bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: egene_temp_file_orthology_annotation_similarity_blast_database_966 164,496 sequences; 82,071,388 total letters Query= Eace_0841_orf1 Length=217 Score E Sequences producing significant alignments: (Bits) Value tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC... 150 3e-36 tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.1... 84.3 3e-16 bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodie... 72.4 1e-12 tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, p... 72.0 1e-12 bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodie... 65.5 1e-10 tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, ... 65.5 1e-10 tpv:TP01_1200 hypothetical protein 59.7 8e-09 xla:734701 pde9a, MGC116558; phosphodiesterase 9A (EC:3.1.4.17... 57.4 3e-08 pfa:PF14_0672 cyclic nucleotide phosphodiesterase, putative; K... 57.0 5e-08 tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K0112... 55.5 1e-07 pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.1... 53.5 5e-07 dre:791145 pde8a, zgc:158458; phosphodiesterase 8A (EC:3.1.4.1... 53.5 5e-07 hsa:5151 PDE8A, FLJ16150, HsT19550; phosphodiesterase 8A (EC:3... 53.5 6e-07 hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-s... 52.8 9e-07 cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01... 52.4 1e-06 mmu:18584 Pde8a, AI551852, Pde8; phosphodiesterase 8A (EC:3.1.... 52.4 1e-06 dre:571011 IBMX-insensitive phosphodiesterase 8B-like; K01120 ... 52.0 2e-06 cpv:cgd3_2320 cGMP phosphodiesterase A4 51.6 2e-06 tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) 51.6 2e-06 mmu:218461 Pde8b, B230331L10Rik, C030047E14Rik; phosphodiester... 51.2 3e-06 hsa:8622 PDE8B, ADSD, FLJ11212, PPNAD3; phosphodiesterase 8B (... 50.8 4e-06 dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-25... 50.4 4e-06 cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K1... 50.4 4e-06 dre:100330859 phosphodiesterase 6A-like; K08718 rod cGMP-speci... 50.4 4e-06 mmu:18587 Pde6b, MGC150321, Pdeb, r, rd, rd-1, rd1, rd10; phos... 50.4 5e-06 hsa:5158 PDE6B, CSNB3, CSNBAD2, PDEB, RP40, rd1; phosphodieste... 49.3 1e-05 dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; ... 49.3 1e-05 dre:393845 pde6c, MGC73085, zgc:73085; phosphodiesterase 6C, c... 49.3 1e-05 dre:100329275 phosphodiesterase 6C-like 49.3 1e-05 tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nu... 48.9 1e-05 dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 ... 48.9 1e-05 tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, pu... 48.9 1e-05 cel:R08D7.6 pde-2; PhosphoDiEsterase family member (pde-2) 48.5 2e-05 hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-depend... 48.5 2e-05 tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, ... 48.5 2e-05 hsa:5145 PDE6A, CGPR-A, PDEA, RP43; phosphodiesterase 6A, cGMP... 47.8 3e-05 mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 ca... 47.0 5e-05 dre:566998 novel protein similar to vertebrate phosphodiestera... 47.0 5e-05 hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4... 47.0 6e-05 mmu:110385 Pde4c, Dpde1, E130301F19Rik, MGC31320, dunce; phosp... 47.0 6e-05 mmu:225600 Pde6a, MGC25111, Pdea, nmf282; phosphodiesterase 6A... 46.6 7e-05 mmu:110855 Pde6c, cpfl1; phosphodiesterase 6C, cGMP specific, ... 46.2 8e-05 dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 ... 46.2 9e-05 tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic n... 45.8 1e-04 mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, ... 45.1 2e-04 dre:559332 pde6b; phosphodiesterase 6B, cGMP-specific, rod, be... 45.1 2e-04 pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:... 44.7 2e-04 xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specifi... 44.7 2e-04 hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17)... 44.7 3e-04 mmu:29863 Pde7b; phosphodiesterase 7B (EC:3.1.4.17); K01120 3'... 44.7 3e-04 > tgo:TGME49_080410 3',5'-cyclic phosphodiesterase, putative (EC:3.1.4.17 1.6.5.3); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1085 Score = 150 bits (379), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 86/220 (39%), Positives = 128/220 (58%), Gaps = 9/220 (4%) Query 1 KRIYLPSTPLECVIRNLDLIQRILFNANMEEDEREQVQELLNEARHNLTFTDNIYRFNAD 60 KR TPL+C++ NL L RE++ L+ E + LT ++N+Y+ A+ Sbjct 641 KRRVDTGTPLDCILGNLSEALEALKRPT--PLNREEIFALMQETINMLTTSENVYQVQAE 698 Query 61 TFSDGFARSYVHDLR---REGISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIG 117 + F RS++ DLR RE +SR+ +LA RR+S + G VE+ E +IG Sbjct 699 YVDNDFTRSFIRDLRMHSREASDF--AVSRLNTLATRRRSVISGRVET--TRTELLEEIG 754 Query 118 TDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHN 177 W + +PL E+G+ +LSPF+LSP+ L+ +L FL EV Y+ PYHN Sbjct 755 NSWDVNMFMLRLKLPRPLVEVGYVLLSPFALSPDACLNTQLLRKFLCEVDKAYRNCPYHN 814 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +LHG+ VCH+++CLLEML++RE + DLE+ S IA+LCHD Sbjct 815 SLHGSMVCHLSICLLEMLRLRESLGDLEEASLIIAALCHD 854 > tgo:TGME49_024840 cAMP phosphodiesterase, putative (EC:3.1.4.17 1.1.99.3) Length=1324 Score = 84.3 bits (207), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 37/102 (36%), Positives = 58/102 (56%), Gaps = 2/102 (1%) Query 116 IGTDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPY 175 +G DW FD LH + + E+G+A+L L P++ L FL + Y++NPY Sbjct 686 VGVDWDFDMLHLNSQTENVIVEVGYALLC--RLVPDLGCEEVRLIRFLHAIQMQYRDNPY 743 Query 176 HNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 HN +H A V H+T CL ML + M+ ++ ++ +A+LCHD Sbjct 744 HNKIHSAEVAHLTECLTRMLNAQRNMNSIDKVTLTVAALCHD 785 > bbo:BBOV_IV010070 23.m06154; 3'5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=485 Score = 72.4 bits (176), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 9/110 (8%) Query 114 AKIGTDWSFDCL---HFGEISRK-PLCEIGFAILSPFS--LSPEISLHRDVLTAFLEEVT 167 A++G +W+ D +F + R P+ +G ++ P + P+ + ++T L + Sbjct 146 AQLGKNWNMDFFAMSNFKFVLRSGPVVAVGHQLIDPVGDKIHPDFN---KLITPVLNSIQ 202 Query 168 DCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 D Y NPYHNALHGA V HM+ LL+ L + +Y++ LE + IA+L HD Sbjct 203 DVYLPNPYHNALHGACVAHMSCVLLKALSLEQYLTPLEQFAYLIAALGHD 252 > tgo:TGME49_002540 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17 1.6.99.5) Length=1670 Score = 72.0 bits (175), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 2/105 (1%) Query 113 SAKIGTDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKE 172 S + DW+FDCL ++S PL ++G+A+L S ++ L DV+ FL V Y Sbjct 1277 SEEAARDWNFDCLRHAQLSPTPLVDVGYALL--HRTSEDMRLPPDVVLRFLTAVEIQYNH 1334 Query 173 NPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 PYHN +HG V + L E+L++ + + + +A LCHD Sbjct 1335 VPYHNCIHGLMVAQKMVALTEVLELSQSIGSRDRALVVVAGLCHD 1379 > bbo:BBOV_IV006510 23.m05980; 3'5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=777 Score = 65.5 bits (158), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 53/100 (53%), Gaps = 2/100 (2%) Query 118 TDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHN 177 TDW+FD L + + + IG+ +L + + + R V+ FL + + Y+ PYHN Sbjct 442 TDWNFDVLEYFKKTPAGFMSIGYTLLQKYQ--EDYGIDRSVVVNFLYRIENQYRNVPYHN 499 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +HGA V LCL + E++S L++ +A+L HD Sbjct 500 KMHGAMVAQKVLCLASYTGLLEHLSILDEALLMVAALSHD 539 > tgo:TGME49_118680 3',5'--cyclic-nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=812 Score = 65.5 bits (158), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 37/103 (35%), Positives = 54/103 (52%), Gaps = 3/103 (2%) Query 116 IGTDWSFDCLHFGE-ISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENP 174 +G D S++ L F + L E+G+ +L+ + + VL FL V Y+EN Sbjct 315 VGIDISYNILEFSKKCPDTVLQEVGYVLLN--RIVCDWGCEDKVLCEFLYMVKTLYRENS 372 Query 175 YHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 YHN +HGA V H +CLL L I M+ L + +A+LCHD Sbjct 373 YHNQIHGAMVAHYMVCLLRGLGINREMNSLSTAACAVAALCHD 415 > tpv:TP01_1200 hypothetical protein Length=840 Score = 59.7 bits (143), Expect = 8e-09, Method: Composition-based stats. Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 2/99 (2%) Query 119 DWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNA 178 DW+F L + + IG +LS F ++ DV+ +FL V CY YHN Sbjct 552 DWNFSILDYFRQNPTGFISIGCVLLSEFQ--THFNIPTDVIYSFLGLVEKCYNNVSYHNQ 609 Query 179 LHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +HG VC LCL + +S ++ I+ LCHD Sbjct 610 MHGVFVCQKLLCLSNFTNVYSRLSVIDRTILIISGLCHD 648 > xla:734701 pde9a, MGC116558; phosphodiesterase 9A (EC:3.1.4.17); K13761 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:3.1.4.35] Length=342 Score = 57.4 bits (137), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 45/76 (59%), Gaps = 6/76 (7%) Query 142 ILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYM 201 +++ F + PE + FL V Y+ENP+HN HG +V M C++ Q++E++ Sbjct 63 LVTEFKMEPE------TVRCFLTSVQKHYQENPFHNFYHGFSVTQMMYCVISQCQLQEHL 116 Query 202 SDLEDISACIASLCHD 217 S ++ ++ +A+LCHD Sbjct 117 SHIDILTLMVAALCHD 132 > pfa:PF14_0672 cyclic nucleotide phosphodiesterase, putative; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=815 Score = 57.0 bits (136), Expect = 5e-08, Method: Composition-based stats. Identities = 52/200 (26%), Positives = 94/200 (47%), Gaps = 19/200 (9%) Query 19 LIQRILFNANMEEDEREQVQELLN-EARHNLTFTDNIYRFNADTFSDGFARSYVHDLRRE 77 + ++L + N++ED +N + N+ F DNI ++ S+ +L++ Sbjct 319 FLNKLLKSCNIKEDMSSNTSVNINGDTYQNMNFHDNINSNIPKNYN-----SFYEELKK- 372 Query 78 GISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGEISRKPLCE 137 L+ L + + ++ ++ C++ K D+SF +G+ S + E Sbjct 373 ------NLNESDILTIAYEVEVLKNIKKIN--CDEIGK-NWDYSFIDSEYGK-STLVILE 422 Query 138 IGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQI 197 +G+ ++SP+ + E L FL + Y NPYHNA HGATVCH++ CL + Sbjct 423 VGYHLISPYIENNENKKK--KLQLFLLLINSMYFPNPYHNANHGATVCHLSKCLAHITDY 480 Query 198 REYMSDLEDISACIASLCHD 217 Y+++ I IAS+ HD Sbjct 481 DSYLNNTYMICYLIASIAHD 500 > tpv:TP01_0664 3',5' cyclic nucleotide phosphodiesterase; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=450 Score = 55.5 bits (132), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 16/131 (12%) Query 93 ARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGE----ISRKPLCEIGFAILSPFS- 147 +RRK +L ++ E +IG +W D + + P+ +G +L Sbjct 91 SRRKKKL-------NSENEYIQQIGLNWHLDLIELSNYPTVLETGPIVVVGKHLLHCVGN 143 Query 148 -LSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLED 206 + P + + L L+ + Y NPYHNALH ATV HM+ L ++ + ++ E+ Sbjct 144 LIHPNFNTN---LIPVLQNLQQHYLANPYHNALHAATVGHMSKLLSNIVTTKRRLNPYEE 200 Query 207 ISACIASLCHD 217 + I+SL HD Sbjct 201 FAFIISSLAHD 211 > pfa:PFL0475w PDE1; cGMP-specific phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=954 Score = 53.5 bits (127), Expect = 5e-07, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 102/225 (45%), Gaps = 18/225 (8%) Query 5 LPSTPLECVIRNLDLIQRILFNANM-EEDEREQVQELLNEARHNLTFTDNIYRF-NADTF 62 +P++P+E ++ N + IL N+ EE+ + + + + + DNI R N + Sbjct 503 IPTSPIEDILNNF---KHILETINIIEENPNHNLTTNIMKIKEKIKNCDNILRTKNINQV 559 Query 63 SDGFARSY-----VHDLRREGISRPRKLSRMTSLAARRKSRL----FGVVESL-SAMCEQ 112 G R + + L + ++ P S + +R+ F + SL S+ ++ Sbjct 560 QIGKYRKFEKVYNIWCLDKMYLNYPLNQEETKSFLSNSLNRISFNSFSNMHSLLSSKFQE 619 Query 113 SAKIGTDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKE 172 DW+ + + + + IG+ +L P + E + ++ L FL + Y + Sbjct 620 HYNDIYDWNGNIENIYKAN--TFISIGYKLLYPLGVL-EANFDKEKLKKFLFRICSYYND 676 Query 173 NPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 PYH +LH A V H + +L ML + +S +++ I+SLCHD Sbjct 677 IPYHTSLHAAQVAHFSKSMLFMLDMNHKISAIDEFCLHISSLCHD 721 > dre:791145 pde8a, zgc:158458; phosphodiesterase 8A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=817 Score = 53.5 bits (127), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 51/100 (51%), Gaps = 2/100 (2%) Query 120 WSFDCLHFGEIS-RKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCY-KENPYHN 177 W FD + + ++PL +G + S F + + L ++L+ + Y NPYHN Sbjct 484 WDFDIFNLESATLKRPLAFLGLKLFSRFGVCEFLGCAEATLRSWLQNIEASYHGSNPYHN 543 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + H A V H T L ++++ + +++++A IA+ HD Sbjct 544 STHAADVLHATAYFLCKERVKQSLDPIDEVAALIAAAVHD 583 > hsa:5151 PDE8A, FLJ16150, HsT19550; phosphodiesterase 8A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=829 Score = 53.5 bits (127), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 2/100 (2%) Query 120 WSFDCLHF-GEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCY-KENPYHN 177 W FD +PL +G + + F + + L ++L+ + Y NPYHN Sbjct 498 WDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHN 557 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + H A V H T L +I+E + +++++A IA+ HD Sbjct 558 STHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHD 597 > hsa:5143 PDE4C, DPDE1, MGC126222; phosphodiesterase 4C, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=712 Score = 52.8 bits (125), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 36/120 (30%), Positives = 49/120 (40%), Gaps = 2/120 (1%) Query 100 FGVVESLSAMCEQSAKIGTDWSFDCLHFGEIS-RKPLCEIGFAILSPFSLSPEISLHRDV 158 FGV + + W D E+S +PL I F+I L + D Sbjct 310 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 369 Query 159 LTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 L +L + Y N YHN+LH A V T LL + +DLE ++A AS HD Sbjct 370 LATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHD 429 > cel:R153.1 pde-4; PhosphoDiEsterase family member (pde-4); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=673 Score = 52.4 bits (124), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 1/100 (1%) Query 119 DWSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHN 177 DW D E+S+ L + F++L +L +H+ L +L + Y+ N YHN Sbjct 348 DWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYRNNHYHN 407 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +H A V LL + E +DLE ++A A HD Sbjct 408 FIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHD 447 > mmu:18584 Pde8a, AI551852, Pde8; phosphodiesterase 8A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=823 Score = 52.4 bits (124), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 2/100 (2%) Query 120 WSFDCLHFGEISR-KPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCY-KENPYHN 177 W FD ++ +PL +G + F + + L ++ + + Y NPYHN Sbjct 493 WDFDIFELEVATQNRPLIYLGLKTFARFGMCEFLQCSETTLRSWFQMIESNYHSSNPYHN 552 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + H A V H T L +I+E + +++++A IA+ HD Sbjct 553 STHAADVLHATAYFLSRDKIKETLDRIDEVAALIAATVHD 592 > dre:571011 IBMX-insensitive phosphodiesterase 8B-like; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=784 Score = 52.0 bits (123), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 50/100 (50%), Gaps = 2/100 (2%) Query 120 WSFDCLHF-GEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEV-TDCYKENPYHN 177 W F+ L ++PL +G I S F + ++ L +L+ + T+ + N YHN Sbjct 450 WEFNILELEAATHKRPLSYLGLKIFSAFGVCEFLNCSESTLRLWLQVIETNYHSSNSYHN 509 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + H A V H T L +++ + L++++A +A+ HD Sbjct 510 STHAADVLHATAYFLRKERVKASLDQLDEVAALLAATVHD 549 > cpv:cgd3_2320 cGMP phosphodiesterase A4 Length=997 Score = 51.6 bits (122), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 0/56 (0%) Query 162 FLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 F E+ Y N YHN LHG VCH+ +CL + ++ +E +++ IASL HD Sbjct 711 FFRELNIRYLNNKYHNELHGTNVCHLAICLSRATGLWSHLDTVERLASVIASLGHD 766 > tgo:TGME49_066920 phosphodiesterase, putative (EC:3.1.4.17) Length=1065 Score = 51.6 bits (122), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 2/102 (1%) Query 116 IGTDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPY 175 +G W+FD L E + L GF +L+ + + LT FL ++ NPY Sbjct 556 VGVAWNFDLLEVEEETGHALSLTGFVLLN--GVVADWGCPPSRLTNFLLSCEAQHQANPY 613 Query 176 HNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 HN H A V H T L + +E + +A+LCHD Sbjct 614 HNQRHAAMVAHATAWLANTVGALNKCDSVERATLYVAALCHD 655 > mmu:218461 Pde8b, B230331L10Rik, C030047E14Rik; phosphodiesterase 8B (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=788 Score = 51.2 bits (121), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 2/100 (2%) Query 120 WSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCY-KENPYHN 177 W F+ ++ K PL +G + S F + ++ L A+L+ + Y N YHN Sbjct 460 WDFNIFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHN 519 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + H A V H T L +++ + L++++A IA+ HD Sbjct 520 STHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHD 559 > hsa:8622 PDE8B, ADSD, FLJ11212, PPNAD3; phosphodiesterase 8B (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=788 Score = 50.8 bits (120), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 2/100 (2%) Query 120 WSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCY-KENPYHN 177 W F+ I+ K PL +G + S F + ++ L A+ + + Y N YHN Sbjct 460 WDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHN 519 Query 178 ALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + H A V H T L +++ + L++++A IA+ HD Sbjct 520 STHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHD 559 > dre:571344 fc68c05, si:ch211-255d18.8, wu:fc68c05; si:ch211-255d18.1 Length=709 Score = 50.4 bits (119), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 42/141 (29%), Positives = 58/141 (41%), Gaps = 3/141 (2%) Query 79 ISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGEIS-RKPLCE 137 IS RKLS SL R FGV ++ + + W D E S +PL Sbjct 262 ISGVRKLSPSPSLPPTCIPR-FGVNTQHESLLAKELEDLDRWGIDIFKIAEYSGNRPLTV 320 Query 138 IGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEMLQ 196 + + I L + D FL + D Y + YHN +H A V T LL Sbjct 321 MMYTIFQERDLLKTFKIPSDTFLTFLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 380 Query 197 IREYMSDLEDISACIASLCHD 217 + + +DLE ++A AS HD Sbjct 381 LEDVFTDLEIMAALFASAIHD 401 > cel:T04D3.3 pde-1; PhosphoDiEsterase family member (pde-1); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=664 Score = 50.4 bits (119), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 90/226 (39%), Gaps = 34/226 (15%) Query 9 PLECVIRNLDLIQRILFNANMEE-----DEREQVQELLNEARHNLTFTDNIYRFNADTFS 63 PLE + RN++ +L A M+E DE + + E+ E T D + + A TF+ Sbjct 166 PLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPE-----TVPDEVREWLAATFT 220 Query 64 DGFARSYVHDLRREGISRPRKLSRMTSLAARRKSRLF--------GVVE-SLSAMCEQSA 114 R+ + R + S+A ++ +F VV+ + + Sbjct 221 ------------RQNAGKKRDKPKFKSVANAIRTGIFFEKLFRKQQVVQCPIPPEIAELM 268 Query 115 KIGTDWSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKE- 172 K WSF E+S L +GF + + + + L +L + Y + Sbjct 269 KEVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKH 328 Query 173 -NPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 NPYHN +H A V + +L + + DLE ++ +L HD Sbjct 329 NNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHD 374 > dre:100330859 phosphodiesterase 6A-like; K08718 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35] Length=858 Score = 50.4 bits (119), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 0/89 (0%) Query 129 EISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGATVCHMT 188 E S L + G + + + + R+ L F+ V+ Y++ YHN HG V Sbjct 513 EFSELDLVKCGIKMYYELGVVDKFHIPRETLVRFVYSVSKGYRKITYHNWRHGFNVGQTM 572 Query 189 LCLLEMLQIREYMSDLEDISACIASLCHD 217 LL ++ Y +DLE ++ A LCHD Sbjct 573 FTLLMTGDLKRYYTDLEAMAMVTAGLCHD 601 > mmu:18587 Pde6b, MGC150321, Pdeb, r, rd, rd-1, rd1, rd10; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide (EC:3.1.4.35); K13756 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:3.1.4.35] Length=856 Score = 50.4 bits (119), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 2/95 (2%) Query 125 LHFGEI--SRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGA 182 HF ++ + L + G + + + + ++VL FL V+ Y+ YHN HG Sbjct 504 FHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGF 563 Query 183 TVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 V LL +++ Y +DLE + A LCHD Sbjct 564 NVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598 > hsa:5158 PDE6B, CSNB3, CSNBAD2, PDEB, RP40, rd1; phosphodiesterase 6B, cGMP-specific, rod, beta (EC:3.1.4.35); K13756 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:3.1.4.35] Length=854 Score = 49.3 bits (116), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 4/101 (3%) Query 121 SFDC--LHFGEI--SRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYH 176 +FD HF ++ + L + G + + + + ++VL FL ++ Y+ YH Sbjct 498 TFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYH 557 Query 177 NALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 N HG V LL +++ Y +DLE + A LCHD Sbjct 558 NWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598 > dre:564465 pde1a; phosphodiesterase 1A, calmodulin-dependent; K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=625 Score = 49.3 bits (116), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 22/228 (9%) Query 10 LECVIRNLDL--IQRILFNANMEEDEREQVQELLNEARHNLTFTDNIYRFNADTFS---- 63 L C+++ LD + + N+E ++E R L D + AD+ Sbjct 38 LRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVR 97 Query 64 DGFARSYVHDL---RREGISRPRKLSRMTSLAA--------RRKSRLFGVVESLSAMCEQ 112 D A ++ + RR +PR S + ++ A RR S + G+ S + Sbjct 98 DWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPSVIT-- 155 Query 113 SAKIGTDWSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYK 171 + K WSFD E S L + + +L+ + L + L +F+E + Y Sbjct 156 ALKDVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYS 215 Query 172 E--NPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + NPYHN +H A V L+ + ++++LE ++ A+ HD Sbjct 216 KHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHD 263 > dre:393845 pde6c, MGC73085, zgc:73085; phosphodiesterase 6C, cGMP-specific, cone, alpha prime (EC:3.1.4.17); K13757 cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:3.1.4.35] Length=852 Score = 49.3 bits (116), Expect = 1e-05, Method: Composition-based stats. Identities = 22/61 (36%), Positives = 34/61 (55%), Gaps = 0/61 (0%) Query 157 DVLTAFLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCH 216 +VLT ++ V Y++ YHN HG V CLL+ ++R Y +DL+ + A+ CH Sbjct 538 EVLTRWMYTVRKGYRDITYHNWRHGFNVGQTMFCLLQTGKLRRYYTDLDAFAMVAAAFCH 597 Query 217 D 217 D Sbjct 598 D 598 > dre:100329275 phosphodiesterase 6C-like Length=852 Score = 49.3 bits (116), Expect = 1e-05, Method: Composition-based stats. Identities = 22/61 (36%), Positives = 34/61 (55%), Gaps = 0/61 (0%) Query 157 DVLTAFLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCH 216 +VLT ++ V Y++ YHN HG V CLL+ ++R Y +DL+ + A+ CH Sbjct 538 EVLTRWMYTVRKGYRDITYHNWRHGFNVGQTMFCLLQTGKLRRYYTDLDAFAMVAAAFCH 597 Query 217 D 217 D Sbjct 598 D 598 > tgo:TGME49_072650 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17) Length=1320 Score = 48.9 bits (115), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 13/115 (11%) Query 116 IGTDWSFDCLHF-GEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENP 174 +G WS D E + L +G+ +L+P + ++ R+V+ FL + Y + P Sbjct 990 VGILWSLDLFKLDKECNGNALLHVGYQLLAPLLAAGYLTCSREVVLDFLYSLQCLYIDTP 1049 Query 175 YHNALHGATVCHMTLCLLEMLQIREYMSDLED------------ISACIASLCHD 217 YHN LH A+V H+ + L + + + +S IA+L HD Sbjct 1050 YHNQLHAASVAHLAFSICHFLDLFAPLENAPGDAAASQPVFAQYLSLAIAALGHD 1104 > dre:572061 pde4a; phosphodiesterase 4A, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=736 Score = 48.9 bits (115), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 63/142 (44%), Gaps = 5/142 (3%) Query 79 ISRPRKLSRMTSLAARRKSRLFGV-VESLSAMCEQSAKIGTDWSFDCLHFGEISR-KPLC 136 IS +KL+ +SL + R FGV E A+ + + W + H E S +PL Sbjct 294 ISGVKKLTHSSSLTSAALPR-FGVKTEQEDALARELNDLNK-WGLNIFHVAEFSNNRPLS 351 Query 137 EIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEML 195 I FAI L + D ++ + D Y N YHN+LH A V T LL Sbjct 352 CIMFAIFQERDLLKTFRIPVDTFITYVMTLEDHYHANVAYHNSLHAADVTQSTHVLLSTP 411 Query 196 QIREYMSDLEDISACIASLCHD 217 + SDLE ++A A+ HD Sbjct 412 ALDAVFSDLEILAALFAAAIHD 433 > tgo:TGME49_020420 3'5'-cyclic nucleotide phosphodiesterase, putative (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=466 Score = 48.9 bits (115), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 56/152 (36%), Gaps = 38/152 (25%) Query 67 ARSYVHDLRREGISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLH 126 +R++ D E R+ S +T A LFG+VE ++G DW D Sbjct 85 SRTWAKDPPSEAKPLARRHSFVTLGAI--DDNLFGLVE----------RVGEDWDLDMFE 132 Query 127 F-GEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGATVC 185 + +R L GF + Y+ NPYHN HGA V Sbjct 133 LCKQTNRMTLMATGFRLQQ-------------------------YRHNPYHNEQHGAAVA 167 Query 186 HMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 HM + LL Q L + +A+L HD Sbjct 168 HMMVFLLRACQAWHMFKPLYQTAIIVAALVHD 199 > cel:R08D7.6 pde-2; PhosphoDiEsterase family member (pde-2) Length=856 Score = 48.5 bits (114), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 43/92 (46%), Gaps = 8/92 (8%) Query 126 HFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGATVC 185 HF S ++GF++L L++ L+ + V+ Y+ PYHN H V Sbjct 377 HFHRASMMFFEDLGFSML--------YKLNKRKLSYLVLRVSAGYRPVPYHNWSHAFAVT 428 Query 186 HMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 H L IR +SD+E +S IA LCHD Sbjct 429 HFCWLTLRTDAIRRALSDMERLSLLIACLCHD 460 > hsa:5137 PDE1C, Hcam3; phosphodiesterase 1C, calmodulin-dependent 70kDa (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=634 Score = 48.5 bits (114), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/169 (26%), Positives = 71/169 (42%), Gaps = 14/169 (8%) Query 60 DTFSDGFARSYVHDLRREGISRPRKLSRMTSLAA--------RRKSRLFGVVESLSAMCE 111 D + F R LRR +PR S + ++ A RR S + G+ S Sbjct 104 DWLASTFTRQMGMMLRRSD-EKPRFKSIVHAVQAGIFVERMYRRTSNMVGL--SYPPAVI 160 Query 112 QSAKIGTDWSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLE--EVTD 168 ++ K WSFD E S L I + +L+ + L + L +F+E EV Sbjct 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220 Query 169 CYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +NPYHN +H A V LL + ++++LE + ++ HD Sbjct 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHD 269 > tgo:TGME49_041880 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:2.1.1.43 3.1.4.17) Length=1281 Score = 48.5 bits (114), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 33/56 (58%), Gaps = 0/56 (0%) Query 162 FLEEVTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 F++ CY+ YHN LHGA V H T+ L L++ ++ E ++ +A+LCHD Sbjct 850 FMKVAQMCYQPTIYHNHLHGAQVAHNTVWLARKLELASSLTAPELVALIVAALCHD 905 > hsa:5145 PDE6A, CGPR-A, PDEA, RP43; phosphodiesterase 6A, cGMP-specific, rod, alpha (EC:3.1.4.35); K08718 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35] Length=860 Score = 47.8 bits (112), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Query 120 WSFDCLHFGEISRKPLCEI-----GFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENP 174 + + HF ++ PL E+ G + + + + ++ L F+ ++ Y++ Sbjct 501 YEINKFHFSDL---PLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKIT 557 Query 175 YHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 YHN HG V LL +++ Y +DLE ++ A+ CHD Sbjct 558 YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600 > mmu:18575 Pde1c; phosphodiesterase 1C (EC:3.1.4.17); K13755 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17] Length=631 Score = 47.0 bits (110), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 45/169 (26%), Positives = 70/169 (41%), Gaps = 14/169 (8%) Query 60 DTFSDGFARSYVHDLRREGISRPRKLSRMTSLAA--------RRKSRLFGVVESLSAMCE 111 D + F R LRR +PR S + ++ A RR S + G+ S Sbjct 104 DWLASTFTRQMGMMLRRSD-EKPRFKSIVHAVQAGIFVERMYRRTSNMVGL--SYPPAVI 160 Query 112 QSAKIGTDWSFDCLHFGEISRK-PLCEIGFAILSPFSLSPEISLHRDVLTAFLE--EVTD 168 + K WSFD E S L I + +L+ + L + L +F+E EV Sbjct 161 DALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220 Query 169 CYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +NPYHN +H A V LL + ++++LE + ++ HD Sbjct 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHD 269 > dre:566998 novel protein similar to vertebrate phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) (PDE4D); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=745 Score = 47.0 bits (110), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 56/141 (39%), Gaps = 3/141 (2%) Query 79 ISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGEIS-RKPLCE 137 IS +KL+ +SL R FGV + + W + E S +PL Sbjct 276 ISGVKKLTHSSSLTNSNIPR-FGVKTETEDELAKELEDVNKWGLNVFKVSEFSGNRPLTV 334 Query 138 IGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEMLQ 196 + + I L + D +L + D Y + YHN +H A V T LL Sbjct 335 MMYTIFQERDLLKTFKIPLDTFITYLMTLEDHYHADVAYHNNIHAADVTQSTHVLLSTPA 394 Query 197 IREYMSDLEDISACIASLCHD 217 + +DLE ++A AS HD Sbjct 395 LEAVFTDLEILAAIFASAIHD 415 > hsa:5144 PDE4D, DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2, STRK1; phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=809 Score = 47.0 bits (110), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 40/141 (28%), Positives = 56/141 (39%), Gaps = 3/141 (2%) Query 79 ISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGEIS-RKPLCE 137 IS +KL +SL R FGV + + + W E+S +PL Sbjct 364 ISGVKKLMHSSSLTNSSIPR-FGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV 422 Query 138 IGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEMLQ 196 I I L + D L +L + D Y + YHN +H A V T LL Sbjct 423 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 482 Query 197 IREYMSDLEDISACIASLCHD 217 + +DLE ++A AS HD Sbjct 483 LEAVFTDLEILAAIFASAIHD 503 > mmu:110385 Pde4c, Dpde1, E130301F19Rik, MGC31320, dunce; phosphodiesterase 4C, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=652 Score = 47.0 bits (110), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 12/159 (7%) Query 61 TFSDGFARSYVHDLRREGISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDW 120 T D + + + +LRR S TSL R FGV + + W Sbjct 282 TEDDPWPMAQITELRR---------SSHTSLPTAAIPR-FGVQTDQEEQLAKELEDTNKW 331 Query 121 SFDCLHFGEIS-RKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNA 178 D E+S +PL + F++ L + D L A+L + Y + YHN+ Sbjct 332 GLDVFKVAELSGNRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTLEGHYHSDVAYHNS 391 Query 179 LHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 +H A V LL + +DLE ++A A HD Sbjct 392 MHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHD 430 > mmu:225600 Pde6a, MGC25111, Pdea, nmf282; phosphodiesterase 6A, cGMP-specific, rod, alpha (EC:3.1.4.35); K08718 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35] Length=860 Score = 46.6 bits (109), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 8/103 (7%) Query 120 WSFDCLHFGEISRKPLCEI-----GFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENP 174 + + HF ++ PL E+ G + + + + ++ L F+ ++ Y+ Sbjct 501 YEINKFHFSDL---PLTELELVKCGIQMYYELRVVDKFHIPQEALVRFMYSLSKGYRRIT 557 Query 175 YHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 YHN HG V LL +++ Y +DLE ++ A+ CHD Sbjct 558 YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600 > mmu:110855 Pde6c, cpfl1; phosphodiesterase 6C, cGMP specific, cone, alpha prime (EC:3.1.4.35); K13757 cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:3.1.4.35] Length=836 Score = 46.2 bits (108), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 0/94 (0%) Query 124 CLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHGAT 183 C I+ L + G + ++ + + +VLT ++ V Y+ YHN HG Sbjct 510 CFSDFPITEHELVKCGLRLFLEINVVEKFKVPVEVLTRWMYTVRKGYRPVTYHNWRHGFN 569 Query 184 VCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 V LL ++++Y +DLE + A+ CHD Sbjct 570 VGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHD 603 > dre:100151215 phosphodiesterase 7A-like (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=490 Score = 46.2 bits (108), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 3/105 (2%) Query 115 KIGTDWSFDCLHFGEISR-KPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVT-DCYKE 172 K+G+ W+FD F ++ L + F +LS + L L + FL V D + + Sbjct 152 KVGS-WNFDIFLFDRLTNGNSLVFLTFHLLSQYGLIELFQLDMVKVRRFLVLVQEDYHNQ 210 Query 173 NPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 NPYHNA+H A V C L ++ + ++ + + +A+ HD Sbjct 211 NPYHNAVHAADVTQAMHCYLREPKLAQSLTSFDILLGLLAAATHD 255 > tgo:TGME49_110520 calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase, putative (EC:3.4.21.69 3.1.4.17) Length=1531 Score = 45.8 bits (107), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 13/112 (11%) Query 111 EQSAKIGTDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEI-SLH----RDVLTAFLEE 165 E IG W FD L F +S PL + L PEI SLH ++V+ L+ Sbjct 1155 EAQMAIGQVWDFDMLSFAALSPNPL-----VEVGLVLLLPEIDSLHCCTDQEVIV-LLQN 1208 Query 166 VTDCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 + Y +NPYH+ +H A V H CL+ L + S ++ +A+ HD Sbjct 1209 LQARYLQNPYHSQVHAAEVVHTAACLMRCLIPQR--SAFANLCTLVAAAAHD 1258 > mmu:238871 Pde4d, 9630011N22Rik, Dpde3; phosphodiesterase 4D, cAMP specific (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=747 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/141 (28%), Positives = 56/141 (39%), Gaps = 3/141 (2%) Query 79 ISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGEIS-RKPLCE 137 IS +KL +SL R FGV + + + W E+S +PL Sbjct 303 ISGVKKLMHSSSLTNSCIPR-FGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV 361 Query 138 IGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEMLQ 196 I I L + D L +L + D Y + YHN +H A V T LL Sbjct 362 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 421 Query 197 IREYMSDLEDISACIASLCHD 217 + +DLE ++A AS HD Sbjct 422 LEAVFTDLEILAAIFASAIHD 442 > dre:559332 pde6b; phosphodiesterase 6B, cGMP-specific, rod, beta; K13756 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:3.1.4.35] Length=854 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 6/96 (6%) Query 122 FDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENPYHNALHG 181 FDC L G + + + + ++VL F+ V+ Y+ YHN HG Sbjct 510 FDCTEL------QLVMCGIQMYYEVGVVKKFQVPQEVLVRFMYSVSKGYRRITYHNWRHG 563 Query 182 ATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 V LL ++++Y +DLE ++ A HD Sbjct 564 FNVGQTMFTLLTTGKLKQYYTDLEVMAMITAGFLHD 599 > pfa:MAL13P1.118 3',5'-cyclic nucleotide phosphodiesterase (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=1139 Score = 44.7 bits (104), Expect = 2e-04, Method: Composition-based stats. Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 4/103 (3%) Query 115 KIGTDWSFDCLHFGEISRKPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKENP 174 K+ +DW F+CL + + S P +I +++ + ++ +++ FL V Y P Sbjct 790 KLLSDWDFNCLTYFDESEYPFFDINLSLICTI----DHNIPINIIINFLCFVEKQYNNVP 845 Query 175 YHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 YHN +H V CL + L I + + + I+ +CHD Sbjct 846 YHNTIHATMVTQKFFCLAKKLGIYDDLEYKIKLVMFISGICHD 888 > xla:444562 pde4b, MGC83972; phosphodiesterase 4B, cAMP-specific; K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=721 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/141 (29%), Positives = 58/141 (41%), Gaps = 3/141 (2%) Query 79 ISRPRKLSRMTSLAARRKSRLFGVVESLSAMCEQSAKIGTDWSFDCLHFGEIS-RKPLCE 137 IS +KL +SL SR FGV M + + W + S +PL Sbjct 294 ISGVKKLKHSSSLNNTSMSR-FGVKTDYEDMLSKELEDLNKWGLNIFKVASYSCNRPLTC 352 Query 138 IGFAILSPFSLSPEISLHRDVLTAFLEEVTDCYKEN-PYHNALHGATVCHMTLCLLEMLQ 196 I +AI L + D L + + D Y + YHN+LH A V T LL Sbjct 353 IMYAIFQERDLLKTFKIPVDTLITYTMTLEDHYHSDVAYHNSLHAADVTQSTHVLLSTPA 412 Query 197 IREYMSDLEDISACIASLCHD 217 + +DLE ++A A+ HD Sbjct 413 LDAVFTDLEILAAIFAAAIHD 433 > hsa:5150 PDE7A, HCP1, PDE7; phosphodiesterase 7A (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=456 Score = 44.7 bits (104), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%) Query 115 KIGTDWSFDCLHFGEISR-KPLCEIGFAILSPFSLSPEISLHRDVLTAFLEEVT-DCYKE 172 K+G +W+FD F ++ L + F + S L L L FL + D + + Sbjct 124 KVG-NWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQ 182 Query 173 NPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 NPYHNA+H A V C L+ ++ ++ + + + IA+ HD Sbjct 183 NPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHD 227 > mmu:29863 Pde7b; phosphodiesterase 7B (EC:3.1.4.17); K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC:3.1.4.17] Length=446 Score = 44.7 bits (104), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 15/112 (13%) Query 114 AKIGTDWSFDCLHFGEISRKP-----LCEI--GFAILSPFSLSPEISLHRDVLTAFLEEV 166 +K+GT W FD F ++ LC + ++ F L ++LHR FL V Sbjct 110 SKVGT-WDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLD-MVTLHR-----FLVMV 162 Query 167 T-DCYKENPYHNALHGATVCHMTLCLLEMLQIREYMSDLEDISACIASLCHD 217 D + NPYHNA+H A V C L+ ++ +++ L+ + +A+ HD Sbjct 163 QEDYHGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHD 214 Lambda K H 0.324 0.137 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 7009334380 Database: egene_temp_file_orthology_annotation_similarity_blast_database_966 Posted date: Sep 16, 2011 8:45 PM Number of letters in database: 82,071,388 Number of sequences in database: 164,496 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40