bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0783_orf1
Length=126
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:... 239 1e-63
pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12... 209 1e-54
bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:... 189 1e-48
tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07... 167 5e-42
cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase... 164 5e-41
dre:561941 protein kinase, X-linked-like; K04345 protein kinas... 104 8e-23
tgo:TGME49_067540 protein kinase, putative (EC:4.1.1.70 2.7.11... 103 1e-22
hsa:5613 PRKX, PKX1; protein kinase, X-linked (EC:2.7.11.1); K... 102 3e-22
pfa:PFL2250c PKB; rac-beta serine/threonine protein kinase, Pf... 101 6e-22
cpv:cgd3_3040 protein kinase, cAMP-dependent, catalytic chain ... 100 1e-21
dre:566430 cGMP dependent protein kinase I 99.0 4e-21
dre:403000 pdpk1b, MGC77318, zgc:77318; 3-phosphoinositide dep... 98.6 5e-21
mmu:19108 Prkx, PKX1, Pkare; protein kinase, X-linked (EC:2.7.... 97.8 8e-21
dre:100125912 prkg2; protein kinase, cGMP-dependent, type II (... 97.4 1e-20
sce:YKL166C TPK3; Tpk3p (EC:2.7.11.11); K04345 protein kinase ... 97.1 1e-20
cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);... 97.1 1e-20
cel:ZK909.2 kin-1; protein KINase family member (kin-1); K0434... 97.1 1e-20
dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,... 96.7 2e-20
hsa:5170 PDPK1, MGC20087, MGC35290, PDK1, PRO0461; 3-phosphoin... 96.3 2e-20
hsa:5568 PRKACG, KAPG, PKACg; protein kinase, cAMP-dependent, ... 95.9 3e-20
mmu:18607 Pdpk1, Pdk1; 3-phosphoinositide dependent protein ki... 95.9 3e-20
cel:C09G4.2 hypothetical protein 95.9 3e-20
mmu:18749 Prkacb, Pkacb; protein kinase, cAMP dependent, catal... 95.5 4e-20
dre:556339 protein kinase, cGMP-dependent, type II-like; K0737... 95.1 5e-20
xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent, ty... 95.1 5e-20
sce:YPL203W TPK2, PKA2, PKA3, YKR1; Tpk2p (EC:2.7.11.11); K043... 95.1 5e-20
mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b; p... 95.1 5e-20
hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK, P... 95.1 5e-20
dre:553164 lats1, Lats, MGC123219, si:dkey-181i3.5, wu:fc19a11... 94.7 6e-20
hsa:5567 PRKACB, DKFZp781I2452, MGC41879, MGC9320, PKACB; prot... 94.7 6e-20
hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,... 94.7 7e-20
mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II; p... 94.4 8e-20
dre:567674 lats2; si:ch211-173o4.2 (EC:2.7.11.1); K08791 LATS,... 94.0 1e-19
hsa:9113 LATS1, WARTS, wts; LATS, large tumor suppressor, homo... 93.6 1e-19
xla:380388 prkacb, MGC53163, XPKAbeta, kin-1, pkacb, prkacba; ... 93.6 1e-19
mmu:16798 Lats1, AW208599; large tumor suppressor (EC:2.7.11.1... 93.6 2e-19
hsa:5566 PRKACA, MGC102831, MGC48865, PKACA; protein kinase, c... 93.2 2e-19
sce:YJL164C TPK1, PKA1, SRA3; Tpk1p (EC:2.7.11.11); K04345 pro... 92.8 3e-19
cel:T20F10.1 wts-1; WarTS (Drosophila) protein kinase homolog ... 92.4 3e-19
hsa:100509979 putative 3-phosphoinositide-dependent protein ki... 92.4 3e-19
mmu:18747 Prkaca, Cs, PKA, PKCD, Pkaca; protein kinase, cAMP d... 92.4 4e-19
ath:AT1G30640 protein kinase, putative 92.0 4e-19
ath:AT3G08720 S6K2; S6K2 (ARABIDOPSIS THALIANA SERINE/THREONIN... 91.3 6e-19
cel:C12D8.10 akt-1; AKT kinase family member (akt-1); K04456 R... 91.3 6e-19
sce:YHR205W SCH9, HRM2, KOM1; Protein kinase involved in trans... 91.3 6e-19
dre:563147 prkacbb, MGC110804, prkacb, wu:fz54b03, zgc:110804;... 91.3 7e-19
ath:AT1G03920 protein kinase, putative 91.3 7e-19
dre:445076 prkacab, zgc:91856; protein kinase, cAMP-dependent,... 90.9 8e-19
xla:414693 stk38l, MGC83214, ndr2; serine/threonine kinase 38 ... 90.9 8e-19
dre:564064 prkacaa, zgc:158799; protein kinase, cAMP-dependent... 90.9 9e-19
> tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=994
Score = 239 bits (610), Expect = 1e-63, Method: Compositional matrix adjust.
Identities = 116/126 (92%), Positives = 122/126 (96%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
KVEF+DLQVVRVVGRGTFGTVKLV+H+PT IRYALKCVSRRSV+AL+QQ HIRLEREIMA
Sbjct 678 KVEFQDLQVVRVVGRGTFGTVKLVRHVPTDIRYALKCVSRRSVIALSQQQHIRLEREIMA 737
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
ENDHPFIIRLVRTFRDK+FLYFLTELVTGGELYDAIRKLGLL R QAQFYLASIVLAIEY
Sbjct 738 ENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLARSQAQFYLASIVLAIEY 797
Query 121 LHERNI 126
LHERNI
Sbjct 798 LHERNI 803
> pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=853
Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats.
Identities = 98/126 (77%), Positives = 112/126 (88%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
KVE +L+ R++GRGTFGTVKLV H PTKIRYALKCVS+RS++ LNQQ++I+LEREI A
Sbjct 535 KVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
ENDHPFIIRLVRTF+D + YFLTELVTGGELYDAIRKLGLL + QAQFYL SI+LAIEY
Sbjct 595 ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654
Query 121 LHERNI 126
LHERNI
Sbjct 655 LHERNI 660
> bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:2.7.11.1);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=887
Score = 189 bits (481), Expect = 1e-48, Method: Compositional matrix adjust.
Identities = 90/130 (69%), Positives = 110/130 (84%), Gaps = 4/130 (3%)
Query 1 KVEFKDLQVVRVVGRG----TFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLER 56
KV+F +L+V++ +G G TFGTVKLV H PT +R+ALKCVSR+ + AL QQ HI+LER
Sbjct 567 KVQFHELKVIKTIGHGKDLGTFGTVKLVDHEPTGVRFALKCVSRKCIRALKQQKHIKLER 626
Query 57 EIMAENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVL 116
EIMA+NDHPFII+LV+TF+D+ +YFLTEL+TGGELYDAIRK+GLL R QAQFY+ASIVL
Sbjct 627 EIMAQNDHPFIIQLVKTFKDESNVYFLTELITGGELYDAIRKIGLLSRPQAQFYIASIVL 686
Query 117 AIEYLHERNI 126
A EYLHER I
Sbjct 687 AFEYLHERQI 696
> tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=892
Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats.
Identities = 82/136 (60%), Positives = 107/136 (78%), Gaps = 10/136 (7%)
Query 1 KVEFKDLQVVRVVGRG----------TFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQD 50
KV F DL VR +G+G TFGTV LV H P+++R+ALKCVS++ +V QQ
Sbjct 576 KVLFDDLHTVRQIGKGIKLSNTISSGTFGTVNLVVHQPSQLRFALKCVSKKLIVYNKQQK 635
Query 51 HIRLEREIMAENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFY 110
+I++E+EIMA+NDHPFII+LV+TF+D++ +YFLTELVTGGEL+DA+RKL LL + QAQFY
Sbjct 636 NIKMEKEIMAQNDHPFIIQLVKTFKDEENIYFLTELVTGGELFDALRKLELLKKPQAQFY 695
Query 111 LASIVLAIEYLHERNI 126
L SI+LA+EYLHER I
Sbjct 696 LGSIILALEYLHERQI 711
> cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase
with 3 cNMP binding domains and a Ser/Thr kinase domain ;
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=965
Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats.
Identities = 72/126 (57%), Positives = 105/126 (83%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
+V+ DL++++ +G+GTFG V +V++I + +YALK +S+ ++ALN Q H++LER I+A
Sbjct 616 RVQMSDLKILQTIGKGTFGVVYMVENIKSGNKYALKKISKSRILALNMQAHVKLERSILA 675
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
NDHPFII+LVRTF+D + +Y LTEL+ GGELYDA++++GLL RYQAQFY+ SI+LA+EY
Sbjct 676 LNDHPFIIKLVRTFKDSENIYLLTELIPGGELYDALQRIGLLTRYQAQFYIGSIILALEY 735
Query 121 LHERNI 126
LHER+I
Sbjct 736 LHERSI 741
> dre:561941 protein kinase, X-linked-like; K04345 protein kinase
A [EC:2.7.11.11]
Length=357
Score = 104 bits (259), Expect = 8e-23, Method: Compositional matrix adjust.
Identities = 53/121 (43%), Positives = 70/121 (57%), Gaps = 0/121 (0%)
Query 6 DLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHP 65
DL + VG GTFG V LV+ T+ +ALK + V+ L Q+ H+ E+E++ E +HP
Sbjct 47 DLDTIATVGTGTFGRVFLVKDKKTRGFFALKAMKIPDVIRLKQEQHVHNEKEVLTEVNHP 106
Query 66 FIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERN 125
F++RL T D FLY L E V GGEL+ +R G FY A IV AIEYLH +
Sbjct 107 FLVRLFWTHHDDRFLYMLMEYVNGGELFSYLRSRGHFSNSTGMFYSAEIVCAIEYLHSKE 166
Query 126 I 126
I
Sbjct 167 I 167
> tgo:TGME49_067540 protein kinase, putative (EC:4.1.1.70 2.7.11.13)
Length=951
Score = 103 bits (258), Expect = 1e-22, Method: Composition-based stats.
Identities = 48/122 (39%), Positives = 78/122 (63%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D Q++RV+G+G++G V LVQ YA+K + + +VV NQ +H R ER+++A H
Sbjct 457 EDFQLLRVIGKGSYGKVMLVQFHQDGGVYAMKMLRKEAVVRRNQVEHTRTERDVLAWVSH 516
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PFI+++ F+ + LYF+ E GGEL+ + + G Y A FY A ++LA+E+LH+
Sbjct 517 PFIVQMHYAFQTRKKLYFVLEYCPGGELFFHLSRAGRFKEYAACFYAAEVLLALEHLHKY 576
Query 125 NI 126
N+
Sbjct 577 NV 578
> hsa:5613 PRKX, PKX1; protein kinase, X-linked (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=358
Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust.
Identities = 52/122 (42%), Positives = 70/122 (57%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + VG GTFG V LV+ K +ALK +S V+ L Q+ H+ E+ ++ E H
Sbjct 47 QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF+IRL T+ D+ FLY L E V GGEL+ +R G FY A I+ AIEYLH +
Sbjct 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
Query 125 NI 126
I
Sbjct 167 EI 168
> pfa:PFL2250c PKB; rac-beta serine/threonine protein kinase,
PfPKB (EC:2.7.1.-); K08286 protein-serine/threonine kinase [EC:2.7.11.-]
Length=735
Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats.
Identities = 46/126 (36%), Positives = 79/126 (62%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
++ + ++V+G G++G V LV+H+ K YA+K + + ++++ NQ +H ++ER I+
Sbjct 397 RIRPESFNYLKVIGEGSYGKVMLVKHVQNKKLYAMKILRKENILSRNQLEHTKVERNILK 456
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
HPFI+++ F+ K LYF+ E GGEL+ + KL A+FY + I+LA+EY
Sbjct 457 CVSHPFIVKMYYAFQTKQKLYFILEYCPGGELFFHLSKLREFSEETAKFYSSEIILALEY 516
Query 121 LHERNI 126
LH+ NI
Sbjct 517 LHDLNI 522
> cpv:cgd3_3040 protein kinase, cAMP-dependent, catalytic chain
; K04345 protein kinase A [EC:2.7.11.11]
Length=392
Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats.
Identities = 47/126 (37%), Positives = 72/126 (57%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K D Q++R +G G+FG V L +H YA+K + + V+ Q DHI E+ I++
Sbjct 79 KYSIDDFQLIRTLGTGSFGRVFLSKHKEDNSIYAIKRLKKSVVIRQKQVDHITNEKAILS 138
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
HPF++R+ TF+D +LY + E V GGE + +R+ ++FY A +VL EY
Sbjct 139 RIKHPFLVRMFGTFKDDRYLYIMMEFVIGGEFFTYLRRCRHFDNETSRFYAAQVVLMFEY 198
Query 121 LHERNI 126
LH +NI
Sbjct 199 LHGKNI 204
> dre:566430 cGMP dependent protein kinase I
Length=528
Score = 99.0 bits (245), Expect = 4e-21, Method: Composition-based stats.
Identities = 49/122 (40%), Positives = 71/122 (58%), Gaps = 1/122 (0%)
Query 6 DLQVVRVVGRGTFGTVKLVQHIPTKIR-YALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
D ++ +G G FG V+LVQ + + +A+K + +R +V QQ+HIR E++IM E
Sbjct 216 DFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHS 275
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
FI+RL RTF+D +LY L E GGEL+ +R G +FY A +V A YLH +
Sbjct 276 DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSK 335
Query 125 NI 126
I
Sbjct 336 GI 337
> dre:403000 pdpk1b, MGC77318, zgc:77318; 3-phosphoinositide dependent
protein kinase-1b (EC:2.7.11.1); K06276 3-phosphoinositide
dependent protein kinase-1 [EC:2.7.11.1]
Length=537
Score = 98.6 bits (244), Expect = 5e-21, Method: Composition-based stats.
Identities = 46/122 (37%), Positives = 74/122 (60%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + +++G G+F TV L + T YA+K + +R ++ N+ +++ ER+IM+ DH
Sbjct 58 EDFRFGKILGEGSFSTVVLAKEHTTGKEYAIKILEKRHIMKENKAQYVKRERDIMSHLDH 117
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF ++L TF+D++ LYF GEL IRK+G +FY A IV A+EYLH++
Sbjct 118 PFFVKLYFTFQDEEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHQK 177
Query 125 NI 126
I
Sbjct 178 GI 179
> mmu:19108 Prkx, PKX1, Pkare; protein kinase, X-linked (EC:2.7.11.1);
K04345 protein kinase A [EC:2.7.11.11]
Length=355
Score = 97.8 bits (242), Expect = 8e-21, Method: Compositional matrix adjust.
Identities = 50/122 (40%), Positives = 70/122 (57%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + VG GTFG V LV+ + ALK +S V+ L Q+ H++ E+ ++ E +H
Sbjct 44 QDWDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINH 103
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF+I+L+ T D FLY L E V GGEL+ +R G + FY IV AIEYLH +
Sbjct 104 PFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSK 163
Query 125 NI 126
I
Sbjct 164 EI 165
> dre:100125912 prkg2; protein kinase, cGMP-dependent, type II
(EC:2.7.11.1); K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=768
Score = 97.4 bits (241), Expect = 1e-20, Method: Composition-based stats.
Identities = 44/125 (35%), Positives = 73/125 (58%), Gaps = 0/125 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAE 61
+ F L+ + +G G FG V+LV+ + +ALKC+ +R +V Q++HI ER I+ E
Sbjct 454 IPFTCLEAIATLGVGGFGRVELVKLKNENVTFALKCIKKRHIVDNRQEEHIYSERRILLE 513
Query 62 NDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYL 121
+ PFI+++ RT++D ++Y L E GGE++ +R G Y A+F + + A +YL
Sbjct 514 TNCPFIVKMYRTYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYL 573
Query 122 HERNI 126
H I
Sbjct 574 HNNGI 578
> sce:YKL166C TPK3; Tpk3p (EC:2.7.11.11); K04345 protein kinase
A [EC:2.7.11.11]
Length=398
Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats.
Identities = 46/126 (36%), Positives = 74/126 (58%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K D Q++R +G G+FG V L++ YALK + + ++V L Q +H ER +++
Sbjct 82 KYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLS 141
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
HPFIIR+ TF+D ++ + + + GGEL+ +RK A+FY A + LA+EY
Sbjct 142 IVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 201
Query 121 LHERNI 126
LH ++I
Sbjct 202 LHSKDI 207
> cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=780
Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust.
Identities = 50/127 (39%), Positives = 79/127 (62%), Gaps = 1/127 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIR-YALKCVSRRSVVALNQQDHIRLEREIM 59
+V K+++ + +G G FG V+LV K + +ALK + ++ +V QQ+HI ER IM
Sbjct 463 QVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIM 522
Query 60 AENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIE 119
E +I++L +TFRD+ F+Y L E+ GGEL+ +R G Y A+FY+A ++ +E
Sbjct 523 METSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLE 582
Query 120 YLHERNI 126
YLH +NI
Sbjct 583 YLHRKNI 589
> cel:ZK909.2 kin-1; protein KINase family member (kin-1); K04345
protein kinase A [EC:2.7.11.11]
Length=381
Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats.
Identities = 43/121 (35%), Positives = 73/121 (60%), Gaps = 0/121 (0%)
Query 6 DLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHP 65
D ++ +G G+FG V LV+H + YA+K + ++ VV L Q +H E+ I+ D P
Sbjct 73 DFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFP 132
Query 66 FIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERN 125
F++ + +F+D LY + E ++GGE++ +R++G ++FY A IVLA EYLH +
Sbjct 133 FLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLD 192
Query 126 I 126
+
Sbjct 193 L 193
> dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,
cGMP-dependent, type Ia (EC:2.7.11.1); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=667
Score = 96.7 bits (239), Expect = 2e-20, Method: Composition-based stats.
Identities = 49/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIR-YALKCVSRRSVVALNQQDHIRLEREIMA 60
+ D ++ +G G FG V+LVQ +++ +A+K + +R +V QQ+HIR E+ IM
Sbjct 351 LNLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQ 410
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
E FI+RL RTF+D +LY L E GGEL+ +R G +FY A +V A Y
Sbjct 411 EAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAY 470
Query 121 LHERNI 126
LH + I
Sbjct 471 LHSKGI 476
> hsa:5170 PDPK1, MGC20087, MGC35290, PDK1, PRO0461; 3-phosphoinositide
dependent protein kinase-1 (EC:2.7.11.1); K06276 3-phosphoinositide
dependent protein kinase-1 [EC:2.7.11.1]
Length=556
Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats.
Identities = 45/122 (36%), Positives = 72/122 (59%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + +++G G+F TV L + + T YA+K + +R ++ N+ ++ ER++M+ DH
Sbjct 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 139
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF ++L TF+D + LYF GEL IRK+G +FY A IV A+EYLH +
Sbjct 140 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 199
Query 125 NI 126
I
Sbjct 200 GI 201
> hsa:5568 PRKACG, KAPG, PKACg; protein kinase, cAMP-dependent,
catalytic, gamma (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust.
Identities = 44/117 (37%), Positives = 75/117 (64%), Gaps = 0/117 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
+R +G G+FG V LV+H T YA+K ++++ VV + Q +HI E+ I+ D PF+++
Sbjct 47 LRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVK 106
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERNI 126
L +F+D +LY + E V GGE++ ++++G A FY A +VLA++YLH ++
Sbjct 107 LQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDL 163
> mmu:18607 Pdpk1, Pdk1; 3-phosphoinositide dependent protein
kinase 1 (EC:2.7.11.1); K06276 3-phosphoinositide dependent
protein kinase-1 [EC:2.7.11.1]
Length=522
Score = 95.9 bits (237), Expect = 3e-20, Method: Composition-based stats.
Identities = 45/122 (36%), Positives = 72/122 (59%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + +++G G+F TV L + + T YA+K + +R ++ N+ ++ ER++M+ DH
Sbjct 83 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 142
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF ++L TF+D + LYF GEL IRK+G +FY A IV A+EYLH +
Sbjct 143 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 202
Query 125 NI 126
I
Sbjct 203 GI 204
> cel:C09G4.2 hypothetical protein
Length=617
Score = 95.9 bits (237), Expect = 3e-20, Method: Composition-based stats.
Identities = 48/125 (38%), Positives = 77/125 (61%), Gaps = 1/125 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAE 61
VE +DLQ V +G G FG V+LV+ ++ YALK +++ +V Q+ H+ ER I+ +
Sbjct 305 VELEDLQRVSTLGMGGFGRVELVRSASSRT-YALKIMNKAHIVETKQESHVVSERRILMQ 363
Query 62 NDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYL 121
D+ +I+R+ +T+RD + +Y L E GGE++ +RK G +FY A + A+EYL
Sbjct 364 CDNDYIVRMYKTYRDSEKIYMLMEPCLGGEIWTILRKKGRFDNDLTRFYCAGAMEALEYL 423
Query 122 HERNI 126
H +NI
Sbjct 424 HRKNI 428
> mmu:18749 Prkacb, Pkacb; protein kinase, cAMP dependent, catalytic,
beta (EC:2.7.11.11); K04345 protein kinase A [EC:2.7.11.11]
Length=338
Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust.
Identities = 46/122 (37%), Positives = 74/122 (60%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + + +G G+FG V LV+H T+ YA+K + ++ VV L Q +H E+ I+ +
Sbjct 29 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEF 88
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF++RL +F+D LY + E V GGE++ +R++G A+FY A IVL EYLH
Sbjct 89 PFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 148
Query 125 NI 126
++
Sbjct 149 DL 150
> dre:556339 protein kinase, cGMP-dependent, type II-like; K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=730
Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 48/124 (38%), Positives = 75/124 (60%), Gaps = 1/124 (0%)
Query 4 FKDLQVVRVVGRGTFGTVKLVQHIPTK-IRYALKCVSRRSVVALNQQDHIRLEREIMAEN 62
K+LQVV +G G FG V+LV+ ++ +ALKC+ ++ +V QQ+HI E+ I+ +
Sbjct 417 LKELQVVATLGMGGFGRVELVKLKDSEDTAFALKCIKKKHIVDTRQQEHIYSEKIILQQT 476
Query 63 DHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLH 122
+ FI+RL RTFRD F+Y L E+ GGEL+ +R + A+F ++ A +YLH
Sbjct 477 NSNFIVRLFRTFRDDKFVYMLLEVCLGGELWSLLRDMSCFDEPTARFCTGCVLEAFDYLH 536
Query 123 ERNI 126
+ I
Sbjct 537 GKGI 540
> xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent,
type II (EC:2.7.11.1); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=783
Score = 95.1 bits (235), Expect = 5e-20, Method: Composition-based stats.
Identities = 45/120 (37%), Positives = 72/120 (60%), Gaps = 0/120 (0%)
Query 4 FKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAEND 63
F++L++V +G G FG V+LV+ + +A+KC+ +R +V QQ+HI E+ I+ E
Sbjct 471 FENLEIVTTLGVGGFGRVELVKVKYENLVFAMKCIKKRHIVDNMQQEHIHSEKNILKEAC 530
Query 64 HPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
PFI++L TF+D ++Y L E GGEL+ +R G A+F + A+EYLH+
Sbjct 531 SPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDETTAKFCTGCVTEALEYLHQ 590
> sce:YPL203W TPK2, PKA2, PKA3, YKR1; Tpk2p (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=380
Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 46/126 (36%), Positives = 75/126 (59%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K D Q++R +G G+FG V LV+ + YA+K + ++ VV + Q +H ER ++
Sbjct 64 KYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLK 123
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
+HPF+IR+ TF+D ++ + + + GGEL+ +RK A+FY A ++LA+EY
Sbjct 124 LVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEY 183
Query 121 LHERNI 126
LH NI
Sbjct 184 LHAHNI 189
> mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b;
protein kinase, cGMP-dependent, type I (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 95.1 bits (235), Expect = 5e-20, Method: Composition-based stats.
Identities = 48/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIR-YALKCVSRRSVVALNQQDHIRLEREIMA 60
++ D ++ +G G FG V+LVQ + + +A+K + +R +V QQ+HIR E++IM
Sbjct 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
FI+RL RTF+D +LY L E GGEL+ +R G +FY A +V A Y
Sbjct 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
Query 121 LHERNI 126
LH + I
Sbjct 475 LHSKGI 480
> hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK,
PKG, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha; protein kinase,
cGMP-dependent, type I (EC:2.7.11.12); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 95.1 bits (235), Expect = 5e-20, Method: Composition-based stats.
Identities = 48/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIR-YALKCVSRRSVVALNQQDHIRLEREIMA 60
++ D ++ +G G FG V+LVQ + + +A+K + +R +V QQ+HIR E++IM
Sbjct 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
FI+RL RTF+D +LY L E GGEL+ +R G +FY A +V A Y
Sbjct 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
Query 121 LHERNI 126
LH + I
Sbjct 475 LHSKGI 480
> dre:553164 lats1, Lats, MGC123219, si:dkey-181i3.5, wu:fc19a11,
zgc:123219; LATS, large tumor suppressor, homolog 1 (Drosophila)
(EC:2.7.11.1); K08791 LATS, large tumor suppressor
[EC:2.7.11.1]
Length=1068
Score = 94.7 bits (234), Expect = 6e-20, Method: Composition-based stats.
Identities = 40/114 (35%), Positives = 75/114 (65%), Gaps = 0/114 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G FG V L + + T YA+K + ++ V+ NQ H++ ER+I+AE D+ +++R
Sbjct 648 IKTLGIGAFGEVCLARKVDTGALYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVR 707
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
L +F+DKD LYF+ + + GG++ + ++G+ AQFY+A ++ A+E +H+
Sbjct 708 LYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFQEDLAQFYIAELICAVESVHK 761
> hsa:5567 PRKACB, DKFZp781I2452, MGC41879, MGC9320, PKACB; protein
kinase, cAMP-dependent, catalytic, beta (EC:2.7.11.11);
K04345 protein kinase A [EC:2.7.11.11]
Length=351
Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust.
Identities = 46/122 (37%), Positives = 73/122 (59%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + + +G G+FG V LV+H T+ YA+K + ++ VV L Q +H E+ I+ +
Sbjct 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF++RL F+D LY + E V GGE++ +R++G A+FY A IVL EYLH
Sbjct 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
Query 125 NI 126
++
Sbjct 162 DL 163
> hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,
type II (EC:2.7.11.12); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=762
Score = 94.7 bits (234), Expect = 7e-20, Method: Composition-based stats.
Identities = 43/123 (34%), Positives = 74/123 (60%), Gaps = 0/123 (0%)
Query 4 FKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAEND 63
F++L+++ +G G FG V+LV+ + +A+KC+ ++ +V QQ+H+ E+ I+ E
Sbjct 450 FQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELC 509
Query 64 HPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
PFI++L RTF+D ++Y L E GGEL+ +R G ++F +A + A +YLH
Sbjct 510 SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHR 569
Query 124 RNI 126
I
Sbjct 570 LGI 572
> mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II;
protein kinase, cGMP-dependent, type II (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=762
Score = 94.4 bits (233), Expect = 8e-20, Method: Composition-based stats.
Identities = 43/123 (34%), Positives = 74/123 (60%), Gaps = 0/123 (0%)
Query 4 FKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAEND 63
F++L+++ +G G FG V+LV+ + +A+KC+ ++ +V QQ+H+ E+ I+ E
Sbjct 450 FQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELC 509
Query 64 HPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
PFI++L RTF+D ++Y L E GGEL+ +R G ++F +A + A +YLH
Sbjct 510 SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHR 569
Query 124 RNI 126
I
Sbjct 570 LGI 572
> dre:567674 lats2; si:ch211-173o4.2 (EC:2.7.11.1); K08791 LATS,
large tumor suppressor [EC:2.7.11.1]
Length=1140
Score = 94.0 bits (232), Expect = 1e-19, Method: Composition-based stats.
Identities = 40/114 (35%), Positives = 75/114 (65%), Gaps = 0/114 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G FG V L + + T YA+K + ++ V+ NQ H++ ER+I+AE D+ +++R
Sbjct 711 IKTLGIGAFGEVCLTRKVDTGALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVR 770
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
L +F+D+D LYF+ + + GG++ + ++G+ A+FY+A + LAIE +H+
Sbjct 771 LYYSFQDRDNLYFVMDYIPGGDMMSLLIRMGVFPEVLARFYVAELTLAIESVHK 824
> hsa:9113 LATS1, WARTS, wts; LATS, large tumor suppressor, homolog
1 (Drosophila) (EC:2.7.11.1); K08791 LATS, large tumor
suppressor [EC:2.7.11.1]
Length=1130
Score = 93.6 bits (231), Expect = 1e-19, Method: Composition-based stats.
Identities = 40/114 (35%), Positives = 74/114 (64%), Gaps = 0/114 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G FG V L + + TK YA K + ++ V+ NQ H++ ER+I+AE D+ +++R
Sbjct 708 IKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVR 767
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
L +F+DKD LYF+ + + GG++ + ++G+ A+FY+A + A+E +H+
Sbjct 768 LYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHK 821
> xla:380388 prkacb, MGC53163, XPKAbeta, kin-1, pkacb, prkacba;
protein kinase, cAMP-dependent, catalytic, beta; K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust.
Identities = 45/121 (37%), Positives = 72/121 (59%), Gaps = 0/121 (0%)
Query 6 DLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHP 65
D ++ +G G+FG V LV+H + YA+K + ++ VV L Q +H E+ I+ + P
Sbjct 43 DFDRMKTLGTGSFGRVMLVKHKGAEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102
Query 66 FIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERN 125
F++RL +F+D LY + E V GGE++ +R++G A+FY A IVL EYLH +
Sbjct 103 FLVRLEYSFKDNSNLYMIMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162
Query 126 I 126
+
Sbjct 163 L 163
> mmu:16798 Lats1, AW208599; large tumor suppressor (EC:2.7.11.1);
K08791 LATS, large tumor suppressor [EC:2.7.11.1]
Length=1129
Score = 93.6 bits (231), Expect = 2e-19, Method: Composition-based stats.
Identities = 40/114 (35%), Positives = 74/114 (64%), Gaps = 0/114 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G FG V L + + TK YA K + ++ V+ NQ H++ ER+I+AE D+ +++R
Sbjct 707 IKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVR 766
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHE 123
L +F+DKD LYF+ + + GG++ + ++G+ A+FY+A + A+E +H+
Sbjct 767 LYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHK 820
> hsa:5566 PRKACA, MGC102831, MGC48865, PKACA; protein kinase,
cAMP-dependent, catalytic, alpha (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 44/113 (38%), Positives = 69/113 (61%), Gaps = 0/113 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G+FG V LV+H T YA+K + ++ VV L Q +H E+ I+ + PF+++
Sbjct 47 IKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLH 122
L +F+D LY + E V GGE++ +R++G A+FY A IVL EYLH
Sbjct 107 LEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
> sce:YJL164C TPK1, PKA1, SRA3; Tpk1p (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=397
Score = 92.8 bits (229), Expect = 3e-19, Method: Composition-based stats.
Identities = 45/125 (36%), Positives = 75/125 (60%), Gaps = 0/125 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAE 61
+ +K+ Q++R +G G+FG V L++ YA+K + + VV L Q +H ER +++
Sbjct 82 IVYKNFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSI 141
Query 62 NDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYL 121
HPFIIR+ TF+D ++ + + + GGEL+ +RK A+FY A + LA+EYL
Sbjct 142 VTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 201
Query 122 HERNI 126
H ++I
Sbjct 202 HSKDI 206
> cel:T20F10.1 wts-1; WarTS (Drosophila) protein kinase homolog
family member (wts-1)
Length=908
Score = 92.4 bits (228), Expect = 3e-19, Method: Composition-based stats.
Identities = 45/122 (36%), Positives = 72/122 (59%), Gaps = 0/122 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K+ V+ +G G FG V LV+ T+ YA+K + + V+ Q H++ ER+I+A
Sbjct 496 KMSKSHFTVISHIGVGAFGKVSLVRKNDTRKVYAMKSLEKADVIMKQQAAHVKAERDILA 555
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
E D P+I+RL +F+D LYF+ E V GG++ + + G+ A+FY+A + AIEY
Sbjct 556 EADSPWIVRLFFSFQDDACLYFIMEYVPGGDMMTLLIQKGIFEEDLARFYIAELACAIEY 615
Query 121 LH 122
+H
Sbjct 616 VH 617
> hsa:100509979 putative 3-phosphoinositide-dependent protein
kinase 2-like
Length=442
Score = 92.4 bits (228), Expect = 3e-19, Method: Composition-based stats.
Identities = 44/122 (36%), Positives = 70/122 (57%), Gaps = 0/122 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D + +++G G+F TV L + + T YA+K + +R ++ N+ ++ ER++M+ DH
Sbjct 99 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 158
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHER 124
PF ++L TF+ LYF GEL IRK+G +FY A IV A+EYLH +
Sbjct 159 PFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 218
Query 125 NI 126
I
Sbjct 219 GI 220
> mmu:18747 Prkaca, Cs, PKA, PKCD, Pkaca; protein kinase, cAMP
dependent, catalytic, alpha (EC:2.7.11.11); K04345 protein
kinase A [EC:2.7.11.11]
Length=351
Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust.
Identities = 43/113 (38%), Positives = 69/113 (61%), Gaps = 0/113 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G+FG V LV+H + YA+K + ++ VV L Q +H E+ I+ + PF+++
Sbjct 47 IKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLH 122
L +F+D LY + E V GGE++ +R++G A+FY A IVL EYLH
Sbjct 107 LEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
> ath:AT1G30640 protein kinase, putative
Length=562
Score = 92.0 bits (227), Expect = 4e-19, Method: Composition-based stats.
Identities = 40/125 (32%), Positives = 76/125 (60%), Gaps = 0/125 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K+ D +++ ++GRG FG V++ + T YA+K + + ++ Q +H++ ER ++A
Sbjct 114 KMGVDDFELLSIIGRGAFGEVRICKEKSTGSVYAMKKLKKSEMLRRGQVEHVKAERNVLA 173
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
E D PFI++L +F+D + LY + E + GG++ + + L + +FY+A +LAIE
Sbjct 174 EVDSPFIVKLCYSFQDDEHLYLIMEYLPGGDMMTLLMRKDTLREDETRFYVAQTILAIES 233
Query 121 LHERN 125
+H+ N
Sbjct 234 IHKHN 238
> ath:AT3G08720 S6K2; S6K2 (ARABIDOPSIS THALIANA SERINE/THREONINE
PROTEIN KINASE 2); kinase/ protein kinase
Length=471
Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats.
Identities = 45/125 (36%), Positives = 75/125 (60%), Gaps = 0/125 (0%)
Query 2 VEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAE 61
V +D +V++VVG+G FG V V+ T YA+K + + +V N ++++ ER+I+ +
Sbjct 135 VGIEDFEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTK 194
Query 62 NDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYL 121
DHPFI++L +F+ K LY + + + GG L+ + GL A+ Y A IV A+ +L
Sbjct 195 IDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHL 254
Query 122 HERNI 126
HE+ I
Sbjct 255 HEKGI 259
> cel:C12D8.10 akt-1; AKT kinase family member (akt-1); K04456
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Length=541
Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats.
Identities = 43/126 (34%), Positives = 73/126 (57%), Gaps = 0/126 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K+ +D ++V+G+GTFG V L + T+ YA+K + + ++A + H E ++
Sbjct 187 KITMEDFDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQ 246
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
HPF+ L +F+++ +L F+ + GGEL+ +RK G +A+FY A IVLA+ Y
Sbjct 247 RCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGY 306
Query 121 LHERNI 126
LH +I
Sbjct 307 LHRCDI 312
> sce:YHR205W SCH9, HRM2, KOM1; Protein kinase involved in transcriptional
activation of osmostress-responsive genes; regulates
G1 progression, cAPK activity, nitrogen activation of
the FGM pathway; involved in life span regulation; homologous
to mammalian Akt/PKB (EC:2.7.11.1); K08286 protein-serine/threonine
kinase [EC:2.7.11.-]
Length=824
Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats.
Identities = 47/125 (37%), Positives = 80/125 (64%), Gaps = 3/125 (2%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIM---AE 61
+D +V+R++G+GTFG V V+ T+ YA+K +S++ +V N+ H ER I+ A
Sbjct 410 QDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTAS 469
Query 62 NDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYL 121
PFI+ L +F+ LY +T+ ++GGEL+ ++K G +A+FY+A +VLA+E+L
Sbjct 470 KSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHL 529
Query 122 HERNI 126
H+ +I
Sbjct 530 HDNDI 534
> dre:563147 prkacbb, MGC110804, prkacb, wu:fz54b03, zgc:110804;
protein kinase, cAMP-dependent, catalytic, beta b; K04345
protein kinase A [EC:2.7.11.11]
Length=351
Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust.
Identities = 45/121 (37%), Positives = 69/121 (57%), Gaps = 0/121 (0%)
Query 6 DLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHP 65
D + +G G+FG V LV+H + YA+K + ++ VV L Q +H E+ I+ P
Sbjct 43 DFDRQKTLGTGSFGRVLLVKHKASDQYYAMKVLDKQKVVKLKQVEHTLNEKRILQAVSFP 102
Query 66 FIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERN 125
F++RL F+D LY + E V GGE++ +R++G A+FY A IVL EYLH +
Sbjct 103 FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162
Query 126 I 126
+
Sbjct 163 L 163
> ath:AT1G03920 protein kinase, putative
Length=569
Score = 91.3 bits (225), Expect = 7e-19, Method: Composition-based stats.
Identities = 42/125 (33%), Positives = 78/125 (62%), Gaps = 0/125 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
K+ D +++ ++G+G FG V++V+ I T +A+K + + ++ Q +H+R ER ++A
Sbjct 131 KMGADDFELLTMIGKGAFGEVRVVREINTGHVFAMKKLKKSEMLRRGQVEHVRAERNLLA 190
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
E D I++L +F+D ++LY + E + GG++ + + L +A+FY+A VLAIE
Sbjct 191 EVDSNCIVKLYCSFQDNEYLYLIMEYLPGGDMMTLLMRKDTLSEDEAKFYIAESVLAIES 250
Query 121 LHERN 125
+H RN
Sbjct 251 IHNRN 255
> dre:445076 prkacab, zgc:91856; protein kinase, cAMP-dependent,
catalytic, alpha, genome duplicate b (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=351
Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust.
Identities = 44/118 (37%), Positives = 71/118 (60%), Gaps = 0/118 (0%)
Query 5 KDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDH 64
+D ++ +G G+FG V LV+H T YA+K ++++ VV L Q +H E+ I+
Sbjct 42 EDFDRLKTLGTGSFGRVMLVRHRETGQHYAMKILNKQKVVKLKQIEHTLNEKRILQAVSF 101
Query 65 PFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLH 122
PF++RL +F+D LY + + V GGE++ +R++G A+FY + IVL EYLH
Sbjct 102 PFLVRLEYSFKDNTNLYMVMQYVQGGEMFSHLRRIGRFSEPHARFYASQIVLTFEYLH 159
> xla:414693 stk38l, MGC83214, ndr2; serine/threonine kinase 38
like (EC:2.7.11.1); K08790 serine/threonine kinase 38 [EC:2.7.11.1]
Length=464
Score = 90.9 bits (224), Expect = 8e-19, Method: Composition-based stats.
Identities = 43/123 (34%), Positives = 74/123 (60%), Gaps = 0/123 (0%)
Query 1 KVEFKDLQVVRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMA 60
++ +D + ++V+GRG FG V+LVQ T YA+K + + ++ Q HIR ER+I+
Sbjct 84 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILV 143
Query 61 ENDHPFIIRLVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEY 120
E D +++++ +F+DK LY + E + GG++ + K L QFY+A VLAI+
Sbjct 144 EADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEATQFYIAETVLAIDA 203
Query 121 LHE 123
+H+
Sbjct 204 IHQ 206
> dre:564064 prkacaa, zgc:158799; protein kinase, cAMP-dependent,
catalytic, alpha, genome duplicate a (EC:2.7.11.11); K04345
protein kinase A [EC:2.7.11.11]
Length=352
Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust.
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 0/117 (0%)
Query 10 VRVVGRGTFGTVKLVQHIPTKIRYALKCVSRRSVVALNQQDHIRLEREIMAENDHPFIIR 69
++ +G G+FG V LV+H + +A+K + ++ VV L Q +H E+ I+ PF++R
Sbjct 48 LKTLGTGSFGRVMLVKHKESGQHFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVR 107
Query 70 LVRTFRDKDFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERNI 126
L +F+D LY + E V GGE++ +R++G A+FY A IVL EYLH ++
Sbjct 108 LEHSFKDNTNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 164
Lambda K H
0.329 0.145 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 2059772308
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40