +S DR S+STL +KVDL KGA+ RG VL+E+FSYIN
Sbjct 315 EYSGDGSLSKRLRTMGLADEVSVVADRTSVSTLFAVKVDLASKGASERGAVLEEVFSYIN 374
Query 372 FLRDHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLID 431
L++ GV + +S++++QS +DFHT+QP M+E ARLAHNLLTYEPYHV+AGDSLL+D
Sbjct 375 LLKNEGVDSKTISSISEQSLVDFHTSQPDPPAMNEVARLAHNLLTYEPYHVLAGDSLLVD 434
Query 432 ADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDLPQHH 484
D + NQLL +M+ AIIAF+DP F DSF+ +P+YG+++++ +LP+
Sbjct 435 PDAQFVNQLLDKMTSDHAIIAFADPQFKRNNDSFDVEPFYGIEYKITNLPKEQ 487
> cpv:cgd1_1680 insulinase like protease, signal peptide ; K01408
insulysin [EC:3.4.24.56]
Length=1033
Score = 274 bits (701), Expect = 5e-73, Method: Compositional matrix adjust.
Identities = 157/477 (32%), Positives = 256/477 (53%), Gaps = 13/477 (2%)
Query 11 SAIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVP 70
S+I G +LKP+ D R +++ L NG+ A+ + S +AGF V GS +P
Sbjct 29 SSIWKSGYSVLKPKTDDRSYKNITLENGITALLIEDKFSEKAGFTVGIKVGSFNNPVYAL 88
Query 71 GLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDR 130
GL H +EH+LFLGT KYP PESYD F+ Q+GG NNAYT EE+T++FN++ + EE LDR
Sbjct 89 GLFHLIEHVLFLGTKKYPAPESYDEFMAQHGGKNNAYTSEERTIYFNEIGEEYLEEGLDR 148
Query 131 FAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNSETL 190
F+ FF PLF EKE++ I++EH KNIPN+ +R ++ +++ PMS+F TGN ETL
Sbjct 149 FSHFFIDPLFYENVIEKEIHIINSEHLKNIPNEFDRLFHMLKTHTNKPMSQFTTGNIETL 208
Query 191 STNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGI---SAGHA 247
P GI + L+ + KYYCG NM V S RSL +QE L+++ G+ + G
Sbjct 209 VDIPNKLGISIPRLLKKMYKKYYCGINMFIVLSSKRSLTDQEKLLQKYFSGVLIDNDGQC 268
Query 248 DWLGMVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVL 307
++ + + G + ++ D K IH++S LW+ + PA L S KQP L
Sbjct 269 EFSSLKKEHGILNKSI--IDQKYLSKKIHVKSLGGRDLLWLIWSFPARLISPVKQPLIYL 326
Query 308 TYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIF 367
+Y+L + SL L+ + + + ++ +++LT +G ++ ++ I+
Sbjct 327 SYILNSKQKNSLFWFLQKNNYITNSNSVYENYTFGSIFIYQLELTSEGLKNQFEIIGLIY 386
Query 368 SYINFLRDHGVGHELVSTMAQQSHIDF--HTTQPSSSIMDEAARLAHNLLTYEPYHVVAG 425
YIN L++ ++ + + +F +T SS M + + ++ Y + ++G
Sbjct 387 KYINKLKESKELLKVYQGIRSLTEREFITNTEMLESSPMHSTSEICSKMIQYGVHAALSG 446
Query 426 DSLLIDADPRLTNQLLQEMSPSKAIIAFSDP-DFTSKVDSFETDPYYGVQFRVLDLP 481
D L+ D D L ++L +SP + SD +F+ + F + V+ + D+P
Sbjct 447 DILIEDVDENLIYEILNAISPFDTLFLVSDEQEFSGTYEKF-----FHVKHAIEDIP 498
> dre:561390 ide, MGC162603, zgc:162603; insulin-degrading enzyme
(EC:3.4.24.56); K01408 insulysin [EC:3.4.24.56]
Length=978
Score = 234 bits (598), Expect = 4e-61, Method: Compositional matrix adjust.
Identities = 145/468 (30%), Positives = 236/468 (50%), Gaps = 15/468 (3%)
Query 12 AIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPG 71
A+ + +DI++ D R++R + +NG+ AI + P ++++ A+ + GSL DPE++ G
Sbjct 5 AVKRVVSDIIRSPEDKREYRGLEFTNGLKAILISDPTTDKSSAALDVHMGSLSDPENISG 64
Query 72 LAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRF 131
LAHF EHMLFLGT KYP+ Y FL+++ G++NA+T E T ++ V+ + ALDRF
Sbjct 65 LAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRF 124
Query 132 AEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSET 189
A+FF PLF +++EVNA+D+EH+KN+ ND R + ++ K P S+F TGN T
Sbjct 125 AQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKLT 184
Query 190 LSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADW 249
L T P +GID+ + L FHS YY + M + +LDE S++ + + +
Sbjct 185 LETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNV-- 242
Query 250 LGMVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTY 309
P P F T PF + +F + +L+V F +P YK P L +
Sbjct 243 ------PVPEFPT-HPFQEEHLRQFYKVVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGH 295
Query 310 LLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG-IKVDLTQKGAAHRGLVLQEIFS 368
L+ + G GSL L+ G + + + + I VDLT++G H ++ +F
Sbjct 296 LIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIFHMFQ 355
Query 369 YINFLRDHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSL 428
YI LR G + + + F +++A L Y ++A + L
Sbjct 356 YIQKLRTEGPQEWVFQECKDLNTVAFRFKDKERP-RGYTSKVAGLLHYYPLEEILAAEYL 414
Query 429 LIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFR 476
L + P L +L ++ P +A F + D T+ +YG Q++
Sbjct 415 LEEFRPDLIEMVLDKLRPENVRVAVVSKSFEGQTD--RTEEWYGTQYK 460
> mmu:15925 Ide, 1300012G03Rik, 4833415K22Rik, AA675336, AI507533;
insulin degrading enzyme (EC:3.4.24.56); K01408 insulysin
[EC:3.4.24.56]
Length=1019
Score = 233 bits (594), Expect = 1e-60, Method: Compositional matrix adjust.
Identities = 148/475 (31%), Positives = 241/475 (50%), Gaps = 17/475 (3%)
Query 12 AIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPG 71
AI + + I+K D R++R +L+NG+ + + P ++++ A+ + GSL DP ++PG
Sbjct 46 AIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPG 105
Query 72 LAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRF 131
L+HF EHMLFLGT KYP+ Y FL+++ G++NA+T E T ++ V+ E ALDRF
Sbjct 106 LSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRF 165
Query 132 AEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSET 189
A+FF PLF +++EVNA+D+EH+KN+ ND R + ++ K P S+F TGN T
Sbjct 166 AQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYT 225
Query 190 LSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPR-SLDEQESLIREKLEGISAGHAD 248
L T P +GID+ + L FHS YY SN++A+ + R SLD+ +L+ + + +
Sbjct 226 LETRPNQEGIDVREELLKFHSTYY-SSNLMAICVLGRESLDDLTNLVVKLFSEVENKNV- 283
Query 249 WLGMVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLT 308
P P F PF + + + +L+V F +P YK P L
Sbjct 284 -------PLPEFPE-HPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLG 335
Query 309 YLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG-IKVDLTQKGAAHRGLVLQEIF 367
+L+ + G GSL L+ G + + + + I VDLT++G H ++ +F
Sbjct 336 HLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMF 395
Query 368 SYINFLRDHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDS 427
YI LR G + + + F +++A L Y V+ +
Sbjct 396 QYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERP-RGYTSKIAGKLHYYPLNGVLTAEY 454
Query 428 LLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDLPQ 482
LL + P L + +L ++ P +A F K D T+ +YG Q++ +P+
Sbjct 455 LLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTD--RTEQWYGTQYKQEAIPE 507
> ath:AT2G41790 peptidase M16 family protein / insulinase family
protein; K01408 insulysin [EC:3.4.24.56]
Length=970
Score = 229 bits (585), Expect = 1e-59, Method: Compositional matrix adjust.
Identities = 143/467 (30%), Positives = 236/467 (50%), Gaps = 21/467 (4%)
Query 17 GNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFL 76
G +ILKP D R++R L N + + + P +++ +++ + GS DP+ + GLAHFL
Sbjct 12 GVEILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFL 71
Query 77 EHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFK 136
EHMLF + KYPE +SY ++T++GG+ NAYT E+T + V F+EALDRFA+FF
Sbjct 72 EHMLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFI 131
Query 137 SPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSETLSTNP 194
PL S +E+ A+D+E+QKN+ +D R + L+K P +F+TGN +TL P
Sbjct 132 KPLMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRP 191
Query 195 KAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQ 254
+AKG+D L F+ ++Y + M V SLD+ + L+ + I + + +
Sbjct 192 QAKGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNK---VVPR 248
Query 255 CPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYT 314
PG +P + + L V++ + ++ Y + P+ L +L+ +
Sbjct 249 FPG------QPCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHE 302
Query 315 GEGSLAKRLRLLGLADGISPAVDRNSIS-TLLGIKVDLTQKGAAHRGLVLQEIFSYINFL 373
GEGSL L+ LG A G+S ++ + + +DLT G H +L +F+YI L
Sbjct 303 GEGSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLL 362
Query 374 RDHGVGHELVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLI 430
+ GV + ++ FH P S I+D +A N+ Y + G SL
Sbjct 363 QQTGVCQWIFDELSAICETKFHYQDKIPPMSYIVD----IASNMQIYPTKDWLVGSSLPT 418
Query 431 DADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRV 477
+P + +++ E+SPS I + F + D E P+Y + +
Sbjct 419 KFNPAIVQKVVDELSPSNFRIFWESQKFEGQTDKAE--PWYNTAYSL 463
> dre:557565 nrd1, si:dkey-171o17.4; nardilysin (N-arginine dibasic
convertase) (EC:3.4.24.61)
Length=1061
Score = 227 bits (578), Expect = 1e-58, Method: Compositional matrix adjust.
Identities = 157/520 (30%), Positives = 244/520 (46%), Gaps = 62/520 (11%)
Query 14 GALGNDILKPEADYRDFRHYQLSNGMHAIAV----------------------------- 44
A N I+K DY+ +R+ +LSNG+ A+ +
Sbjct 38 AADSNTIIKSPNDYKTYRYIELSNGLKALLISDVSSQSESCRESVDKEVEEEGDRGSASD 97
Query 45 ---HHPR-------SNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 94
H R ++ A+ + GS DP D+PGLAHFLEHM+F+G+ KYP +D
Sbjct 98 ISKHSERGKQSCRSEKQSAAALCISVGSFSDPADLPGLAHFLEHMVFMGSEKYPVENGFD 157
Query 95 GFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDA 154
FL ++GG++NA TD E+T+F V EALDR+A+FF PL ++EV A+D+
Sbjct 158 AFLKKHGGSDNASTDCERTIFQFDVQRKYLREALDRWAQFFICPLMIPDAVDREVEAVDS 217
Query 155 EHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKY 212
E+Q P D R SLAK PMS+F GN++TL P+ K I+ +RLRDF +Y
Sbjct 218 EYQMAQPLDSNRKEMLFGSLAKAGHPMSKFFWGNAQTLKQEPREKKINTYERLRDFWRRY 277
Query 213 YCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGPMF-DTVKPFDHTNS 271
Y M S +LD E +RE I G+ P F D PFD +
Sbjct 278 YSAQYMTLAVQSKETLDTLEEWVREIFVQIPNN-----GL---PKADFSDLQDPFDTPDF 329
Query 272 GKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGEGS----LAKRLRLLG 327
K + +L +++ LP Y+ +P +++L+ + G GS L KR L
Sbjct 330 CKLYRVVPVQKVHALTISWALPPQAKHYRVKPLHYISWLIGHEGVGSVLSLLRKRCWALS 389
Query 328 LADGISPA-VDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHELVSTM 386
L G S + D+NS ++ I + L+ +G + V+ IF Y+ L+ G + +
Sbjct 390 LFGGNSESGFDQNSTYSIFSISITLSDEGLQNFLQVIHIIFQYLKMLQSVGPQQRIYEEI 449
Query 387 AQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQL----LQ 442
+ +FH + + I + A ++ N+ + H + GD L+ D +P ++ + L
Sbjct 450 QKIEANEFHYQEQTEPI-EFVANMSENMQLFPKEHFLCGDQLMFDFNPEASHCVISAALS 508
Query 443 EMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDLPQ 482
++P KA I P E ++G Q+ V D+PQ
Sbjct 509 LLTPGKANILLLSPQHDGLCPLKEK--WFGTQYSVEDIPQ 546
> sce:YLR389C STE23; Metalloprotease involved, with homolog Axl1p,
in N-terminal processing of pro-A-factor to the mature
form; member of the insulin-degrading enzyme family (EC:3.4.24.-);
K01408 insulysin [EC:3.4.24.56]
Length=1027
Score = 224 bits (572), Expect = 4e-58, Method: Compositional matrix adjust.
Identities = 142/473 (30%), Positives = 245/473 (51%), Gaps = 30/473 (6%)
Query 19 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 78
D LKP+ D R +R +L N + A+ + P++++A ++ N G+ DP+++PGLAHF EH
Sbjct 63 DFLKPDLDERSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEH 122
Query 79 MLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 138
+LF+G+ K+P+ Y +L+++GG++NAYT + T +F +V ALDRF+ FF P
Sbjct 123 LLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCP 182
Query 139 LFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL--AKGPMSRFATGNSETLSTNPKA 196
LF++ +KE+NA+++E++KN+ ND R + +SL K P +F+TGN ETL T PK
Sbjct 183 LFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKE 242
Query 197 KGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 256
G+++ D L FH +Y +N++ + I L RE L+ +S D V
Sbjct 243 NGLNVRDELLKFHKNFY-SANLMKLCI----------LGREDLDTLSDWTYDLFKDVANN 291
Query 257 G---PMF-DTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLE 312
G P++ + + +H K I ++ L ++F +P ++ +P +L++L+
Sbjct 292 GREVPLYAEPIMQPEHLQ--KIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIG 349
Query 313 YTGEGSLAKRLRLLGLADGISPAVDRNSI-STLLGIKVDLTQKGAAHRGLVLQEIFSYIN 371
+ G GSL L+ LG A+ +S S + + +DLT G H V+ IF YI
Sbjct 350 HEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIE 409
Query 372 FLRDHGVGHELVSTMAQQSHIDFHTTQ---PSSSIMDEAARLAHNLLTYEPYHVVAGDSL 428
L++ + + + S+ F Q PSS++ A L + Y P + L
Sbjct 410 MLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKD---YIPVSRILAMGL 466
Query 429 LIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDLP 481
L +P L Q + P + + + +++ + +YG ++V+D P
Sbjct 467 LTKYEPDLLTQYTDALVPENSRVTL----ISRSLETDSAEKWYGTAYKVVDYP 515
> cpv:cgd2_930 peptidase'insulinase-like peptidase' ; K01408 insulysin
[EC:3.4.24.56]
Length=1013
Score = 224 bits (570), Expect = 8e-58, Method: Compositional matrix adjust.
Identities = 126/396 (31%), Positives = 212/396 (53%), Gaps = 6/396 (1%)
Query 11 SAIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVP 70
+ + + N+I KP D +R L N + + V ++ +G +++ G DPE++
Sbjct 6 TNLKEIQNEITKPIYDDNKYRALVLKNNLRVLLVQDENTDISGASMSVFVGCQQDPEELN 65
Query 71 GLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDR 130
GLAHFLEHMLFLG++++P P +D ++ NGG++NA+TD T +F ++ + +FE ALD
Sbjct 66 GLAHFLEHMLFLGSARHPNPSDFDDYMKLNGGSSNAFTDNLSTSYFFEIKNESFEHALDL 125
Query 131 FAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSE 188
F+ FF PLF +Y ++EVNA+++EH KN+ +D ++ I S+A+ P+ +F TG+ E
Sbjct 126 FSAFFICPLFDTKYVDREVNAVNSEHNKNLLSDLWIRYHVISSIARNGHPLRKFGTGSIE 185
Query 189 TLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGI---SAG 245
TL P+ KGIDL+ L++FH+KYY +NM +S LDE ES + I +
Sbjct 186 TLKYEPEKKGIDLIAELKNFHNKYYSSNNMFLTLVSNCDLDELESYAIKYFSEIVDKNIA 245
Query 246 HADWLGMVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTS 305
D+ G Q P ++ + +++ E + F +P K P
Sbjct 246 RVDYFGEFQKERPYLSIMESPEDGALESMVYVIPNKDEKKVSFNFQIPDLRKFRKGLPEM 305
Query 306 VLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQE 365
T +L + G GSL LR G +S ++ + L I + LT+KGA V++
Sbjct 306 YFTNILGHEGPGSLTSALRRNGWCLALSSGLNEMYSANLFEIIITLTEKGAREVLSVIEY 365
Query 366 IFSYINFLRDHGVGHELVSTMAQQSHIDF-HTTQPS 400
+++N + + + E+VS + + S + F + +PS
Sbjct 366 TLNFVNLVIKNEIDMEVVSDLEKLSQLVFDYRNRPS 401
> cel:C02G6.2 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=816
Score = 220 bits (561), Expect = 8e-57, Method: Compositional matrix adjust.
Identities = 144/473 (30%), Positives = 236/473 (49%), Gaps = 27/473 (5%)
Query 18 NDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLE 77
N I+K D R+ R +L+NG+ + V P ++++ ++A G L DP ++PGLAHF E
Sbjct 14 NSIVKGPQDERECRGLELTNGLRVLLVSDPTTDKSAVSLAVKAGHLMDPWELPGLAHFCE 73
Query 78 HMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 137
HMLFLGTSKYP + FL+ N G+ NA T+ + T + V ALDRF +FF
Sbjct 74 HMLFLGTSKYPLENEFTKFLSDNAGSYNACTEPDHTYYHFDVKPDQLYGALDRFVQFFLC 133
Query 138 PLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK-GPMSR-FATGNSETLSTNPK 195
P F++ E+EV A+D+EH N+ +D R RSL++ G +R F TGN +TL + +
Sbjct 134 PQFTKSATEREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRKFCTGNKKTLLEDAR 193
Query 196 AKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIR----EKLEGISAGHADWLG 251
KGI+ D L +F+ K+Y + M I SLD ES +R + ++ A W
Sbjct 194 KKGIEPRDALLEFYKKWYSSNIMTCCIIGKESLDVLESYLRTLEFDAIQNKKAESKVWAE 253
Query 252 MVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLL 311
P + K I + + + + F P Y QP + +L+
Sbjct 254 FQYGPDQL------------AKKIDVVPIKDKKLVSIIFPFPDLNNEYLSQPGHYIAHLI 301
Query 312 EYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG---IKVDLTQKGAAHRGLVLQEIFS 368
+ G GS++ L+ LG A + P + +I+ G + +DL+ +G H ++Q +F+
Sbjct 302 GHKGPGSISSELKRLGWASSLKP--ESKTIAAGFGYFNVTMDLSTEGLEHVDEIIQLMFN 359
Query 369 YINFLRDHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPY-HVVAGDS 427
YI L+ G + +A+ S I+F + + A ++A N L Y P+ H+++
Sbjct 360 YIGMLQSAGPQQWIHEELAELSAIEFR-FKDREPLTKNAIKVARN-LQYIPFEHILSSRY 417
Query 428 LLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDL 480
LL +P +LL ++PS ++ F + + +P YG + +V D+
Sbjct 418 LLTKYNPERIKELLSTLTPSNMLVRVVSKKFKEQ-EGNTNEPVYGTEMKVTDI 469
> dre:565850 fk24c07; wu:fk24c07; K01411 nardilysin [EC:3.4.24.61]
Length=1091
Score = 217 bits (552), Expect = 1e-55, Method: Compositional matrix adjust.
Identities = 136/442 (30%), Positives = 218/442 (49%), Gaps = 19/442 (4%)
Query 50 NEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTD 109
++ A+ GS DP D+PGLAHFLEHM+F+G+ KYP +D FL ++GG++NA TD
Sbjct 144 KQSAAALCIGVGSFSDPNDLPGLAHFLEHMVFMGSEKYPSENGFDAFLKKHGGSDNASTD 203
Query 110 EEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWY 169
E+T+F V F+EALDR+A+FF PL ++EV A+D+E+Q P+D R
Sbjct 204 CERTIFQFDVQRKRFKEALDRWAQFFICPLMIEDAIDREVEAVDSEYQLAKPSDSHRKEM 263
Query 170 TIRSLAKG--PMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRS 227
SLAK PMS+F GN++TL T PK K I++ RLR+F ++Y M S S
Sbjct 264 LFGSLAKPDHPMSKFCWGNAQTLKTEPKEKNINVYKRLREFWKRHYSAHYMTLAVQSKES 323
Query 228 LDEQESLIREKLEGISAGHADWLGMVQCPGPMF-DTVKPFDHTNSGKFIHMQSFSSEPSL 286
LD E +RE + G ++ P F D + PF+ K + +L
Sbjct 324 LDTLEEWVREIFSQVPNN-----GQLK---PDFSDKLNPFETPAFNKLYRVVPVRKVHAL 375
Query 287 WVAFGLPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLR----LLGLADGISP-AVDRNSI 341
+ + LP Y+ +P + +L+ + G GS+ LR L L G S D+N+
Sbjct 376 TITWALPPQEKHYRVKPLHYIAWLIGHEGTGSILSMLRRKCWALALFGGNSETGFDQNTT 435
Query 342 STLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHELVSTMAQQSHIDFHTTQPSS 401
++ I + LT +G + V +F Y+ L+ G + + + +FH + +
Sbjct 436 YSIFSISITLTDEGFQNFYEVAHLVFQYLKMLQTLGPQQRIYEEIQKIEANEFHYQEQTD 495
Query 402 SIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSK 461
I + + N+ + + GD L+ + P + + L ++P KA + P+ +
Sbjct 496 PI-EYVEDICENMQLFPKEDFLTGDQLMFEFKPEVISAALNLLTPEKANLLLLSPEHEGQ 554
Query 462 VDSFETDPYYGVQFRVLDLPQH 483
E ++G Q+ D+ QH
Sbjct 555 CPLREK--WFGTQYSTEDIEQH 574
> mmu:230598 Nrd1, 2600011I06Rik, AI875733, MGC25477, NRD-C; nardilysin,
N-arginine dibasic convertase, NRD convertase 1 (EC:3.4.24.61);
K01411 nardilysin [EC:3.4.24.61]
Length=1161
Score = 213 bits (543), Expect = 9e-55, Method: Compositional matrix adjust.
Identities = 136/439 (30%), Positives = 214/439 (48%), Gaps = 19/439 (4%)
Query 50 NEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTD 109
++ A+ GS DP+D+PGLAHFLEHM+F+G+ KYP+ +D FL ++GG++NA TD
Sbjct 220 KQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTD 279
Query 110 EEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWY 169
E+TVF V F+EALDR+A+FF PL R ++EV A+D+E+Q P+D R
Sbjct 280 CERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEM 339
Query 170 TIRSLAKG--PMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRS 227
SLA+ PM +F GN+ETL PK ID RLR+F +YY M V S +
Sbjct 340 LFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKET 399
Query 228 LDEQESLIREKLEGISAGHADWLGMVQCPGPMFDTVK-PFDHTNSGKFIHMQSFSSEPSL 286
LD E + E I G+ P P F + PFD K + +L
Sbjct 400 LDTLEKWVTEIFSQIPNN-----GL---PKPNFSHLTDPFDTPAFNKLYRVVPIRKIHAL 451
Query 287 WVAFGLPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGI-----SPAVDRNSI 341
+ + LP Y+ +P +++L+ + G+GS+ LR A + ++NS
Sbjct 452 TITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNST 511
Query 342 STLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHELVSTMAQQSHIDFHTTQPSS 401
++ I + LT +G H V +F Y+ L+ G + + + +FH Q +
Sbjct 512 YSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFH-YQEQT 570
Query 402 SIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSK 461
++ + N+ Y + GD LL + P + + L ++ P KA + +
Sbjct 571 DPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGR 630
Query 462 VDSFETDPYYGVQFRVLDL 480
D E ++G Q+ + D+
Sbjct 631 CDLKEK--WFGTQYSIEDI 647
> hsa:4898 NRD1, hNRD1, hNRD2; nardilysin (N-arginine dibasic
convertase) (EC:3.4.24.61); K01411 nardilysin [EC:3.4.24.61]
Length=1151
Score = 213 bits (543), Expect = 1e-54, Method: Compositional matrix adjust.
Identities = 136/438 (31%), Positives = 215/438 (49%), Gaps = 19/438 (4%)
Query 51 EAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDE 110
++ A+ GS DP+D+PGLAHFLEHM+F+G+ KYP+ +D FL ++GG++NA TD
Sbjct 210 QSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDC 269
Query 111 EKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYT 170
E+TVF V F+EALDR+A+FF PL R ++EV A+D+E+Q P+D R
Sbjct 270 ERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEML 329
Query 171 IRSLAKG--PMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSL 228
SLA+ PM +F GN+ETL P+ ID RLR+F +YY M V S +L
Sbjct 330 FGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETL 389
Query 229 DEQESLIREKLEGISAGHADWLGMVQCPGPMFDTVK-PFDHTNSGKFIHMQSFSSEPSLW 287
D E + E I G+ P P F + PFD K + +L
Sbjct 390 DTLEKWVTEIFSQIPNN-----GL---PRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALT 441
Query 288 VAFGLPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGI-----SPAVDRNSIS 342
+ + LP Y+ +P +++L+ + G+GS+ LR A + ++NS
Sbjct 442 ITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTY 501
Query 343 TLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHELVSTMAQQSHIDFHTTQPSSS 402
++ I + LT +G H V +F Y+ L+ G + + + +FH Q +
Sbjct 502 SVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFH-YQEQTD 560
Query 403 IMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKV 462
++ + N+ Y ++ GD LL + P + + L ++ P KA + K
Sbjct 561 PVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKC 620
Query 463 DSFETDPYYGVQFRVLDL 480
D E ++G Q+ + D+
Sbjct 621 DLKEK--WFGTQYSIEDI 636
> ath:AT1G06900 catalytic/ metal ion binding / metalloendopeptidase/
zinc ion binding; K01411 nardilysin [EC:3.4.24.61]
Length=1024
Score = 204 bits (520), Expect = 5e-52, Method: Compositional matrix adjust.
Identities = 135/443 (30%), Positives = 224/443 (50%), Gaps = 25/443 (5%)
Query 48 RSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAY 107
++ +A A+ + GS DP + GLAHFLEHMLF+G++++P+ YD +L+++GG++NAY
Sbjct 103 QTKKAAAAMCVSMGSFLDPPEAQGLAHFLEHMLFMGSTEFPDENEYDSYLSKHGGSSNAY 162
Query 108 TDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDER- 166
T+ E T + +V + AL RF++FF +PL + E+EV A+D+E + + ND R
Sbjct 163 TEMEHTCYHFEVKREFLQGALKRFSQFFVAPLMKTEAMEREVLAVDSEFNQALQNDACRL 222
Query 167 AWYTIRSLAKG-PMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISP 225
+ AKG P +RFA GN ++LS G+DL + + + +YY G M V I
Sbjct 223 QQLQCYTSAKGHPFNRFAWGNKKSLS-GAMENGVDLRECIVKLYKEYYHGGLMKLVVIGG 281
Query 226 RSLDEQESLIREKLEGISAGHADWLGMVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPS 285
SLD ES + E + G + ++ GP++ GK +++
Sbjct 282 ESLDMLESWVVELFGDVKNG-SKIRPTLEAEGPIW---------KGGKLYRLEAVKDVHI 331
Query 286 LWVAFGLPATLTSYKKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGISPAV-----DRNS 340
L + + LP ++Y K+P L +LL + G GSL L+ G A +S V +R+S
Sbjct 332 LDLTWTLPPLRSAYVKKPEDYLAHLLGHEGRGSLHSFLKAKGWATSLSAGVGDDGINRSS 391
Query 341 ISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDHGVGHELVSTMAQQSHIDFH--TTQ 398
++ + G+ + LT G ++ I+ Y+ LRD + + ++DF Q
Sbjct 392 LAYVFGMSIHLTDSGLEKIYDIIGYIYQYLKLLRDVSPQEWIFKELQDIGNMDFRFAEEQ 451
Query 399 PSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQEMSPSKAIIAFSDPDF 458
P+ D AA L+ N+L Y HV+ GD + DP+L L+ +P I
Sbjct 452 PAD---DYAAELSENMLAYPVEHVIYGDYVYQTWDPKLIEDLMGFFTPQNMRIDVVSKSI 508
Query 459 TSKVDSFETDPYYGVQFRVLDLP 481
S + F+ +P++G + D+P
Sbjct 509 KS--EEFQQEPWFGSSYIEEDVP 529
Score = 32.7 bits (73), Expect = 3.4, Method: Compositional matrix adjust.
Identities = 13/38 (34%), Positives = 23/38 (60%), Gaps = 0/38 (0%)
Query 10 LSAIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHP 47
+ ++ AL N ++K D R +R +L NG+ A+ +H P
Sbjct 4 MKSVSALDNVVVKSPNDRRLYRVIELENGLCALLIHDP 41
> cel:Y70C5C.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=985
Score = 204 bits (518), Expect = 9e-52, Method: Compositional matrix adjust.
Identities = 145/465 (31%), Positives = 221/465 (47%), Gaps = 21/465 (4%)
Query 20 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 79
ILK D R++R +L+NG+ + V P ++++ A+ N G L DP ++PGLAHF EHM
Sbjct 16 ILKGAQDEREYRGLELTNGIRVLLVSDPTTDKSAAALDVNVGHLMDPWELPGLAHFCEHM 75
Query 80 LFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 139
LFLGT+KYP Y FLT + G NA T + T +F +V ALDRF +FF SP
Sbjct 76 LFLGTAKYPSENEYFKFLTAHAGRANANTATDHTNYFFEVKPDQLPGALDRFVQFFLSPQ 135
Query 140 FSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNSETLSTNPKAK 197
F+ E+EV A+D+EH N+ ND R RS AK +F TGN +TL + + +
Sbjct 136 FTESATEREVCAVDSEHSNNLNNDAWRFLQVHRSCAKPGHDYGKFGTGNKKTLLEDARKQ 195
Query 198 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPG 257
GI+ D L FH K+Y + M I SLD ES L D + +
Sbjct 196 GIEPRDALLQFHKKWYSSNIMTCCIIGKESLDVLESY----LGTFEFAAIDNKKLERQIW 251
Query 258 PMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGEG 317
F PF GK I + + ++F P + QP +++L+ + G G
Sbjct 252 KEF----PFGPEQLGKRIDVVPIKDTRQISISFPFPDLTGEFLSQPEHYISHLIGHEGHG 307
Query 318 SLAKRLRLLGLADGI-SPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRDH 376
SL L+ LG + S V + + + ++L+ +G H ++Q +F+YI ++
Sbjct 308 SLLSELKRLGWVVSLQSGYVVQAAGFGNFQVGIELSTEGLEHVDEIIQLMFNYIGMMQSS 367
Query 377 GVGHELVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPY-HVVAGDSLLIDA 432
G + +A+ + F QP + AARL P+ HV++ LL +
Sbjct 368 GPKQWVHEELAELRAVTFRFKDKEQPMAMASCVAARLQRI-----PFKHVLSSPHLLTNY 422
Query 433 DPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRV 477
+P +LL + PS I F + + +P YG + +V
Sbjct 423 EPVRIKELLSMLIPSNMKIQVVSQKFKGQ-EGNTNEPVYGTEIKV 466
> cel:F44E7.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=1051
Score = 202 bits (514), Expect = 2e-51, Method: Compositional matrix adjust.
Identities = 138/474 (29%), Positives = 223/474 (47%), Gaps = 33/474 (6%)
Query 20 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 79
I+K D R++R +L+NG+ + V P ++++ A+ G L DP ++PGLAHF EHM
Sbjct 75 IVKGAQDAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHM 134
Query 80 LFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 139
LFLGT+KYP Y FL + G++NAYT + T + V ALDRF +FF SP
Sbjct 135 LFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQ 194
Query 140 FSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNSETLSTNPKAK 197
F+ E+EV A+D+EH N+ ND R RS +K +F TGN +TL + + K
Sbjct 195 FTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKK 254
Query 198 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIR----EKLEGISAGHADWLGMV 253
GI+ D L FH K+Y M + L+ ES + + +E W
Sbjct 255 GIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEF- 313
Query 254 QCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEY 313
P+ K I + + ++F P + QP +++L+ +
Sbjct 314 -----------PYGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGH 362
Query 314 TGEGSLAKRLRLLGLADGISPAVDRNSISTLLG---IKVDLTQKGAAHRGLVLQEIFSYI 370
G GSL L+ LG + D ++ + G + +DL+ +G H ++Q +F+YI
Sbjct 363 EGPGSLLSELKRLGWVSSLQS--DSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYI 420
Query 371 NFLRDHGVGHELVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPY-HVVAGD 426
L+ G + +A+ S + F QP + ++ AA L Y P+ H+++
Sbjct 421 GMLQSAGPKQWVHDELAELSAVKFRFKDKEQPMTMAINVAAS-----LQYIPFEHILSSR 475
Query 427 SLLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDL 480
LL +P +LL +SP+ + F + + +P YG + +V D+
Sbjct 476 YLLTKYEPERIKELLSMLSPANMQVRVVSQKFKGQ-EGNTNEPVYGTEMKVTDI 528
> tgo:TGME49_069890 M16 family peptidase, putative (EC:3.4.24.56)
Length=941
Score = 202 bits (514), Expect = 3e-51, Method: Compositional matrix adjust.
Identities = 139/472 (29%), Positives = 222/472 (47%), Gaps = 13/472 (2%)
Query 1 AASVGLCVGLSAIGALGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANT 60
A +V L + ++ +L + KP D R++R+ +L N + A+ V P +EA ++
Sbjct 6 AVTVSLSWVILSLLSLLFPVRKPRNDSRNYRYIELPNELRALLVSDPECDEAAASMRVGV 65
Query 61 GSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVT 120
GS+ DP +PGLAHF EHMLF G+ ++P + F+ +GG NA+T + TVF +
Sbjct 66 GSMSDPPKIPGLAHFTEHMLFQGSKRFPGTHDFFDFVHNHGGYTNAFTSKFSTVFSFSIG 125
Query 121 DSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK-GPM 179
E LDR A+ F +PL + KEVNA+ +E+ ++ +D R + IR AK GP
Sbjct 126 PGFLEPGLDRLADLFSAPLLKSENLLKEVNAVHSEYIIDLTDDGRRKHHLIRQTAKGGPF 185
Query 180 SRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKL 239
S F GN E+L K +GID V +R+FH+K+Y + M + SLD ES +R+
Sbjct 186 SNFTVGNLESLMERTKQQGIDPVKAMREFHNKWYSSNLMTLAVVGRESLDVLESHVRKHF 245
Query 240 EGISAGHADWLGMVQCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSY 299
+ G +C + P D G + + F LP ++
Sbjct 246 GNVPNGRVTPPVFEECS----EAFIPLDPNELGTETLVVPEADLHDATFVFYLPPQAKNW 301
Query 300 KKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHR 359
+ +P ++ +LE+ G SL+ +L+ GL + + T+L + V LT+ G +
Sbjct 302 RSKPLQFISEMLEHEGPTSLSSKLKREGLITSLVTDYWSPELCTVLQVNVRLTEGGRSKE 361
Query 360 GLVLQEIFSYINFLRDHGVGHE---LVSTMAQQSHIDF-HTTQPSSSIMDEAARLAHNLL 415
V + + FLR+ GV V+ MA+ + F P + R L
Sbjct 362 S-VYKIGHALFTFLRNLGVSRPERWRVTEMAKIRQLGFAFADMPDPYAL--TVRAVEGLN 418
Query 416 TYEPYHVVAGDSLLIDADPRLTNQLLQE-MSPSKAIIAFSDPDFTSKVDSFE 466
Y P V+AGD L+ DP + Q +Q+ + P + D + VD E
Sbjct 419 YYTPEEVIAGDRLIYHFDPDIIQQYVQKFLVPDNVRLFIFDKKLAADVDREE 470
> cel:C02G6.1 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=980
Score = 199 bits (505), Expect = 3e-50, Method: Compositional matrix adjust.
Identities = 142/472 (30%), Positives = 225/472 (47%), Gaps = 52/472 (11%)
Query 18 NDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLE 77
+ I+K D R++R +L+NG+ + V P ++++ A+ G L DP ++PGLAHF E
Sbjct 14 DSIVKGAQDDREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCE 73
Query 78 HMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 137
HMLFLGT+KYP Y FLT N G NA T + T + V ALDRF +FF S
Sbjct 74 HMLFLGTAKYPTENEYSKFLTDNAGHRNAVTASDHTNYHFDVKPDQLRGALDRFVQFFLS 133
Query 138 PLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNSETLSTNPK 195
P F+ E+EV A+D+EH N+ ND R RSL+K ++F TGN +TL +
Sbjct 134 PQFTESATEREVCAVDSEHSNNLNNDLWRLSQVDRSLSKPGHDYAKFGTGNKKTLLEEAR 193
Query 196 AKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQC 255
KG++ D L F+ K+Y + M I SLD +S ++ LE
Sbjct 194 KKGVEPRDALLQFYKKWYSSNIMTCCIIGKESLDVLQSHLK-TLE--------------- 237
Query 256 PGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTG 315
FDT++ K + + ++ P +G P L K+ +L+ + G
Sbjct 238 ----FDTIE-------NKKVERKVWNENP-----YG-PEQLG--KRIDRKFFAHLIRHKG 278
Query 316 EGSLAKRLRLLGLADGISPAVDRNSIST---LLGIKVDLTQKGAAHRGLVLQEIFSYINF 372
GSL L+ LG + + D N+I+ +L + +DL+ G + ++Q + +YI
Sbjct 279 PGSLLVELKRLGWVNSLKS--DSNTIAAGFGILNVTMDLSTGGLENVDEIIQLMLNYIGM 336
Query 373 LRDHGVGHELVSTMAQQSHIDFH---TTQPSSSIMDEAARLAHNLLTYEPY-HVVAGDSL 428
L+ G + +A S + F QP ++ AA L Y P H+++ L
Sbjct 337 LKSFGPQQWIHDELADLSDVKFRFKDKEQPMKMAINIAASLQ-----YIPIEHILSSRYL 391
Query 429 LIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRVLDL 480
L +P +LL ++PS ++ F + + +P YG + +V D+
Sbjct 392 LTKYEPERIKELLSTLTPSNMLVRVVSQKFKEQ-EGNTNEPVYGTEMKVTDI 442
> cel:C28F5.4 hypothetical protein; K01408 insulysin [EC:3.4.24.56]
Length=856
Score = 190 bits (483), Expect = 8e-48, Method: Compositional matrix adjust.
Identities = 129/414 (31%), Positives = 200/414 (48%), Gaps = 40/414 (9%)
Query 18 NDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLE 77
+ I+K D + +R +L+NG+ + V ++ + A+ G L DP ++PGLAHF E
Sbjct 15 DSIVKGSQDTKKYRGLELTNGLRVLLVSDSKTRVSAVALDVKVGHLMDPWELPGLAHFCE 74
Query 78 HMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 137
HMLFLGT+KYP Y +L N G +NAYTD + T + +V ALDRFA+FF
Sbjct 75 HMLFLGTAKYPSEREYFKYLAANNGDSNAYTDTDHTNYSFEVRSEKLYGALDRFAQFFLD 134
Query 138 PLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK--GPMSRFATGNSETLSTNPK 195
P F+ E+EV A++ E+ + D R RSL+K S+FA GN +TL +P+
Sbjct 135 PQFTESATEREVCAVNCEYLDKVNEDFWRCLQVERSLSKPGHDYSKFAIGNKKTLLEDPR 194
Query 196 AKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQC 255
KGI+ D L DF+ +Y M + SLD ES +LG +
Sbjct 195 TKGIEPRDVLLDFYKNWYSSDIMTCCIVGKESLDVLES---------------YLGSFK- 238
Query 256 PGPMFDTVK------------PFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQP 303
FD +K PF K I + + + + F P + QP
Sbjct 239 ----FDAIKNTRKERKIWKDSPFGPDQLAKRIEIVPIQNTGQVSIKFPFPDLNGEFLSQP 294
Query 304 TSVLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLG---IKVDLTQKGAAHRG 360
+ +L+ + G GSL L+ LG IS D ++I++ G + +DL+ +G H
Sbjct 295 GDYIAHLIGHEGPGSLLSELKRLGWV--ISLEADNHTIASGFGVFSVTMDLSTEGLEHVD 352
Query 361 LVLQEIFSYINFLRDHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNL 414
V+Q +F++I FL+ G + +A+ + +DF + M++A+ LA L
Sbjct 353 DVIQLVFNFIGFLKSSGPQKWIHDELAELNAVDFRFDDVKHT-MEKASILAECL 405
> eco:b2821 ptrA, ECK2817, JW2789, ptr; protease III (EC:3.4.24.55);
K01407 protease III [EC:3.4.24.55]
Length=962
Score = 190 bits (482), Expect = 1e-47, Method: Compositional matrix adjust.
Identities = 145/462 (31%), Positives = 218/462 (47%), Gaps = 25/462 (5%)
Query 20 ILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHM 79
I K + D R ++ +L NGM + V P++ ++ A+ GSL DPE GLAH+LEHM
Sbjct 34 IRKSDKDNRQYQAIRLDNGMVVLLVSDPQAVKSLSALVVPVGSLEDPEAYQGLAHYLEHM 93
Query 80 LFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPL 139
+G+ KYP+ +S +L +GG++NA T +T F+ +V + A A+DR A+ PL
Sbjct 94 SLMGSKKYPQADSLAEYLKMHGGSHNASTAPYRTAFYLEVENDALPGAVDRLADAIAEPL 153
Query 140 FSRQYEEKEVNAIDAEHQKNIPNDDER-AWYTIRSLAKG-PMSRFATGNSETLSTNPKAK 197
++Y E+E NA++AE D R A + ++ P S+F+ GN ETLS P
Sbjct 154 LDKKYAERERNAVNAELTMARTRDGMRMAQVSAETINPAHPGSKFSGGNLETLSDKP--- 210
Query 198 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMV---Q 254
G + L+DFH KYY + M AV S + L E ++ AD G V +
Sbjct 211 GNPVQQALKDFHEKYYSANLMKAVIYSNKPLPE-----------LAKMAADTFGRVPNKE 259
Query 255 CPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYT 314
P TV G IH L V F + ++ + ++TYL+
Sbjct 260 SKKPEI-TVPVVTDAQKGIIIHYVPALPRKVLRVEFRIDNNSAKFRSKTDELITYLIGNR 318
Query 315 GEGSLAKRLRLLGLADGISPAVD--RNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINF 372
G+L+ L+ GL +GIS D N S +L I LT KG A+R V+ IFSY+N
Sbjct 319 SPGTLSDWLQKQGLVEGISANSDPIVNGNSGVLAISASLTDKGLANRDQVVAAIFSYLNL 378
Query 373 LRDHGVGHELVSTMAQQSHIDFHTTQPS-SSIMDEAARLAHNLLTYEPYHVVAGDSLLID 431
LR+ G+ + +A IDF PS + MD LA ++ H + ++
Sbjct 379 LREKGIDKQYFDELANVLDIDFRY--PSITRDMDYVEWLADTMIRVPVEHTLDAVNIADR 436
Query 432 ADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGV 473
D + + L M+P A I + P ++ D Y V
Sbjct 437 YDAKAVKERLAMMTPQNARIWYISPKEPHNKTAYFVDAPYQV 478
> cpv:cgd2_920 peptidase'insulinase-like peptidase'
Length=1028
Score = 188 bits (477), Expect = 5e-47, Method: Compositional matrix adjust.
Identities = 136/475 (28%), Positives = 223/475 (46%), Gaps = 17/475 (3%)
Query 18 NDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLE 77
+DI+ PE + R +R +L NG+ A V + +G + G++Y P+++ GLAHFLE
Sbjct 15 DDIVLPECEDRKYRALELKNGLTAFLVSDKETKTSGCCLTVYIGAMYSPKNLNGLAHFLE 74
Query 78 HMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 137
HMLF GT KYP + Y F+ +GG + T T ++ ++ ++AF EALDRF+ FF
Sbjct 75 HMLFCGTKKYPNVDEYQKFIASHGGKRHGSTTRSTTTYYFEIKNNAFNEALDRFSSFFTE 134
Query 138 PLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSETLSTNPK 195
PLF + EKEV+AI+ E +D+ ++ + L+ P++ F TGN ETL PK
Sbjct 135 PLFCKDMTEKEVSAIENEFHLKYHSDERVRFHLLGQLSNKSHPLNCFTTGNKETLEFKPK 194
Query 196 AKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQC 255
GI+L L F+S YY + M + LD E E I + +
Sbjct 195 KLGINLHSELLKFYSSYYSSNIMSIILYGKEDLDTLEKYTIEYFSKIPNHQVNCFDYTK- 253
Query 256 PGPMFDTVKPFDH-TNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYT 314
+F + P+ T+ GK I + + ++ L + F LP + + ++ +
Sbjct 254 ---IFMEIPPYTRETSIGKIIKLIPYETDKRLKIYFPLPPLDKYNDSCAPAYIANIIGHK 310
Query 315 GEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLR 374
GEG ++ LR LA G S A+ L V LT +G + G VL+ IF+++ +
Sbjct 311 GEGGISSILRAKKLATGASFAITNEDPCALAQFGVVLTDEGYNNIGQVLEIIFNFLVLFK 370
Query 375 DHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDA-- 432
V ELV + F T QP SI D + A L + + ++
Sbjct 371 ATPVIPELVDEFIGITRAGF-TYQPKFSIRDLFSLPAKYLKYKCKFEEILSSGFVVKKFS 429
Query 433 -DPRLTNQLLQEMSPSKAIIAFS----DPDFTSKVDSFETDPYYGVQFRVLDLPQ 482
D + +L+ +S I S + ++ ++F + YYG ++ + +L +
Sbjct 430 QDDVFS--ILEYLSNDNFFILLSSQAIEEEYKKNQENFIVEHYYGTKYSISELDE 482
> ath:AT3G57470 peptidase M16 family protein / insulinase family
protein; K01408 insulysin [EC:3.4.24.56]
Length=891
Score = 180 bits (456), Expect = 1e-44, Method: Compositional matrix adjust.
Identities = 115/402 (28%), Positives = 196/402 (48%), Gaps = 15/402 (3%)
Query 79 MLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 138
MLF + KYPE +SY ++T++GG+ NAYT E T + + +F EALDRFA+FF P
Sbjct 1 MLFYASEKYPEEDSYSKYITEHGGSTNAYTSSEDTNYHFDINTDSFYEALDRFAQFFIQP 60
Query 139 LFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSETLSTNPKA 196
L S +E+ A+D+EHQ N+ +D R + L++ P +F+TGN +TL P+
Sbjct 61 LMSTDATMREIKAVDSEHQNNLLSDSWRMAQLQKHLSREDHPYHKFSTGNMDTLHVRPEE 120
Query 197 KGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 256
G+D L F+ ++Y + M V +LD+ + L+ +GI + G+ + P
Sbjct 121 NGVDTRSELIKFYDEHYSANIMHLVVYGKENLDKTQGLVEALFQGIRNTNQ---GIPRFP 177
Query 257 GPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGE 316
G +P + + L V++ + +++ Y++ P L L+ + GE
Sbjct 178 G------QPCTLDHLQVLVKAVPIMQGHELSVSWPVTPSISHYEEAPCRYLGDLIGHEGE 231
Query 317 GSLAKRLRLLGLADGI-SPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 375
GSL L++LG A G+ + D + + + +DLT G H +L +F YI L+
Sbjct 232 GSLFHALKILGWATGLYAGEADWSMEYSFFNVSIDLTDAGHEHMQDILGLLFEYIKVLQQ 291
Query 376 HGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLLIDADPR 435
GV + ++ +FH Q + A ++ N+ Y H + G SL +P
Sbjct 292 SGVSQWIFDELSAICEAEFH-YQAKIDPISYAVDISSNMKIYPTKHWLVGSSLPSKFNPA 350
Query 436 LTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETDPYYGVQFRV 477
+ ++L E+SP+ I + F + D E P+Y + +
Sbjct 351 IVQKVLDELSPNNVRIFWESNKFEGQTDKVE--PWYNTAYSL 390
> cpv:cgd3_4260 peptidase'insulinase like peptidase' ; K01408
insulysin [EC:3.4.24.56]
Length=1172
Score = 172 bits (436), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 124/444 (27%), Positives = 209/444 (47%), Gaps = 12/444 (2%)
Query 21 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 80
+KP + FR+ +L N + V H + + +A GS +P+ PGLAH+LEH+L
Sbjct 61 IKPAKSDKQFRYIKLKNELEVFLVSHNDTKVSSANIAVKVGSYMEPDSFPGLAHYLEHLL 120
Query 81 FLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 140
F+ T KYPE + ++ ++ + G NAYT++ T + + S+FE AL F+EFFKSPLF
Sbjct 121 FINTEKYPELDGFNKLISLHNGYTNAYTEDTSTSYLFSIDSSSFEAALSMFSEFFKSPLF 180
Query 141 SRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETLSTNPKAKG 198
Y EKE+ +I+ E + R + L+ + RF+ GN ETL T P+++G
Sbjct 181 DENYVEKELMSIENEFNFRKDSLFFRFNHVTHELSDKRSLFGRFSYGNIETLKTIPESQG 240
Query 199 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 258
I+L D + F+ K Y + MV S +LDE + I + L + P
Sbjct 241 INLRDEVIKFYQKEYSSNRMVLALASNHTLDELTQFAYKYFSNIENKN---LPVNSIKTP 297
Query 259 MFD-TVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYK-KQPTSVLTYLLEYTGE 316
+ + + PF+ T + + +++ L + F + + +K K T + L+ +
Sbjct 298 IQNGNLNPFN-TMINQLVVIETLDDSRILKLIFPMKEYMVQHKNKVRTMYIDKLISFDRP 356
Query 317 GSLAKRLRLLGLADGIS-PAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 375
GSL L+ L + +D N T I +LT G + G +L FS I F +
Sbjct 357 GSLGHHLKSKKLILNMDFSIIDDNLGFTNAVIGFELTIDGEKNIGYILLSFFSVIKFASN 416
Query 376 HGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYE--PYHVVAGDSLLIDAD 433
+ E+ I F P+S+ D++ + + +E P V+ D + + D
Sbjct 417 NEFSKEIYDEWKNLIDISFKYEDPTST-SDQSEEIVTYYIKHECKPEDVLYSDYYMDEFD 475
Query 434 PRLTNQLLQEMSPSKAIIAFSDPD 457
P + ++ +++P II PD
Sbjct 476 PNIYKEINSQLTPENLIITLERPD 499
> cpv:cgd3_4270 peptidase'insulinase like peptidase' ; K01408
insulysin [EC:3.4.24.56]
Length=1176
Score = 163 bits (413), Expect = 1e-39, Method: Compositional matrix adjust.
Identities = 121/444 (27%), Positives = 202/444 (45%), Gaps = 12/444 (2%)
Query 21 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 80
+KP + FR+ +L N + V H + + + GS +P+ PGLAH+LEH+L
Sbjct 65 IKPAKSDKQFRYIKLKNELEVFLVSHNDTKVSSANIVVKVGSYMEPDSFPGLAHYLEHLL 124
Query 81 FLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 140
F+ T KYPE + ++ F+ + G Y+ K + + FE AL F+EFFKSPLF
Sbjct 125 FINTEKYPEFDGFNEFVLLHNGNFETYSLRSKARYRFNIDSPFFEVALSMFSEFFKSPLF 184
Query 141 SRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETLSTNPKAKG 198
Y EKE+ +ID E + R + L+ + RF+ GN ETL T P+++G
Sbjct 185 DENYAEKELMSIDDEFNLCKYSKSTRFLLVMGELSDKRSFFGRFSYGNIETLKTIPESQG 244
Query 199 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 258
I+L D + F+ K Y + MV S +LDE + I + L + P
Sbjct 245 INLRDEVIKFYQKEYSSNRMVLALASNHTLDELTQFAYKYFSNIENKN---LPVNSIKTP 301
Query 259 MFD-TVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSY-KKQPTSVLTYLLEYTGE 316
+ + + PF+ T + + +++ L + F + + + K T + L+ +
Sbjct 302 IQNGNLNPFN-TMINQLVVIETLDDSRILKLIFPMKEYMVQHNNKARTLYIDKLISFDRP 360
Query 317 GSLAKRLRLLGLA-DGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 375
GSL L+ L D +D + T I +LT G + G +L FS I F +
Sbjct 361 GSLGHHLKSKKLILDVYFSLIDDDLGFTNAVIGFELTIDGEKNIGYILLSFFSAIKFASN 420
Query 376 HGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTYE--PYHVVAGDSLLIDAD 433
+ E+ + +I F P+S+ D+ + + YE P V+ D + + D
Sbjct 421 NEFSKEIYDEWRKLLYISFKYEDPTST-FDQCKEIVTYYIQYECKPEDVLYSDYYMDEFD 479
Query 434 PRLTNQLLQEMSPSKAIIAFSDPD 457
P + ++ +++P II PD
Sbjct 480 PNIYKEINSQLTPENLIITLERPD 503
> tgo:TGME49_044480 insulin-degrading enzyme, putative (EC:3.4.24.56)
Length=299
Score = 135 bits (340), Expect = 3e-31, Method: Compositional matrix adjust.
Identities = 89/303 (29%), Positives = 144/303 (47%), Gaps = 25/303 (8%)
Query 19 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 78
DI KP+ + R +R +L N + V P ++ A A+ N GS +DP V GLAHF EH
Sbjct 8 DIDKPKTNKRSYRFVKLPNHLSVWLVSDPAADLASAALDINVGSYFDPPPVEGLAHFCEH 67
Query 79 MLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 138
MLFLGT K+P+ Y F+ Q+GG NAYT+ T + FF +P
Sbjct 68 MLFLGTEKFPDETEYSNFIKQHGGCTNAYTEHTHTNY---------------HFSFFIAP 112
Query 139 LFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSETLSTNPKA 196
L + E+E+NA+D++ + + ND R W + LA P +RF+ GN +L PKA
Sbjct 113 LSTEIAAERELNAVDSKFRLRLVNDFIRRWQLLHKLANPDHPFNRFSCGNQVSLQEVPKA 172
Query 197 KGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADW---LGMV 253
G D+ L FH +Y + M V + SLD + ++ + I +V
Sbjct 173 LGADVRHELLAFHKTWYSANIMTLVGLGTDSLDCLQGMVEKYFGTIKDKQVPVRPSRAIV 232
Query 254 QCPGPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEY 313
P+F H + + +++ + + F LP + +++ + + L++L +
Sbjct 233 DPSVPVFRR-----HEDLQQVVYIVPIKDQREIHFEFVLPPQIDAWRTKHSRCLSHLAGH 287
Query 314 TGE 316
G+
Sbjct 288 EGK 290
> cpv:cgd2_4270 secreted insulinase-like peptidase
Length=1257
Score = 132 bits (331), Expect = 4e-30, Method: Compositional matrix adjust.
Identities = 70/214 (32%), Positives = 113/214 (52%), Gaps = 3/214 (1%)
Query 31 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 90
+ Y S G+ + V E+ F+ G DP+++ GLAH +EH++FLG+ + P P
Sbjct 94 KAYTTSKGLKTLLVSDNTMLESAFSFGIGCGYYQDPDNLAGLAHLMEHVVFLGSQENPNP 153
Query 91 ESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVN 150
+D FL + GGA NAYT + T+F+ E + F + +P+ + E++
Sbjct 154 VGWDEFLLKKGGAANAYTSADTTIFYVLSPPRELESVMSYFTKMLVNPVIDERSSVSEID 213
Query 151 AIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETLSTNPKAKGIDLVDRLRDF 208
A++ EH+KNIPN LA + P +F TGN ETL N K I+L D L+++
Sbjct 214 AVNQEHEKNIPNKVRAMIELAMYLAPEECPARKFGTGNKETLYINSKKNNINLKDALKEY 273
Query 209 HSKYYCGSNMVAVTISPRSLDEQESLIREKLEGI 242
H+ Y N V + P+S +E+ I +K++G+
Sbjct 274 HTNCYTSDNASIVIMGPQS-NEELVKIADKIDGL 306
> sce:YPR122W AXL1, FUS5, STE22; Axl1p (EC:3.4.24.-); K01422
[EC:3.4.99.-]
Length=1208
Score = 130 bits (327), Expect = 1e-29, Method: Compositional matrix adjust.
Identities = 77/229 (33%), Positives = 119/229 (51%), Gaps = 9/229 (3%)
Query 28 RDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLF-LGTSK 86
R + +L NG+ A+ + P + ++ TGS DP+D+ GLAH EHM+ G+ K
Sbjct 22 RTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDPKDIAGLAHLCEHMILSAGSKK 81
Query 87 YPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDS------AFEEALDRFAEFFKSPLF 140
YP+P + + +N G+ NA+T E+T F+ ++ ++ FE LD FA FFK PLF
Sbjct 82 YPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLF 141
Query 141 SRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKG--PMSRFATGNSETLSTNPKAKG 198
+ KE+ AI +EH+ NI + + ++ R LA P SRF+TGN +LS+ P+ K
Sbjct 142 NPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKK 201
Query 199 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHA 247
I L L + + G N+ P+S++ L K I A
Sbjct 202 IKLKSSLNTYFENNFFGENITLCIRGPQSVNILTKLALSKFGDIKPKSA 250
> cpv:cgd6_5520 peptidase'insulinase like peptidase' ; K01408
insulysin [EC:3.4.24.56]
Length=570
Score = 129 bits (325), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 114/466 (24%), Positives = 202/466 (43%), Gaps = 38/466 (8%)
Query 17 GNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFL 76
N LK +R +L+N + + P + G + GS DPE +PGLAH L
Sbjct 51 NNQFLKHNYTENKYRFIKLNNELDVFLISRPGKHTYG-TLHIQVGSHNDPEYIPGLAHLL 109
Query 77 EHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFK 136
+ LF+ T KYPE + F+ + G +A+TD E T ++ K+ + EEALDRF++ F
Sbjct 110 KQSLFINTKKYPEIYGFYKFIHLHFGETSAFTDLEYTRYYFKINSNVIEEALDRFSQSFI 169
Query 137 SPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNSETLSTNPKA 196
PLF + EKE+ I+ H+ +I E ++ + + K ++ N+ET P
Sbjct 170 DPLFDEHFIEKEI--ININHENDIYKKQE--YFNLSIIRK--LTNNNNNNNETFKLEPIL 223
Query 197 KGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 256
K ID+ + + F+ Y + M+ V S +S+DE L ++ + + Q P
Sbjct 224 KEIDIRNEIIRFYQNEYSSNKMILVLTSNKSIDE--------LTNLAIKYFSKIQNKQLP 275
Query 257 GPMFDTVKPFDHTN-----SGKFIHMQSFSSEPSLWVAFGLPATLTSYKK-----QPTSV 306
FD F+HTN K I +S + + + L +K
Sbjct 276 LKSFDEEIIFNHTNPYEYLKKKIIFAESIHKKNLITLYLPFETKLNGNEKLIIIYIIMKY 335
Query 307 LTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSIS-TLLGIKVDLTQKGAAHRGLVLQE 365
+ + L L K+L L + I I L I ++LT G + +L+E
Sbjct 336 INHNLNSNKFQYLNKKL----LINDIKCHFYTQEIQFNLFKIYIELTINGIKNIEYILKE 391
Query 366 IFSYINFLRDHGVGHELVSTM---AQQSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHV 422
I+S I +++++ +++ + + ++ P++ I+D+ + L+ P +V
Sbjct 392 IYSAIIYIKENISFEQILQDYNHSQNEQYYNYVDDSPNNQIIDKY--FNYKLM---PKYV 446
Query 423 VAGDSLLIDADPRLTNQLLQEMSPSKAIIAFSDPDFTSKVDSFETD 468
+ + + N +L E+ P +I + F D FE +
Sbjct 447 IINNIETNQINENTINSILSEIEPENMLILINTNKFNKLFDHFENN 492
> cpv:cgd3_4240 insulinase like peptidase ; K01408 insulysin [EC:3.4.24.56]
Length=1113
Score = 124 bits (312), Expect = 6e-28, Method: Compositional matrix adjust.
Identities = 102/402 (25%), Positives = 175/402 (43%), Gaps = 28/402 (6%)
Query 19 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 78
+ +KP+ + +L G+ + + + GS + ++ GLAHFLEH
Sbjct 21 EFIKPKESSFKCKFERLKTGLEVFLISSEKLTSTSVNLVVKVGSANEGSEIDGLAHFLEH 80
Query 79 MLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSP 138
+FLGT K+P + F+ GGA NA TD T + + + E AL+RF EFFKSP
Sbjct 81 SVFLGTEKFPGQNEFGKFVRTYGGATNASTDILMTHYSFFIPNQFLEPALERFCEFFKSP 140
Query 139 LFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGP--MSRFATGNSETLSTNPKA 196
LFS +Y + E+N ++ E N + ++ +A S+F GNS+TL P+
Sbjct 141 LFSEEYLQNEINIVENEFLSKTNNFYTLLEHVLKQIADETHIYSKFFYGNSKTLKKIPEK 200
Query 197 KGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCP 256
GI L +R F +YY NMV +S S+ E L IS + +
Sbjct 201 NGISLRERTIRFFEEYYGSKNMVLFILSNISIQE--------LSKISYKYFSNVRSCSRL 252
Query 257 GPMFDTVKPFDHT----NSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLL- 311
P +++ F S K + + + L + F LP + + L++ L
Sbjct 253 SPKPESLSLFPELPYLGISKKLVKIHLNINASQLMLMFSLPKKEYGLSRIFSQYLSFFLC 312
Query 312 EYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIK-----VDLTQKGAAHRGLVLQEI 366
+GEG L ++ + + N + LG + LT++G + ++ +
Sbjct 313 PKSGEGLLNDIIQ-----KNLCHKISLNETYSQLGFSYITFYLFLTKEGVFNIREIILSL 367
Query 367 FSYINFLRDHGVGHELVSTMAQQSHIDF---HTTQPSSSIMD 405
FS ++ + E + +A + +++F T PS I++
Sbjct 368 FSAFQIIKKTELIDEYIQRIANKDYLNFLKIEDTLPSIQILE 409
> cpv:cgd3_4170 secreted insulinase like peptidase
Length=1289
Score = 113 bits (282), Expect = 2e-24, Method: Compositional matrix adjust.
Identities = 93/443 (20%), Positives = 192/443 (43%), Gaps = 13/443 (2%)
Query 21 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 80
+K D +R+ +L NG+ A V + ++ A+ + G LYDP + GL++ +++ L
Sbjct 59 IKSRVDKAKYRYIKLKNGLKAFLVSKEDAEKSEVAILVDVGFLYDPPKIIGLSNLVQYSL 118
Query 81 FLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 140
L + +YP + F+ G E+ TV+ + E++ RF+ +F SPL
Sbjct 119 LLASYQYPNINEFHNFIKLLNGRMYLDLHEKSTVYSFTIGTEYLSESIFRFSSYFHSPLL 178
Query 141 SRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFAT---GNSETLSTNPKAK 197
+ K + I ++ + + ++ A I G ++F T GN TL NP
Sbjct 179 NNDTINKAMLTIFSQLNR-MKRNEFWAKREIEREIIGLNAKFDTFYYGNKNTLLNNPHLS 237
Query 198 GIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPG 257
++ +++R + SK+Y +NM + LD+ E + ++ + ++ +V+
Sbjct 238 EGEIYEKVRHYFSKFYSPNNMKLAIVGREPLDKLEKYV---IQNFAHIKSNGFNIVRIDD 294
Query 258 PMFDTVKPFDHTNSGKFIHMQSFSSE--PSLWVAFGLPATLTSYKKQPTSVLTYLLEYTG 315
V PF S + ++ F ++ + F + + ++K+ PT + YLL+
Sbjct 295 SYKYIVNPFIRI-SKNIVTIRRFKKTGINTINLRFPIEIQVVNWKRIPTMYIKYLLDGNY 353
Query 316 EGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIFSYINFLRD 375
+G L K L+ +G+++ I V + L I +DL H +++ + S + ++ +
Sbjct 354 KGILRKYLKSIGISNPIKVGVVNYEGFSTLDISIDLYNSQLRHSWNLVKAVISAVKYIIE 413
Query 376 HGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARLAHNLLTY--EPYHVVAGDSLLIDAD 433
V +V + I F+ + + D A + + Y +P ++ D ++ D
Sbjct 414 LPVSERIVEEAKNVADIIFNYRETEFT-RDLAYNIVYKASKYRIKPQEIIYADEVMEIVD 472
Query 434 PRLTNQLLQEMSPSKAIIAFSDP 456
+ + + I F P
Sbjct 473 ISFIKAFISSIKIDQVSIFFFTP 495
> tgo:TGME49_006510 peptidase M16 domain containing protein (EC:4.1.1.70
3.4.24.13 3.4.24.56 3.4.21.10 3.4.24.35 3.2.1.91)
Length=2435
Score = 94.7 bits (234), Expect = 8e-19, Method: Compositional matrix adjust.
Identities = 73/233 (31%), Positives = 108/233 (46%), Gaps = 25/233 (10%)
Query 20 ILKPEADYRDFRHYQLSN-GMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 78
+ KP D + + + + +A+ FAV+ G +DP +PG+AH LEH
Sbjct 204 VRKPPRDTSAYSVFSVPALKLEGVAIADQEEAVGSFAVSVGCGFFHDPPAIPGVAHQLEH 263
Query 79 MLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKV-TDSAFEEALDRFAEFFKS 137
++FLG S+D F++Q GG +NA+T E T FF TD+ E F
Sbjct 264 LIFLGAEGEEAATSWDEFVSQRGGTHNAHTTAELTTFFVAAPTDTLPELLDRLLLHLFHP 323
Query 138 PLFSRQYEEKEVNAIDAEHQKNIPNDD----ERAWYTIRSLAKGPMS------------- 180
L + Q+ EV A+ EH+KN P+ E A SLA S
Sbjct 324 LLAAEQF-ASEVMAVQFEHEKNQPDVARVLLELAMAVTPSLASPASSATQDEVPTSFYRP 382
Query 181 ----RFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNM-VAVTISPRSL 228
+F TG+ +TL P +G+D++ LR+FH K Y NM +AV + RS+
Sbjct 383 EVARKFGTGDFDTLCKTPLEQGLDVLKALREFHGKCYKPENMTIAVRMGRRSV 435
Score = 40.8 bits (94), Expect = 0.012, Method: Compositional matrix adjust.
Identities = 49/193 (25%), Positives = 79/193 (40%), Gaps = 15/193 (7%)
Query 302 QPTSVLTYLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGL 361
QPT++L YLLEY GE +L RL+ GL S + + +LT +G
Sbjct 639 QPTALLEYLLEYPGEAALLNRLKAQGLIADAEYVDYTTSQKAFVALLFELTDEGEEKFED 698
Query 362 VLQEIFSYINFLRDHGVGHELV------STMAQQSHIDFHTTQPSSSIMDEAARLAHNLL 415
V+ +Y LR ++ + +A +S S+++ A +LA +L
Sbjct 699 VVSATLAYAEQLRTSVTETYILDFFDEFARVANRSWTYKDPEDAVSAVIAAAEKLA--VL 756
Query 416 TYEPYHVVAGDSLL-IDADPRLTNQLLQE------MSPSKAIIAFSDPDFTSKVDSFETD 468
P V+AG + + D L +L+E + + AI+ + +
Sbjct 757 PQRPDMVIAGGEFVSLPGDRTLLVDVLKEELESFGRARASAIVVLPEDTARGSAEVVHAF 816
Query 469 PYYGVQFRVLDLP 481
YGVQF V LP
Sbjct 817 RPYGVQFSVSALP 829
> cpv:cgd3_4180 secreted insulinase like peptidase
Length=1215
Score = 82.4 bits (202), Expect = 4e-15, Method: Compositional matrix adjust.
Identities = 98/474 (20%), Positives = 187/474 (39%), Gaps = 37/474 (7%)
Query 7 CVGLSAIGALGNDI--------LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAA 58
C+ I LG + +K + D ++ +L N M V + + ++
Sbjct 51 CLAKPIITKLGRTVSEVESSSFIKSKIDGSTYKFMKLQNQMSVFLVSNNNFEYSIITLSV 110
Query 59 NTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNK 118
GS+ DPED+PGL ++ L LGT ++ + ++ F+ G + E +VF K
Sbjct 111 GVGSVMDPEDLPGLVSLVQESLCLGTYRFFDHSNFCNFIISINGEIDMEVYERNSVFTIK 170
Query 119 VTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIR--SLAK 176
V LDR ++ ++P F + + + + N + IR SL
Sbjct 171 VGSQYISTVLDRLSDMIRNPSFPEKLFFAKTKEYSGTFESLLNNSEFLFQCVIRDISLDD 230
Query 177 GPMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIR 236
R +++ + I+L++++++F+ + Y S M V S ++
Sbjct 231 HIFKRLNVLTDKSIKEAREISEINLLEQVKNFYYQQYSSSIMTLVVASKHTI-------- 282
Query 237 EKLEGISAGHADWLGMVQCPGPM-FDTVKPFDHTN---SGKFIHMQSFSSEPSLWVAFGL 292
KL + + + P+ FD K H + G I++++ S L + F +
Sbjct 283 AKLSNEVVLNFSLVKNLNISNPLPFDLAKIVRHPHLGVVGNAIYVKAHSIN-ELILEFPI 341
Query 293 PATLTSYKKQPTSVLTYLLEYTGEGSLAKRLRLLGLADGISPAVD--RNSISTLLGIKVD 350
+ P+S L YLL+ E SL+ L G + + R S S+ I+
Sbjct 342 DYQEVLWDSSPSSYLEYLLKDNSEKSLSNFLIKKGWISKMDAVTNSHRYSFSS-FEIRFL 400
Query 351 LTQKGAAHRGLVLQEIFSYINFLRDHGVGHELVSTMAQ------QSHIDFHTTQPSSSIM 404
LT KG ++Q F + ++ V E+++ + Q + D Q S I+
Sbjct 401 LTSKGIDKIKSIIQTTFIALEHIKSSPVNQEILAEIKQILKYKFDYYFDVSPRQISKQII 460
Query 405 DEAARLAHNLLTYEPYHVVAGDSLLIDADPRLTNQLLQEMSPSKAIIAFSDPDF 458
D + ++ P V+ +L+ D+ + L ++S ++ DF
Sbjct 461 D-----SFDIKGCSPEEVLIAGNLIRDSSFEEISAFLNKISIENLLVFVKLTDF 509
> cpv:cgd3_4280 secreted insulinase like peptidase, signal peptide
Length=1244
Score = 77.8 bits (190), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 95/447 (21%), Positives = 186/447 (41%), Gaps = 32/447 (7%)
Query 22 KPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGF-AVAANTGSLYDPEDVPGLAHFLEHML 80
KP R++R+ +LSN + V+ ++ E F ++ + G DPE++PGL+ +L + L
Sbjct 105 KPIGCTREYRYLRLSNSLKVFMVY-DKTTEISFGSMNLDFGFASDPENIPGLSRYLLYTL 163
Query 81 FLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 140
G+ K + + ++ + A + + F + + FE AL FA F +
Sbjct 164 LFGSLKKKFTRQFALLIKKHKCSYRASISRDNSRFDFDILSNEFEIALKIFANMFINLNT 223
Query 141 SRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNSETLSTNPKAKGID 200
+ E+ I A+ N+ N+ + + + + S T NS + +
Sbjct 224 NDNIHEE----IFAKLVNNLANNINFDSFRLSDILQEISSPTKTDNSSYDWNLLEYMQLH 279
Query 201 LVDR------LRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQ 254
+D+ LR+F ++YY M +S ++LDEQ S++R+ I G ++ + ++
Sbjct 280 HLDKFKSKRLLREFFNQYYRADRMTLTILSNKTLDEQTSIVRKYFNKIRRGDSNIITRLR 339
Query 255 CPG-----PMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGL-PATLTSYKKQPTSVLT 308
P P++D++ GK + S L + F L + +P +
Sbjct 340 LPESGIKHPLYDSI--------GKILVFNSPRRSSLLKLIFPLNNISKIKLSSKPMFFFS 391
Query 309 YLLEYTGEGSLAKRLRLLGLADGISPAVDRNSISTLLGIKVDLTQKGAAHRGL--VLQEI 366
+ +GSL L + + NSI + +D+ + + ++Q I
Sbjct 392 MYISSKRKGSLYYYFYKHELVTEMKIYLS-NSIFGYYSLIIDINLQNLGELSIIHIIQGI 450
Query 367 FSYINFLRDHGVGHELVSTMAQQSHIDFHTTQPSSSIMDEAARL--AHNLLTYEPYHVVA 424
FS +R+ EL + A+ + +S I DE + A N+L P V++
Sbjct 451 FSVFEMMRNSKPKLELYN-QAKTLKMKRFKHSANSFIYDECKNIQDAFNILKCPPEKVLS 509
Query 425 GDSLLIDADPRLTNQLLQEMSPSKAII 451
S+ + + L ++L + P +I
Sbjct 510 ARSIYTEYNLELHYKILSNLKPGNMLI 536
> cpv:cgd3_4210 secreted insulinase like peptidase, signal peptide
Length=1254
Score = 75.5 bits (184), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 82/387 (21%), Positives = 155/387 (40%), Gaps = 31/387 (8%)
Query 19 DILKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEH 78
D +K D + +L N + V S + + GS +P+ PGLA L
Sbjct 86 DFIKSVKDSNKYSFIRLKNDIQVFLVSQRSSLFSSITLGVRVGSSMEPKKFPGLATLLSE 145
Query 79 MLFLGTSKYPE---PESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFF 135
+LF K P+ YD F++ N G T + + F EAL +F +
Sbjct 146 LLFYDW-KRPDVGRETPYDLFISSNSGIFKTKVAPFLTEYHLSIKHEYFSEALIKFCSYL 204
Query 136 KSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA-KGPMSR-FATGNSETLSTN 193
KS R + + + A+ ++ + + + ++ L+ +G ++ F GN + L N
Sbjct 205 KSFSPKRIHLDPAMEALQSDFEALMGMSSIKLKQILKELSVEGHVNHGFHMGNMKRLMAN 264
Query 194 PKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMV 253
L+ L F+ YY + M +S +S+DE LEG++ D
Sbjct 265 IDFDTEALLFELIKFYGSYYSSNLMTISIVSDKSIDE--------LEGLARTFFD----- 311
Query 254 QCPGPMFDTVKPFDHTN---------SGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPT 304
+ P + PFD +N + K I ++S V F +P +K +P
Sbjct 312 EIPNQSKQLITPFDLSNEIIHPYIDLNNKVIQVKSAEENTYFTVIFPIPHQSPLWKYKPA 371
Query 305 SVLTYLLEYTGEGSLAKRLRLLGLADGISPA--VDRNSISTLLGIKVDLTQKGAAHRGLV 362
+++ SL L+ +G+ G+ V+ N S + I+ L KG +
Sbjct 372 EYISFFFTDYSNKSLYSYLKGIGIILGLETMIEVNDNGFSNFI-IRFKLNSKGEKAIVKI 430
Query 363 LQEIFSYINFLRDHGVGHELVSTMAQQ 389
L+ S++ +++ + +++ + ++
Sbjct 431 LEITLSFLKLIKEVSISETIINQIRKK 457
> ath:AT3G02090 MPPBETA; mitochondrial processing peptidase beta
subunit, putative; K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=531
Score = 70.9 bits (172), Expect = 1e-11, Method: Compositional matrix adjust.
Identities = 55/191 (28%), Positives = 88/191 (46%), Gaps = 10/191 (5%)
Query 31 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 90
R L NG+ + + A V + GS ++ ++ G AHFLEHM+F GT +
Sbjct 98 RVTTLPNGLRVATESNLSAKTATVGVWIDAGSRFESDETNGTAHFLEHMIFKGTDRR-TV 156
Query 91 ESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVN 150
+ + + GG NAYT E+T ++ KV DS +ALD A+ ++ F Q +E +
Sbjct 157 RALEEEIEDIGGHLNAYTSREQTTYYAKVLDSNVNQALDVLADILQNSKFEEQRINRERD 216
Query 151 AIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETLSTNPKAKGIDLVDRLRDF 208
I E Q+ DE + + A P+ R G ++ + K I D L+++
Sbjct 217 VILREMQEVEGQTDEVVLDHLHATAFQYTPLGRTILGPAQNV------KSITRED-LQNY 269
Query 209 HSKYYCGSNMV 219
+Y S MV
Sbjct 270 IKTHYTASRMV 280
> cpv:cgd3_4250 secreted insulinase like peptidase, signal peptide
Length=1198
Score = 67.4 bits (163), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 92/445 (20%), Positives = 185/445 (41%), Gaps = 24/445 (5%)
Query 21 LKPEADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 80
+KP +D + F+ +L+N + I P +E ++ GS++DP ++ GL +L +++
Sbjct 74 MKPISD-QSFKLLKLNNDIEVILNSAPNVDECTASILNRVGSMHDPSNLHGLGFYLMNIM 132
Query 81 FLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLF 140
++ YD F N + + ++F E L +E KSP+F
Sbjct 133 LSASNSDVGSGLYD-FCIDNSLSLSYQIYSTYSLFHVTTPMVLLENVLKLVSEMLKSPVF 191
Query 141 SRQYEEKEVNAIDAEHQKNIPNDDERAWYT--IRSLAKGPMSRFATGNSETLSTNPKAKG 198
+ + EK +N + E++ + N + T + S K +R G+ +TL T P++K
Sbjct 192 TDEVMEKALNIL--ENKTTLDNHSYNIFSTNLVLSDPKSIFTRDRFGSRDTLKTIPQSKK 249
Query 199 IDLVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHADWLGMVQCPGP 258
ID+ L F ++ Y + ++ + + L+ + GI + +
Sbjct 250 IDVKQSLIKFFNEQYSSNRLMLSLKCNLPIQVMQDLVAKYFNGIINKNLPINTQYKSINN 309
Query 259 MFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQ-PTSVLTYLLEYTGEG 317
+ + P ++ GK ++ S +L + F L L Y K P + + EG
Sbjct 310 L--IINPLSYS-VGKIMYRID-ESNQTLMLLFPLKNYLQPYMKSGPIFFINNYICANKEG 365
Query 318 SLAKRLRLLGLADGISPAVDRNSISTLLGIK--VDLTQKGAAHRGLVLQEIFSYINFLRD 375
+L + L+ ++ V N +S I+ +LT G + +++ F IN ++D
Sbjct 366 TLMRFLKQKNYIKNMNCHVS-NDMSGFSNIQFSFNLTNNGLFNVQNIIRAFFLSINKIKD 424
Query 376 HGVGHELVSTMAQ------QSHIDFHTTQPSSSIMDEAARLAHNLLTYEPYHVVAGDSLL 429
+ + + Q +S + S SI++ + + ++ G +
Sbjct 425 LKLDINIYNKTNQNILKEIKSSNKYFANLNSLSILNNYFKFNSSSFK----SIILGVNEF 480
Query 430 IDADPRLTNQLLQEMSPSKAIIAFS 454
+ D L Q+L E++P II F+
Sbjct 481 SNFDLNLHRQILMEINPQNMIIIFN 505
> eco:b1494 pqqL, ECK1488, JW1489, pqqE, pqqM, yddC; predicted
peptidase; K07263 zinc protease [EC:3.4.24.-]
Length=931
Score = 67.0 bits (162), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 64/235 (27%), Positives = 112/235 (47%), Gaps = 40/235 (17%)
Query 34 QLSNGM-HAIAVH-HPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP- 90
QL NG+ + I H HP+ ++ + +TGSL + ++ G+AHF+EHM+F GT +P
Sbjct 39 QLDNGLRYMIYPHAHPK-DQVNLWLQIHTGSLQEEDNELGVAHFVEHMMFNGTKTWPGNK 97
Query 91 --ESYDGFLTQNGGANNAYTDEEKTVF---FNKVTDSAFEEALDRFAEFFKSPLFSRQYE 145
E+++ + G NAYT ++TV+ ++ + F+E+ + F E
Sbjct 98 VIETFESMGLRFGRDVNAYTSYDETVYQVSLPTTQKQNLQQVMAIFSEWSNAATF----E 153
Query 146 EKEVNAIDAEHQKNIPNDDERA-----WYTIRSLAKGPMSRFATGNSETLSTNPKAKGID 200
+ EV+A ++ + ++ RA W T S A+ P F N+ L P I
Sbjct 154 KLEVDA-----ERGVITEEWRAHQDAKWRT--SQARRP---FLLANTRNLDREP----IG 199
Query 201 LVD--------RLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGISAGHA 247
L+D +LR F+ ++Y +NM + + E +LI++ L + A A
Sbjct 200 LMDTVATVTPAQLRQFYQRWYQPNNMTFIVVGDIDSKEALALIKDNLSKLPANKA 254
> pfa:PF11_0226 petidase, M16 family
Length=2024
Score = 60.8 bits (146), Expect = 1e-08, Method: Composition-based stats.
Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 15/209 (7%)
Query 22 KPEADYRDFRHYQL-SNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHML 80
K E D+ ++ +++L SN + + + + S + GF+++ N G D ++PG+++ L H +
Sbjct 670 KGENDWNEYEYFKLKSNELKVLGIINKYSPKGGFSISVNCGGYDDFREIPGISNLLRHAI 729
Query 81 FLGTSKYPEPESYDGFLTQNG---GANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKS 137
F Y + L++ G NN+ E T ++ L F++
Sbjct 730 F-----YKSEKRITTLLSELGKYSSENNSRIGESFTTYYAIGKSENIYNILTLFSQNLFY 784
Query 138 PLFSRQYEEKEVNAIDAEH---QKNIPNDDERAWYTIRSLAKGPMSRFATGNSETLSTNP 194
PLF + E EV I+ ++ + N N + I L F GN TL N
Sbjct 785 PLFDEDFIENEVREINNKYISMENNSLNCLKIISQFITDLKYSKF--FFHGNYITLCNNV 842
Query 195 KAKGIDLVDRLRDFHSKYYCGSNMVAVTI 223
G+++ L +FH K Y NM A+TI
Sbjct 843 LKNGLNIKKLLYNFHKKCYQPKNM-ALTI 870
> ath:AT5G42390 metalloendopeptidase
Length=1265
Score = 58.2 bits (139), Expect = 7e-08, Method: Compositional matrix adjust.
Identities = 64/223 (28%), Positives = 91/223 (40%), Gaps = 38/223 (17%)
Query 19 DILKPEADYRDFRHY--------------QLSNGMHAIAVHH---PRSNEAGFAVAANTG 61
D+L PE D + + QL NG+ + + + P EA V + G
Sbjct 170 DLLPPEIDSAELEAFLGCELPSHPKLHRGQLKNGLRYLILPNKVPPNRFEAHMEV--HVG 227
Query 62 SLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGANNAYTDEEKTVFF----- 116
S+ + ED G+AH +EH+ FLG+ K + L G +NAYTD TVF
Sbjct 228 SIDEEEDEQGIAHMIEHVAFLGSKKREK-------LLGTGARSNAYTDFHHTVFHIHSPT 280
Query 117 --NKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSL 174
D F LD E P F EKE AI +E Q + N E + L
Sbjct 281 HTKDSEDDLFPSVLDALNEIAFHPKFLSSRVEKERRAILSELQ--MMNTIE--YRVDCQL 336
Query 175 AKGPMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSN 217
+ S G + + K D VD++R FH ++Y +N
Sbjct 337 LQHLHSENKLGRRFPIGLEEQIKKWD-VDKIRKFHERWYFPAN 378
> cpv:cgd3_4200 secreted insulinase like peptidase, signal peptide
Length=1286
Score = 57.8 bits (138), Expect = 8e-08, Method: Compositional matrix adjust.
Identities = 73/352 (20%), Positives = 137/352 (38%), Gaps = 19/352 (5%)
Query 25 ADYRDFRHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGT 84
D +R+ +L NG+ V + + ++ GS +DP+ + G+++ + LF
Sbjct 159 GDENKYRYIKLDNGLKVFLVSNSLLYTSSLSLGIEVGSAHDPKGIDGVSYLITQELFKKE 218
Query 85 SKYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQY 144
+ L N G N +++ T++ + F ++ F + +
Sbjct 219 QNVTSDTDFRKLLDDNNGYFNVESNKFSTIYSYNIKSKYFMSSVSAFRKRLDKTKITWSS 278
Query 145 EEKEVNAID--AEHQKNIPNDDERAWYTIRSLAKGPMSRFATGNSETLSTNPKAKGIDLV 202
++ ++ + E K + + E S + RF G +ETL P + +
Sbjct 279 LDESISQVTELTEIFKRVDSLQELQLKRELSNSSHAFHRFPYGTNETLREIPSKNNLSVH 338
Query 203 DRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLE-----GISAGH-ADWLGMVQCP 256
+ F KYY MV + SL+ E L+R + G++ G ++ G V P
Sbjct 339 EEAIRFKKKYYSPHLMVLSIATSLSLETVEELVRNEFSDLFSTGVTPGKPEEFSGNVTHP 398
Query 257 GPMFDTVKPFDHTNSGKFIHMQSFSSEPSLWVAFGLPATLTSYKKQPTSVLTYLLEYTGE 316
+DT+ GKFI ++S + E + + F +P +K + S + Y L
Sbjct 399 ---YDTL-------IGKFIEVKSRTPEAYITMEFPIPNQSKLWKYKLGSYVKYFLTQRFH 448
Query 317 GSLAKRLRLLGLADGIS-PAVDRNSISTLLGIKVDLTQKGAAHRGLVLQEIF 367
++ LG I V+ ++ + L IK L V+Q IF
Sbjct 449 DGFLDKMTNLGWVREIEVDIVNHDTGFSNLVIKAILVDSDRDKLVRVIQAIF 500
> dre:503532 pmpcb, zgc:110738; peptidase (mitochondrial processing)
beta (EC:3.4.24.64); K01412 mitochondrial processing
peptidase [EC:3.4.24.64]
Length=470
Score = 55.8 bits (133), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 48/164 (29%), Positives = 77/164 (46%), Gaps = 12/164 (7%)
Query 59 NTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGAN-NAYTDEEKTVFFN 117
+ GS Y+ E G AHFLEHM F GT K + + +N GA+ NAYT E+TV++
Sbjct 72 DAGSRYENEHNNGTAHFLEHMAFKGTRKRSQLDLE--LEIENMGAHLNAYTSREQTVYYA 129
Query 118 KVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA-- 175
K A++ A+ ++ E+E I E Q+ N E + + + A
Sbjct 130 KAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQ 189
Query 176 KGPMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMV 219
+ P+ R G +E + T + DLV ++ + +Y G +V
Sbjct 190 ETPLGRTILGPTENIKTINRG---DLV----EYITTHYKGPRIV 226
> tgo:TGME49_036210 mitochondrial-processing peptidase beta subunit,
putative (EC:3.4.24.64); K01412 mitochondrial processing
peptidase [EC:3.4.24.64]
Length=524
Score = 55.1 bits (131), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 37/117 (31%), Positives = 57/117 (48%), Gaps = 7/117 (5%)
Query 35 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 94
L NG+ P A V ++GS YD ++ G AHFLEHM F GT + +
Sbjct 74 LPNGIRVATQRLPFHQTATVGVWIDSGSRYDTKETNGAAHFLEHMTFKGTKRRSRIQLEQ 133
Query 95 GFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVN 150
+N GA+ NAYT E+TV++ K AF++ + + + L + +E+ V
Sbjct 134 EI--ENMGAHLNAYTSREQTVYYAK----AFKKDIPQCVDILSDILLNSTIDEEAVQ 184
> ath:AT5G56730 peptidase M16 family protein / insulinase family
protein
Length=956
Score = 55.1 bits (131), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 54/221 (24%), Positives = 96/221 (43%), Gaps = 29/221 (13%)
Query 16 LGNDILKPEADYRDFRHYQLSNGMHAIAVHHPRSN-----EAGFAVAANTGSLYDPEDVP 70
LGN++ ADY +L NG+ +++ R N A A+A GS+ + ED
Sbjct 31 LGNELEPFGADYG-----RLDNGL----IYYVRRNSKPRMRAALALAVKVGSVLEEEDQR 81
Query 71 GLAHFLEHMLFLGTSKYPE---PESYDGFLTQNGGANNAYTDEEKTVF--FNKVTD-SAF 124
G+AH +EH+ F T++Y + + + G NA T ++T++ F V
Sbjct 82 GVAHIVEHLAFSATTRYTNHDIVKFLESIGAEFGPCQNAMTTADETIYELFVPVDKPELL 141
Query 125 EEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQ--KNIPNDDERAWYTIRSLAKGPMSRF 182
+A+ AEF S++ EKE A+ E++ +N + + + + R
Sbjct 142 SQAISILAEFSSEIRVSKEDLEKERGAVMEEYRGNRNATGRMQDSHWQLMMEGSKYAERL 201
Query 183 ATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTI 223
G + + + P A ++ F+ K+Y NM V +
Sbjct 202 PIGLEKVIRSVPAAT-------VKQFYQKWYHLCNMAVVAV 235
> sce:YLR163C MAS1, MIF1; Mas1p (EC:3.4.24.64); K01412 mitochondrial
processing peptidase [EC:3.4.24.64]
Length=462
Score = 54.7 bits (130), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 48/191 (25%), Positives = 81/191 (42%), Gaps = 10/191 (5%)
Query 31 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 90
R +L NG+ + P ++ A + + GS + G AHFLEH+ F GT +
Sbjct 27 RTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRSQ- 85
Query 91 ESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVN 150
+ + + G NAYT E TV++ K +A+D ++ + E+E +
Sbjct 86 QGIELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAVDILSDILTKSVLDNSAIERERD 145
Query 151 AIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETLSTNPKAKGIDLVDRLRDF 208
I E ++ DE + + + P+ R G + + K I D L+D+
Sbjct 146 VIIRESEEVDKMYDEVVFDHLHEITYKDQPLGRTILGPIKNI------KSITRTD-LKDY 198
Query 209 HSKYYCGSNMV 219
+K Y G MV
Sbjct 199 ITKNYKGDRMV 209
> hsa:9512 PMPCB, Beta-MPP, MPP11, MPPB, MPPP52, P-52; peptidase
(mitochondrial processing) beta (EC:3.4.24.64); K01412 mitochondrial
processing peptidase [EC:3.4.24.64]
Length=489
Score = 54.3 bits (129), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 12/175 (6%)
Query 59 NTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYDGFLTQNGGAN-NAYTDEEKTVFFN 117
+ GS Y+ E G AHFLEHM F GT K + + +N GA+ NAYT E+TV++
Sbjct 86 DAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLE--LEIENMGAHLNAYTSREQTVYYA 143
Query 118 KVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDAEHQKNIPNDDERAWYTIRSLA-- 175
K A++ A+ ++ E+E I E Q+ N E + + + A
Sbjct 144 KAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQ 203
Query 176 KGPMSRFATGNSETLSTNPKAKGIDLVDRLRDFHSKYYCGSNMVAVTISPRSLDE 230
+ R G +E + + + DLV D+ + +Y G +V S DE
Sbjct 204 NTALGRTILGPTENIKSISRK---DLV----DYITTHYKGPRIVLAAAGGVSHDE 251
> mmu:73078 Pmpcb, 3110004O18Rik, MPP11, MPPB, MPPP52; peptidase
(mitochondrial processing) beta (EC:3.4.24.64); K01412 mitochondrial
processing peptidase [EC:3.4.24.64]
Length=489
Score = 54.3 bits (129), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 54/189 (28%), Positives = 85/189 (44%), Gaps = 15/189 (7%)
Query 35 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 94
L NG+ +A + + + + GS Y+ E G AHFLEHM F GT K + +
Sbjct 63 LENGLR-VASENSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLE- 120
Query 95 GFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAID 153
+N GA+ NAYT E+TV++ K A++ A+ ++ E+E I
Sbjct 121 -LEIENMGAHLNAYTSREQTVYYAKAFSRDLPRAVEILADIIQNSTLGEAEIERERGVIL 179
Query 154 AEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETL-STNPKAKGIDLVDRLRDFHS 210
E Q+ N E + + + A + R G +E + S N K DLV D+ +
Sbjct 180 REMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRK----DLV----DYIT 231
Query 211 KYYCGSNMV 219
+Y G +V
Sbjct 232 THYKGPRIV 240
> bbo:BBOV_IV001260 21.m02910; mitochondrial processing peptidase
beta subunit; K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=514
Score = 52.8 bits (125), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query 35 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 94
L NG+ +V P N V ++GS ++ ++ G AHFLEHM+F GT E +
Sbjct 71 LKNGLRVASVWMP-GNSTTVGVWIDSGSRFETKETNGAAHFLEHMIFKGTKNRSRLE-LE 128
Query 95 GFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDA 154
+ Q G NAYT E+T ++ + + + ++ ++ L E E + I
Sbjct 129 EEIEQKGAHLNAYTAREQTGYYARCFNKDVPWCTELLSDILQNSLIEPSQMEAEKHVILR 188
Query 155 EHQK 158
E ++
Sbjct 189 EMEE 192
> dre:393793 uqcrc1, MGC73404, zgc:73404, zgc:85750; ubiquinol-cytochrome
c reductase core protein I (EC:1.10.2.2); K00414
ubiquinol-cytochrome c reductase core subunit 1 [EC:1.10.2.2]
Length=474
Score = 52.4 bits (124), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 59/223 (26%), Positives = 91/223 (40%), Gaps = 27/223 (12%)
Query 31 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 90
R L NG+ IA + GS ++ E G FLEHM F GT K+P+
Sbjct 43 RLTTLDNGLR-IASEETNQPTCTVGLWIGCGSRFETEKNNGAGFFLEHMAFKGTKKHPQ- 100
Query 91 ESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFS-------RQ 143
+ + + GG NAYT E T ++ K +A++ AE +S S R
Sbjct 101 SALEQAVESMGGHLNAYTSREHTAYYMKTLSKDLPKAVELLAEVVQSLSLSEAEMEQQRT 160
Query 144 YEEKEVNAIDAEHQKNIPNDDERAWYTIRSLAK---GPMSRFATGNSETLSTNPKAKGID 200
+E+ I+ Q + + +L+ GP + N TL+ N D
Sbjct 161 VALRELEEIEGSLQDVCLDLLHATAFQGTALSHSVFGP-----SANIRTLTRN------D 209
Query 201 LVDRLRDFHSKYYCGSNMVAVTISPRSLDEQESLIREKLEGIS 243
L+ ++ + ++ MV T S DE SL ++ L GIS
Sbjct 210 LL----EYINCHFKAPRMVLATAGGVSHDEVVSLAKQHLGGIS 248
> tpv:TP01_0151 biquinol-cytochrome C reductase complex core protein
I (EC:1.10.2.2); K01412 mitochondrial processing peptidase
[EC:3.4.24.64]
Length=518
Score = 51.2 bits (121), Expect = 9e-06, Method: Compositional matrix adjust.
Identities = 35/131 (26%), Positives = 62/131 (47%), Gaps = 2/131 (1%)
Query 35 LSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEPESYD 94
L NG+ V P S+ + V ++GS ++ + G AHFLEHM+F GT K +
Sbjct 77 LKNGLRVATVWMPGSS-STVGVWIDSGSRFETPETNGSAHFLEHMIFKGT-KSRSRHQLE 134
Query 95 GFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEVNAIDA 154
+ G NAYT E+T ++ + ++ + ++ ++ L + E E + I
Sbjct 135 EQIEHKGAHLNAYTSREQTAYYARCFNNDIPWCTELLSDILQNSLIDPDHMENEKHVILR 194
Query 155 EHQKNIPNDDE 165
E ++ + DE
Sbjct 195 EMEEVEKSHDE 205
> pfa:PFI1625c organelle processing peptidase, putative; K01412
mitochondrial processing peptidase [EC:3.4.24.64]
Length=484
Score = 51.2 bits (121), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 44/177 (24%), Positives = 79/177 (44%), Gaps = 6/177 (3%)
Query 31 RHYQLSNGMHAIAVHHPRSNEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTSKYPEP 90
R +LSN + +A H + ++GS Y+ + G+AHFLEHM+F GT K
Sbjct 43 RVTELSNKL-KVATVHTNCEIPTIGLWISSGSKYENKKNNGVAHFLEHMIFKGTKKRNRI 101
Query 91 ESYDGFLTQNGGAN-NAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYEEKEV 149
+ +N GA+ NAYT E+T ++ K + + ++ ++ + +F E E
Sbjct 102 QLEKEI--ENMGAHLNAYTAREQTGYYCKCFKNDIKWCIELLSDILSNSIFDDNLIELEK 159
Query 150 NAIDAEHQKNIPNDDERAWYTIRSLA--KGPMSRFATGNSETLSTNPKAKGIDLVDR 204
+ I E ++ DE + + A P+ G E + + ID +++
Sbjct 160 HVILREMEEVEKCKDEVIFDKLHMTAFRDHPLGFTILGPEENIKNMKRKDIIDYINK 216
> cpv:cgd5_3400 mitochondrial processing peptidase beta subunit
; K01412 mitochondrial processing peptidase [EC:3.4.24.64]
Length=375
Score = 50.8 bits (120), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 36/140 (25%), Positives = 65/140 (46%), Gaps = 4/140 (2%)
Query 29 DFRHYQLSNGMHAIAVHHPRS---NEAGFAVAANTGSLYDPEDVPGLAHFLEHMLFLGTS 85
D + +LSNGM + N F + ++GS + G+AHFLEH++F GT
Sbjct 40 DLKISKLSNGMRVATMKFGIDSIPNSLTFGLWVDSGSRNEDPGKNGIAHFLEHLIFKGTY 99
Query 86 KYPEPESYDGFLTQNGGANNAYTDEEKTVFFNKVTDSAFEEALDRFAEFFKSPLFSRQYE 145
E + + G NAYT E+TV+ + + + +D ++ K+ F +
Sbjct 100 NRSRKE-IESQIEDLGAHLNAYTTREQTVYQIRCFNQDLPKCMDLLSDIIKNSKFCKSAI 158
Query 146 EKEVNAIDAEHQKNIPNDDE 165
E+E + E ++ +++E
Sbjct 159 EQEKGVVLREMEEVSKSEEE 178
Lambda K H
0.317 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 23056905652
Database: egene_temp_file_orthology_annotation_similarity_blast_database_865
Posted date: Sep 17, 2011 11:19 AM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40