bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_1547_orf1
Length=152
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_034360 DNA topoisomerase I, putative ; K03163 DNA t... 206 2e-53
bbo:BBOV_II007450 18.m06618; DNA topoisomerase (EC:5.99.1.2); ... 175 5e-44
tpv:TP02_0198 DNA topoisomerase I; K03163 DNA topoisomerase I ... 166 2e-41
pfa:PFE0520c topoisomerase I (EC:5.99.1.2); K03163 DNA topoiso... 151 8e-37
cpv:cgd7_3350 eukaryotic DNA topoisomerase I ; K03163 DNA topo... 149 3e-36
ath:AT5G55300 TOP1ALPHA (DNA TOPOISOMERASE I ALPHA); DNA topoi... 100 1e-21
ath:AT5G55310 TOP1BETA (DNA TOPOISOMERASE 1 BETA); DNA topoiso... 92.4 5e-19
hsa:7150 TOP1, TOPI; topoisomerase (DNA) I (EC:5.99.1.2); K031... 90.9 2e-18
mmu:21969 Top1, AI467334, D130064I21Rik, Top-1; topoisomerase ... 89.7 3e-18
xla:399263 top1.1, top1; topoisomerase (DNA) I, gene 1 (EC:5.9... 89.0 5e-18
dre:415098 top1mt; mitochondrial topoisomerase I (EC:5.99.1.2) 86.3 3e-17
dre:553496 top1l, wu:fc66a02, zgc:136349; topoisomerase (DNA) ... 83.6 2e-16
mmu:72960 Top1mt, 2900052H09Rik; DNA topoisomerase 1, mitochon... 78.6 7e-15
hsa:116447 TOP1MT; topoisomerase (DNA) I, mitochondrial (EC:5.... 78.2 1e-14
xla:734592 top1.2, MGC115546; topoisomerase (DNA) I, gene 2 75.5
dre:334557 fl27b11, wu:fl27b11; zgc:173742 75.1 8e-14
dre:327179 top1, fd15f07, wu:fd15f07; topoisomerase (DNA) I 73.9 2e-13
cel:M01E5.5 top-1; TOPoisomerase family member (top-1); K03163... 73.6 3e-13
sce:YOL006C TOP1, MAK1, MAK17; Top1p (EC:5.99.1.2); K03163 DNA... 70.5 2e-12
ath:AT4G26701 DNA binding / DNA topoisomerase type I 55.5 6e-08
pfa:MAL7P1.105 conserved Plasmodium protein, unknown function 32.3 0.66
hsa:259282 BOD1L, FAM44A, FLJ33215, KIAA1327; biorientation of... 31.6 1.0
ath:AT1G27920 MAP65-8 (MICROTUBULE-ASSOCIATED PROTEIN 65-8) 31.2 1.3
ath:AT2G45720 armadillo/beta-catenin repeat family protein 31.2 1.5
ath:AT3G10800 BZIP28; BZIP28; DNA binding / transcription factor 30.4 2.2
sce:YNL123W NMA111, YNM3; Nma111p 30.0 2.9
dre:573110 cbx4, MGC198077, MGC198079, im:6911625, zgc:158588;... 30.0 3.3
mmu:72296 Rusc1, 2210403N08Rik, AA408288, NESCA; RUN and SH3 d... 30.0 3.4
sce:YKL072W STB6; Protein that binds Sin3p in a two-hybrid assay 28.9 7.1
mmu:665775 Bod1l, A230054D04Rik, AI853319, FAM44A, mKIAA1327; ... 28.9 7.4
xla:394289 rock2, rocka-a, xROK; Rho-associated, coiled-coil c... 28.5 8.3
> tgo:TGME49_034360 DNA topoisomerase I, putative ; K03163 DNA
topoisomerase I [EC:5.99.1.2]
Length=953
Score = 206 bits (524), Expect = 2e-53, Method: Compositional matrix adjust.
Identities = 95/151 (62%), Positives = 123/151 (81%), Gaps = 2/151 (1%)
Query 4 LNVDISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEF 63
++ D+S+V +LVQFYNDANRAVAILCNHQRS+PKQHAASM +++HQ ++ED+RECEE+
Sbjct 775 ISCDVSNVGELVQFYNDANRAVAILCNHQRSVPKQHAASMQKMEHQQLMLDEDIRECEEY 834
Query 64 LAFCKK--DKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRM 121
L F KK K++++F F SD K +G PRK+ VR+GMKED +++ L K++ HLL++
Sbjct 835 LEFLKKPPSKRKERFTFVSDVKDFQGNPRKTNVRDGMKEDVCARRLQALLKRRADHLLKI 894
Query 122 HIKDSNKTVALGTSKINYMDPRITVAFCKKY 152
+KD NKTVALGTSKINYMDPRITVAFCKKY
Sbjct 895 KLKDDNKTVALGTSKINYMDPRITVAFCKKY 925
> bbo:BBOV_II007450 18.m06618; DNA topoisomerase (EC:5.99.1.2);
K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=701
Score = 175 bits (443), Expect = 5e-44, Method: Compositional matrix adjust.
Identities = 82/147 (55%), Positives = 109/147 (74%), Gaps = 1/147 (0%)
Query 6 VDISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLA 65
VD++DVN+L+ FYN+ANR VAILCNHQRSIPKQH +SM+++Q Q I E++ E + ++
Sbjct 528 VDVTDVNELISFYNEANRRVAILCNHQRSIPKQHESSMSKMQAQAELISEEIAELQAYMK 587
Query 66 FCKKDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKD 125
+ + + Q K F F+S KG PRK+ R+GMK +A KK+ K+ + H ++M IKD
Sbjct 588 YLESN-QTKPFTFESRTVDAKGNPRKAATRQGMKLEACQKKLETAMKRSKVHAIKMRIKD 646
Query 126 SNKTVALGTSKINYMDPRITVAFCKKY 152
NKTVALGTSKINYMDPRITVAFCK+Y
Sbjct 647 DNKTVALGTSKINYMDPRITVAFCKRY 673
> tpv:TP02_0198 DNA topoisomerase I; K03163 DNA topoisomerase
I [EC:5.99.1.2]
Length=1003
Score = 166 bits (421), Expect = 2e-41, Method: Compositional matrix adjust.
Identities = 86/155 (55%), Positives = 110/155 (70%), Gaps = 13/155 (8%)
Query 8 ISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFC 67
I +V++L+QFYN ANR VAILCNHQRSIPKQH SM +L+ Q ++ED++E E+ C
Sbjct 824 IGNVSELLQFYNYANREVAILCNHQRSIPKQHETSMTKLKLQAKMLKEDIQELNEY---C 880
Query 68 K--KDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKI--------AQLKKKKQTH 117
K + + +FKF+S K + G PRK + + GMK +A K+ A LKKK++ H
Sbjct 881 KHLQSNSKGEFKFESKTKDVNGNPRKLITKPGMKLEAAKNKLSTLNYLCFAPLKKKQKDH 940
Query 118 LLRMHIKDSNKTVALGTSKINYMDPRITVAFCKKY 152
++M IKDSNKTVALGTSKINYMDPRITVAFCKKY
Sbjct 941 AIKMTIKDSNKTVALGTSKINYMDPRITVAFCKKY 975
> pfa:PFE0520c topoisomerase I (EC:5.99.1.2); K03163 DNA topoisomerase
I [EC:5.99.1.2]
Length=839
Score = 151 bits (381), Expect = 8e-37, Method: Compositional matrix adjust.
Identities = 78/149 (52%), Positives = 109/149 (73%), Gaps = 1/149 (0%)
Query 4 LNVDISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEF 63
+ VD+S++N+L+ FYN+ANR VAILCNHQRSIPKQH +M++++ Q+ ED++E +++
Sbjct 664 IEVDVSNINELINFYNNANREVAILCNHQRSIPKQHDTTMSKIKKQIELYNEDIKEYKKY 723
Query 64 LAFCKKDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHI 123
L KK+ K+F F S TL G R + V+E MKE++ KK+ L KK + +M +
Sbjct 724 LQHLKKN-SDKKFIFVSKVSTLDGTLRPNKVKENMKEESCKKKLITLIKKVELLNNQMKV 782
Query 124 KDSNKTVALGTSKINYMDPRITVAFCKKY 152
+D NKT+ALGTSKINYMDPRITVAFCKK+
Sbjct 783 RDDNKTIALGTSKINYMDPRITVAFCKKF 811
> cpv:cgd7_3350 eukaryotic DNA topoisomerase I ; K03163 DNA topoisomerase
I [EC:5.99.1.2]
Length=653
Score = 149 bits (377), Expect = 3e-36, Method: Compositional matrix adjust.
Identities = 80/153 (52%), Positives = 99/153 (64%), Gaps = 9/153 (5%)
Query 6 VDISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLA 65
VDI++VN +++FYNDANR VAILCNHQRS+PKQH +SM ++ Q +EEDL+ CE FL
Sbjct 476 VDITNVNDILRFYNDANREVAILCNHQRSVPKQHESSMEKMIKQQQELEEDLKICEAFLK 535
Query 66 FCKKDKQQKQFKFKSDFKTL------KGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLL 119
KK+ + SD L G+ RK + D V KKI +K K L
Sbjct 536 ILKKNNKSVTI---SDLPKLSTEVSFNGKQRKYPINLNSSLDVVQKKIDSIKSKISNLYL 592
Query 120 RMHIKDSNKTVALGTSKINYMDPRITVAFCKKY 152
++ IKD NKTVAL TSKINYMDPRI+VAFCKKY
Sbjct 593 KIKIKDDNKTVALNTSKINYMDPRISVAFCKKY 625
> ath:AT5G55300 TOP1ALPHA (DNA TOPOISOMERASE I ALPHA); DNA topoisomerase
type I; K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=916
Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust.
Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 13/144 (9%)
Query 9 SDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCK 68
DV Q + Y AN+ VAI+CNHQR++ K H A + +L ++ ++E L+E + L K
Sbjct 755 GDVTQKIVVYQKANKEVAIICNHQRTVSKTHGAQIEKLTARIEELKEVLKELKTNLDRAK 814
Query 69 KDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKDSNK 128
K K L+G K + ++ +A KKIAQ K + MH K+ K
Sbjct 815 KGKPP-----------LEGSDGKKI--RSLEPNAWEKKIAQQSAKIEKMERDMHTKEDLK 861
Query 129 TVALGTSKINYMDPRITVAFCKKY 152
TVALGTSKINY+DPRITVA+CK++
Sbjct 862 TVALGTSKINYLDPRITVAWCKRH 885
> ath:AT5G55310 TOP1BETA (DNA TOPOISOMERASE 1 BETA); DNA topoisomerase
type I; K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=917
Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust.
Identities = 56/144 (38%), Positives = 79/144 (54%), Gaps = 13/144 (9%)
Query 9 SDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCK 68
DV + V Y AN+ VAI+CNHQR++ K H A + +L ++ + E ++E L K
Sbjct 753 GDVPEKVVVYQQANKEVAIICNHQRTVSKSHGAQVEKLAVKIEELREQIKELNIDLDRAK 812
Query 69 KDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKDSNK 128
K + SD K + + +A+ KKI Q + K + M K+ K
Sbjct 813 KGRTPL---MGSDGKR----------KRNLTPEALEKKIMQTQGKIEKMERDMQTKEDMK 859
Query 129 TVALGTSKINYMDPRITVAFCKKY 152
TVALGTSKINYMDPRITVA+CK++
Sbjct 860 TVALGTSKINYMDPRITVAWCKRH 883
> hsa:7150 TOP1, TOPI; topoisomerase (DNA) I (EC:5.99.1.2); K03163
DNA topoisomerase I [EC:5.99.1.2]
Length=765
Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 57/143 (39%), Positives = 78/143 (54%), Gaps = 33/143 (23%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVAILCNHQR+ PK SM LQ ++ A +E L + L
Sbjct 619 YNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSA---------- 668
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKK----QTHLLRMHI----KDSNKT 129
K+D K +K DA KK+ + KKK + L+++ + ++ NK
Sbjct 669 -KADAKVMK--------------DAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQ 713
Query 130 VALGTSKINYMDPRITVAFCKKY 152
+ALGTSK+NY+DPRITVA+CKK+
Sbjct 714 IALGTSKLNYLDPRITVAWCKKW 736
> mmu:21969 Top1, AI467334, D130064I21Rik, Top-1; topoisomerase
(DNA) I (EC:5.99.1.2); K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=767
Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust.
Identities = 56/143 (39%), Positives = 78/143 (54%), Gaps = 33/143 (23%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVAILCNHQR+ PK SM LQ ++ A ++ L + L
Sbjct 621 YNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSA---------- 670
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKK----QTHLLRMHI----KDSNKT 129
K+D K +K DA KK+ + KKK + L+++ + ++ NK
Sbjct 671 -KADAKVMK--------------DAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQ 715
Query 130 VALGTSKINYMDPRITVAFCKKY 152
+ALGTSK+NY+DPRITVA+CKK+
Sbjct 716 IALGTSKLNYLDPRITVAWCKKW 738
> xla:399263 top1.1, top1; topoisomerase (DNA) I, gene 1 (EC:5.99.1.2);
K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=829
Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust.
Identities = 57/159 (35%), Positives = 87/159 (54%), Gaps = 34/159 (21%)
Query 2 EVLNVDISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECE 61
E+ N D +V + YN ANRAVAILCNHQR+ PK SM LQ ++ A ++ L +
Sbjct 660 ELTNSD-DNVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQGKIDAKKDQLADA- 717
Query 62 EFLAFCKKDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKK----QTH 117
+ +FK+ K + + ++ D KK+ + KKK +
Sbjct 718 -----------------RREFKSAKADAK-------VRRDEKTKKLVESKKKAVQRIEEQ 753
Query 118 LLRMHI----KDSNKTVALGTSKINYMDPRITVAFCKKY 152
L+++ + ++ NK +ALGTSK+NY+DPRI+VA+CKKY
Sbjct 754 LMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKY 792
> dre:415098 top1mt; mitochondrial topoisomerase I (EC:5.99.1.2)
Length=600
Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust.
Identities = 62/149 (41%), Positives = 84/149 (56%), Gaps = 17/149 (11%)
Query 4 LNVDISDVNQLVQFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEF 63
L D V + + YN ANRAVAILCNHQR+ PK SM LQ ++ +E + E +
Sbjct 440 LTSDDCTVEEKILSYNRANRAVAILCNHQRAAPKTFEKSMQLLQEKIQKKKEQIEEARKE 499
Query 64 LAFCKKDKQQKQFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHI 123
L K+ KQ D T + K V + K+ AV + QLKK + L+
Sbjct 500 L------KEAKQV----DKDTPSDKSSKLVEK---KQKAVQRLCDQLKKLQ----LQETD 542
Query 124 KDSNKTVALGTSKINYMDPRITVAFCKKY 152
++ NK +ALGTSK+NY+DPRITVA+CKK+
Sbjct 543 REENKVIALGTSKLNYLDPRITVAWCKKH 571
> dre:553496 top1l, wu:fc66a02, zgc:136349; topoisomerase (DNA)
I, like; K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=758
Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 25/139 (17%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVAILCNHQR+ PK SM LQ ++ A +E L E +
Sbjct 612 YNRANRAVAILCNHQRAPPKTFEKSMQNLQTKIDAKKEQLVEAK---------------- 655
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHI----KDSNKTVALG 133
+ LKG + VR+ K ++ + ++ + L+++ + ++ NK +ALG
Sbjct 656 -----RELKGAKADAKVRKDEKFKKAVEAKKKALQRVEEQLMKLEVQATDREENKQIALG 710
Query 134 TSKINYMDPRITVAFCKKY 152
TSK+NY+DPRI+VA+CKK+
Sbjct 711 TSKLNYLDPRISVAWCKKF 729
> mmu:72960 Top1mt, 2900052H09Rik; DNA topoisomerase 1, mitochondrial
(EC:5.99.1.2); K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=593
Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust.
Identities = 48/135 (35%), Positives = 77/135 (57%), Gaps = 18/135 (13%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVA+LCNHQR++PK SM LQ ++ + + E + L K + +
Sbjct 448 YNRANRAVAVLCNHQRAVPKTFEKSMQTLQKKIETKKAQVAEAQVEL-----QKAETDLR 502
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKDSNKTVALGTSKI 137
+ D K KS +++ + + +++A+L K K+ NK VALGT+K+
Sbjct 503 MRGDSKP------KSFLQKQRRLLKLEEQLARLCAKATD-------KEENKQVALGTAKL 549
Query 138 NYMDPRITVAFCKKY 152
NY+DPRI++A+CK++
Sbjct 550 NYLDPRISIAWCKRF 564
> hsa:116447 TOP1MT; topoisomerase (DNA) I, mitochondrial (EC:5.99.1.2);
K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=601
Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 25/139 (17%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANR VAILCNHQR+ P SM LQ ++ A +E + E + + + + K
Sbjct 455 YNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARA-----ELRRARAEHK 509
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHI----KDSNKTVALG 133
+ D K+ +VL+K +L +K Q L ++ + K+ NK VALG
Sbjct 510 AQGDGKS----------------RSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALG 553
Query 134 TSKINYMDPRITVAFCKKY 152
TSK+NY+DPRI++A+CK++
Sbjct 554 TSKLNYLDPRISIAWCKRF 572
> xla:734592 top1.2, MGC115546; topoisomerase (DNA) I, gene 2
Length=503
Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/143 (35%), Positives = 75/143 (52%), Gaps = 33/143 (23%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVAILCNHQR+ PK SMA L+ ++ A +E +
Sbjct 357 YNRANRAVAILCNHQRAPPKTFDQSMANLKSKIDAKKEQI-------------------- 396
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKK----KKQTHLLRMHI----KDSNKT 129
K E +++ K+ L K+ + KK + + L+RM + ++ NK
Sbjct 397 -----LLAKKELKEAKKEAKEKDSEKLNKVVESKKRAVQRTEEQLMRMEVQATDREENKQ 451
Query 130 VALGTSKINYMDPRITVAFCKKY 152
+AL TSK+NY+DPRI+VA+CKK+
Sbjct 452 IALSTSKLNYLDPRISVAWCKKW 474
> dre:334557 fl27b11, wu:fl27b11; zgc:173742
Length=609
Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust.
Identities = 53/137 (38%), Positives = 74/137 (54%), Gaps = 25/137 (18%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVA+LCNHQR+ PK SMA LQ ++ + +E L LA
Sbjct 463 YNRANRAVAVLCNHQRAPPKSFDQSMANLQAKIDSRKEQLD-----LA------------ 505
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHI----KDSNKTVALG 133
K + K K E + S + + KK Q + + LL+M + ++ NK +AL
Sbjct 506 -KKELKQAKKEAKGSSDNKLLVVVEKKKKAVQ---RCEEQLLKMEVQATDREENKQIALS 561
Query 134 TSKINYMDPRITVAFCK 150
TSK+NY+DPRI+VA+CK
Sbjct 562 TSKLNYLDPRISVAWCK 578
> dre:327179 top1, fd15f07, wu:fd15f07; topoisomerase (DNA) I
Length=748
Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 51/137 (37%), Positives = 69/137 (50%), Gaps = 21/137 (15%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANRAVA+LCNHQR+ PK SM LQ K D+++KQ
Sbjct 602 YNRANRAVALLCNHQRAPPKTFEKSMQNLQ-------------------TKIDEKKKQLS 642
Query 78 FKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKD--SNKTVALGTS 135
K++ E K+ KK A + +Q L + D NK +ALGTS
Sbjct 643 AAKKEHKAAKADAKALHDEKSKKAVETKKKAVQRISEQLMKLEVQATDREENKQIALGTS 702
Query 136 KINYMDPRITVAFCKKY 152
K+NY+DPRI+V++CKK+
Sbjct 703 KLNYLDPRISVSWCKKW 719
> cel:M01E5.5 top-1; TOPoisomerase family member (top-1); K03163
DNA topoisomerase I [EC:5.99.1.2]
Length=806
Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust.
Identities = 54/138 (39%), Positives = 77/138 (55%), Gaps = 34/138 (24%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCK---KDKQQK 74
YN ANR VAILCNHQR++ K SM +L+ ++ +++++E E L + K+K QK
Sbjct 668 YNRANRQVAILCNHQRAVSKGFDESMQKLEQKIKDKKKEVKEAEAALKSARGAEKEKAQK 727
Query 75 QFKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKDSNKTVALGT 134
++ + +KE QLKK K + KD NK +ALGT
Sbjct 728 KY-------------------DRLKE--------QLKKLK----ISRTDKDENKQIALGT 756
Query 135 SKINYMDPRITVAFCKKY 152
SK+NY+DPRITVA+CKK+
Sbjct 757 SKLNYIDPRITVAWCKKF 774
> sce:YOL006C TOP1, MAK1, MAK17; Top1p (EC:5.99.1.2); K03163 DNA
topoisomerase I [EC:5.99.1.2]
Length=769
Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 53/196 (27%), Positives = 85/196 (43%), Gaps = 61/196 (31%)
Query 18 YNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFK 77
YN ANR VAILCNHQR++ K HA ++ + +++ +E C+ + KD +K+ K
Sbjct 545 YNAANRTVAILCNHQRTVTKGHAQTVEKANNRIQELEWQKIRCKRAILQLDKDLLKKEPK 604
Query 78 FKSDFKTLKGEPRKSV----------------VREG----------MKEDAVLKKIAQLK 111
+ + L E ++ VRE + E + + + ++
Sbjct 605 YFEEIDDLTKEDEATIHKRIIDREIEKYQRKFVRENDKRKFEKEELLPESQLKEWLEKVD 664
Query 112 KKKQ-----------------------------------THLLRMHIKDSNKTVALGTSK 136
+KKQ T +++ K+ N V+LGTSK
Sbjct 665 EKKQEFEKELKTGEVELKSSWNSVEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLGTSK 724
Query 137 INYMDPRITVAFCKKY 152
INY+DPR++V FCKKY
Sbjct 725 INYIDPRLSVVFCKKY 740
> ath:AT4G26701 DNA binding / DNA topoisomerase type I
Length=69
Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 24/32 (75%), Positives = 28/32 (87%), Gaps = 0/32 (0%)
Query 121 MHIKDSNKTVALGTSKINYMDPRITVAFCKKY 152
M K+ KTVALGTSKINYMDPRITVA+CK++
Sbjct 10 MQTKEDLKTVALGTSKINYMDPRITVAWCKRH 41
> pfa:MAL7P1.105 conserved Plasmodium protein, unknown function
Length=104
Score = 32.3 bits (72), Expect = 0.66, Method: Compositional matrix adjust.
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 3/71 (4%)
Query 36 PKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFKFKSDFKTLKGEPRKSVV- 94
PK H + +Q+ L IE +E E ++A K+K +K++K ++ K+ K K V+
Sbjct 22 PKVHVSGWYDIQNDLDYIEHYNKEKEFYIAEYPKNKFEKRYK-NTNRKSTKNISDKKVIF 80
Query 95 -REGMKEDAVL 104
+EG + D+ L
Sbjct 81 YQEGYESDSWL 91
> hsa:259282 BOD1L, FAM44A, FLJ33215, KIAA1327; biorientation
of chromosomes in cell division 1-like
Length=3051
Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats.
Identities = 24/100 (24%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query 16 QFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQ 75
++Y+D++ + + ++SI K+ + R Q +EE ++ E K Q +
Sbjct 479 KYYSDSDDELTVE-QRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRS 537
Query 76 FKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQ 115
+ T EP+ + ++E +KE VL+K L KK++
Sbjct 538 SVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRK 577
> ath:AT1G27920 MAP65-8 (MICROTUBULE-ASSOCIATED PROTEIN 65-8)
Length=592
Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust.
Identities = 21/65 (32%), Positives = 34/65 (52%), Gaps = 11/65 (16%)
Query 27 ILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFKFKSDFKTLK 86
+LC +RS+P + L+ QL +I LRE +KD++ KQ F+++K
Sbjct 115 LLCLGERSVPGRPEKKGGTLREQLDSIAPALREMR-----LRKDERVKQ------FRSVK 163
Query 87 GEPRK 91
GE +K
Sbjct 164 GEIQK 168
> ath:AT2G45720 armadillo/beta-catenin repeat family protein
Length=553
Score = 31.2 bits (69), Expect = 1.5, Method: Composition-based stats.
Identities = 14/42 (33%), Positives = 23/42 (54%), Gaps = 0/42 (0%)
Query 47 QHQLSAIEEDLRECEEFLAFCKKDKQQKQFKFKSDFKTLKGE 88
+ QL A+ E L+E E C +KQ+ + K +SD +L +
Sbjct 74 KEQLQAVLETLKETIELANVCVSEKQEGKLKMQSDLDSLSAK 115
> ath:AT3G10800 BZIP28; BZIP28; DNA binding / transcription factor
Length=675
Score = 30.4 bits (67), Expect = 2.2, Method: Composition-based stats.
Identities = 25/111 (22%), Positives = 53/111 (47%), Gaps = 17/111 (15%)
Query 30 NHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFKFKSDFKTLKGEP 89
NHQ+S S+++ + + +LR C+ + K D + + D +
Sbjct 146 NHQKS-------SVSKRKKENGDSSGELRSCK----YQKSDDKSVATNNEGD----DDDD 190
Query 90 RKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKDSNKTVALGTSKINYM 140
++ ++R+ ++ ++++L+KK+QT L +K N T+A KI Y+
Sbjct 191 KRKLIRQIRNRESA--QLSRLRKKQQTEELERKVKSMNATIAELNGKIAYV 239
> sce:YNL123W NMA111, YNM3; Nma111p
Length=997
Score = 30.0 bits (66), Expect = 2.9, Method: Composition-based stats.
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 2/58 (3%)
Query 87 GEPRKSVVREGMKEDAVLKKIAQLKKKKQTHLLRMHIKDSNKTVALGTSKINYMDPRI 144
G+PR S+V G +VL+ A+++ + ++RM + +N+ + S+++Y + +I
Sbjct 753 GKPRVSIVDAGFGSISVLQ--ARIRGVPEEWIMRMEHESNNRLQFITVSRVSYTEDKI 808
> dre:573110 cbx4, MGC198077, MGC198079, im:6911625, zgc:158588;
chromobox homolog 4 (Pc class homolog, Drosophila); K11452
chromobox protein 4
Length=477
Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust.
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 0/39 (0%)
Query 28 LCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAF 66
+C+ S P + A L+ LS ED+R C++ L+F
Sbjct 344 ICDRPNSSPAKVDAKSNHLKRHLSEPSEDVRNCKQLLSF 382
> mmu:72296 Rusc1, 2210403N08Rik, AA408288, NESCA; RUN and SH3
domain containing 1
Length=893
Score = 30.0 bits (66), Expect = 3.4, Method: Composition-based stats.
Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 0/40 (0%)
Query 21 ANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLREC 60
A+RAV LC+H + P Q + L ++ ++ED C
Sbjct 836 ADRAVRALCDHTAAGPDQLSFQRGELLRVIATVDEDWLRC 875
> sce:YKL072W STB6; Protein that binds Sin3p in a two-hybrid assay
Length=766
Score = 28.9 bits (63), Expect = 7.1, Method: Compositional matrix adjust.
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 0/56 (0%)
Query 32 QRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQFKFKSDFKTLKG 87
QR I + LQ +SA+E L E E C K ++ KF S KT KG
Sbjct 59 QRKISTLITSYTGNLQDTISAVEVALPEDPEEWPCCLKKYHEELLKFSSPKKTAKG 114
> mmu:665775 Bod1l, A230054D04Rik, AI853319, FAM44A, mKIAA1327;
biorientation of chromosomes in cell division 1-like
Length=3032
Score = 28.9 bits (63), Expect = 7.4, Method: Composition-based stats.
Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 1/100 (1%)
Query 16 QFYNDANRAVAILCNHQRSIPKQHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQKQ 75
++Y+D++ + + ++SI K+ + R + +EE ++ E K Q K
Sbjct 477 KYYSDSDDELTVE-QRRQSIAKEKEERLLRRRINREKLEEKRKQKAEKTKSSKVKSQGKS 535
Query 76 FKFKSDFKTLKGEPRKSVVREGMKEDAVLKKIAQLKKKKQ 115
D EP+ ++E +KE VL+K L K+++
Sbjct 536 TVDLEDSSAKTLEPKAPRIKEVLKERKVLEKKVALSKRRR 575
> xla:394289 rock2, rocka-a, xROK; Rho-associated, coiled-coil
containing protein kinase 2; K04514 Rho-associated, coiled-coil
containing protein kinase [EC:2.7.11.1]
Length=1370
Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust.
Identities = 14/36 (38%), Positives = 24/36 (66%), Gaps = 0/36 (0%)
Query 38 QHAASMARLQHQLSAIEEDLRECEEFLAFCKKDKQQ 73
Q + ++ LQ ++S +EEDL++ +E LA +KQQ
Sbjct 624 QGSEVISDLQGRISVLEEDLKKGKELLARADAEKQQ 659
Lambda K H
0.319 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 3264639800
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40