bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0592_orf1
Length=315
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_046550 eukaryotic aspartyl protease, putative (EC:3... 429 7e-120
pfa:PF08_0108 plasmepsin X (EC:3.4.23.1); K06002 pepsin A [EC:... 251 2e-66
bbo:BBOV_IV007890 23.m06476; aspartyl protease 242 1e-63
cpv:cgd6_660 secreted pepsinogen like aspartyl protease having... 174 3e-43
tpv:TP03_0306 pepsin A (EC:3.4.23.1); K06002 pepsin A [EC:3.4.... 174 5e-43
pfa:PF14_0281 plasmepsin IX; K01386 [EC:3.4.23.-] 165 2e-40
bbo:BBOV_IV010360 23.m06120; aspartyl protease 163 8e-40
mmu:13034 Ctse, A430072O03Rik, C920004C08Rik, CE, CatE; cathep... 145 1e-34
hsa:5222 PGA5, PGA3, PGA4; pepsinogen 5, group I (pepsinogen A... 141 3e-33
hsa:643834 PGA3, DKFZp666J2410, PGA4, PGA5; pepsinogen 3, grou... 140 7e-33
hsa:643847 PGA4, FLJ58952, FLJ77962, PGA3, PGA5; pepsinogen 4,... 140 7e-33
tpv:TP01_0692 pepsinogen; K06002 pepsin A [EC:3.4.23.1] 134 5e-31
xla:373564 pga4, pga-A; pepsinogen 4, group I (pepsinogen A); ... 133 7e-31
xla:373573 ctse-b, CE2, cate, ce1, ce2-A; cathepsin E (EC:3.4.... 133 8e-31
mmu:16541 Napsa, KAP, Kdap, NAP1, SNAPA, pronapsin; napsin A a... 133 9e-31
xla:373572 ctse-a, CE1, cate, ce1-A, ce2, ctse; cathepsin E (E... 130 5e-30
xla:398994 napsa, MGC68767, kap, kdap, nap1, napa, snapa; naps... 129 2e-29
mmu:58803 Pga5, 1110035E17Rik, Pepf; pepsinogen 5, group I (EC... 128 2e-29
hsa:1510 CTSE, CATE; cathepsin E (EC:3.4.23.34); K01382 cathep... 126 8e-29
hsa:9476 NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA; napsin A asparti... 123 8e-28
hsa:1509 CTSD, CLN10, CPSD, MGC2311; cathepsin D (EC:3.4.23.5)... 122 1e-27
tgo:TGME49_062940 eukaryotic aspartyl protease, putative (EC:3... 121 4e-27
tpv:TP03_0056 cathepsin E (EC:3.4.23.34); K01386 [EC:3.4.23.-] 117 4e-26
xla:443829 MGC82347 protein; K01379 cathepsin D [EC:3.4.23.5] 117 4e-26
mmu:13033 Ctsd, CD, CatD; cathepsin D (EC:3.4.23.5); K01379 ca... 117 6e-26
dre:65225 ctsd, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09... 115 2e-25
xla:443721 ctsd; cathepsin D (EC:3.4.23.5); K01379 cathepsin D... 115 3e-25
xla:373563 pgc-A; pepsinogen C (EC:3.4.23.3); K01377 gastricsi... 114 5e-25
mmu:109820 Pgc, 2210410L06Rik, MGC117575, Upg-1, Upg1; progast... 113 1e-24
dre:336746 fa94d12, wu:fa94d12; zgc:63831; K01379 cathepsin D ... 112 2e-24
dre:114367 nots, LAP, MGC192423, ctsel, zgc:103608; nothepsin 110 8e-24
mmu:100044656 renin-1-like 109 1e-23
mmu:19701 Ren1, D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1,... 108 2e-23
cel:R12H7.2 asp-4; ASpartyl Protease family member (asp-4); K0... 108 2e-23
mmu:229697 Cym, Gm131; chymosin (EC:3.4.23.4); K01378 chymosin... 108 3e-23
bbo:BBOV_III003510 17.m07331; eukaryotic aspartyl protease fam... 108 3e-23
mmu:19702 Ren2, Ren, Ren-2, Ren-B, Rn-2, Rnr; renin 2 tandem d... 106 1e-22
dre:405786 ren; renin (EC:3.4.23.15); K01380 renin [EC:3.4.23.15] 103 7e-22
hsa:5972 REN, FLJ10761, HNFJ2; renin (EC:3.4.23.15); K01380 re... 102 2e-21
sce:YPL154C PEP4, PHO9, PRA1, yscA; Pep4p (EC:3.4.23.25); K013... 97.4 7e-20
cpv:cgd6_3820 membrane bound aspartyl proteinase with a signal... 95.9 2e-19
pfa:PFC0495w plasmepsin VI (EC:3.4.23.-); K01386 [EC:3.4.23.-] 95.9 2e-19
xla:398557 cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3... 95.1 3e-19
ath:AT4G04460 aspartyl protease family protein; K08245 phyteps... 82.4 2e-15
cel:Y39B6A.20 asp-1; ASpartyl Protease family member (asp-1) 80.5 7e-15
ath:AT1G62290 aspartyl protease family protein; K08245 phyteps... 80.5 7e-15
pfa:PF14_0077 plasmepsin II; K06008 plasmepsin II [EC:3.4.23.39] 77.4 7e-14
ath:AT1G69100 aspartic-type endopeptidase 77.0 9e-14
cel:Y39B6A.23 hypothetical protein 75.9 2e-13
ath:AT4G22050 aspartyl protease family protein 75.5 3e-13
> tgo:TGME49_046550 eukaryotic aspartyl protease, putative (EC:3.4.23.1);
K06002 pepsin A [EC:3.4.23.1]
Length=643
Score = 429 bits (1103), Expect = 7e-120, Method: Compositional matrix adjust.
Identities = 200/296 (67%), Positives = 239/296 (80%), Gaps = 5/296 (1%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
GRIEGSTG+D+F +GP+ V+GQ+FGLVE E HN HGNIF++INFEGIVGL FP+MSSTG
Sbjct 347 GRIEGSTGIDDFTVGPFLVKGQSFGLVESEGGHNMHGNIFKTINFEGIVGLAFPEMSSTG 406
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVE 120
PIYDN++ Q ++++EFAFY+AK S VSA+FFGGVDPRF+E PIHMFPV REHYWE
Sbjct 407 TVPIYDNIISQGTLKENEFAFYMAKGSQVSALFFGGVDPRFYEAPIHMFPVTREHYWETS 466
Query 121 LDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD-SFLEQY 179
LDAIY+G+KKFCC EGTKNYVI+DSGTSFNT+PS E+ L+MIPS+EC DD F +
Sbjct 467 LDAIYIGDKKFCCEEGTKNYVILDSGTSFNTMPSGELGKLLDMIPSKECNLDDPEFTSDF 526
Query 180 PNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVF 239
P TY+IGGV F L P+ YLVRSK N CKPAYMQIDVPS FGHAYILGS++FMRH++TVF
Sbjct 527 PTITYVIGGVKFPLTPEQYLVRSKKNECKPAYMQIDVPSQFGHAYILGSVAFMRHYYTVF 586
Query 240 RRSDGVNPSLVGIARAVHSEENKAYLQQVADSYPINIGNSSASEDLLAVRRSTNAP 295
RRSDG PSLVGIARAVH+++N AYL V + YP G EDL+ + RS +AP
Sbjct 587 RRSDGTRPSLVGIARAVHNDDNSAYLSNVLNEYP---GAHIRKEDLM-MERSMSAP 638
> pfa:PF08_0108 plasmepsin X (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=573
Score = 251 bits (642), Expect = 2e-66, Method: Compositional matrix adjust.
Identities = 122/251 (48%), Positives = 174/251 (69%), Gaps = 7/251 (2%)
Query 9 VDNFKLGPYDVRGQTFGLVERETEHNQHG--NIFQSINFEGIVGLGFPDMSSTGATPIYD 66
D F LG + VR QTFGLVE E+ +N++G NIF I+FEGIVGLGFP M S G P +D
Sbjct 322 TDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISFEGIVGLGFPGMLSAGNIPFFD 381
Query 67 NMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVELDAIYV 126
N+L+Q +F+FY++ S + GG+ F+E I+M PV++E YWEV+LD +Y+
Sbjct 382 NLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGDIYMLPVLKESYWEVKLDELYI 441
Query 127 GEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD--SFLEQYPNSTY 184
G+++ CC E ++YVI D+GTS+NT+PS++M++FL +I S C E + L+ YP Y
Sbjct 442 GKERICCDE--ESYVIFDTGTSYNTMPSSQMKTFLNLIHSTACTEQNYKDILKSYPIIKY 499
Query 185 IIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSDG 244
+ G + L P++Y++ + ++C PAYMQIDVPS+ HAY+LGS+SFMR+FFTVF R
Sbjct 500 VFGELIIELHPEEYMILND-DVCMPAYMQIDVPSERNHAYLLGSLSFMRNFFTVFVRGTE 558
Query 245 VNPSLVGIARA 255
PS+VG+ARA
Sbjct 559 SRPSMVGVARA 569
> bbo:BBOV_IV007890 23.m06476; aspartyl protease
Length=463
Score = 242 bits (618), Expect = 1e-63, Method: Compositional matrix adjust.
Identities = 120/250 (48%), Positives = 161/250 (64%), Gaps = 6/250 (2%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G IEG +D +G V Q +V+ E Q NIF INFEGIVGL FP+MSS
Sbjct 217 GEIEGYPALDTVTIGETVVPKQALAVVDSENSGTQISNIFNKINFEGIVGLAFPEMSSIP 276
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVE 120
PI+D+M N++ EFAFY++ + S + GGVDP+++ I MFPVVREHYWEV+
Sbjct 277 GMPIFDHMALLRNMKHKEFAFYISNNDKDSKLMLGGVDPQYYTGKIKMFPVVREHYWEVK 336
Query 121 LDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLEQYP 180
LDA+YVG++K CC +G +Y+I DSGTS NT+PS+ + F+ + C DD E YP
Sbjct 337 LDALYVGDEKLCC-DGESSYLIFDSGTSLNTVPSSYFDRFISHFKIKTC--DD--YEVYP 391
Query 181 NSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVFR 240
TY+IGG LEP Y++ S C PAYMQ+DVPS+FG+A+I+GS +FMRH+ TV+
Sbjct 392 TITYVIGGEHIKLEPHQYMLSSNGR-CLPAYMQLDVPSEFGNAFIVGSNAFMRHYLTVYH 450
Query 241 RSDGVNPSLV 250
R + S+V
Sbjct 451 RGSNGSKSMV 460
> cpv:cgd6_660 secreted pepsinogen like aspartyl protease having
a signal peptide ; K01386 [EC:3.4.23.-]
Length=633
Score = 174 bits (442), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 102/333 (30%), Positives = 163/333 (48%), Gaps = 69/333 (20%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVER-ETEHNQHGNIFQSINFEGIVGLGFPDMSST 59
G+I G ++ K + + G++E+ E N +IF +I EG++GLGF MSS+
Sbjct 257 GKIYGKLILETLKFDNFQLNKHVIGIIEQVENTENSKIDIFDAIELEGVLGLGFTQMSSS 316
Query 60 GAT--PIYDNMLQQANVEKSEFAFYVAK------------DSPVSAIFFGGVDPRFFEPP 105
P+ + + Q ++ + F+ Y+ P + + GG+D FE
Sbjct 317 KKLQLPLIERLQSQGLIQNNIFSIYINDYRIKPINNNDKLSKPCAILLLGGIDQNLFEEE 376
Query 106 IHMFPVVREHYWEVELDAIYVGEKKFCCAEG----------------------------- 136
+H+ PV+REHYW+VEL+++Y+G+ K+CC G
Sbjct 377 LHILPVIREHYWQVELESLYIGDTKYCCDYGSLAYEWENLENEHLYKKFGHYEDPPMDVY 436
Query 137 --------------TKNYVIIDSGTSFNTLPSNEMESFL-EMIPSQECGE--------DD 173
T YVI DSGTSF TLP+ E F+ E P +C + D
Sbjct 437 IYKTFNKSIDKTNRTPGYVIFDSGTSFYTLPNFEYNHFIKEYQPFGDCSQIHLDSKKIDP 496
Query 174 SFLEQYPNSTYIIG-GVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFM 232
++ +PN TY G V+ P+ YL ++ CKP M IDVP ++GH+Y+LGS+ FM
Sbjct 497 KIIQHFPNITYTFKDGFQLVIPPELYLTPNEQGKCKPGIMMIDVPGEYGHSYLLGSL-FM 555
Query 233 RHFFTVFRRSDGVNPSLVGIARAVHSEENKAYL 265
R ++TV+ ++ S VGIA+A H+++ + Y+
Sbjct 556 RSYYTVYAKNIPKIGSAVGIAKAKHNKDTRKYI 588
> tpv:TP03_0306 pepsin A (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=328
Score = 174 bits (440), Expect = 5e-43, Method: Compositional matrix adjust.
Identities = 93/208 (44%), Positives = 129/208 (62%), Gaps = 26/208 (12%)
Query 43 INFEGIVGLGFPDMSSTGATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFF 102
INFEGIVGL F +MSS + +N+ + ++EFAFY+ + + + FGG DPRF+
Sbjct 120 INFEGIVGLAFAEMSSISGPSVLENIFSLNRLSENEFAFYIGGEDAL--LMFGGADPRFY 177
Query 103 EPPIHMFPVVREHYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLE 162
E + MFPVVREHYWEV LDAIY+G K CC + +YVI DSGTS N++PS E +F
Sbjct 178 EGELKMFPVVREHYWEVALDAIYLGNTKICCNQ--PSYVIFDSGTSLNSVPSAEFHTFTT 235
Query 163 MIPSQECGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGH 222
+I Q+ GE+ L ++Y + + C P +MQ+DVPS+FGH
Sbjct 236 LI--QQGGEE------------------IRLGAEEY-IYVDGDECIPGFMQLDVPSEFGH 274
Query 223 AYILGSMSFMRHFFTVFRRSDGVNPSLV 250
AY+LGS +FM+ +FT+FR S+ PS+V
Sbjct 275 AYVLGSNTFMQFYFTLFRHSN-YKPSMV 301
> pfa:PF14_0281 plasmepsin IX; K01386 [EC:3.4.23.-]
Length=627
Score = 165 bits (418), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 67/134 (50%), Positives = 98/134 (73%), Gaps = 0/134 (0%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G I+G GV+ FK+GP++++ Q+FGLV+RE + N+F+ INFEGIVGL FP+M STG
Sbjct 294 GIIQGVIGVETFKIGPFEIKNQSFGLVKREKASDNKSNVFERINFEGIVGLAFPEMLSTG 353
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVE 120
+ +Y+N++ ++ +EF+ Y+ KDS SA+ FGGVD FFE I+MFPVV+E+YWE+
Sbjct 354 KSTLYENLMSSYKLQHNEFSIYIGKDSKYSALIFGGVDKNFFEGDIYMFPVVKEYYWEIH 413
Query 121 LDAIYVGEKKFCCA 134
D +Y+ +KFCC
Sbjct 414 FDGLYIDHQKFCCG 427
Score = 150 bits (378), Expect = 7e-36, Method: Compositional matrix adjust.
Identities = 70/136 (51%), Positives = 102/136 (75%), Gaps = 7/136 (5%)
Query 140 YVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLEQ----YPNSTYIIGGVGFVLEP 195
Y+I DSGTSFN++P +E+E F ++PS++C DDS ++Q YPN TY+I + F L P
Sbjct 491 YLIFDSGTSFNSVPKDEIEYFFRVVPSKKC--DDSNIDQVVSSYPNLTYVINKMPFTLTP 548
Query 196 QDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARA 255
YLVR K ++CKPA+M+I+V S++GHAYILG+ +FMR+++TV+RR + N S VGIA+A
Sbjct 549 SQYLVR-KNDMCKPAFMEIEVSSEYGHAYILGNATFMRYYYTVYRRGNNNNSSYVGIAKA 607
Query 256 VHSEENKAYLQQVADS 271
VH+EEN+ YL + +
Sbjct 608 VHTEENEKYLSSLHNK 623
> bbo:BBOV_IV010360 23.m06120; aspartyl protease
Length=532
Score = 163 bits (412), Expect = 8e-40, Method: Compositional matrix adjust.
Identities = 93/276 (33%), Positives = 152/276 (55%), Gaps = 21/276 (7%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLV----ERET------EHNQHGNIF-QSINFEGIV 49
G + G+ G D+F +G + V+GQ F ++ ++ T + Q+ +IF Q F G++
Sbjct 252 GVVLGTLGYDDFTIGGFTVKGQLFAMMRDIPDKSTNDILTVSNGQNVDIFTQETPFNGMI 311
Query 50 GLGFPDMSSTGATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMF 109
GLGF D+ + P+Y ++ E F+FY +++ SA GG D R + P+ M
Sbjct 312 GLGFKDLMVMNSEPLYQRYMKVVGAEPI-FSFYYSRNGVGSAFLVGGADERLHKGPMQMM 370
Query 110 PVVREHYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQEC 169
PVV +YW+VEL+ ++VG++K CC + ++Y + D+GT+FN++P + + LE P EC
Sbjct 371 PVVPGYYWQVELEEVFVGKRKVCCDK--QSYAVFDTGTAFNSMPHAAINTLLEEYPFYEC 428
Query 170 GED--DSFLEQYPNSTYIIG-GVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYIL 226
+ + P Y GV L P+ Y S+ +C+PA+MQI+V G Y+L
Sbjct 429 NAENMNRVYAALPTIKYTFSNGVQAKLTPEQYTYESEG-VCRPAFMQINVDVAGGEGYLL 487
Query 227 GSMSFMRHFFTVFRRSDGVNPSLVGIARAVHSEENK 262
GSM+FM H++TV+ G ++GIA + H K
Sbjct 488 GSMAFMPHYYTVYY---GGESPMIGIAPSNHENAPK 520
> mmu:13034 Ctse, A430072O03Rik, C920004C08Rik, CE, CatE; cathepsin
E (EC:3.4.23.34); K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 145 bits (367), Expect = 1e-34, Method: Compositional matrix adjust.
Identities = 88/266 (33%), Positives = 139/266 (52%), Gaps = 22/266 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D + V GQ FG +E G F + F+GI+GLG+P +++ G
Sbjct 143 GSLTGIIGADQVSVEGLTVDGQQFGESVKEP-----GQTFVNAEFDGILGLGYPSLAAGG 197
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
TP++DNM+ Q V F+ Y++ D S + FGG DP F ++ PV ++ YW
Sbjct 198 VTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQAYW 257
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQ----ECGEDD 173
++ LD I VG+ C+EG + I+D+GTS T P ++++ E I + E D
Sbjct 258 QIALDGIQVGDTVMFCSEGCQ--AIVDTGTSLITGPPDKIKQLQEAIGATPIDGEYAVDC 315
Query 174 SFLEQYPNSTYIIGGVGFVLEPQDYLVRSKA---NICKPAYMQIDVPSDFGHAYILGSMS 230
+ L+ PN T++I V + L P DY++ C + +D+P G +ILG +
Sbjct 316 ATLDTMPNVTFLINEVSYTLNPTDYILPDLVEGMQFCGSGFQGLDIPPPAGPLWILGDV- 374
Query 231 FMRHFFTVFRRSDGVNPSLVGIARAV 256
F+R F++VF R + + VG+A AV
Sbjct 375 FIRQFYSVFDRGN----NQVGLAPAV 396
> hsa:5222 PGA5, PGA3, PGA4; pepsinogen 5, group I (pepsinogen
A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 141 bits (356), Expect = 3e-33, Method: Compositional matrix adjust.
Identities = 80/249 (32%), Positives = 137/249 (55%), Gaps = 15/249 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D ++G Q FGL E E G+ F+GI+GL +P +SS+G
Sbjct 140 GSMTGILGYDTVQVGGISDTNQIFGLSETE-----PGSFLYYAPFDGILGLAYPSISSSG 194
Query 61 ATPIYDNMLQQANVEKSEFAFYV-AKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEV 119
ATP++DN+ Q V + F+ Y+ A D S + FGG+D ++ ++ PV E YW++
Sbjct 195 ATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI 254
Query 120 ELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD-----S 174
+D+I + + CAEG + I+D+GTS T P++ + + I + E + D S
Sbjct 255 TVDSITMNGETIACAEGCQ--AIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCS 312
Query 175 FLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRH 234
+ P+ + I GV + + P Y+++S+ + C + ++VP++ G +ILG + F+R
Sbjct 313 AISSLPDIVFTINGVQYPVPPSAYILQSEGS-CISGFQGMNVPTESGELWILGDV-FIRQ 370
Query 235 FFTVFRRSD 243
+FTVF R++
Sbjct 371 YFTVFDRAN 379
> hsa:643834 PGA3, DKFZp666J2410, PGA4, PGA5; pepsinogen 3, group
I (pepsinogen A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 140 bits (352), Expect = 7e-33, Method: Compositional matrix adjust.
Identities = 79/249 (31%), Positives = 137/249 (55%), Gaps = 15/249 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D ++G Q FGL E E G+ F+GI+GL +P +SS+G
Sbjct 140 GSMTGILGYDTVQVGGISDTNQIFGLSETE-----PGSFLYYAPFDGILGLAYPSISSSG 194
Query 61 ATPIYDNMLQQANVEKSEFAFYV-AKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEV 119
ATP++DN+ Q V + F+ Y+ A D S + FGG+D ++ ++ PV E YW++
Sbjct 195 ATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI 254
Query 120 ELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD-----S 174
+D+I + + CAEG + I+D+GTS T P++ + + I + E + D S
Sbjct 255 TVDSITMNGEAIACAEGCQ--AIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCS 312
Query 175 FLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRH 234
+ P+ + I GV + + P Y+++S+ + C + +++P++ G +ILG + F+R
Sbjct 313 AISSLPDIVFTINGVQYPVPPSAYILQSEGS-CISGFQGMNLPTESGELWILGDV-FIRQ 370
Query 235 FFTVFRRSD 243
+FTVF R++
Sbjct 371 YFTVFDRAN 379
> hsa:643847 PGA4, FLJ58952, FLJ77962, PGA3, PGA5; pepsinogen
4, group I (pepsinogen A) (EC:3.4.23.1); K06002 pepsin A [EC:3.4.23.1]
Length=388
Score = 140 bits (352), Expect = 7e-33, Method: Compositional matrix adjust.
Identities = 79/249 (31%), Positives = 137/249 (55%), Gaps = 15/249 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D ++G Q FGL E E G+ F+GI+GL +P +SS+G
Sbjct 140 GSMTGILGYDTVQVGGISDTNQIFGLSETE-----PGSFLYYAPFDGILGLAYPSISSSG 194
Query 61 ATPIYDNMLQQANVEKSEFAFYV-AKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEV 119
ATP++DN+ Q V + F+ Y+ A D S + FGG+D ++ ++ PV E YW++
Sbjct 195 ATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQI 254
Query 120 ELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD-----S 174
+D+I + + CAEG + I+D+GTS T P++ + + I + E + D S
Sbjct 255 TVDSITMNGEAIACAEGCQ--AIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCS 312
Query 175 FLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRH 234
+ P+ + I GV + + P Y+++S+ + C + +++P++ G +ILG + F+R
Sbjct 313 AISSLPDIVFTINGVQYPVPPSAYILQSEGS-CISGFQGMNLPTESGELWILGDV-FIRQ 370
Query 235 FFTVFRRSD 243
+FTVF R++
Sbjct 371 YFTVFDRAN 379
> tpv:TP01_0692 pepsinogen; K06002 pepsin A [EC:3.4.23.1]
Length=377
Score = 134 bits (336), Expect = 5e-31, Method: Compositional matrix adjust.
Identities = 67/169 (39%), Positives = 102/169 (60%), Gaps = 10/169 (5%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G I+G G+DN +G + Q FGLV E+ N+F+ I F+GI+GLGFP ++
Sbjct 204 GTIKGVLGIDNVTIGQDTIEKQIFGLVNEESS-----NVFKVIKFQGIIGLGFPKLAFDH 258
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVE 120
T +YDN +Q N ++ F + + S + GGVD RF+ ++M PVVRE+YWE++
Sbjct 259 HTSLYDNYSKQIN---ADLIFSLYFSNQYSYVMIGGVDERFYVGDLYMLPVVREYYWEIK 315
Query 121 LDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQEC 169
L ++VG K CC + ++YVI DSGTSFNT+P ++ F ++ + C
Sbjct 316 LYELWVGNVKLCCDD--ESYVIFDSGTSFNTMPHDQFLYFKHIVSPKIC 362
> xla:373564 pga4, pga-A; pepsinogen 4, group I (pepsinogen A);
K06002 pepsin A [EC:3.4.23.1]
Length=384
Score = 133 bits (335), Expect = 7e-31, Method: Compositional matrix adjust.
Identities = 74/249 (29%), Positives = 130/249 (52%), Gaps = 15/249 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D ++G + Q FGL E E G+ F+GI+GL FP ++S+
Sbjct 136 GSMSGFLGYDTLQVGNIQISNQMFGLSESE-----PGSFLYYSPFDGILGLAFPSIASSQ 190
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPV-SAIFFGGVDPRFFEPPIHMFPVVREHYWEV 119
ATP++DNM Q + ++ F+ Y++ D S + FGGVD ++ ++ P+ E YW++
Sbjct 191 ATPVFDNMWSQGLIPQNLFSVYLSSDGQTGSYVLFGGVDNSYYSGSLNWVPLTAETYWQI 250
Query 120 ELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGE-----DDS 174
LD++ + + C++ + I+D+GTS T PS + + I + + + +
Sbjct 251 TLDSVSINGQVIACSQSCQ--AIVDTGTSLMTGPSTPIANIQNYIGASQDSNGQYVINCN 308
Query 175 FLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRH 234
+ P + I GV + L P Y VR C + +++P++ G +ILG + F+R
Sbjct 309 NISNMPTIVFTINGVQYPLSPSAY-VRQNQQGCSSGFQAMNLPTNSGDLWILGDV-FIRQ 366
Query 235 FFTVFRRSD 243
+FTVF R++
Sbjct 367 YFTVFDRAN 375
> xla:373573 ctse-b, CE2, cate, ce1, ce2-A; cathepsin E (EC:3.4.23.34);
K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 133 bits (335), Expect = 8e-31, Method: Compositional matrix adjust.
Identities = 83/263 (31%), Positives = 142/263 (53%), Gaps = 19/263 (7%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G+D+ + V+ Q FG E +E G+ F +F+GI+GLG+P ++ G
Sbjct 138 GSLSGVIGIDSVTVEGILVQNQQFG--ESVSEP---GSTFVDASFDGILGLGYPSIAVGG 192
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD--SPVSA-IFFGGVDPRFFEPPIHMFPVVREHYW 117
TP++DNM+ Q VE F+ Y+++D SPV + FGG D F ++ PV + YW
Sbjct 193 CTPVFDNMIAQNLVELPMFSVYMSRDPNSPVGGELVFGGFDASRFSGQLNWVPVTNQGYW 252
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMI-PSQECGE---DD 173
+++LD I + + C+ G + I+D+GTS T PS+++ +I S G+ D
Sbjct 253 QIQLDNIQINGEVVFCSGGCQ--AIVDTGTSMITGPSSDIVQLQSIIGASAANGDYEVDC 310
Query 174 SFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMR 233
+ L + P T+ I G+G+ + PQ Y ++ +C + +D+ G +ILG + F+
Sbjct 311 TVLNKMPTMTFTINGIGYQMTPQQYTLQDDDGVCSSGFQGLDISPPAGPLWILGDV-FIG 369
Query 234 HFFTVFRRSDGVNPSLVGIARAV 256
+++VF R + + VG+A V
Sbjct 370 QYYSVFDRGN----NRVGLAPVV 388
> mmu:16541 Napsa, KAP, Kdap, NAP1, SNAPA, pronapsin; napsin A
aspartic peptidase; K08565 napsin-A [EC:3.4.23.-]
Length=419
Score = 133 bits (335), Expect = 9e-31, Method: Compositional matrix adjust.
Identities = 88/274 (32%), Positives = 134/274 (48%), Gaps = 19/274 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
GR+ G DN +G TFG E IF +F+GI+GLGFP ++ G
Sbjct 139 GRLSGILSQDNLTIGGIHDAFVTFGEALWEPSL-----IFALAHFDGILGLGFPTLAVGG 193
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVS---AIFFGGVDPRFFEPPIHMFPVVREHYW 117
P D M++Q +EK F+FY+ +DS S + GG DP + PP+ PV YW
Sbjct 194 VQPPLDAMVEQGLLEKPVFSFYLNRDSEGSDGGELVLGGSDPAHYVPPLTFIPVTIPAYW 253
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLE 177
+V ++++ VG CA+G I+D+GTS T PS E+ + + I F++
Sbjct 254 QVHMESVKVGTGLSLCAQGCS--AILDTGTSLITGPSEEIRALNKAIGGYPFLNGQYFIQ 311
Query 178 -----QYPNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAYILGSM 229
P ++ +GGV F L QDY+++ S +C + +D+P G +ILG +
Sbjct 312 CSKTPTLPPVSFHLGGVWFNLTGQDYVIKILQSDVGLCLLGFQALDIPKPAGPLWILGDV 371
Query 230 SFMRHFFTVFRRSDGVNPSLVGIARAVHSEENKA 263
F+ + VF R D VG+ARA ++A
Sbjct 372 -FLGPYVAVFDRGDKNVGPRVGLARAQSRSTDRA 404
> xla:373572 ctse-a, CE1, cate, ce1-A, ce2, ctse; cathepsin E
(EC:3.4.23.34); K01382 cathepsin E [EC:3.4.23.34]
Length=397
Score = 130 bits (328), Expect = 5e-30, Method: Compositional matrix adjust.
Identities = 80/264 (30%), Positives = 138/264 (52%), Gaps = 21/264 (7%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G+D + V+ Q FG E +E G+ F F+GI+GLG+P ++
Sbjct 138 GSLSGVIGIDAVTVEGILVQNQQFG--ESVSEP---GSTFVDAEFDGILGLGYPSIAVGD 192
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAI----FFGGVDPRFFEPPIHMFPVVREHY 116
TP++DNM+ Q VE F+ Y++++ P SA+ FGG D F ++ PV + Y
Sbjct 193 CTPVFDNMIAQNLVELPMFSVYMSRN-PNSAVGGELVFGGFDASRFSGQLNWVPVTNQGY 251
Query 117 WEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGE----D 172
W+++LD + + + C+ G + I+D+GTS T PS+++ +I + D
Sbjct 252 WQIQLDNVQINGEVLFCSGGCQ--AIVDTGTSLITGPSSDIVQLQNIIGASAANGDYEVD 309
Query 173 DSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFM 232
S L + P T+ I G+G+ + PQ Y ++ +C + +D+P G +ILG + F+
Sbjct 310 CSVLNEMPTVTFTINGIGYQMTPQQYTLQDGGGVCSSGFQGLDIPPPAGPLWILGDV-FI 368
Query 233 RHFFTVFRRSDGVNPSLVGIARAV 256
+++VF R + + VG+A V
Sbjct 369 GQYYSVFDRGN----NRVGLAPVV 388
> xla:398994 napsa, MGC68767, kap, kdap, nap1, napa, snapa; napsin
A aspartic peptidase; K01379 cathepsin D [EC:3.4.23.5]
Length=392
Score = 129 bits (323), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 74/252 (29%), Positives = 130/252 (51%), Gaps = 19/252 (7%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D +G +V QTF + Q G +F +F+GI+G+G+PD+S G
Sbjct 133 GSLSGFLSQDTVSIGSIEVANQTFAEAIK-----QPGIVFVFAHFDGILGMGYPDISVDG 187
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSA---IFFGGVDPRFFEPPIHMFPVVREHYW 117
P++DNM+QQ +E++ F+FY+++D + + GG DP ++ H V R YW
Sbjct 188 VVPVFDNMMQQNLLEENVFSFYLSRDPMATVGGELILGGTDPNYYTGDFHYLNVTRMAYW 247
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSF-- 175
+++ D + V + C G + I+D+GTS T P E+ + + I + + F
Sbjct 248 QIKADEVRVNNQLVLCKGGCQ--AIVDTGTSLITGPKEEIRALHKAIGAFPLFAGEYFIN 305
Query 176 ---LEQYPNSTYIIGGVGFVLEPQDYLVRSKA---NICKPAYMQIDVPSDFGHAYILGSM 229
++ P ++I+GGV + L + Y+++ IC +M +D+ G +ILG +
Sbjct 306 CKRIQSLPTVSFILGGVAYNLTGEQYILKISKFGHTICLSGFMGLDIRPPAGPIWILGDV 365
Query 230 SFMRHFFTVFRR 241
F+ ++TVF R
Sbjct 366 -FIGQYYTVFDR 376
> mmu:58803 Pga5, 1110035E17Rik, Pepf; pepsinogen 5, group I (EC:3.4.23.1);
K06002 pepsin A [EC:3.4.23.1]
Length=387
Score = 128 bits (322), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 75/250 (30%), Positives = 135/250 (54%), Gaps = 16/250 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D ++G V Q FGL E G + F+GI+GLG+P++ G
Sbjct 138 GEMSGFLAYDTVRIGDLTVVAQAFGLSLEEP-----GIFMEYAVFDGILGLGYPNLGLQG 192
Query 61 ATPIYDNMLQQANVEKSEFAFYV-AKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEV 119
TP++DN+ Q + ++ FAFY+ +KD S + GGVDP ++ +H PV + YW++
Sbjct 193 ITPVFDNLWLQGLIPQNLFAFYLSSKDEKGSMLMLGGVDPSYYHGELHWVPVSKPSYWQL 252
Query 120 ELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLE-- 177
+D+I + + C G + I+D+GTS T P + + + +I ++ G+ + FL+
Sbjct 253 AVDSISMNGEVIACDGGCQG--IMDTGTSLLTGPRSSIVNIQNLIGAKASGDGEYFLKCD 310
Query 178 ---QYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQ-IDVPSDFGHAYILGSMSFMR 233
P+ + IG V + + Y+ + +++ C+ + + +D PSD ++LG + F+R
Sbjct 311 TINTLPDIVFTIGSVTYPVPASAYIRKDRSHNCRSNFEEGMDDPSD-PEMWVLGDV-FLR 368
Query 234 HFFTVFRRSD 243
+FTVF R++
Sbjct 369 LYFTVFDRAN 378
> hsa:1510 CTSE, CATE; cathepsin E (EC:3.4.23.34); K01382 cathepsin
E [EC:3.4.23.34]
Length=396
Score = 126 bits (317), Expect = 8e-29, Method: Compositional matrix adjust.
Identities = 85/266 (31%), Positives = 133/266 (50%), Gaps = 22/266 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D + V GQ FG E TE G F F+GI+GLG+P ++ G
Sbjct 142 GSLSGIIGADQVSVEGLTVVGQQFG--ESVTEP---GQTFVDAEFDGILGLGYPSLAVGG 196
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
TP++DNM+ Q V+ F+ Y++ + S + FGG D F ++ PV ++ YW
Sbjct 197 VTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYW 256
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQ----ECGEDD 173
++ LD I VG C+EG + I+D+GTS T PS++++ I + E +
Sbjct 257 QIALDNIQVGGTVMFCSEGCQ--AIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVEC 314
Query 174 SFLEQYPNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAYILGSMS 230
+ L P+ T+ I GV + L P Y + C + +D+ G +ILG +
Sbjct 315 ANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDV- 373
Query 231 FMRHFFTVFRRSDGVNPSLVGIARAV 256
F+R F++VF R + + VG+A AV
Sbjct 374 FIRQFYSVFDRGN----NRVGLAPAV 395
> hsa:9476 NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA; napsin A aspartic
peptidase; K08565 napsin-A [EC:3.4.23.-]
Length=420
Score = 123 bits (309), Expect = 8e-28, Method: Compositional matrix adjust.
Identities = 80/284 (28%), Positives = 139/284 (48%), Gaps = 19/284 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
GR++G D +G ++G + E E + +F +F+GI+GLGFP +S G
Sbjct 144 GRVDGILSEDKLTIG--GIKGASVIFGEALWEPSL---VFAFAHFDGILGLGFPILSVEG 198
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSP---VSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
P D +++Q ++K F+FY+ +D + GG DP + PP+ PV YW
Sbjct 199 VRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYW 258
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD---- 173
++ ++ + VG CA+G I+D+GTS T P+ E+ + I +
Sbjct 259 QIHMERVKVGPGLTLCAKGCA--AILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIIL 316
Query 174 -SFLEQYPNSTYIIGGVGFVLEPQDYLVRSKAN---ICKPAYMQIDVPSDFGHAYILGSM 229
S + + P ++++GGV F L DY++++ N +C + +DVP G +ILG +
Sbjct 317 CSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQALDVPPPAGPFWILGDV 376
Query 230 SFMRHFFTVFRRSDGVNPSLVGIARAVHSEENKAYLQQVADSYP 273
F+ + VF R D + + VG+ARA + + + +P
Sbjct 377 -FLGTYVAVFDRGDMKSSARVGLARARTRGADLGWGETAQAQFP 419
> hsa:1509 CTSD, CLN10, CPSD, MGC2311; cathepsin D (EC:3.4.23.5);
K01379 cathepsin D [EC:3.4.23.5]
Length=412
Score = 122 bits (307), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 76/262 (29%), Positives = 129/262 (49%), Gaps = 37/262 (14%)
Query 14 LGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTGATPIYDNMLQQAN 73
LG V Q FG + Q G F + F+GI+G+ +P +S P++DN++QQ
Sbjct 169 LGGVKVERQVFGEATK-----QPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKL 223
Query 74 VEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVELDAIYVGEKK 130
V+++ F+FY+++D P + GG D ++++ + V R+ YW+V LD + V
Sbjct 224 VDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGL 283
Query 131 FCCAEGTKNYVIIDSGTSFNTLPSNEMESFLE------------MIPSQECGEDDSFLEQ 178
C EG + I+D+GTS P +E+ + MIP ++ +
Sbjct 284 TLCKEGCE--AIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEK-------VST 334
Query 179 YPNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAYILGSMSFMRHF 235
P T +GG G+ L P+DY ++ + +C +M +D+P G +ILG + F+ +
Sbjct 335 LPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDV-FIGRY 393
Query 236 FTVFRRSDGVNPSLVGIARAVH 257
+TVF R + + VG A A
Sbjct 394 YTVFDRDN----NRVGFAEAAR 411
> tgo:TGME49_062940 eukaryotic aspartyl protease, putative (EC:3.4.23.34)
Length=469
Score = 121 bits (303), Expect = 4e-27, Method: Compositional matrix adjust.
Identities = 86/267 (32%), Positives = 135/267 (50%), Gaps = 31/267 (11%)
Query 10 DNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSS-----TGATPI 64
D +G V+ QT GL +E+ H F + F+G+VGLGFPD++ A P+
Sbjct 183 DTVSIGGIRVQNQTLGLALQESVHP-----FADLPFDGLVGLGFPDVAGEEGLPPDALPL 237
Query 65 YDNMLQQANVEKSEFAFYVAKD-SPVSAIFFGGVDPR--FFEPPIHMFPVVREHYWEVEL 121
D+M++Q ++++ FA Y+++D + I FG V+PR F FPV+ YWEV +
Sbjct 238 VDSMMKQKLLKRNAFAVYMSEDLNQPGEITFGSVNPRHTFEGHKPQWFPVISLDYWEVGV 297
Query 122 DAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLEQYPN 181
+ + K E T+ +D+G+S T PS + L+ S ED S P
Sbjct 298 HGLRLNRKSLGFCERTRCKAAVDTGSSLITGPSKVINPLLK---SLNVAEDCSNKGNLPT 354
Query 182 STYIIGG-----VGFVLEPQDYLV-----RSKANICKPAYMQIDVPSDFGHAYILGSMSF 231
T+I+ V F L+P DYLV + + C ++ +DVP+ G ++LG+ SF
Sbjct 355 VTFILEDTAGRLVKFPLKPSDYLVEEVDSQGRLVTCVAGFIPMDVPAPRGPLFVLGN-SF 413
Query 232 MRHFFTVFRRSDGVNPSLVGIARAVHS 258
+R F+T+F R +VG RA H+
Sbjct 414 IRKFYTIFDRDH----MMVGFMRANHN 436
> tpv:TP03_0056 cathepsin E (EC:3.4.23.34); K01386 [EC:3.4.23.-]
Length=513
Score = 117 bits (294), Expect = 4e-26, Method: Compositional matrix adjust.
Identities = 87/299 (29%), Positives = 151/299 (50%), Gaps = 43/299 (14%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDM---S 57
G + G DN K+G +V+ Q+ GL E+EH F + F+G+VGLGFPD
Sbjct 233 GECVLALGFDNVKIGSLNVKHQSIGLSVLESEHP-----FGDLPFDGLVGLGFPDTELKE 287
Query 58 STGATPIYDNMLQQANVEKSE----FAFYVAKDSPVSAIFFGGVDPRFFEP--PIHMFPV 111
S TPI+D++ Q + S F Y SP ++ FG +DP++ P FPV
Sbjct 288 SKKLTPIFDSIRNQVPLTYSTVNRIFNCYNLTKSP-GSLSFGSIDPKYVLPGHKPWWFPV 346
Query 112 VREHYWEVELDAIYVG------EKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIP 165
V+ YWE+E+ ++ V ++K+ A ID+G+S + PS+ + LE I
Sbjct 347 VKTDYWEIEVSSLLVDGEPVQFDRKYNAA--------IDTGSSLISGPSDVIIPLLEKIT 398
Query 166 SQECGEDDSFLEQYPNSTYIIG-----GVGFVLEPQDYLVRSKA-NICKPAYMQIDVPSD 219
+ ED S +++ P +++ V F L+P+DY+++ + +C + +D+P
Sbjct 399 VE---EDCSNIDKLPRLSFVFSDVMGRKVKFDLDPEDYVLKDEVEKVCMVGVLPMDMPEP 455
Query 220 FGHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARAVHSEENKAYLQQVADSYPINIGN 278
+++G+ +F+R + ++F R V VG+ A H + N+ +Q++D + GN
Sbjct 456 KKPLFVIGA-NFLRRYISIFDRDQMV----VGLVPASHDQNNENKQEQLSDKFKAPDGN 509
> xla:443829 MGC82347 protein; K01379 cathepsin D [EC:3.4.23.5]
Length=401
Score = 117 bits (294), Expect = 4e-26, Method: Compositional matrix adjust.
Identities = 69/255 (27%), Positives = 130/255 (50%), Gaps = 21/255 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D +G ++ Q FG + Q G F + F+GI+G+ +P +S G
Sbjct 147 GSLSGYLSKDTVTIGNLGIKEQLFGEAIK-----QPGVTFIAAKFDGILGMAYPIISVDG 201
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
+P++DN++ Q VE + F+FY+ ++ P + GG DP+++ H V R+ YW
Sbjct 202 VSPVFDNIMAQKLVESNVFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFHYLNVTRKAYW 261
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESF------LEMIPSQECGE 171
++ +D + VG++ C G + I+D+GTS T P E+ + + +I Q +
Sbjct 262 QIHMDQLGVGDQLTLCKGGCE--AIVDTGTSLITGPLEEVTALQKAIGAVPLIQGQYMVQ 319
Query 172 DDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSK---ANICKPAYMQIDVPSDFGHAYILGS 228
D + P + +GG + L + Y+++ + IC +M +++P G +ILG
Sbjct 320 CDK-IPTLPVISLTLGGQVYTLTGEQYIMKVSQRGSTICLSGFMGLNIPPPAGPLWILGD 378
Query 229 MSFMRHFFTVFRRSD 243
+ F+ +++VF R++
Sbjct 379 V-FIGQYYSVFDRAN 392
> mmu:13033 Ctsd, CD, CatD; cathepsin D (EC:3.4.23.5); K01379
cathepsin D [EC:3.4.23.5]
Length=410
Score = 117 bits (293), Expect = 6e-26, Method: Compositional matrix adjust.
Identities = 74/256 (28%), Positives = 125/256 (48%), Gaps = 37/256 (14%)
Query 19 VRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTGATPIYDNMLQQANVEKSE 78
V Q FG + Q G +F + F+GI+G+G+P +S P++DN++QQ V+K+
Sbjct 172 VEKQIFGEATK-----QPGIVFVAAKFDGILGMGYPHISVNNVLPVFDNLMQQKLVDKNI 226
Query 79 FAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVELDAIYVGEKKFCCAE 135
F+FY+ +D P + GG D +++ + V R+ YW+V +D + VG + C
Sbjct 227 FSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQLEVGNELTLCKG 286
Query 136 GTKNYVIIDSGTSFNTLPSNEMESFLE------------MIPSQECGEDDSFLEQYPNST 183
G + I+D+GTS P E++ + MIP ++ + P
Sbjct 287 GCE--AIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEYMIPCEK-------VSSLPTVY 337
Query 184 YIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVFR 240
+GG + L P Y+++ IC +M +D+P G +ILG + F+ ++TVF
Sbjct 338 LKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDV-FIGSYYTVFD 396
Query 241 RSDGVNPSLVGIARAV 256
R + + VG A AV
Sbjct 397 RDN----NRVGFANAV 408
> dre:65225 ctsd, catD, fb93e11, fj17b09, wu:fb93e11, wu:fj17b09;
cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3.4.23.5]
Length=399
Score = 115 bits (288), Expect = 2e-25, Method: Compositional matrix adjust.
Identities = 74/267 (27%), Positives = 132/267 (49%), Gaps = 23/267 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D +G V Q FG + Q G F + F+GI+G+ +P +S G
Sbjct 141 GSLSGYLSQDTCTIGDIAVEKQIFGEAIK-----QPGVAFIAAKFDGILGMAYPRISVDG 195
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
P++D M+ Q VEK+ F+FY+ ++ P + GG DP+++ + + R+ YW
Sbjct 196 VPPVFDMMMSQKKVEKNVFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFNYVDISRQAYW 255
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESF---LEMIPSQECGE--- 171
++ +D + +G C G + V + TS T P+ E+++ + IP + GE
Sbjct 256 QIHMDGMSIGSGLSLCKGGCEAIVDTGTSTSLITGPAAEVKALQKAIGAIPLMQ-GEYMV 314
Query 172 DDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKA---NICKPAYMQIDVPSDFGHAYILGS 228
D + P ++ +GG + L + Y+++ +IC +M +D+P G +ILG
Sbjct 315 DCKKVPTLPTISFSLGGKVYSLTGEQYILKESQGGHDICLSGFMGLDIPPPAGPLWILGD 374
Query 229 MSFMRHFFTVFRRSDGVNPSLVGIARA 255
+ F+ ++TVF R + + VG A+A
Sbjct 375 V-FIGQYYTVFDREN----NRVGFAKA 396
> xla:443721 ctsd; cathepsin D (EC:3.4.23.5); K01379 cathepsin
D [EC:3.4.23.5]
Length=399
Score = 115 bits (287), Expect = 3e-25, Method: Compositional matrix adjust.
Identities = 74/266 (27%), Positives = 135/266 (50%), Gaps = 23/266 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D +G V+GQ F + Q G F + F+GI+G+G+P +S G
Sbjct 145 GSLTGYLSKDTVTIGDLAVKGQLFAEAVK-----QPGITFVAAKFDGILGMGYPRISVDG 199
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
P++D++++Q V+ + F+FY+ ++ P + GG DP ++ V R+ YW
Sbjct 200 VPPVFDDIMEQKLVDSNLFSFYLNRNPDTQPGGELLLGGTDPTYYTGDFSYMNVTRKAYW 259
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQEC--GEDDSF 175
++ +D + VG++ C G + I+D+GTS T P E+ + I + GE
Sbjct 260 QIRMDQLSVGDQLTLCKGGCE--AIVDTGTSLITGPVEEVAALQRAIGAIPLIRGEYMIL 317
Query 176 LEQYPNS---TYIIGGVGFVLEPQDYLVR-SKA--NICKPAYMQIDVPSDFGHAYILGSM 229
+ P+ ++ GG + L + Y+++ SKA +C ++ +D+P G +I+G +
Sbjct 318 CDNIPSLPVISFTFGGRVYSLTGEQYVLKISKAGRTVCLSGFLGLDIPPPAGPLWIIGDV 377
Query 230 SFMRHFFTVFRRSDGVNPSLVGIARA 255
F+ ++TVF R++ VG A+A
Sbjct 378 -FIGQYYTVFDRAN----DRVGFAKA 398
> xla:373563 pgc-A; pepsinogen C (EC:3.4.23.3); K01377 gastricsin
[EC:3.4.23.3]
Length=383
Score = 114 bits (285), Expect = 5e-25, Method: Compositional matrix adjust.
Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 17/248 (6%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D + + Q FGL E E N F F+GI+GL +P ++ G
Sbjct 131 GSLTGILGYDTVTIQNVAISQQEFGLSETEPGTN-----FVYAQFDGILGLAYPSIAVGG 185
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSA--IFFGGVDPRFFEPPIHMFPVVREHYWE 118
AT + M+QQ + + F FY++ S + + FGGVD ++ I+ PV E YW+
Sbjct 186 ATTVMQGMMQQNLLNQPIFGFYLSGQSSQNGGEVAFGGVDQNYYTGQIYWTPVTSETYWQ 245
Query 119 VELDAIYV-GEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD---- 173
+ + + G+ C++G + I+D+GTS T P + S ++ I +Q+
Sbjct 246 IGIQGFSINGQATGWCSQGCQ--AIVDTGTSLLTAPQSVFSSLIQSIGAQQDQNGQYVVS 303
Query 174 -SFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGH-AYILGSMSF 231
S ++ P ++ I GV F L P Y+++ + C M +PS G +ILG + F
Sbjct 304 CSNIQNLPTISFTISGVSFPLPPSAYVLQQSSGYCTIGIMPTYLPSQNGQPLWILGDV-F 362
Query 232 MRHFFTVF 239
+R +++V+
Sbjct 363 LREYYSVY 370
> mmu:109820 Pgc, 2210410L06Rik, MGC117575, Upg-1, Upg1; progastricsin
(pepsinogen C) (EC:3.4.23.3); K01377 gastricsin [EC:3.4.23.3]
Length=392
Score = 113 bits (282), Expect = 1e-24, Method: Compositional matrix adjust.
Identities = 76/263 (28%), Positives = 129/263 (49%), Gaps = 24/263 (9%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G G D ++ V Q FGL E N+ G F F+GI+GL +P +SS G
Sbjct 140 GSLTGFFGYDTLRVQSIQVPNQEFGLSE-----NEPGTNFVYAQFDGIMGLAYPGLSSGG 194
Query 61 ATPIYDNMLQQANVEKSEFAFYVA--KDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWE 118
AT ML + + + F Y+ + S I FGGVD + + PV +E YW+
Sbjct 195 ATTALQGMLGEGALSQPLFGVYLGSQQGSNGGQIVFGGVDENLYTGELTWIPVTQELYWQ 254
Query 119 VELDAIYVGEKK--FCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSF- 175
+ +D +G + +C + G + I+D+GTS +P+ + L+ I +QE GE +
Sbjct 255 ITIDDFLIGNQASGWCSSSGCQG--IVDTGTSLLVMPAQYLNELLQTIGAQE-GEYGQYF 311
Query 176 -----LEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGH-AYILGSM 229
+ P T+++ GV F L P Y+++ + + C + + ++ G +ILG +
Sbjct 312 VSCDSVSSLPTLTFVLNGVQFPLSPSSYIIQEEGS-CMVGLESLSLNAESGQPLWILGDV 370
Query 230 SFMRHFFTVFRRSD---GVNPSL 249
F+R ++ VF + G+ PS+
Sbjct 371 -FLRSYYAVFDMGNNRVGLAPSV 392
> dre:336746 fa94d12, wu:fa94d12; zgc:63831; K01379 cathepsin
D [EC:3.4.23.5]
Length=412
Score = 112 bits (279), Expect = 2e-24, Method: Compositional matrix adjust.
Identities = 69/252 (27%), Positives = 122/252 (48%), Gaps = 19/252 (7%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D L +V GQ F + Q G +F F+G++G+ +P +S
Sbjct 158 GSLSGFISQDTVNLAGLNVTGQQFAEAVK-----QPGIVFAVARFDGVLGMAYPAISVDR 212
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSA---IFFGGVDPRFFEPPIHMFPVVREHYW 117
TP++D + + ++ F+FY+ +D + GG D ++F +H V R+ YW
Sbjct 213 VTPVFDTAMAAKILPQNIFSFYINRDPAGDVGGELMLGGFDQQYFNGDLHYVNVTRKAYW 272
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPS-----QECGED 172
++++D + VG C G + I+D+GTS T P E+ + + I + E D
Sbjct 273 QIKMDEVQVGSTLTLCKSGCQ--AIVDTGTSMITGPVQEVRALQKAIGAIPLLMGEYWID 330
Query 173 DSFLEQYPNSTYIIGGVGFVLEPQDYLVRSK---ANICKPAYMQIDVPSDFGHAYILGSM 229
+ P ++ +GG F L Q+Y+++ N+C +M +D+P G +ILG +
Sbjct 331 CKKIPTLPVVSFSLGGKMFNLTGQEYVMKMSHMGMNVCLSGFMAMDIPPPAGPLWILGDV 390
Query 230 SFMRHFFTVFRR 241
F+ ++TVF R
Sbjct 391 -FIGRYYTVFDR 401
> dre:114367 nots, LAP, MGC192423, ctsel, zgc:103608; nothepsin
Length=416
Score = 110 bits (275), Expect = 8e-24, Method: Compositional matrix adjust.
Identities = 77/266 (28%), Positives = 131/266 (49%), Gaps = 23/266 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G D K+G V+ Q FG E G F F+G++GLGFP ++
Sbjct 150 GHLLGVMARDELKVGSVRVQNQVFGEAVYEP-----GFSFVLAQFDGVLGLGFPQLAEEK 204
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSP--VSAIFFGGVDPRFFEPPIHMFPVVREHYWE 118
+P++D M++Q +++ F+FY+ + + FG D F PPI+ PV ++ YW+
Sbjct 205 GSPVFDTMMEQNMLDQPVFSFYLTNNGSGFGGELVFGANDESRFLPPINWIPVTQKGYWQ 264
Query 119 VELDAIYV-GEKKFCCAEGTKNYVIIDSGTSFNTLPSNE---MESFLEMIPSQECGE--- 171
++LDA+ V G F I+D+GTS P+ + ++ F+ P+ GE
Sbjct 265 IKLDAVKVQGALSFSDRSVQGCQAIVDTGTSLIGGPARDILILQQFIGATPTAN-GEFVV 323
Query 172 DDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKAN---ICKPAYMQIDVPSDFGHAYILGS 228
D + P +++I V + L + Y+ R N IC + I+VPS G +ILG
Sbjct 324 DCVRVSSLPVVSFLINSVEYSLSGEQYVRRETLNNKQICFSGFQSIEVPSPAGPVWILGD 383
Query 229 MSFMRHFFTVFRRSDGVNPSLVGIAR 254
+ F+ ++++ R + + VG+AR
Sbjct 384 V-FLSQVYSIYDRGE----NRVGLAR 404
> mmu:100044656 renin-1-like
Length=425
Score = 109 bits (273), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 67/254 (26%), Positives = 131/254 (51%), Gaps = 21/254 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNI-FQSINFEGIVGLGFPDMSST 59
GR++G D +G V QTFG E + I F F+G++G+GFP +
Sbjct 173 GRVKGFLSQDVVTVGGITVT-QTFG------EVTELPLIPFMLAKFDGVLGMGFPAQAVG 225
Query 60 GATPIYDNMLQQANVEKSEFAFYVAKDSPV--SAIFFGGVDPRFFEPPIHMFPVVREHYW 117
G TP++D++L Q +++ F+ Y + S + + GG DP+ ++ H + + W
Sbjct 226 GVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSW 285
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD---- 173
++ + + VG C EG V++D+G+SF + P++ ++ ++ + ++E D+
Sbjct 286 QITMKGVSVGSSTLLCEEGCA--VVVDTGSSFISAPTSSLKLIMQALGAKEKRIDEYVVN 343
Query 174 -SFLEQYPNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAYILGSM 229
S + P+ ++ +GG + L DY+++ + +C A +D+P G ++LG+
Sbjct 344 CSQVPTLPDISFDLGGRAYTLSSTDYVLQYPYRRDKLCTLALHAMDIPPPTGPVWVLGA- 402
Query 230 SFMRHFFTVFRRSD 243
+F+R F+T F R +
Sbjct 403 TFIRKFYTEFDRHN 416
> mmu:19701 Ren1, D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1,
Rnr; renin 1 structural (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=402
Score = 108 bits (271), Expect = 2e-23, Method: Compositional matrix adjust.
Identities = 68/259 (26%), Positives = 130/259 (50%), Gaps = 31/259 (11%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNI-FQSINFEGIVGLGFPDMSST 59
GR++G D+ +G V QTFG E + I F F+G++G+GFP +
Sbjct 150 GRVKGFLSQDSVTVGGITVT-QTFG------EVTELPLIPFMLAKFDGVLGMGFPAQAVG 202
Query 60 GATPIYDNMLQQANVEKSEFAFYVAKDSPV--SAIFFGGVDPRFFEPPIHMFPVVREHYW 117
G TP++D++L Q +++ F+ Y + S + + GG DP+ ++ H + + W
Sbjct 203 GVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSW 262
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLE 177
++ + + VG C EG V++D+G+SF + P++ ++ + Q G + +E
Sbjct 263 QITMKGVSVGSSTLLCEEGCA--VVVDTGSSFISAPTSSLKLIM-----QALGAKEKRIE 315
Query 178 QY----------PNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAY 224
+Y P+ ++ +GG + L DY+++ + +C A +D+P G +
Sbjct 316 EYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVW 375
Query 225 ILGSMSFMRHFFTVFRRSD 243
+LG+ +F+R F+T F R +
Sbjct 376 VLGA-TFIRKFYTEFDRHN 393
> cel:R12H7.2 asp-4; ASpartyl Protease family member (asp-4);
K01379 cathepsin D [EC:3.4.23.5]
Length=444
Score = 108 bits (271), Expect = 2e-23, Method: Compositional matrix adjust.
Identities = 62/214 (28%), Positives = 115/214 (53%), Gaps = 15/214 (7%)
Query 37 GNIFQSINFEGIVGLGFPDMSSTGATPIYDNMLQQANVEKSEFAFYVAK--DSPVSA-IF 93
G F + F+GI+G+ +P+++ G P+++ + +Q V + F+F++ + DS + I
Sbjct 191 GITFVAAKFDGILGMAYPEIAVLGVQPVFNTLFEQKKVPSNLFSFWLNRNPDSEIGGEIT 250
Query 94 FGGVDPRFFEPPIHMFPVVREHYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLP 153
FGG+D R + PI PV R+ YW+ ++D + VG C+ G + I D+GTS P
Sbjct 251 FGGIDSRRYVEPITYVPVTRKGYWQFKMDKV-VGSGVLGCSNGCQ--AIADTGTSLIAGP 307
Query 154 SNEMESFLEMIPSQECGEDDSFLE-----QYPNSTYIIGGVGFVLEPQDYLVR---SKAN 205
++E+ I ++ + + + P +++IGG F L+ +DY+++
Sbjct 308 KAQIEAIQNFIGAEPLIKGEYMISCDKVPTLPPVSFVIGGQEFSLKGEDYVLKVSQGGKT 367
Query 206 ICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVF 239
IC +M ID+P G +ILG + F+ +++VF
Sbjct 368 ICLSGFMGIDLPERVGELWILGDV-FIGRYYSVF 400
> mmu:229697 Cym, Gm131; chymosin (EC:3.4.23.4); K01378 chymosin
[EC:3.4.23.4]
Length=379
Score = 108 bits (270), Expect = 3e-23, Method: Compositional matrix adjust.
Identities = 75/262 (28%), Positives = 130/262 (49%), Gaps = 26/262 (9%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
GR+EG D + V QT GL +E G+IF F+GI+GL +P +S
Sbjct 138 GRMEGFLAYDTVTVSDIVVSHQTVGLSTQEP-----GDIFTYSPFDGILGLAYPTFASKY 192
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYWEVE 120
+ PI+DNM+ + V + F+ Y++++ S + G +D +F +H PV + YW+
Sbjct 193 SVPIFDNMMNRHLVAQDLFSVYMSRNEQGSMLTLGAIDQSYFIGSLHWVPVTVQGYWQFT 252
Query 121 LDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSF----- 175
+D I + + C G ++D+GT+ T P ++ + ++I + + G +D F
Sbjct 253 VDRITINGEVVACQGGCP--AVLDTGTALLTGPGRDILNIQQVIGAVQ-GHNDQFDIDCW 309
Query 176 -LEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSFMRH 234
L+ P + I G F L P Y + + C + Q H +ILG + F+R
Sbjct 310 RLDIMPTVVFEIHGREFPLPPYAYTNQVQG-FCSSGFKQ------GSHMWILGDV-FIRE 361
Query 235 FFTVFRRSDGVNPSLVGIARAV 256
F++VF R++ + VG+A+A+
Sbjct 362 FYSVFDRAN----NRVGLAKAI 379
> bbo:BBOV_III003510 17.m07331; eukaryotic aspartyl protease family
protein
Length=521
Score = 108 bits (269), Expect = 3e-23, Method: Compositional matrix adjust.
Identities = 83/304 (27%), Positives = 140/304 (46%), Gaps = 55/304 (18%)
Query 6 STGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPD---MSSTGAT 62
+ G D K+GP +V+ Q+ GL E++H F + F+G+VGLGFPD + G
Sbjct 221 ALGSDTVKIGPLEVKNQSIGLATYESDHP-----FGDLPFDGLVGLGFPDKMYKDTDGML 275
Query 63 PIYDNMLQQANVEKSEFAFYVAKD-SPVSAIFFGGVDPRFFEP--PIHMFPVVREHYWEV 119
P+ DN++QQ + ++ AFY++KD + ++ FG +DPR+ P FPVV +WE+
Sbjct 276 PLLDNIMQQKLLNRNLVAFYMSKDKTQPGSMSFGSIDPRYVLPGHSPWWFPVVATDFWEI 335
Query 120 ELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIP-SQECGEDDSFLEQ 178
++AI + K K ID+G+S + PS + L+ + S +C S L Q
Sbjct 336 AMEAILIDGKPMKLE--NKYNAAIDTGSSLISGPSEVVGPLLDRLALSPDC----SNLNQ 389
Query 179 YPNSTYII-----GGVGFVLEPQDYLVR------------------------------SK 203
P +++ + F + P DY+ R ++
Sbjct 390 LPTISFVFVDMNGRKIKFDMSPDDYVERIEYDDSEFIATKNEPNNDATEQNKNAEIKATE 449
Query 204 ANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARAVHSEENKA 263
C M +DVP G +++G ++F+ + +F R D + LV A V E +
Sbjct 450 NTQCVIGIMTMDVPKPKGPLFVMG-VNFINRYMAIFDR-DAMAVGLVPSAHKVDEREEQR 507
Query 264 YLQQ 267
L++
Sbjct 508 KLEE 511
> mmu:19702 Ren2, Ren, Ren-2, Ren-B, Rn-2, Rnr; renin 2 tandem
duplication of Ren1 (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=424
Score = 106 bits (264), Expect = 1e-22, Method: Compositional matrix adjust.
Identities = 64/253 (25%), Positives = 128/253 (50%), Gaps = 19/253 (7%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
GR++G D+ +G V QTFG V F F+G++G+GFP + G
Sbjct 172 GRVKGFLSQDSVTVGGITVT-QTFGEVTELPLIP-----FMLAQFDGVLGMGFPAQAVGG 225
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPV--SAIFFGGVDPRFFEPPIHMFPVVREHYWE 118
TP++D++L Q +++ F+ Y + + + GG DP ++ H + + W+
Sbjct 226 VTPVFDHILSQGVLKEKVFSVYYNRGPHLLGGEVVLGGSDPEHYQGDFHYVSLSKTDSWQ 285
Query 119 VELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDD----- 173
+ + + VG C EG + V++D+G+SF + P++ ++ ++ + ++E +
Sbjct 286 ITMKGVSVGSSTLLCEEGCE--VVVDTGSSFISAPTSSLKLIMQALGAKEKRLHEYVVSC 343
Query 174 SFLEQYPNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFGHAYILGSMS 230
S + P+ ++ +GG + L DY+++ + +C A +D+P G ++LG+ +
Sbjct 344 SQVPTLPDISFNLGGRAYTLSSTDYVLQYPNRRDKLCTVALHAMDIPPPTGPVWVLGA-T 402
Query 231 FMRHFFTVFRRSD 243
F+R F+T F R +
Sbjct 403 FIRKFYTEFDRHN 415
> dre:405786 ren; renin (EC:3.4.23.15); K01380 renin [EC:3.4.23.15]
Length=395
Score = 103 bits (258), Expect = 7e-22, Method: Compositional matrix adjust.
Identities = 61/228 (26%), Positives = 116/228 (50%), Gaps = 18/228 (7%)
Query 40 FQSINFEGIVGLGFPDMSSTGATPIYDNMLQQANVEKSEFAFYVAKDS---PVSAIFFGG 96
F F+G++G+G+P+++ G TP++D ++ Q ++++ F+ Y ++D P + GG
Sbjct 175 FILAKFDGVLGMGYPNVAIDGITPVFDRIMSQHVLKENVFSVYYSRDPTHIPGGELVLGG 234
Query 97 VDPRFFEPPIHMFPVVREHYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNE 156
DP + P H + WEV + + VG C +G +ID+G+S+ T P++
Sbjct 235 TDPNYHTGPFHYINTKEQGKWEVIMKGVSVGADILFCKDGCT--AVIDTGSSYITGPASS 292
Query 157 MESFLEMIPSQECGEDD-----SFLEQYPNSTYIIGGVGFVLEPQDYLVRSK---ANICK 208
+ ++ I + E E + + P + +GG + L +DY++ +IC
Sbjct 293 ISILMKTIGAVELAEGGYTVSCNVVRLLPTVAFHLGGQEYSLTDEDYILWQSEFGEDICT 352
Query 209 PAYMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARAV 256
+ +DVP G +ILG+ +F+ ++T F R + + +G ARAV
Sbjct 353 VTFKALDVPPPTGPVWILGA-NFIARYYTEFDRGN----NRIGFARAV 395
> hsa:5972 REN, FLJ10761, HNFJ2; renin (EC:3.4.23.15); K01380
renin [EC:3.4.23.15]
Length=406
Score = 102 bits (253), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 58/220 (26%), Positives = 112/220 (50%), Gaps = 23/220 (10%)
Query 40 FQSINFEGIVGLGFPDMSSTGATPIYDNMLQQANVEKSEFAFYVAKDSPVS-----AIFF 94
F F+G+VG+GF + + TPI+DN++ Q +++ F+FY +DS S I
Sbjct 185 FMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVL 244
Query 95 GGVDPRFFEPPIHMFPVVREHYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPS 154
GG DP+ +E H +++ W++++ + VG C +G ++D+G S+ + +
Sbjct 245 GGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGC--LALVDTGASYISGST 302
Query 155 NEMESFLEMIPSQ--------ECGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVR---SK 203
+ +E +E + ++ +C E + P+ ++ +GG + L DY+ + S
Sbjct 303 SSIEKLMEALGAKKRLFDYVVKCNEGPTL----PDISFHLGGKEYTLTSADYVFQESYSS 358
Query 204 ANICKPAYMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSD 243
+C A +D+P G + LG+ +F+R F+T F R +
Sbjct 359 KKLCTLAIHAMDIPPPTGPTWALGA-TFIRKFYTEFDRRN 397
> sce:YPL154C PEP4, PHO9, PRA1, yscA; Pep4p (EC:3.4.23.25); K01381
saccharopepsin [EC:3.4.23.25]
Length=405
Score = 97.4 bits (241), Expect = 7e-20, Method: Compositional matrix adjust.
Identities = 78/270 (28%), Positives = 122/270 (45%), Gaps = 33/270 (12%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G +EG D +G + Q F E G F F+GI+GLG+ +S
Sbjct 155 GSLEGYISQDTLSIGDLTIPKQDFAEATSEP-----GLTFAFGKFDGILGLGYDTISVDK 209
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVS----AIFFGGVDPRFFEPPIHMFPVVREHY 116
P + N +QQ +++ FAFY+ S + FGG+D F+ I PV R+ Y
Sbjct 210 VVPPFYNAIQQDLLDEKRFAFYLGDTSKDTENGGEATFGGIDESKFKGDITWLPVRRKAY 269
Query 117 WEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFL 176
WEV+ + I +G++ AE + ID+GTS TLPS EMI + E G +
Sbjct 270 WEVKFEGIGLGDE---YAELESHGAAIDTGTSLITLPS----GLAEMI-NAEIGAKKGWT 321
Query 177 EQY----------PNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYIL 226
QY P+ + G F + P DY + + C A +D P G I+
Sbjct 322 GQYTLDCNTRDNLPDLIFNFNGYNFTIGPYDYTLEVSGS-CISAITPMDFPEPVGPLAIV 380
Query 227 GSMSFMRHFFTVFRRSDGVNPSLVGIARAV 256
G +F+R +++++ + VG+A+A+
Sbjct 381 GD-AFLRKYYSIYDLGNNA----VGLAKAI 405
> cpv:cgd6_3820 membrane bound aspartyl proteinase with a signal
peptide plus transmembrane domain
Length=467
Score = 95.9 bits (237), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 73/291 (25%), Positives = 141/291 (48%), Gaps = 43/291 (14%)
Query 8 GVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSS--TGATPIY 65
G + +G + Q+FG+ E+ + F + F+G+VGLGFPD +S I
Sbjct 170 GKEVINIGKLKIEDQSFGMAIEEST-----SPFAELPFDGLVGLGFPDKNSKKNNIPTIV 224
Query 66 DNMLQQANVEKSEFAFYVAKDSPV-SAIFFGGVDPRFF--EPPIHMFPVVREHYWEVELD 122
+N+ ++ + ++ F Y+++DS +I FG DP++ I + HYWE+++
Sbjct 225 ENIKERNILPRNLFGVYISRDSSTPGSISFGAADPKYTISGQKITWHRLTGSHYWEIKIK 284
Query 123 AIYVG--EKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLEQYP 180
I + +C + ID+G+S +T PS+ M ++IP + GE + +L P
Sbjct 285 DIKINGVSTNYCFGDCK---AAIDTGSSVSTAPSSFMRKITKVIPME--GECNRYLSS-P 338
Query 181 NSTYII-----GGVGFVLEPQDYLVRS---------------KANICKPAYMQIDVPSDF 220
TY+I + ++PQDY++ + + C Y+ +D+P+
Sbjct 339 RITYVIEDIHGNEIEMHMDPQDYVIDEGGPSSFNAFSYYWGPQEHYCSIGYIPLDIPAPR 398
Query 221 GHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARAVHSEENKAYLQQVADS 271
G ++LG+ +F+R ++++F R + +VG A HS+ ++ ++S
Sbjct 399 GPLFVLGN-NFIRKYYSIFDRDN----LMVGFTLAKHSKYGPMFISLSSNS 444
> pfa:PFC0495w plasmepsin VI (EC:3.4.23.-); K01386 [EC:3.4.23.-]
Length=432
Score = 95.9 bits (237), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 80/266 (30%), Positives = 127/266 (47%), Gaps = 30/266 (11%)
Query 10 DNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGF--PDMSSTG--ATPIY 65
D+ L ++ Q GL E+ H F + F+GIVGLGF PD S A+P+
Sbjct 179 DDVYLKGLKIKHQCIGLAIEESLHP-----FSDLPFDGIVGLGFSDPDFRSQNKYASPLI 233
Query 66 DNMLQQANVEKSEFAFYVAKDSPVS-AIFFGGVDPRFFE--PPIHMFPVVREHYWEVELD 122
+ + +Q ++++ F+FYV K S AI FG + ++ I FPV+ +YWE+ L
Sbjct 234 ETIKKQNLLKRNIFSFYVPKKLEKSGAITFGKANKKYTVEGKSIEWFPVISLYYWEINLL 293
Query 123 AIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQECGEDDSFLEQYPNS 182
I + K E K ID+G+S T PS ++ LE I + D S E P
Sbjct 294 DIQLSHKNLFLCESKKCRAAIDTGSSLITGPSTFIQPLLEKINLE---RDCSNKESLPII 350
Query 183 TYIIGGV-----GFVLEPQDYLVR---SKANI--CKPAYMQIDVPSDFGHAYILGSMSFM 232
++++ V P+DY++ ++ N C M +DVP G +I G+ SF+
Sbjct 351 SFVLKNVEGKEITLDFMPEDYIIEEGDTENNTLECVIGIMPLDVPPPRGPIFIFGN-SFI 409
Query 233 RHFFTVFRRSDGVNPSLVGIARAVHS 258
R ++T+F L+G+ A H+
Sbjct 410 RKYYTIFDNDH----KLIGLIEANHN 431
> xla:398557 cathepsin D (EC:3.4.23.5); K01379 cathepsin D [EC:3.4.23.5]
Length=409
Score = 95.1 bits (235), Expect = 3e-19, Method: Compositional matrix adjust.
Identities = 51/167 (30%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G I G D +G + Q FG + Q G F + F+GI+G+ +P +S G
Sbjct 145 GSISGYLSKDTVTIGNLGYKEQIFGEAIK-----QPGVTFIAAKFDGILGMAYPIISVDG 199
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKD---SPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
+P +DN++ Q VE + F+FY+ ++ P + GG DP+++ H V R+ YW
Sbjct 200 VSPCFDNIMAQKLVESNVFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFHYLNVTRKAYW 259
Query 118 EVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMI 164
++ +D + VG++ C G + I+D+GTS T P E+ + I
Sbjct 260 QIHMDQLGVGDQLTLCKGGCE--AIVDTGTSLITGPVEEVAALQRAI 304
> ath:AT4G04460 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=508
Score = 82.4 bits (202), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 62/188 (32%), Positives = 96/188 (51%), Gaps = 19/188 (10%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G I G D+ K+G V+ Q F +E +E G F F+GI+GLGF ++S
Sbjct 152 GAISGYFSNDDVKVGDIVVKEQEF--IEATSEP---GITFLLAKFDGILGLGFKEISVGN 206
Query 61 ATPIYDNMLQQANVEKSEFAFYV---AKDSPVSAIFFGGVDPRFFEPPIHMFPVVREHYW 117
+TP++ NM+++ V++ F+F++ KD I FGGVDP+ F+ PV + YW
Sbjct 207 STPVWYNMVEKGLVKEPIFSFWLNRNPKDPEGGEIVFGGVDPKHFKGEHTFVPVTHKGYW 266
Query 118 EVEL-DAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESF-----LEMIPSQECGE 171
+ ++ D G+ CA+G I DSGTS T PS + + I S+EC
Sbjct 267 QFDMGDLQIAGKPTGYCAKGCS--AIADSGTSLLTGPSTVITMINHAIGAQGIVSREC-- 322
Query 172 DDSFLEQY 179
+ ++QY
Sbjct 323 -KAVVDQY 329
Score = 41.2 bits (95), Expect = 0.005, Method: Compositional matrix adjust.
Identities = 33/105 (31%), Positives = 47/105 (44%), Gaps = 18/105 (17%)
Query 160 FLEMIPSQ------ECGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANI---CKPA 210
+ IP+Q +CG S P T+ IGG F L PQDY+ + + C
Sbjct 412 LCDHIPTQNQQSAVDCGRVSSM----PIVTFSIGGRSFDLTPQDYIFKIGEGVESQCTSG 467
Query 211 YMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARA 255
+ +D+ G +ILG + FM + TVF G VG A+A
Sbjct 468 FTAMDIAPPRGPLWILGDI-FMGPYHTVFDYGKG----RVGFAKA 507
> cel:Y39B6A.20 asp-1; ASpartyl Protease family member (asp-1)
Length=396
Score = 80.5 bits (197), Expect = 7e-15, Method: Compositional matrix adjust.
Identities = 67/270 (24%), Positives = 120/270 (44%), Gaps = 28/270 (10%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G G G D G V+ Q FG+ ++F +GI+GLG+P ++
Sbjct 139 GSCNGYLGKDVLNFGGLTVQSQEFGV------STHLADVFGYQPVDGILGLGWPALAVDQ 192
Query 61 ATPIYDNMLQQANVEKSEFAFY------VAKDSPVSAIFFGGVDPRFFEPPIHMFPVVRE 114
P N++ Q ++ F + +A+ +P I +G +D + P+ +
Sbjct 193 VVPPMQNLIAQKQLDAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAK 252
Query 115 HYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIP------SQE 168
YW+ LDA VG +E K+ VI D+GTS+ P+ + + ++ ++
Sbjct 253 TYWQFPLDAFAVGTY----SETKKDQVISDTGTSWLGAPNTIVSAIVKQTKAVFDWSTEL 308
Query 169 CGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPS-DFGHAYILG 227
D S ++ P+ + IGG F ++ +Y++ + K A + S FG ++ILG
Sbjct 309 YTVDCSTMKTQPDLIFTIGGAQFPVKSVEYVLDLQLGGGKCALAVFSMGSGGFGPSWILG 368
Query 228 SMSFMRHFFTVFRRSDGVNPSLVGIARAVH 257
+F+R + V+ +G +G A AVH
Sbjct 369 D-TFIRQYCNVYDIGNG----QIGFATAVH 393
> ath:AT1G62290 aspartyl protease family protein; K08245 phytepsin
[EC:3.4.23.40]
Length=513
Score = 80.5 bits (197), Expect = 7e-15, Method: Compositional matrix adjust.
Identities = 63/217 (29%), Positives = 103/217 (47%), Gaps = 25/217 (11%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G I G D +G V+ Q F +E +E G F F+G++GLGF +++
Sbjct 154 GSISGFFSYDAVTVGDLVVKDQEF--IETTSEP---GLTFLVAKFDGLLGLGFQEIAVGN 208
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVS----AIFFGGVDPRFFEPPIHMFPVVREHY 116
ATP++ NML+Q +++ F+F++ +D P S I FGGVDP+ F PV + Y
Sbjct 209 ATPVWYNMLKQGLIKRPVFSFWLNRD-PKSEEGGEIVFGGVDPKHFRGEHTFVPVTQRGY 267
Query 117 WEVELDAIYV-GEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIP-----SQECG 170
W+ ++ + + GE C G I DSGTS P+ + + I SQ+C
Sbjct 268 WQFDMGEVLIAGESTGYCGSGCS--AIADSGTSLLAGPTAVVAMINKAIGASGVVSQQC- 324
Query 171 EDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANIC 207
+ ++QY + + + E Q + S+ +C
Sbjct 325 --KTVVDQYGQTILDL----LLAETQPKKICSQIGLC 355
Score = 42.4 bits (98), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query 165 PSQECGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVR---SKANICKPAYMQIDVPSDFG 221
P+ E D S L + P ++ IGG F L P++Y+++ C + +D+P G
Sbjct 424 PNGESAVDCSQLSKMPTVSFTIGGKVFDLAPEEYVLKIGEGPVAQCISGFTALDIPPPRG 483
Query 222 HAYILGSMSFMRHFFTVF 239
+ILG + FM + TVF
Sbjct 484 PLWILGDV-FMGKYHTVF 500
> pfa:PF14_0077 plasmepsin II; K06008 plasmepsin II [EC:3.4.23.39]
Length=453
Score = 77.4 bits (189), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 70/227 (30%), Positives = 107/227 (47%), Gaps = 37/227 (16%)
Query 45 FEGIVGLGFPDMSSTGATPIYDNMLQQANVEKSEFAFYV-AKDSPVSAIFFGGVDPRFFE 103
F+GI+GLG+ D+S PI + Q +E + F FY+ D + GG++ RF+E
Sbjct 244 FDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYE 303
Query 104 PPIHMFPVVREHYWEVELDAIYVG----EKKFCCAEGTKNYVIIDSGTSFNTLPSNEMES 159
P+ + + YW++ LDA +VG EK C I+DSGTS T+P++ +
Sbjct 304 GPLTYEKLNHDLYWQITLDA-HVGNIMLEKANC---------IVDSGTSAITVPTDFLNK 353
Query 160 FLE--------MIPSQECGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSK---ANICK 208
L+ +P ++S + P + + LEP+ YL + +C
Sbjct 354 MLQNLDVIKVPFLPFYVTLCNNS---KLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCM 410
Query 209 PAYMQIDVPSDFGHAYILGSMSFMRHFFTVFRRSDGVNPSLVGIARA 255
+ +D P +ILG FMR +FTVF D N S VGIA A
Sbjct 411 LNIIGLDFPVP---TFILGD-PFMRKYFTVF---DYDNQS-VGIALA 449
> ath:AT1G69100 aspartic-type endopeptidase
Length=367
Score = 77.0 bits (188), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 66/267 (24%), Positives = 117/267 (43%), Gaps = 22/267 (8%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G DN +G ++ Q L + F+S+ F+G++GLG + G
Sbjct 112 GSVVGILAQDNVNVGGVVIKSQDLFLARNPDTY------FRSVKFDGVIGLGIKSSRAQG 165
Query 61 ATPIYDNMLQQANVEKSEFAFYV-------AKDSPVSAIFFGGVDPRFFEPPIHMFPV-V 112
+ +++NM++Q + K F+ Y+ +D I FGG DP+ F+ P+ +
Sbjct 166 SVTVWENMVKQKLITKPIFSLYLRPHKGDGGEDPNGGQIMFGGFDPKQFKGEHVYVPMKL 225
Query 113 REHYWEVELDAIYVGEK---KFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPSQEC 169
+ W++++ IY+ K FC + + ++DSG++ P + + I + +
Sbjct 226 SDDRWKIKMSKIYINGKPAINFC--DDVECTAMVDSGSTDIFGPDEAVGKIYKEIGATKV 283
Query 170 GEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSM 229
P+ + IGG L DY V K N K ++I + ++LG
Sbjct 284 IIRCEQFPALPDIYFEIGGKHLRLTKHDY-VEVKTNPKKRCRLRIVKSKNRRKDWVLGE- 341
Query 230 SFMRHFFTVFRRSDGVNPSLVGIARAV 256
+FM F TVF D P +G A A+
Sbjct 342 AFMTKFHTVFDYGDVKTPR-IGFAEAI 367
> cel:Y39B6A.23 hypothetical protein
Length=395
Score = 75.9 bits (185), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 62/271 (22%), Positives = 121/271 (44%), Gaps = 28/271 (10%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G G G D +LG V+ Q FG+ G++ S +GI GLG+P +S
Sbjct 139 GTSSGYLGTDVLQLGGLTVKAQEFGVATN------LGSVLGSEPMDGIFGLGWPAISVDQ 192
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVS------AIFFGGVDPRFFEPPIHMFPVVRE 114
TP N++ Q ++ F+ +V + VS I +G VD + + ++ + +
Sbjct 193 VTPPMQNLISQKQLDAPLFSIWVDRKLQVSQGGTGGLITYGAVDTKNCDAQVNYVALSSK 252
Query 115 HYWEVELDAIYVGEKKFCCAEGTKNYVIIDSGTSFNTLPSNEMESFLEMIPS------QE 168
YW+ +D + +G E I D+G+++ LP+ + + ++ + +
Sbjct 253 TYWQFPMDGVAIGNYAMMKQE----QAISDTGSAWLGLPNPVLNAIVQQTKATYDWNYEI 308
Query 169 CGEDDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVP-SDFGHAYILG 227
D S ++ P+ + IGG+ + ++ +Y++ + + + FG +Y+LG
Sbjct 309 YTLDCSTMQTQPDLVFTIGGMQYPVKSIEYILDLGLGNGRCVLAMLSYSNTGFGPSYVLG 368
Query 228 SMSFMRHFFTVFRRSDGVNPSLVGIARAVHS 258
+ F+R F V+ + + +G A A HS
Sbjct 369 HV-FIRQFCNVYD----IGNARIGFANAHHS 394
> ath:AT4G22050 aspartyl protease family protein
Length=354
Score = 75.5 bits (184), Expect = 3e-13, Method: Compositional matrix adjust.
Identities = 73/248 (29%), Positives = 118/248 (47%), Gaps = 29/248 (11%)
Query 1 GRIEGSTGVDNFKLGPYDVRGQTFGLVERETEHNQHGNIFQSINFEGIVGLGFPDMSSTG 60
G + G VD +G + QTF E + F+ + F+GI+GL F D + G
Sbjct 110 GSLTGFLSVDTVTVGGISITSQTF----IEGVKTPYKEFFKKMPFDGILGLRFTDPLNFG 165
Query 61 ATPIYDNMLQQANVEKSEFAFYVAKDSPVSAI-----FFGGVDPRFFEPPIHMFPVVREH 115
T ++ +M+ Q + K+ F+ ++ + S I FGG+ P F H + V
Sbjct 166 -TSVWHSMVFQGKIAKNVFSIWLRRFSNSGEINGGEVVFGGIIPAHFSGD-HTYVDVEGP 223
Query 116 YWEVELDAIYVGEKKF-CCAEGTKNYVIIDSGTSFNTLP---SNEMESFLEMIPSQECGE 171
+ I+VG K C+ G K I+DSG+S +P ++E+ ++ + P+ C
Sbjct 224 GNFFAMSNIWVGGKNTNICSSGCK--AIVDSGSSNINVPMDSADEIHRYIGVEPN--CNN 279
Query 172 DDSFLEQYPNSTYIIGGVGFVLEPQDYLVRSKANICKPAYMQIDVPSDFGHAYILGSMSF 231
E P+ T+ IGG FVL P DY+ RS++ C ++ ++ H + LG + F
Sbjct 280 ----FETLPDVTFTIGGKAFVLTPLDYIRRSRSQ-CTSKFVG---KTNRSH-WTLG-IPF 329
Query 232 MRHFFTVF 239
MR F TVF
Sbjct 330 MRVFHTVF 337
Lambda K H
0.319 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 12920510708
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40