bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0378_orf1
Length=344
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:... 407 4e-113
pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12... 325 2e-88
tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07... 267 5e-71
bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:... 247 6e-65
cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase... 228 2e-59
mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II; p... 142 2e-33
hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,... 140 6e-33
hsa:5575 PRKAR1B, PRKAR1; protein kinase, cAMP-dependent, regu... 134 4e-31
mmu:19085 Prkar1b, AI385716, RIbeta; protein kinase, cAMP depe... 134 5e-31
hsa:5573 PRKAR1A, CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR... 132 1e-30
xla:444805 prkar1b, MGC82149, prkar1; protein kinase, cAMP-dep... 132 2e-30
xla:432155 prkar1a, pkr1; protein kinase, cAMP-dependent, regu... 132 2e-30
mmu:19084 Prkar1a, 1300018C22Rik, RIalpha, Tse-1, Tse1; protei... 131 3e-30
dre:100125912 prkg2; protein kinase, cGMP-dependent, type II (... 131 4e-30
xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent, ty... 130 5e-30
dre:550427 prkar1ab, zgc:112145; protein kinase, cAMP-dependen... 130 6e-30
sce:YIL033C BCY1, SRA1; Bcy1p; K04739 cAMP-dependent protein k... 129 1e-29
dre:767685 prkar1b, MGC153624, zgc:153624; protein kinase, cAM... 129 2e-29
dre:494533 prkar1aa, im:7047729, prkar1a, zgc:92515; protein k... 129 2e-29
dre:100329979 protein kinase, cAMP-dependent, regulatory, type... 129 2e-29
dre:556339 protein kinase, cGMP-dependent, type II-like; K0737... 124 4e-28
tgo:TGME49_042070 cAMP-dependent protein kinase regulatory sub... 123 1e-27
cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);... 122 2e-27
cel:R07E4.6 kin-2; protein KINase family member (kin-2); K0473... 120 9e-27
pfa:PFL1110c PKAr; CAMP-dependent protein kinase regulatory su... 119 2e-26
hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK, P... 117 9e-26
mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b; p... 116 1e-25
cpv:cgd7_120 cAMP-dependent protein kinase regulatory subunit ... 113 9e-25
dre:326020 fd58b04, wu:fd58b04; si:dkey-121j17.5 112 1e-24
dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,... 112 2e-24
tgo:TGME49_111300 cAMP-dependent protein kinase regulatory sub... 108 3e-23
dre:405894 prkar2ab, MGC85886, prkar2a, zgc:85886; protein kin... 108 4e-23
dre:100329437 protein kinase, cAMP-dependent, regulatory, type... 107 6e-23
dre:556042 prkar2aa, MGC153742, wu:fb55f12, wu:fj29e12, wu:fj3... 105 2e-22
dre:566430 cGMP dependent protein kinase I 102 3e-21
mmu:19087 Prkar2a, 1110061A24Rik, AI317181, AI836829, RII(alph... 100 6e-21
hsa:5576 PRKAR2A, MGC3606, PKR2, PRKAR2; protein kinase, cAMP-... 98.2 4e-20
hsa:5577 PRKAR2B, PRKAR2, RII-BETA; protein kinase, cAMP-depen... 95.9 2e-19
tpv:TP02_0494 cAMP-dependent protein kinase regulatory subunit... 94.7 5e-19
mmu:19088 Prkar2b, AI451071, AW061005, Pkarb2, RII(beta); prot... 94.4 6e-19
xla:414594 prkar2b, MGC83177; protein kinase, cAMP-dependent, ... 92.0 3e-18
dre:100331387 cAMP-dependent protein kinase, regulatory subuni... 89.4 2e-17
ath:AT2G20050 ATP binding / cAMP-dependent protein kinase regu... 88.6 3e-17
bbo:BBOV_II005430 18.m06452; cAMP-dependent protein kinase reg... 82.4 2e-15
dre:100332846 acyl-CoA synthetase long-chain family member 6-like 77.4 7e-14
tgo:TGME49_019070 cAMP-dependent protein kinase regulatory sub... 71.2 6e-12
cel:C09G4.2 hypothetical protein 68.2 4e-11
dre:795338 si:dkey-196h17.4 59.3 2e-08
cel:T20G5.5 epac-1; Exchange Protein Activated by Cyclic AMP f... 58.2 4e-08
tgo:TGME49_004470 cyclic nucleotide-binding domain containing ... 57.4 7e-08
> tgo:TGME49_111360 cGMP-dependent protein kinase, putative (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=994
Score = 407 bits (1045), Expect = 4e-113, Method: Compositional matrix adjust.
Identities = 205/351 (58%), Positives = 265/351 (75%), Gaps = 9/351 (2%)
Query 1 AVRKMSGSSATAPKGEMPTASTG-TPEQQQQQQQQQEQQQQRQPQH-QQSQQQQQEPQQQ 58
++ ++ G+ A+A E+ A G P++++ EQ + + +++ P+
Sbjct 52 SLARVDGTRASA--AELERAPDGVCPDREEPGTANAEQGGVTEKKDTRETLAGMNSPKTL 109
Query 59 QEQQQPPDRKTSQPQQSDDAAAPP----KPGGERK-VQKAIMQQDDTQAEDARLLSHLEK 113
+ + Q D K P Q + AP KPGG+RK QKAI++QDD+ E+ +L +HL
Sbjct 110 EAEAQEDDLKREAPNQDVPSEAPEGPKEKPGGDRKPAQKAILKQDDSHTEEEKLNAHLAY 169
Query 114 REKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIV 173
REKT D +LI+ SL ANLVCSSLN+ E++ALA A+QFFTF KGD+VTKQGE GSYFFI+
Sbjct 170 REKTPADFALIQDSLKANLVCSSLNEGEIDALAVAMQFFTFKKGDVVTKQGEPGSYFFII 229
Query 174 HSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLK 233
HSG F+V+VNDK VN + +G+AFGEI+LIHN+ R+A++ S + ALWGVQR FRETLK
Sbjct 230 HSGTFDVLVNDKRVNAMDKGKAFGEIALIHNTERSATVVASSTEGALWGVQRHTFRETLK 289
Query 234 QLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILK 293
QLSSRNFAENRQFLASV+FF+MLTEAQKNVITNALVV++F+ GQPIVKEG+ GD+LYILK
Sbjct 290 QLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVENFKPGQPIVKEGDAGDVLYILK 349
Query 294 SGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
SGKA+VSI G+++R+L+KGDYFGERALLY EPRSATI AEE TVCVSIGR+
Sbjct 350 SGKAKVSIGGREIRMLRKGDYFGERALLYKEPRSATITAEEFTVCVSIGRE 400
Score = 86.3 bits (212), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 71/246 (28%), Positives = 111/246 (45%), Gaps = 30/246 (12%)
Query 114 REKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGEN------- 166
RE L ++ L N++ +L S+V L Q + +V G +
Sbjct 399 RELLDRVLGNLQHVLFRNIMVEALQQSKVYELFQGDQLSKLIEAAVVKDYGADYVILDKE 458
Query 167 ----GSYFFIVHSGEFEVIV----------NDKVVNKIVEGQAFGEISLIHNSAR--TAS 210
G FF V GE V K+ + GQAFGE + N R
Sbjct 459 NKTKGIRFFFVLEGELSVYAYAQNPATKEEERKLAATLKRGQAFGE-EYVLNPTRPFNHY 517
Query 211 IKTLSE-KAALWGVQRQVFRETLKQLS---SRNFAENRQFLASVEFFQMLTEAQKNVITN 266
+K++ K AL+ V TL + +F R + + F+ L++ Q ++
Sbjct 518 VKSVGPCKLALF--TSSVLTATLGGEDIDETLDFNNKRAIIRKMYIFRYLSDHQMTMLIK 575
Query 267 ALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQKGDYFGERALLYDEPR 326
A + +G+ I+KEGE+G +I+K+G+ + N K +R L + DYFGERALLYDEPR
Sbjct 576 AFKTVRYMSGEYIIKEGERGTRFFIIKAGEVAILKNNKRLRTLGRHDYFGERALLYDEPR 635
Query 327 SATIIA 332
+A++ A
Sbjct 636 TASVCA 641
Score = 68.6 bits (166), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 34/114 (29%), Positives = 61/114 (53%), Gaps = 0/114 (0%)
Query 120 DLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFE 179
D + R+ + + L+D ++ L A + + G+ + K+GE G+ FFI+ +GE
Sbjct 548 DFNNKRAIIRKMYIFRYLSDHQMTMLIKAFKTVRYMSGEYIIKEGERGTRFFIIKAGEVA 607
Query 180 VIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLK 233
++ N+K + + FGE +L+++ RTAS+ S LW V + VF E +K
Sbjct 608 ILKNNKRLRTLGRHDYFGERALLYDEPRTASVCANSAGVDLWVVDKSVFNEIIK 661
> pfa:PF14_0346 PKG; cGMP-dependent protein kinase (EC:2.7.11.12);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=853
Score = 325 bits (832), Expect = 2e-88, Method: Compositional matrix adjust.
Identities = 154/261 (59%), Positives = 198/261 (75%), Gaps = 1/261 (0%)
Query 83 KPGGERKVQKAIMQQDDTQAEDARLLSHLEKREKTGTDLSLIRSSLSANLVCSSLNDSEV 142
K G ER +KAI DD ED+ + HLE REK D+ +I++SL NLVCS+LND+E+
Sbjct 8 KKGNERNKKKAIFSNDDFTGEDSLMEDHLELREKLSEDIDMIKTSLKNNLVCSTLNDNEI 67
Query 143 EALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLI 202
L+N +QFF F G++V KQGE GSYFFI++SG+F+V VNDK V + +G +FGE +LI
Sbjct 68 LTLSNYMQFFVFKSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSSFGEAALI 127
Query 203 HNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKN 262
HN+ R+A+I ++ LWGVQR FR TLKQLS+RNF ENR F+ SV F MLTEAQKN
Sbjct 128 HNTQRSATIIAETD-GTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQKN 186
Query 263 VITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQKGDYFGERALLY 322
+ITNA V+Q+F++G+ IVK+G+ GD+LYILK GKA V IN +++R+L+KG YFGERALLY
Sbjct 187 MITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEKGSYFGERALLY 246
Query 323 DEPRSATIIAEEETVCVSIGR 343
DEPRSATIIA+E T C SI R
Sbjct 247 DEPRSATIIAKEPTACASICR 267
Score = 87.8 bits (216), Expect = 6e-17, Method: Compositional matrix adjust.
Identities = 52/172 (30%), Positives = 92/172 (53%), Gaps = 5/172 (2%)
Query 170 FFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNS-ARTASIKTLSEKAALWGVQRQVF 228
+ IV G+ E+ ++D + + G +FG+ +++ +IK+L E + +
Sbjct 333 YIIVLEGKVELFLDDTSIGILSRGMSFGDQYVLNQKQPFKHTIKSL-EVCKIALITETCL 391
Query 229 RETLKQL---SSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEK 285
+ L +S ++ + + + F+ LT+ Q N++ A + G I++EGE
Sbjct 392 ADCLGNNNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEV 451
Query 286 GDILYILKSGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETV 337
G YI+K+G+ + N K +R L K DYFGERALLYDEPR+A++I++ V
Sbjct 452 GSRFYIIKNGEVEIVKNKKRLRTLGKNDYFGERALLYDEPRTASVISKVNNV 503
Score = 61.2 bits (147), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 47/199 (23%), Positives = 96/199 (48%), Gaps = 3/199 (1%)
Query 125 RSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVND 184
R+ + + V L +++ + NA F G+ + KQG+ G +I+ G+ V +ND
Sbjct 168 RTFIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYIND 227
Query 185 KVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAE-N 243
+ + + +G FGE +L+++ R+A+I E A + R++ L L F
Sbjct 228 EEIRVLEKGSYFGERALLYDEPRSATI-IAKEPTACASICRKLLNIVLGNLQVVLFRNIM 286
Query 244 RQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYIL-KSGKARVSIN 302
+ L E F+ + Q N + + +V+ + A I+ + + + YI+ GK + ++
Sbjct 287 TEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLD 346
Query 303 GKDVRLLQKGDYFGERALL 321
+ +L +G FG++ +L
Sbjct 347 DTSIGILSRGMSFGDQYVL 365
Score = 59.7 bits (143), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 30/108 (27%), Positives = 57/108 (52%), Gaps = 0/108 (0%)
Query 125 RSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVND 184
+S + + L D + L A + + +GD + ++GE GS F+I+ +GE E++ N
Sbjct 410 KSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNK 469
Query 185 KVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETL 232
K + + + FGE +L+++ RTAS+ + W V + VF + +
Sbjct 470 KRLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQII 517
> tpv:TP03_0511 cGMP-dependent protein kinase (EC:2.7.1.37); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=892
Score = 267 bits (682), Expect = 5e-71, Method: Compositional matrix adjust.
Identities = 130/252 (51%), Positives = 180/252 (71%), Gaps = 10/252 (3%)
Query 103 EDARLLSHLEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTK 162
ED ++ HL KREK+ +D S I+ SL+ N++ S+LND E+ A +++ ++ F+ G VT+
Sbjct 50 EDTEIVKHLVKREKSESDKSFIKKSLANNVIFSALNDLEMSAFVDSMSYYVFSVGSKVTE 109
Query 163 QGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKT--LSEKA-- 218
QG NGSYFF+++ G F+V ++ K+VN + G AFGEISLI+++ RTA++K ++E
Sbjct 110 QGTNGSYFFVINEGIFDVYIDGKLVNTMERGTAFGEISLINDTPRTATVKVRGVTENVKA 169
Query 219 ------ALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQS 272
+LWGV R VFRETLK +S +++NR FL SV+ F+MLTE QKN++TNA V
Sbjct 170 SSDTLGSLWGVNRTVFRETLKNISMEVYSQNRSFLDSVKIFEMLTENQKNMVTNAFVESK 229
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIA 332
F G IV +G+ GD+LYI+K GKA V IN + VR L G YFGERALLYDEPRSATI+A
Sbjct 230 FVPGDRIVTQGDFGDVLYIIKEGKADVLINDEKVRTLTNGQYFGERALLYDEPRSATIVA 289
Query 333 EEETVCVSIGRD 344
E+TVCVS+GR+
Sbjct 290 TEDTVCVSLGRE 301
Score = 84.0 bits (206), Expect = 8e-16, Method: Compositional matrix adjust.
Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 12/191 (6%)
Query 154 FTKGDIVTKQGEN--GSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGE-------ISLIHN 204
F GD++ + E G FFI+ G +++ D + + G +FGE I H
Sbjct 349 FKPGDVILHREEKIKGIRFFILLEGSVQILYEDNEIGIMERGDSFGEEYVLSPEIPFAHT 408
Query 205 SARTASIKTLSEKAALWGVQRQVFRETL-KQLSSRNFAENRQF--LASVEFFQMLTEAQK 261
+ K L + + +E L L N + + + F+ L+EA
Sbjct 409 VKCIINDKRAEGSCKLALLTKHAIQEILGTDLIDEKLDYNNKLSVIKKMYIFRYLSEAHL 468
Query 262 NVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQKGDYFGERALL 321
+++ + ++ G+ I++EGE GD YI+ G + +G +R L K DYFGERALL
Sbjct 469 DMLIKKFKSKRYKKGEYIIREGEVGDSFYIISKGDVDIIKSGTRLRTLGKNDYFGERALL 528
Query 322 YDEPRSATIIA 332
YDEPR+A+++
Sbjct 529 YDEPRTASVVC 539
Score = 52.4 bits (124), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 39/143 (27%), Positives = 72/143 (50%), Gaps = 14/143 (9%)
Query 98 DDTQAEDARLLSHLEKR---EKTGTDLSLIRSSLSAN---------LVCSSLNDSEVEAL 145
+D +AE + L+ L K E GTDL I L N + L+++ ++ L
Sbjct 414 NDKRAEGSCKLALLTKHAIQEILGTDL--IDEKLDYNNKLSVIKKMYIFRYLSEAHLDML 471
Query 146 ANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNS 205
+ + KG+ + ++GE G F+I+ G+ ++I + + + + FGE +L+++
Sbjct 472 IKKFKSKRYKKGEYIIREGEVGDSFYIISKGDVDIIKSGTRLRTLGKNDYFGERALLYDE 531
Query 206 ARTASIKTLSEKAALWGVQRQVF 228
RTAS+ S + LW V++ VF
Sbjct 532 PRTASVVCSSANSDLWVVEKSVF 554
> bbo:BBOV_I004690 19.m02237; cGMP dependent protein kinase (EC:2.7.11.1);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=887
Score = 247 bits (630), Expect = 6e-65, Method: Compositional matrix adjust.
Identities = 131/294 (44%), Positives = 184/294 (62%), Gaps = 7/294 (2%)
Query 57 QQQEQQQPPDRKTSQPQQSDDAAAPPKPGGERKV--QKAIMQQDDTQAEDARLLSHLEKR 114
++Q++ +K S A P G + V Q + ++ E + L + R
Sbjct 3 KEQDELSHEFKKLHIVHSSTKAWKPNNYQGSKGVRSQPVNVAHNEECDEVSTLAKYATSR 62
Query 115 EKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVH 174
+KT D++LIR +L+ NLVC SLN+ E++A ++ F G V +QG+NG+YFFI+
Sbjct 63 DKTDKDITLIRHALANNLVCESLNEYEIDAFIGSMSSFELPAGAPVVRQGDNGTYFFIIS 122
Query 175 SGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAA----LWGVQRQVFRE 230
G+F+V V+ + VN + G AFGEISLIHN+ R+A++K + KA LWGV R VFR+
Sbjct 123 EGDFDVYVDGEHVNSMTRGTAFGEISLIHNTPRSATVK-VKNKAGNCGKLWGVTRVVFRD 181
Query 231 TLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILY 290
TLK++S RN+ ENR+F+ V F+ LTE K+ ITNALV F G+ IVK+G+ GD LY
Sbjct 182 TLKRISLRNYTENREFIDCVTIFENLTEENKSCITNALVELRFSPGESIVKQGDPGDDLY 241
Query 291 ILKSGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
++K G A V +N VR + KG YFGERA+LY EPRSATI A + +CVSI RD
Sbjct 242 LIKQGSADVYVNDIRVRTITKGQYFGERAILYSEPRSATIKAIDYVICVSITRD 295
Score = 85.5 bits (210), Expect = 3e-16, Method: Compositional matrix adjust.
Identities = 60/196 (30%), Positives = 95/196 (48%), Gaps = 13/196 (6%)
Query 153 TFTKGDIVTKQGE--NGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTAS 210
+F KG ++ + G +FIV G V+ + + + G +FGE + H A
Sbjct 342 SFRKGAVILDRETLLKGIRYFIVLEGSVRVLYDGNELGTMQRGDSFGEEYITH--ANLPF 399
Query 211 IKTLSEKAALWGVQRQVF--RETLKQ-LSSRNFAENRQF------LASVEFFQMLTEAQK 261
T+ V + F + ++ L N +E + L + + L+E Q
Sbjct 400 NHTVIADGGNVNVSKLAFFTKHAMQLILGGENLSEKLDYNNKMAALRKIYILRHLSEKQI 459
Query 262 NVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQKGDYFGERALL 321
+++ AL ++ I EGE GD+LYI+KSG+ + NG +R L K DYFGERALL
Sbjct 460 DMLIKALKTLRYKLNDTIFNEGEIGDMLYIIKSGEVAIIKNGVKIRTLGKHDYFGERALL 519
Query 322 YDEPRSATIIAEEETV 337
YDE RSA++++ V
Sbjct 520 YDEQRSASVVSNATYV 535
Score = 54.3 bits (129), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 27/108 (25%), Positives = 58/108 (53%), Gaps = 0/108 (0%)
Query 126 SSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDK 185
++L + L++ +++ L A++ + D + +GE G +I+ SGE +I N
Sbjct 443 AALRKIYILRHLSEKQIDMLIKALKTLRYKLNDTIFNEGEIGDMLYIIKSGEVAIIKNGV 502
Query 186 VVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLK 233
+ + + FGE +L+++ R+AS+ + + LW V++ VF E ++
Sbjct 503 KIRTLGKHDYFGERALLYDEQRSASVVSNATYVDLWVVEKPVFMELME 550
> cpv:cgd8_750 cyclic nucleotide (cGMP)-dependent protein kinase
with 3 cNMP binding domains and a Ser/Thr kinase domain ;
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=965
Score = 228 bits (582), Expect = 2e-59, Method: Compositional matrix adjust.
Identities = 114/295 (38%), Positives = 186/295 (63%), Gaps = 4/295 (1%)
Query 52 QQEPQQQQEQQQPPDRKTSQPQQSDDAAAPPKPGGERKVQKAIMQQDDTQAEDA---RLL 108
++ +++ ++ + P+ K + A + GG K I +D ++
Sbjct 25 EELSKEENDEIEYPEEKMVVFRDRQKANIQSRIGGLSKNMSNISNAGGGMEDDYEQNMVI 84
Query 109 SHLEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGS 168
SHL+ REKT D+ I +L+ N+V +SLN+SE+ L +++ ++ + G++V +QG +G
Sbjct 85 SHLKDREKTEEDIKTISKALAGNVVGASLNESEIATLVSSMHYYEYEVGEVVIEQGASGF 144
Query 169 YFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVF 228
YFF++ +G F V +N VN + EG AFGE++LIHN+ R+A+I + EK LWG+ R F
Sbjct 145 YFFVISTGSFGVEINGNRVNTMSEGTAFGELALIHNTPRSATILVI-EKGGLWGLGRSTF 203
Query 229 RETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDI 288
R+TL+ +SSRN+ ENR F+ S+ F LT+ QK++++ ALV + F Q I++E E G++
Sbjct 204 RDTLRLISSRNYEENRAFIESLSIFSGLTDKQKSLLSEALVREIFVKDQVIIREKEIGNV 263
Query 289 LYILKSGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
LY++KSG V + K +R L +GD FGER+L++DEPRSAT+IA T C+++ R
Sbjct 264 LYMIKSGIVGVFVEDKYIRSLNEGDAFGERSLMFDEPRSATVIANATTECLTLNR 318
Score = 80.1 bits (196), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 41/87 (47%), Positives = 57/87 (65%), Gaps = 0/87 (0%)
Query 244 RQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSING 303
R + S FQ ++E Q +++ +L + F +G+ IV +G+KG +IL+SG+ V N
Sbjct 491 RDAIKSCFVFQYVSEQQLSLLVKSLRLVKFTSGEKIVVQGDKGTAFFILQSGEVAVYRNN 550
Query 304 KDVRLLQKGDYFGERALLYDEPRSATI 330
K +R L K DYFGERALLYDE RSATI
Sbjct 551 KFIRYLGKNDYFGERALLYDELRSATI 577
Score = 63.2 bits (152), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 30/112 (26%), Positives = 64/112 (57%), Gaps = 0/112 (0%)
Query 117 TGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSG 176
G +++ R ++ + V +++ ++ L +++ FT G+ + QG+ G+ FFI+ SG
Sbjct 483 VGLEINRKRDAIKSCFVFQYVSEQQLSLLVKSLRLVKFTSGEKIVVQGDKGTAFFILQSG 542
Query 177 EFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVF 228
E V N+K + + + FGE +L+++ R+A+I+ + + LW V ++ F
Sbjct 543 EVAVYRNNKFIRYLGKNDYFGERALLYDELRSATIEAATPEVHLWTVDKEAF 594
> mmu:19092 Prkg2, AW212535, CGKII, MGC130517, Prkgr2, cGK-II;
protein kinase, cGMP-dependent, type II (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=762
Score = 142 bits (358), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 80/236 (33%), Positives = 133/236 (56%), Gaps = 8/236 (3%)
Query 116 KTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHS 175
K ++ LI +L+ N L+ +++ + + + +G V KQGE G++ F++
Sbjct 151 KDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAE 210
Query 176 GEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQL 235
G EV +K+++ I FGE+++++N RTAS+K ++ W + R+VF+ +++
Sbjct 211 GRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAIT-NVKTWALDREVFQNIMRRT 269
Query 236 SSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSG 295
+ E R FL SV + L E + I + L V+ + G I++EGE+G +IL G
Sbjct 270 AQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKG 329
Query 296 KARV--SINGKD----VRLLQKGDYFGERALLYDEPRSATIIAEEETV-CVSIGRD 344
K +V S G D ++ LQKG+YFGE+AL+ D+ RSA IIAEE V C+ I R+
Sbjct 330 KVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRE 385
> hsa:5593 PRKG2, PRKGR2, cGKII; protein kinase, cGMP-dependent,
type II (EC:2.7.11.12); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=762
Score = 140 bits (353), Expect = 6e-33, Method: Compositional matrix adjust.
Identities = 78/236 (33%), Positives = 133/236 (56%), Gaps = 8/236 (3%)
Query 116 KTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHS 175
K ++ LI +L+ N L+ +++ + + + +G + KQGE G++ F++
Sbjct 151 KDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAE 210
Query 176 GEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQL 235
G EV +K+++ I FGE+++++N RTAS+K ++ W + R+VF+ +++
Sbjct 211 GRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAIT-NVKTWALDREVFQNIMRRT 269
Query 236 SSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSG 295
+ + R FL SV + L E + I + L V+ + G I++EGE+G +IL G
Sbjct 270 AQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKG 329
Query 296 KARV--SINGKD----VRLLQKGDYFGERALLYDEPRSATIIAEEETV-CVSIGRD 344
K +V S G D ++ LQKG+YFGE+AL+ D+ RSA IIAEE V C+ I R+
Sbjct 330 KVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRE 385
> hsa:5575 PRKAR1B, PRKAR1; protein kinase, cAMP-dependent, regulatory,
type I, beta (EC:2.7.11.1); K04739 cAMP-dependent
protein kinase regulator
Length=381
Score = 134 bits (337), Expect = 4e-31, Method: Compositional matrix adjust.
Identities = 89/286 (31%), Positives = 150/286 (52%), Gaps = 12/286 (4%)
Query 67 RKTSQPQQSDD--AAAPPKPGGERKVQKAIMQQDDTQAEDARLLSHLEKR-EKTGTDLSL 123
+ SQ D+ + PP P + + ++ + + EDA +S++ K K ++
Sbjct 70 KSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDA--VSYVRKVIPKDYKTMTA 127
Query 124 IRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVN 183
+ ++S N++ + L+D+E + +A+ T G+ V +QG G F++V GE +V VN
Sbjct 128 LAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVN 187
Query 184 DKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAEN 243
+ V I EG +FGE++LI+ + R A++K ++ LWG+ R +R L + R
Sbjct 188 GEWVTNISEGGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILMGSTLRKRKMY 246
Query 244 RQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV---- 299
+FL+ V + L + ++ + +AL F G+ IV +GE GD YI+ G A V
Sbjct 247 EEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRR 306
Query 300 SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
S N + V + L DYFGE ALL + PR+AT++A CV + R
Sbjct 307 SPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDR 352
Score = 60.8 bits (146), Expect = 7e-09, Method: Compositional matrix adjust.
Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ + AG+ ++++G +GD Y++ G+ V +NG+ V + +
Sbjct 137 LFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISE 196
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ + I RD
Sbjct 197 GGSFGELALIYGTPRAATVKAKTDLKLWGIDRD 229
> mmu:19085 Prkar1b, AI385716, RIbeta; protein kinase, cAMP dependent
regulatory, type I beta (EC:2.7.11.1); K04739 cAMP-dependent
protein kinase regulator
Length=381
Score = 134 bits (337), Expect = 5e-31, Method: Compositional matrix adjust.
Identities = 94/305 (30%), Positives = 160/305 (52%), Gaps = 14/305 (4%)
Query 50 QQQQEPQQQQEQQQPPDRKTSQPQ-QSDD---AAAPPKPGGERKVQKAIMQQDDTQAEDA 105
++ E +++E +Q R+ S Q S D + PP P + + ++ + + EDA
Sbjct 51 REHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKARRRRGGVSAEVYTEEDA 110
Query 106 RLLSHLEKR-EKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQG 164
+S++ K K ++ + ++S N++ S L+D+E + +A+ T G+ V +QG
Sbjct 111 --VSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIGGETVIQQG 168
Query 165 ENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQ 224
G F+++ GE +V VN + V I EG +FGE++LI+ + R A++K ++ LWG+
Sbjct 169 NEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTD-LKLWGID 227
Query 225 RQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGE 284
R +R L + R +FL+ V + L + ++ + +AL F G+ IV +GE
Sbjct 228 RDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGE 287
Query 285 KGDILYILKSGKARV----SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVC 338
GD YI+ G A V S N + V + L DYFGE ALL + PR+AT++A C
Sbjct 288 PGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKC 347
Query 339 VSIGR 343
V + R
Sbjct 348 VKLDR 352
Score = 59.7 bits (143), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 29/93 (31%), Positives = 54/93 (58%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ + G+ ++++G +GD Y++ G+ V +NG+ V + +
Sbjct 137 LFSHLDDNERSDIFDAMFPVTHIGGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISE 196
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ + I RD
Sbjct 197 GGSFGELALIYGTPRAATVKAKTDLKLWGIDRD 229
> hsa:5573 PRKAR1A, CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR1,
PPNAD1, PRKAR1, TSE1; protein kinase, cAMP-dependent, regulatory,
type I, alpha (tissue specific extinguisher 1) (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=381
Score = 132 bits (333), Expect = 1e-30, Method: Compositional matrix adjust.
Identities = 93/304 (30%), Positives = 160/304 (52%), Gaps = 20/304 (6%)
Query 51 QQQEPQQQQEQQQPPDRKTSQPQQSDDAAAPPKPG----GERKVQKAIMQQDDTQAEDAR 106
+++E +Q Q Q+ R S+ +D +PP P G R+ + AI + T+ + A
Sbjct 58 EKEEAKQIQNLQKAGTRTDSR----EDEISPPPPNPVVKGRRR-RGAISAEVYTEEDAAS 112
Query 107 LLSH-LEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGE 165
+ + K KT ++ + ++ N++ S L+D+E + +A+ +F G+ V +QG+
Sbjct 113 YVRKVIPKDYKT---MAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGD 169
Query 166 NGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQR 225
G F+++ GE +V VN++ + EG +FGE++LI+ + R A++K + LWG+ R
Sbjct 170 EGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKT-NVKLWGIDR 228
Query 226 QVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEK 285
+R L + R +FL+ V + L + ++ + +AL F GQ IV +GE
Sbjct 229 DSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEP 288
Query 286 GDILYILKSGKARV----SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCV 339
GD +I+ G A V S N + V + L DYFGE ALL + PR+AT++A CV
Sbjct 289 GDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCV 348
Query 340 SIGR 343
+ R
Sbjct 349 KLDR 352
Score = 61.2 bits (147), Expect = 6e-09, Method: Compositional matrix adjust.
Identities = 30/93 (32%), Positives = 54/93 (58%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ SF AG+ ++++G++GD Y++ G+ V +N + + +
Sbjct 137 LFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGE 196
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 197 GGSFGELALIYGTPRAATVKAKTNVKLWGIDRD 229
> xla:444805 prkar1b, MGC82149, prkar1; protein kinase, cAMP-dependent,
regulatory, type I,beta; K04739 cAMP-dependent protein
kinase regulator
Length=381
Score = 132 bits (331), Expect = 2e-30, Method: Compositional matrix adjust.
Identities = 92/303 (30%), Positives = 159/303 (52%), Gaps = 17/303 (5%)
Query 51 QQQEPQQQQEQQQPPDRKTSQPQQSDDAAAPPKPGG---ERKVQKAIMQQDDTQAEDARL 107
+++E +Q QQ+ R S+ D+ + PP R+ + AI + T+ + A
Sbjct 57 EKEETRQTLNQQKSGSRSDSR---EDEISPPPHMNSVVKGRRRRGAISAEVYTEEDAASY 113
Query 108 LSH-LEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGEN 166
+ + K KT ++ + ++ N++ + L+D+E + +A+ T+ G+ V +QG+
Sbjct 114 VRKVIPKDYKT---MAALAKAIEKNVLFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDE 170
Query 167 GSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQ 226
G F++V GE +V VN+ + I EG +FGE++LI+ + R A++K + LWG+ R
Sbjct 171 GDNFYVVDQGEMDVYVNNDWMTSIGEGGSFGELALIYGTPRAATVKAKT-NVKLWGIDRD 229
Query 227 VFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKG 286
+R L + R +FL+ V + L + ++ + +AL F GQ IV +GE G
Sbjct 230 SYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289
Query 287 DILYILKSGKA----RVSINGKDVRLLQKG--DYFGERALLYDEPRSATIIAEEETVCVS 340
D +I+ G A R S N + V + + G DYFGE ALL + PR+AT++A CV
Sbjct 290 DEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVK 349
Query 341 IGR 343
+ R
Sbjct 350 LDR 352
Score = 58.9 bits (141), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 28/93 (30%), Positives = 54/93 (58%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ ++ AG+ ++++G++GD Y++ G+ V +N + + +
Sbjct 137 LFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVVDQGEMDVYVNNDWMTSIGE 196
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 197 GGSFGELALIYGTPRAATVKAKTNVKLWGIDRD 229
> xla:432155 prkar1a, pkr1; protein kinase, cAMP-dependent, regulatory,
type I, alpha (tissue specific extinguisher 1) (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=381
Score = 132 bits (331), Expect = 2e-30, Method: Compositional matrix adjust.
Identities = 92/303 (30%), Positives = 160/303 (52%), Gaps = 17/303 (5%)
Query 51 QQQEPQQQQEQQQPPDRKTSQPQQSDDAAAPPKPGG---ERKVQKAIMQQDDTQAEDARL 107
+++E +Q QQ+ R S+ D+ + PP R+ + AI + T+ + A
Sbjct 57 EKEEARQILNQQKSGSRSDSR---EDEISPPPHMNSVVKGRRRRGAISAEVYTEEDAASY 113
Query 108 LSH-LEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGEN 166
+ + K KT ++ + ++ N++ + L+D+E + +A+ T+ G+ V +QG+
Sbjct 114 VRKVIPKDYKT---MAALAKAIEKNVLFAHLDDTERSDIFDAMFSVTYISGETVIQQGDE 170
Query 167 GSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQ 226
G F++V GE +V VN++ + I EG +FGE++LI+ + R A++K + LWG+ R
Sbjct 171 GDNFYVVDQGEMDVYVNNEWMTSIGEGGSFGELALIYGTPRAATVKAKT-NVKLWGIDRD 229
Query 227 VFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKG 286
+R L + R +FL+ V + L + ++ + +AL F GQ IV +GE G
Sbjct 230 SYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 289
Query 287 DILYILKSGKARV----SINGKDVRLLQKG--DYFGERALLYDEPRSATIIAEEETVCVS 340
D +I+ G A V S N + V + + G DYFGE ALL + PR+AT++A CV
Sbjct 290 DEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVK 349
Query 341 IGR 343
+ R
Sbjct 350 LDR 352
Score = 58.5 bits (140), Expect = 4e-08, Method: Compositional matrix adjust.
Identities = 27/93 (29%), Positives = 55/93 (59%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ ++ +G+ ++++G++GD Y++ G+ V +N + + + +
Sbjct 137 LFAHLDDTERSDIFDAMFSVTYISGETVIQQGDEGDNFYVVDQGEMDVYVNNEWMTSIGE 196
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 197 GGSFGELALIYGTPRAATVKAKTNVKLWGIDRD 229
> mmu:19084 Prkar1a, 1300018C22Rik, RIalpha, Tse-1, Tse1; protein
kinase, cAMP dependent regulatory, type I, alpha (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=381
Score = 131 bits (330), Expect = 3e-30, Method: Compositional matrix adjust.
Identities = 93/304 (30%), Positives = 160/304 (52%), Gaps = 20/304 (6%)
Query 51 QQQEPQQQQEQQQPPDRKTSQPQQSDDAAAPPKPG----GERKVQKAIMQQDDTQAEDAR 106
+++E +Q Q Q+ R S+ +D +PP P G R+ + AI + T+ + A
Sbjct 58 EKEEARQIQCLQKTGIRTDSR----EDEISPPPPNPVVKGRRR-RGAISAEVYTEEDAAS 112
Query 107 LLSH-LEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGE 165
+ + K KT ++ + ++ N++ S L+D+E + +A+ +F G+ V +QG+
Sbjct 113 YVRKVIPKDYKT---MAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGD 169
Query 166 NGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQR 225
G F+++ GE +V VN++ + EG +FGE++LI+ + R A++K + LWG+ R
Sbjct 170 EGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKT-NVKLWGIDR 228
Query 226 QVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEK 285
+R L + R +FL+ V + L + ++ + +AL F GQ IV +GE
Sbjct 229 DSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEP 288
Query 286 GDILYILKSGKARV----SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCV 339
GD +I+ G A V S N + V + L DYFGE ALL + PR+AT++A CV
Sbjct 289 GDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCV 348
Query 340 SIGR 343
+ R
Sbjct 349 KLDR 352
Score = 60.5 bits (145), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 30/93 (32%), Positives = 54/93 (58%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ SF AG+ ++++G++GD Y++ G+ V +N + + +
Sbjct 137 LFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGE 196
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 197 GGSFGELALIYGTPRAATVKAKTNVKLWGIDRD 229
> dre:100125912 prkg2; protein kinase, cGMP-dependent, type II
(EC:2.7.11.1); K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=768
Score = 131 bits (329), Expect = 4e-30, Method: Compositional matrix adjust.
Identities = 75/229 (32%), Positives = 128/229 (55%), Gaps = 9/229 (3%)
Query 123 LIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIV 182
L+ +L+ N L +V+ + + T+ +G+ V KQGE G++ F++ G+ +V
Sbjct 165 LLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQ 224
Query 183 NDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAE 242
++K++ I FGE+++++N RTAS+K S W + R+VF ++ + +
Sbjct 225 HNKLLTSIAVWTTFGELAILYNCTRTASVKAASN-VKTWALDREVFHNIMRMTAEARHEQ 283
Query 243 NRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSIN 302
R FL SV L + I + L + + G I++EGE+G+ YI+ +GK +V+ +
Sbjct 284 YRNFLRSVSLLASLPGDKLTKIVDCL-EEYYNKGDYIIREGEEGNTFYIIANGKIKVTQS 342
Query 303 GKD------VRLLQKGDYFGERALLYDEPRSATIIAEEETV-CVSIGRD 344
+D + L KGDYFGE+AL+ D+ RSA IIAEE+ V C+ I R+
Sbjct 343 TQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRE 391
Score = 48.5 bits (114), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 31/131 (23%), Positives = 70/131 (53%), Gaps = 12/131 (9%)
Query 125 RSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVND 184
R+ L + + +SL ++ + + ++ + + KGD + ++GE G+ F+I+ +G+ +V +
Sbjct 285 RNFLRSVSLLASLPGDKLTKIVDCLEEY-YNKGDYIIREGEEGNTFYIIANGKIKVTQST 343
Query 185 K------VVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSR 238
+ ++N + +G FGE +LI + R+A+I + + R+ F +T+
Sbjct 344 QDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVG----- 398
Query 239 NFAENRQFLAS 249
F E +++L S
Sbjct 399 TFDELKKYLQS 409
> xla:444025 prkg2, MGC82580; protein kinase, cGMP-dependent,
type II (EC:2.7.11.1); K07376 protein kinase, cGMP-dependent
[EC:2.7.11.12]
Length=783
Score = 130 bits (328), Expect = 5e-30, Method: Compositional matrix adjust.
Identities = 70/229 (30%), Positives = 131/229 (57%), Gaps = 8/229 (3%)
Query 123 LIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIV 182
LI +L+ N +++ +++ + + + +G+ + +QGE GS F++ G+ EV
Sbjct 180 LISDALNKNQFTKRMDNHQIQDMVECMYERIYLQGEFIIRQGEPGSQIFVLADGKAEVFQ 239
Query 183 NDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAE 242
+ K++ I FGE+++++N RTAS+K ++ W + R+VF+ +++ + E
Sbjct 240 DSKLLTSIPVWTTFGELAILYNCTRTASVKAIT-NVRTWALDREVFQNIMRKTAQSKHEE 298
Query 243 NRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV--S 300
+FL SV + L + + I + L ++ + G I++EGE+G +I+ GK +V S
Sbjct 299 YLRFLKSVSLLKKLPDHKLMKIADCLELEYYETGDYIIREGEEGSTFFIIAKGKVKVTQS 358
Query 301 INGKD----VRLLQKGDYFGERALLYDEPRSATIIAEEETV-CVSIGRD 344
G + ++LL+KGDYFGE+AL+ D+ RSA I+A E V C+ + R+
Sbjct 359 AEGYEEPQYIKLLEKGDYFGEKALISDDVRSANILAYGERVECLVMDRE 407
> dre:550427 prkar1ab, zgc:112145; protein kinase, cAMP-dependent,
regulatory, type I, alpha (tissue specific extinguisher
1) b (EC:2.7.11.1); K04739 cAMP-dependent protein kinase regulator
Length=379
Score = 130 bits (327), Expect = 6e-30, Method: Compositional matrix adjust.
Identities = 89/300 (29%), Positives = 156/300 (52%), Gaps = 13/300 (4%)
Query 51 QQQEPQQQQEQQQPPDRKTSQPQQSDDAAAPPKPGGERKVQKAIMQQDDTQAEDARLLSH 110
+++E +Q QQ+ R S+ D+ + P P + + ++ + + EDA S+
Sbjct 57 EKEESKQLLNQQKASSRSDSR---EDEVSPPMNPVVKGRRRRGAISAEVYTEEDA--ASY 111
Query 111 LEKR-EKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSY 169
+ K K ++ + ++ N++ S L+D+E + +A+ T+ G+IV +QG+ G
Sbjct 112 VRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVTYIAGEIVIQQGDEGDN 171
Query 170 FFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFR 229
F+++ GE +V VN + I EG +FGE++LI+ + R A+++ + LWG+ R +R
Sbjct 172 FYVIDQGEMDVYVNSEWATSIGEGGSFGELALIYGTPRAATVRAKT-NVKLWGIDRDSYR 230
Query 230 ETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDIL 289
L + R +FL+ V + L + ++ + +AL F Q IV +GE GD
Sbjct 231 RILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDSQKIVVQGEPGDEF 290
Query 290 YILKSGKARV----SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
+I+ G A V S N + V + L DYFGE ALL + PR+AT++A CV + R
Sbjct 291 FIILEGCAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDR 350
Score = 57.8 bits (138), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 28/93 (30%), Positives = 54/93 (58%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ ++ AG+ ++++G++GD Y++ G+ V +N + + +
Sbjct 135 LFSHLDDNERSDIFDAMFPVTYIAGEIVIQQGDEGDNFYVIDQGEMDVYVNSEWATSIGE 194
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 195 GGSFGELALIYGTPRAATVRAKTNVKLWGIDRD 227
> sce:YIL033C BCY1, SRA1; Bcy1p; K04739 cAMP-dependent protein
kinase regulator
Length=416
Score = 129 bits (324), Expect = 1e-29, Method: Compositional matrix adjust.
Identities = 73/231 (31%), Positives = 124/231 (53%), Gaps = 2/231 (0%)
Query 114 REKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIV 173
+EK+ L + S+ N + + L+ + N ++ + KG + KQG+ G YF++V
Sbjct 165 KEKSEQQLQRLEKSIRNNFLFNKLDSDSKRLVINCLEEKSVPKGATIIKQGDQGDYFYVV 224
Query 174 HSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLK 233
G + VND VN G +FGE++L++NS R A++ S+ LW + R FR+ L
Sbjct 225 EKGTVDFYVNDNKVNSSGPGSSFGELALMYNSPRAATVVATSD-CLLWALDRLTFRKILL 283
Query 234 QLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILK 293
S + L S+ + LT + + +AL + ++ G+ I++EG++G+ Y+++
Sbjct 284 GSSFKKRLMYDDLLKSMPVLKSLTTYDRAKLADALDTKIYQPGETIIREGDQGENFYLIE 343
Query 294 SGKARVSINGKDV-RLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
G VS G+ V L+ DYFGE ALL D PR AT+ A + T ++G+
Sbjct 344 YGAVDVSKKGQGVINKLKDHDYFGEVALLNDLPRQATVTATKRTKVATLGK 394
> dre:767685 prkar1b, MGC153624, zgc:153624; protein kinase, cAMP-dependent,
regulatory, type I, beta (EC:2.7.11.1); K04739
cAMP-dependent protein kinase regulator
Length=380
Score = 129 bits (323), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 80/239 (33%), Positives = 132/239 (55%), Gaps = 10/239 (4%)
Query 111 LEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYF 170
+ K KT T L+ ++S N++ + L+D+E + +A+ T G+ V +QG+ G F
Sbjct 117 IPKDYKTMTALA---KAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNF 173
Query 171 FIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRE 230
+++ GE +V VN + V I EG +FGE++LI+ + R A++K ++ LWG+ R +R
Sbjct 174 YVIDQGEVDVYVNGEWVTSIGEGGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRR 232
Query 231 TLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILY 290
L + R +FL+ V + L + ++ + +AL F G+ IV +GE GD +
Sbjct 233 ILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGEKIVVQGEPGDDFF 292
Query 291 ILKSGKARV----SINGKDVRLLQKG--DYFGERALLYDEPRSATIIAEEETVCVSIGR 343
I+ G A V S N + V + + G DYFGE ALL + PR+AT++A CV + R
Sbjct 293 IITEGTASVLQRRSDNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDR 351
Score = 61.6 bits (148), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 30/93 (32%), Positives = 56/93 (60%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ + AG+ ++++G++GD Y++ G+ V +NG+ V + +
Sbjct 136 LFAHLDDNERSDIFDAMFPVTHIAGETVIQQGDEGDNFYVIDQGEVDVYVNGEWVTSIGE 195
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ + I RD
Sbjct 196 GGSFGELALIYGTPRAATVKAKTDLKLWGIDRD 228
> dre:494533 prkar1aa, im:7047729, prkar1a, zgc:92515; protein
kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific
extinguisher 1) a
Length=379
Score = 129 bits (323), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 73/229 (31%), Positives = 126/229 (55%), Gaps = 7/229 (3%)
Query 121 LSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEV 180
++ + ++ N++ + L+D+E + +A+ T+ G+ V +QG+ G F+++ GE +V
Sbjct 123 MAALAKAIEKNVLFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDV 182
Query 181 IVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNF 240
VN++ V I EG +FGE++LI+ + R A+++ LWG+ R +R L + R
Sbjct 183 YVNNEWVTSIGEGGSFGELALIYGTPRAATVRA-KTNVKLWGIDRDSYRRILMGSTLRKR 241
Query 241 AENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV- 299
+FL+ V + L + ++ + +AL F GQ IV +G+ GD +I+ G A V
Sbjct 242 KMYEEFLSKVSILESLDKWERLTVADALETVQFEDGQKIVVQGQPGDEFFIILEGSAAVL 301
Query 300 ---SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
S N + V + L DYFGE ALL + PR+AT++A CV + R
Sbjct 302 QRRSENEEFVEVGRLAPSDYFGEIALLMNRPRAATVVARGPLKCVKLDR 350
Score = 59.7 bits (143), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 29/93 (31%), Positives = 55/93 (59%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ ++ AG+ ++++G++GD Y++ G+ V +N + V + +
Sbjct 135 LFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWVTSIGE 194
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 195 GGSFGELALIYGTPRAATVRAKTNVKLWGIDRD 227
> dre:100329979 protein kinase, cAMP-dependent, regulatory, type
I, alpha (tissue specific extinguisher 1) a-like; K04739
cAMP-dependent protein kinase regulator
Length=379
Score = 129 bits (323), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 73/229 (31%), Positives = 126/229 (55%), Gaps = 7/229 (3%)
Query 121 LSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEV 180
++ + ++ N++ + L+D+E + +A+ T+ G+ V +QG+ G F+++ GE +V
Sbjct 123 MAALAKAIEKNVLFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDV 182
Query 181 IVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNF 240
VN++ V I EG +FGE++LI+ + R A+++ LWG+ R +R L + R
Sbjct 183 YVNNEWVTSIGEGGSFGELALIYGTPRAATVRA-KTNVKLWGIDRDSYRRILMGSTLRKR 241
Query 241 AENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV- 299
+FL+ V + L + ++ + +AL F GQ IV +G+ GD +I+ G A V
Sbjct 242 KMYEEFLSKVSILESLDKWERLTVADALETVQFEDGQKIVVQGQPGDEFFIILEGSAAVL 301
Query 300 ---SINGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
S N + V + L DYFGE ALL + PR+AT++A CV + R
Sbjct 302 QRRSENEEFVEVGRLAPSDYFGEIALLMNRPRAATVVARGPLKCVKLDR 350
Score = 59.7 bits (143), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 29/93 (31%), Positives = 55/93 (59%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F L + +++ I +A+ ++ AG+ ++++G++GD Y++ G+ V +N + V + +
Sbjct 135 LFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWVTSIGE 194
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE AL+Y PR+AT+ A+ I RD
Sbjct 195 GGSFGELALIYGTPRAATVRAKTNVKLWGIDRD 227
> dre:556339 protein kinase, cGMP-dependent, type II-like; K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=730
Score = 124 bits (312), Expect = 4e-28, Method: Compositional matrix adjust.
Identities = 72/238 (30%), Positives = 132/238 (55%), Gaps = 9/238 (3%)
Query 114 REKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIV 173
R+ +GT LI +L N L + + + + +V ++GE G++ +++
Sbjct 118 RKDSGTK-KLINEALMKNDFLKKLEPQHTREMVDCMYEKIYGAEQLVIQEGEPGNFLYVL 176
Query 174 HSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLK 233
G EVI N K + ++ G AFGE+++++N RTA++K +S+ + +W + RQ F+ +
Sbjct 177 AEGLLEVIQNGKFLGQMRPGTAFGELAILYNCKRTATVKAVSQ-SHIWALDRQTFQTIMM 235
Query 234 QLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILK 293
+ + E FL SV + L E + I + L + F G+ I++EGE+G+ +I+
Sbjct 236 RSTQARHEEYFSFLRSVSLLKDLPEEKLAKIIDCLEIDYFDKGEYIIREGEEGNTFFIIA 295
Query 294 SGKARVS------INGKDVRLLQKGDYFGERALLYDEPRSATIIAEE-ETVCVSIGRD 344
G+ V+ ++++ L+ GDYFGE+AL+ ++ RSA IIA+E +T C+ + RD
Sbjct 296 KGEVSVTQTTEGFTEPQEIKTLRVGDYFGEKALISEDVRSANIIAKENDTQCLVVDRD 353
Score = 41.2 bits (95), Expect = 0.007, Method: Compositional matrix adjust.
Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 9/107 (8%)
Query 135 SSLNDSEVEALA---NAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEV------IVNDK 185
S L D E LA + ++ F KG+ + ++GE G+ FFI+ GE V +
Sbjct 253 SLLKDLPEEKLAKIIDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVTQTTEGFTEPQ 312
Query 186 VVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETL 232
+ + G FGE +LI R+A+I V R F E +
Sbjct 313 EIKTLRVGDYFGEKALISEDVRSANIIAKENDTQCLVVDRDNFNEMV 359
> tgo:TGME49_042070 cAMP-dependent protein kinase regulatory subunit,
putative (EC:2.7.10.2); K04739 cAMP-dependent protein
kinase regulator
Length=308
Score = 123 bits (308), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 66/226 (29%), Positives = 124/226 (54%), Gaps = 7/226 (3%)
Query 124 IRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVN 183
I + ++ + SSL+ ++E + NA Q + KG ++ +QG++G +++ +GE +V+
Sbjct 47 ITKVIESSFLFSSLDIEDLETVINAFQEVSVKKGTVIIRQGDDGDRLYLIETGEVDVMKK 106
Query 184 ------DKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSS 237
+K + K+ G AFGE++L++N+ R A++ ++ LW + R F ++ ++
Sbjct 107 FPGEKENKFLCKMHPGDAFGELALMYNAPRAATV-IAADDMLLWALDRDSFTNIVRDAAA 165
Query 238 RNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKA 297
+ + L V + + +++ +++AL ++ G I+KEGE GD YIL G A
Sbjct 166 KKREIFEESLKEVRILEDMDPYERSKLSDALRTATYEDGDVIIKEGETGDTFYILLEGAA 225
Query 298 RVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
N K V +KG +FGE ALL D+PR+AT++A+ + R
Sbjct 226 EAIKNDKVVMEYKKGGFFGELALLKDQPRAATVVAKSHVQVAYMDR 271
Score = 61.6 bits (148), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 42/148 (28%), Positives = 73/148 (49%), Gaps = 11/148 (7%)
Query 102 AEDARLLSHLEK-------REKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTF 154
A D LL L++ R+ + SL + ++ E L++A++ T+
Sbjct 142 AADDMLLWALDRDSFTNIVRDAAAKKREIFEESLKEVRILEDMDPYERSKLSDALRTATY 201
Query 155 TKGDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTL 214
GD++ K+GE G F+I+ G E I NDKVV + +G FGE++L+ + R A++
Sbjct 202 EDGDVIIKEGETGDTFYILLEGAAEAIKNDKVVMEYKKGGFFGELALLKDQPRAATVVAK 261
Query 215 SEKAALWGVQRQVFRETL---KQLSSRN 239
S + + R+ F+ L +Q+ RN
Sbjct 262 SHVQVAY-MDRKSFKRLLGPVEQILMRN 288
Score = 57.8 bits (138), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 32/87 (36%), Positives = 54/87 (62%), Gaps = 6/87 (6%)
Query 264 ITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV--SING-KDVRLLQK---GDYFGE 317
+ NA S + G I+++G+ GD LY++++G+ V G K+ + L K GD FGE
Sbjct 68 VINAFQEVSVKKGTVIIRQGDDGDRLYLIETGEVDVMKKFPGEKENKFLCKMHPGDAFGE 127
Query 318 RALLYDEPRSATIIAEEETVCVSIGRD 344
AL+Y+ PR+AT+IA ++ + ++ RD
Sbjct 128 LALMYNAPRAATVIAADDMLLWALDRD 154
> cel:F55A8.2 egl-4; EGg Laying defective family member (egl-4);
K07376 protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=780
Score = 122 bits (307), Expect = 2e-27, Method: Compositional matrix adjust.
Identities = 72/233 (30%), Positives = 126/233 (54%), Gaps = 7/233 (3%)
Query 111 LEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYF 170
L+ KT +IR ++ N L ++ L N + G V ++GE G
Sbjct 179 LQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRL 238
Query 171 FIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRE 230
F+V GE +V ++ K+ G GE+++++N RTAS++ L++ LW + R VF+
Sbjct 239 FVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTD-VQLWVLDRSVFQM 297
Query 231 TLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILY 290
++L ++ FL V FQ L+E + + + + + + G I+++GEKGD +
Sbjct 298 ITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFF 357
Query 291 ILKSGKARVS--ING----KDVRLLQKGDYFGERALLYDEPRSATIIAEEETV 337
++ SG+ +V+ I G +++R+L +GD+FGERALL +E R+A IIA+ V
Sbjct 358 VINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGV 410
Score = 41.6 bits (96), Expect = 0.004, Method: Compositional matrix adjust.
Identities = 25/111 (22%), Positives = 54/111 (48%), Gaps = 6/111 (5%)
Query 133 VCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVI------VNDKV 186
+ +L++ + +A+ + + G + +QGE G FF+++SG+ +V +
Sbjct 319 IFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPRE 378
Query 187 VNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSS 237
+ + +G FGE +L+ RTA+I + + + R+ F + + L S
Sbjct 379 IRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLES 429
> cel:R07E4.6 kin-2; protein KINase family member (kin-2); K04739
cAMP-dependent protein kinase regulator
Length=376
Score = 120 bits (300), Expect = 9e-27, Method: Compositional matrix adjust.
Identities = 78/272 (28%), Positives = 140/272 (51%), Gaps = 16/272 (5%)
Query 81 PPKPGGERK--VQKAIMQQDDTQAEDARLLSHLEKREKTGTDLSLIRSSLSANLVCSSLN 138
PPK G R+ + +++DDT+ + + K + T L S++ NL+ + L
Sbjct 85 PPKRSGGRRTGISAEPIKEDDTEYKKVVI----PKDDATRRSLE---SAMRKNLLFAHLE 137
Query 139 DSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGE 198
+ E + + +A+ + G+ + +QGE G F+++ G +V VN + V I EG +FGE
Sbjct 138 EDEQKTMYDAMFPVEKSAGETIIEQGEEGDNFYVIDKGTVDVYVNHEYVLTINEGGSFGE 197
Query 199 ISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTE 258
++LI+ + R A++ ++ LW + R +R L ++ +FL+ V+ L +
Sbjct 198 LALIYGTPRAATVIAKTD-VKLWAIDRLTYRRILMGSVTKKRKMYDEFLSKVQILADLDQ 256
Query 259 AQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKD------VRLLQKG 312
++ + +AL F G +V++G+ GD +I+ G+A V D V L
Sbjct 257 WERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANVLQKRSDDAPFDVVGHLGMS 316
Query 313 DYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
DYFGE ALL D PR+AT++A+ C+ + R+
Sbjct 317 DYFGEIALLLDRPRAATVVAKTHLKCIKLDRN 348
> pfa:PFL1110c PKAr; CAMP-dependent protein kinase regulatory
subunit, putative; K04739 cAMP-dependent protein kinase regulator
Length=441
Score = 119 bits (297), Expect = 2e-26, Method: Compositional matrix adjust.
Identities = 72/227 (31%), Positives = 121/227 (53%), Gaps = 10/227 (4%)
Query 124 IRSSLSANLVCSSLNDSEVEALANAVQFF--TFTKGDIVTKQGENGSYFFIVHSGEFEVI 181
IR +L+ + + + LN E E + NA FF KG + +G+ G +++ GE E+
Sbjct 180 IREALNESFLFNHLNKKEFEIIVNA--FFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIY 237
Query 182 V---NDK--VVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLS 236
N+K V+ + FGE++L++NS R A+ L+ K LW + R+ F +K +
Sbjct 238 KTKENNKKEVLTVLKSKDVFGELALLYNSKRAATATALT-KCHLWALDRESFTYIIKDMV 296
Query 237 SRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGK 296
++ L+ V + + ++ + + L +S+ G+ I+KEGE+GD +IL G
Sbjct 297 AKKRKMYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGN 356
Query 297 ARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
A S + K ++ KGDYFGE ALL ++PR+ATI A+ V + R
Sbjct 357 AVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDR 403
Score = 54.3 bits (129), Expect = 6e-07, Method: Compositional matrix adjust.
Identities = 33/97 (34%), Positives = 52/97 (53%), Gaps = 5/97 (5%)
Query 241 AENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV- 299
A+ R+ L F L + + +I NA ++ G I+ EG+ GD+LY++ G+ +
Sbjct 178 AKIREALNESFLFNHLNKKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIY 237
Query 300 ---SINGKDV-RLLQKGDYFGERALLYDEPRSATIIA 332
N K+V +L+ D FGE ALLY+ R+AT A
Sbjct 238 KTKENNKKEVLTVLKSKDVFGELALLYNSKRAATATA 274
> hsa:5592 PRKG1, CGKI, DKFZp686K042, FLJ36117, MGC71944, PGK,
PKG, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha; protein kinase,
cGMP-dependent, type I (EC:2.7.11.12); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 117 bits (292), Expect = 9e-26, Method: Compositional matrix adjust.
Identities = 67/228 (29%), Positives = 120/228 (52%), Gaps = 7/228 (3%)
Query 123 LIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIV 182
LI+ ++ N +L S+++ + + + + K + K+G+ GS +++ G+ EV
Sbjct 93 LIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTK 152
Query 183 NDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAE 242
+ + G+ FGE+++++N RTA++KTL LW + RQ F+ + + E
Sbjct 153 EGVKLCTMGPGKVFGELAILYNCTRTATVKTLV-NVKLWAIDRQCFQTIMMRTGLIKHTE 211
Query 243 NRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV--- 299
+FL SV FQ L E + + + L + G+ I+++G +GD +I+ G V
Sbjct 212 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 271
Query 300 ---SINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
S + +R L KGD+FGE+AL ++ R+A +IA E C+ I RD
Sbjct 272 DSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRD 319
> mmu:19091 Prkg1, AW125416, CGKI, MGC132849, Prkg1b, Prkgr1b;
protein kinase, cGMP-dependent, type I (EC:2.7.11.12); K07376
protein kinase, cGMP-dependent [EC:2.7.11.12]
Length=671
Score = 116 bits (290), Expect = 1e-25, Method: Compositional matrix adjust.
Identities = 66/228 (28%), Positives = 121/228 (53%), Gaps = 7/228 (3%)
Query 123 LIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIV 182
LI+ ++ N +L S+++ + + + + K + K+G+ GS +++ G+ EV
Sbjct 93 LIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTK 152
Query 183 NDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAE 242
+ + G+ FGE+++++N RTA++KTL LW + RQ F+ + + E
Sbjct 153 EGVKLCTMGPGKVFGELAILYNCTRTATVKTLV-NVKLWAIDRQCFQTIMMRTGLIKHTE 211
Query 243 NRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV--- 299
+FL SV FQ L + + + + L + G+ I+++G +GD +I+ G+ V
Sbjct 212 YMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTRE 271
Query 300 ---SINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
S + +R L KGD+FGE+AL ++ R+A +IA E C+ I RD
Sbjct 272 DSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRD 319
> cpv:cgd7_120 cAMP-dependent protein kinase regulatory subunit
; K04739 cAMP-dependent protein kinase regulator
Length=345
Score = 113 bits (283), Expect = 9e-25, Method: Compositional matrix adjust.
Identities = 67/214 (31%), Positives = 111/214 (51%), Gaps = 6/214 (2%)
Query 124 IRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVN 183
IR L + + +SL+D E++ + A + K + QG+NG +I+ G E
Sbjct 90 IREKLLESFMFTSLDDDELKTVILACVETSVKKDTEIITQGDNGDKLYIIDQGVVECYKK 149
Query 184 D-----KVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSR 238
K + + G AFGE++L++N R AS+ ++ LW + R+ F +K +S+
Sbjct 150 TSTEPRKHLCDLNPGDAFGELALLYNCPRAASVVAKTD-CLLWALDRETFNHIVKGSASK 208
Query 239 NFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKAR 298
+ FL VE + + + N +T L F GQ I+K+GE+GD Y++ +G A
Sbjct 209 RISTYETFLKEVEILKTMDVYELNKLTMVLKSSIFEDGQEIIKQGEQGDTFYLIITGNAV 268
Query 299 VSINGKDVRLLQKGDYFGERALLYDEPRSATIIA 332
+ +V ++GDYFGE ALL + PR+AT+ A
Sbjct 269 ALKDNVEVMSYKRGDYFGELALLRNAPRAATVKA 302
Score = 50.1 bits (118), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 34/105 (32%), Positives = 55/105 (52%), Gaps = 6/105 (5%)
Query 245 QFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSG-----KARV 299
+ L S F + + K VI A V S + I+ +G+ GD LYI+ G K
Sbjct 93 KLLESFMFTSLDDDELKTVIL-ACVETSVKKDTEIITQGDNGDKLYIIDQGVVECYKKTS 151
Query 300 SINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
+ K + L GD FGE ALLY+ PR+A+++A+ + + ++ R+
Sbjct 152 TEPRKHLCDLNPGDAFGELALLYNCPRAASVVAKTDCLLWALDRE 196
> dre:326020 fd58b04, wu:fd58b04; si:dkey-121j17.5
Length=663
Score = 112 bits (281), Expect = 1e-24, Method: Compositional matrix adjust.
Identities = 66/234 (28%), Positives = 125/234 (53%), Gaps = 5/234 (2%)
Query 115 EKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVH 174
+KT ++ S I ++ N L++ ++ + + ++ GD + K+G G +IV
Sbjct 89 QKTSSETSQIVKAIGKNDFLRRLDEEQISMMVDLMKVLDCRAGDEIIKEGTEGDSMYIVA 148
Query 175 SGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQ 234
+GE +V + + + G FGE+++++N RTAS+K +S LW ++RQ +R +
Sbjct 149 AGELKVTQAGRDLRILSPGDMFGELAILYNCKRTASVKAIS-AVKLWCIERQTYRSIMTN 207
Query 235 LSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKS 294
S + FL + + L + Q + I +++ F+ + IV+EG +G+ YI+
Sbjct 208 KSKMKREQLMGFLKTARTLKALNDVQLSKIIDSMEEVRFQDNEVIVREGAEGNTFYIILK 267
Query 295 GKARVS--ING--KDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G+ V+ +NG K +R + +G++FGE AL+ + R+AT A +C SI +D
Sbjct 268 GEVLVTKKVNGQQKTIRKMGEGEHFGELALIREILRTATCTAVGVVICFSIDKD 321
> dre:394005 prkg1a, MGC63955, prkg1, zgc:63955; protein kinase,
cGMP-dependent, type Ia (EC:2.7.11.1); K07376 protein kinase,
cGMP-dependent [EC:2.7.11.12]
Length=667
Score = 112 bits (280), Expect = 2e-24, Method: Compositional matrix adjust.
Identities = 65/230 (28%), Positives = 123/230 (53%), Gaps = 11/230 (4%)
Query 123 LIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIV 182
LI+S++ N +L S+++ + + + + K + K+G+ GS +++ G+ EV
Sbjct 89 LIKSAILDNDFMKNLEMSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTK 148
Query 183 NDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAE 242
+ + G+ FGE+++++N RTA+++T+S LW + RQ F+ + + AE
Sbjct 149 EGLKLCTMGPGKVFGELAILYNCTRTATVRTVSS-VKLWAIDRQCFQTIMMRTGLIKHAE 207
Query 243 NRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSIN 302
+ L SV F+ L E + + + L + G I+++G +GD +I+ GK V++
Sbjct 208 YMELLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGK--VTMT 265
Query 303 GKD--------VRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
+D +R + +GD FGE+AL ++ R+A +IA E C+ I RD
Sbjct 266 REDCPGQEPVYLRSMGRGDSFGEKALQGEDIRTANVIAAETVTCLVIDRD 315
> tgo:TGME49_111300 cAMP-dependent protein kinase regulatory subunit,
putative (EC:2.7.11.12); K04739 cAMP-dependent protein
kinase regulator
Length=410
Score = 108 bits (269), Expect = 3e-23, Method: Compositional matrix adjust.
Identities = 63/215 (29%), Positives = 118/215 (54%), Gaps = 11/215 (5%)
Query 128 LSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEV--IVN-- 183
L + + +SL++ ++ + A+Q + ++G++G +IV SGE +++
Sbjct 160 LRQSFLFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYIVQSGELNCSKLIDGE 219
Query 184 DKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAEN 243
++VV + G AFGE++L++N+ R A++ ++S LW + R F +K +++ +
Sbjct 220 ERVVKVVGPGDAFGELALLYNAPRAATVTSVS-ACDLWELGRDTFNAIVKDAATKRRSMY 278
Query 244 RQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSING 303
FL SV + ++ + +AL + F G IV++GE GD+ YI++ G A + +
Sbjct 279 DSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGSAVATKSF 338
Query 304 K------DVRLLQKGDYFGERALLYDEPRSATIIA 332
+V+ Q GDYFGE AL+ +EPR+A +IA
Sbjct 339 GPGQPPIEVKKYQAGDYFGELALINEEPRAANVIA 373
Score = 61.6 bits (148), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 34/97 (35%), Positives = 56/97 (57%), Gaps = 4/97 (4%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVS--INGKD--VR 307
F L E N + A+ + A +++EG+ G+ LYI++SG+ S I+G++ V+
Sbjct 165 LFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYIVQSGELNCSKLIDGEERVVK 224
Query 308 LLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
++ GD FGE ALLY+ PR+AT+ + +GRD
Sbjct 225 VVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRD 261
Score = 38.5 bits (88), Expect = 0.037, Method: Compositional matrix adjust.
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 12/99 (12%)
Query 122 SLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVI 181
S+ S L + + ++ E +A+A++ FT G + +QGE G F+IV G
Sbjct 276 SMYDSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGS---A 332
Query 182 VNDKV---------VNKIVEGQAFGEISLIHNSARTASI 211
V K V K G FGE++LI+ R A++
Sbjct 333 VATKSFGPGQPPIEVKKYQAGDYFGELALINEEPRAANV 371
> dre:405894 prkar2ab, MGC85886, prkar2a, zgc:85886; protein kinase,
cAMP-dependent, regulatory, type II, alpha, B; K04739
cAMP-dependent protein kinase regulator
Length=422
Score = 108 bits (269), Expect = 4e-23, Method: Compositional matrix adjust.
Identities = 58/200 (29%), Positives = 109/200 (54%), Gaps = 16/200 (8%)
Query 157 GDIVTKQGENGSYFFIVHSGEFEVIVND----KVVNKIVEGQAFGEISLIHNSARTASIK 212
G+ + QG++G F+++ G +E+++ V + +FGE++L++N+ R A+I+
Sbjct 185 GECIINQGDDGDNFYVIERGVYEIVIQQDGLQHSVGRYDHKGSFGELALMYNTPRAATIR 244
Query 213 TLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQS 272
L E ALW + R F + + +++ F+ V + L +++ I + L ++S
Sbjct 245 ALQE-GALWALDRATFHRLIVKNNAKKRRMYESFIECVPLLKSLQLSERMKIVDVLGMRS 303
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGKD--VRLLQ---------KGDYFGERALL 321
F G+ I+++G+ D YI++SG+ R+ I K +LLQ +G YFGE AL+
Sbjct 304 FSDGERIIQQGDSADCFYIVESGEVRIMIRSKTRACQLLQEEVEVARCSRGQYFGELALV 363
Query 322 YDEPRSATIIAEEETVCVSI 341
PR+A++ A +T C+ I
Sbjct 364 TKRPRAASVYAVGDTRCLVI 383
Score = 45.8 bits (107), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 29/99 (29%), Positives = 51/99 (51%), Gaps = 6/99 (6%)
Query 250 VEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDV--- 306
+ F+ L E Q + +++ + G+ I+ +G+ GD Y+++ G + I +
Sbjct 159 ILLFKTLEEDQLAEVLDSMFEVLVKPGECIINQGDDGDNFYVIERGVYEIVIQQDGLQHS 218
Query 307 --RLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGR 343
R KG FGE AL+Y+ PR+ATI A +E ++ R
Sbjct 219 VGRYDHKGS-FGELALMYNTPRAATIRALQEGALWALDR 256
> dre:100329437 protein kinase, cAMP-dependent, regulatory, type
II, alpha-like
Length=385
Score = 107 bits (268), Expect = 6e-23, Method: Compositional matrix adjust.
Identities = 58/202 (28%), Positives = 109/202 (53%), Gaps = 16/202 (7%)
Query 157 GDIVTKQGENGSYFFIVHSGEFEVIVND----KVVNKIVEGQAFGEISLIHNSARTASIK 212
G+ + QG++G F+++ G +E+++ V + +FGE++L++N+ R A+I+
Sbjct 185 GECIINQGDDGDNFYVIERGVYEIVIQQDGLQHSVGRYDHKGSFGELALMYNTPRAATIR 244
Query 213 TLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQS 272
L E ALW + R F + + +++ F+ V + L +++ I + L ++S
Sbjct 245 ALQE-GALWALDRATFHRLIVKNNAKKRRMYESFIECVPLLKSLQLSERMKIVDVLGMRS 303
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGKD--VRLLQ---------KGDYFGERALL 321
F G+ I+++G+ D YI++SG+ R+ I K +LLQ +G YFGE AL+
Sbjct 304 FSDGERIIQQGDSADCFYIVESGEVRIMIRSKTRACQLLQEEVEVARCSRGQYFGELALV 363
Query 322 YDEPRSATIIAEEETVCVSIGR 343
PR+A++ A +T C+ R
Sbjct 364 TKRPRAASVYAVGDTRCLGKNR 385
> dre:556042 prkar2aa, MGC153742, wu:fb55f12, wu:fj29e12, wu:fj33e06,
zgc:153742; protein kinase, cAMP-dependent, regulatory,
type II, alpha A; K04739 cAMP-dependent protein kinase regulator
Length=397
Score = 105 bits (262), Expect = 2e-22, Method: Compositional matrix adjust.
Identities = 57/200 (28%), Positives = 111/200 (55%), Gaps = 18/200 (9%)
Query 158 DIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQ-----AFGEISLIHNSARTASIK 212
D V QG++G F+++ G ++++V V V GQ +FGE++L++N+ R A+I
Sbjct 161 DHVIDQGDDGDNFYVIERGVYDIVVQKDGVGCCV-GQYNNKGSFGELALMYNTPRAATI- 218
Query 213 TLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQS 272
++ ALWG+ R FR + + +++ F+ S+ + L +++ I + L V++
Sbjct 219 IAKDEGALWGLDRATFRRLIVKNNAKKRRMYECFIESIPLLKSLELSERMKIVDVLGVKT 278
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGK-----------DVRLLQKGDYFGERALL 321
F+ G+ I+ +G+K D YI++SG+ ++ + K ++ +G YFGE AL+
Sbjct 279 FQDGERIIMQGDKADCFYIVESGEVKIMMKSKTKADRQDNAEVEIARCSRGQYFGELALV 338
Query 322 YDEPRSATIIAEEETVCVSI 341
++PR+A+ A + C+ I
Sbjct 339 TNKPRAASAYAIGDVKCLVI 358
> dre:566430 cGMP dependent protein kinase I
Length=528
Score = 102 bits (253), Expect = 3e-21, Method: Compositional matrix adjust.
Identities = 56/158 (35%), Positives = 91/158 (57%), Gaps = 7/158 (4%)
Query 193 GQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEF 252
G+ FGE+++++N RTA+++TL+ LW + RQ F+ + + AE +FL SV
Sbjct 20 GKVFGELAILYNCTRTATVQTLTN-VKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPT 78
Query 253 FQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVS----INGKDVRL 308
FQ L E + + + L + G+ I+++G +GD +I+ GK V+ NG V L
Sbjct 79 FQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYL 138
Query 309 --LQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
L KGD+FGE+AL ++ R+A +IA E C+ I R+
Sbjct 139 RALGKGDWFGEKALQGEDIRTANVIAAEAVTCLVIDRE 176
Score = 35.8 bits (81), Expect = 0.22, Method: Compositional matrix adjust.
Identities = 34/141 (24%), Positives = 63/141 (44%), Gaps = 14/141 (9%)
Query 145 LANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDK------VVNKIVEGQAFGE 198
LA+ ++ ++ G+ + +QG G FFI+ G+ V D + + +G FGE
Sbjct 90 LADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYLRALGKGDWFGE 149
Query 199 ISLIHNSARTASIKTLSEKAALWGVQRQVFRET---LKQLSSRNFAE---NRQFLASVEF 252
+L RTA++ +E + R+ F+ L +S++ + + ++ A F
Sbjct 150 KALQGEDIRTANV-IAAEAVTCLVIDRESFKHLIGGLDDVSNKGYDDAGAKAKYEAENAF 208
Query 253 FQMLTEAQKNVITNALVVQSF 273
F L N+I + L V F
Sbjct 209 FSNLKLVDFNII-DTLGVGGF 228
> mmu:19087 Prkar2a, 1110061A24Rik, AI317181, AI836829, RII(alpha);
protein kinase, cAMP dependent regulatory, type II alpha
(EC:2.7.11.1); K04739 cAMP-dependent protein kinase regulator
Length=402
Score = 100 bits (250), Expect = 6e-21, Method: Compositional matrix adjust.
Identities = 55/196 (28%), Positives = 106/196 (54%), Gaps = 17/196 (8%)
Query 160 VTKQGENGSYFFIVHSGEFEVIVND----KVVNKIVEGQAFGEISLIHNSARTASIKTLS 215
V QG++G F+++ G ++++V + V + +FGE++L++N+ R A+I S
Sbjct 164 VIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIIATS 223
Query 216 EKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRA 275
E +LWG+ R FR + + +++ F+ SV F+ L +++ I + + + ++
Sbjct 224 E-GSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKD 282
Query 276 GQPIVKEGEKGDILYILKSGKARVSINGK------------DVRLLQKGDYFGERALLYD 323
G+ I+ +GEK D YI++SG+ + I K ++ KG YFGE AL+ +
Sbjct 283 GERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTN 342
Query 324 EPRSATIIAEEETVCV 339
+PR+A+ A + C+
Sbjct 343 KPRAASAYAVGDVKCL 358
> hsa:5576 PRKAR2A, MGC3606, PKR2, PRKAR2; protein kinase, cAMP-dependent,
regulatory, type II, alpha (EC:2.7.11.1); K04739
cAMP-dependent protein kinase regulator
Length=404
Score = 98.2 bits (243), Expect = 4e-20, Method: Compositional matrix adjust.
Identities = 53/198 (26%), Positives = 106/198 (53%), Gaps = 17/198 (8%)
Query 160 VTKQGENGSYFFIVHSGEFEVIVND----KVVNKIVEGQAFGEISLIHNSARTASIKTLS 215
V QG++G F+++ G ++++V + V + +FGE++L++N+ R A+I S
Sbjct 166 VIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATS 225
Query 216 EKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRA 275
E +LWG+ R FR + + +++ F+ SV + L +++ I + + + ++
Sbjct 226 E-GSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKD 284
Query 276 GQPIVKEGEKGDILYILKSGKARVSINGK------------DVRLLQKGDYFGERALLYD 323
G+ I+ +GEK D YI++SG+ + I + ++ KG YFGE AL+ +
Sbjct 285 GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTN 344
Query 324 EPRSATIIAEEETVCVSI 341
+PR+A+ A + C+ +
Sbjct 345 KPRAASAYAVGDVKCLVM 362
> hsa:5577 PRKAR2B, PRKAR2, RII-BETA; protein kinase, cAMP-dependent,
regulatory, type II, beta (EC:2.7.11.1); K04739 cAMP-dependent
protein kinase regulator
Length=418
Score = 95.9 bits (237), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 51/200 (25%), Positives = 108/200 (54%), Gaps = 16/200 (8%)
Query 157 GDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQ----AFGEISLIHNSARTASIK 212
G+ V QG++G F+++ G F++ V V + V +FGE++L++N+ R A+I
Sbjct 178 GEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATI- 236
Query 213 TLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQS 272
T + ALWG+ R FR + + +++ F+ S+ F + L +++ + + + +
Sbjct 237 TATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKV 296
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGK-----------DVRLLQKGDYFGERALL 321
+ G+ I+ +G+ D +I++SG+ ++++ K ++ +G YFGE AL+
Sbjct 297 YNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALV 356
Query 322 YDEPRSATIIAEEETVCVSI 341
++PR+A+ A C+++
Sbjct 357 TNKPRAASAHAIGTVKCLAM 376
> tpv:TP02_0494 cAMP-dependent protein kinase regulatory subunit;
K04739 cAMP-dependent protein kinase regulator
Length=285
Score = 94.7 bits (234), Expect = 5e-19, Method: Compositional matrix adjust.
Identities = 60/223 (26%), Positives = 119/223 (53%), Gaps = 11/223 (4%)
Query 121 LSLIRSSLSANLVCSSLNDSEVEAL---ANAVQFFTFTKGDIVTKQGENGSYFFIVHSGE 177
+ +I+S + V SS D V+A A ++ F+ + GD++ KQG++G +++ SG
Sbjct 24 MEMIKSCFLFSGVTSSGLDLLVKAFDFKAAKIKLFS-SAGDVLIKQGDDGDKLYLIESGT 82
Query 178 FEVIVN-----DKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETL 232
EV ++ + + +G FGE++L++NS R A++ +E LW + R F +
Sbjct 83 VEVTKKSASGAEEFLCTLTDGDYFGELALMYNSPRAATVVAKTE-MHLWTLDRTTFNHVV 141
Query 233 KQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYIL 292
+ + + LA ++ F+ + + + +ALV +++ + ++K+GE G L+++
Sbjct 142 RMAVIKKREKYDSILAKLDLFKKVGPYDRCRLADALVERTYE-DETVIKQGEPGSSLFMV 200
Query 293 KSGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEE 335
G+A + K V+ GDYFGE + +PR++T+ A+ E
Sbjct 201 LEGQAESFVENKLVKSYNPGDYFGEIGFILKKPRASTVKAKLE 243
Score = 42.0 bits (97), Expect = 0.004, Method: Compositional matrix adjust.
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 3/78 (3%)
Query 160 VTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEK-- 217
V KQGE GS F+V G+ E V +K+V G FGEI I R +++K E+
Sbjct 187 VIKQGEPGSSLFMVLEGQAESFVENKLVKSYNPGDYFGEIGFILKKPRASTVKAKLEREN 246
Query 218 -AALWGVQRQVFRETLKQ 234
L G V + +K
Sbjct 247 FINLLGPMEDVLNKNIKN 264
> mmu:19088 Prkar2b, AI451071, AW061005, Pkarb2, RII(beta); protein
kinase, cAMP dependent regulatory, type II beta (EC:2.7.11.1);
K04739 cAMP-dependent protein kinase regulator
Length=416
Score = 94.4 bits (233), Expect = 6e-19, Method: Compositional matrix adjust.
Identities = 51/201 (25%), Positives = 109/201 (54%), Gaps = 16/201 (7%)
Query 156 KGDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQ----AFGEISLIHNSARTASI 211
+G+ V QG++G F+++ G F++ V V + V +FGE++L++N+ R A+I
Sbjct 175 EGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATI 234
Query 212 KTLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQ 271
T + ALWG+ R FR + + +++ F+ S+ F + L +++ + + + +
Sbjct 235 -TATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTK 293
Query 272 SFRAGQPIVKEGEKGDILYILKSGKARVSINGK-----------DVRLLQKGDYFGERAL 320
+ G+ I+ +G+ D +I++SG+ ++++ K ++ +G YFGE AL
Sbjct 294 VYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELAL 353
Query 321 LYDEPRSATIIAEEETVCVSI 341
+ ++PR+A+ A C+++
Sbjct 354 VTNKPRAASAHAIGTVKCLAM 374
> xla:414594 prkar2b, MGC83177; protein kinase, cAMP-dependent,
regulatory, type II, beta; K04739 cAMP-dependent protein kinase
regulator
Length=402
Score = 92.0 bits (227), Expect = 3e-18, Method: Compositional matrix adjust.
Identities = 54/206 (26%), Positives = 108/206 (52%), Gaps = 28/206 (13%)
Query 157 GDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQ----AFGEISLIHNSARTASIK 212
G+ V QG++G F+++ G +++ V V + V +FGE++L++N+ R A+I
Sbjct 162 GEHVIDQGDDGDNFYVIDRGTYDIFVKSDGVARCVCAYDNRGSFGELALMYNTPRAATIV 221
Query 213 TLSEKAALWGVQRQVFRETLKQLSSR------NFAENRQFLASVEFFQMLTEAQKNVITN 266
S A+WG+ R FR + + +++ NF E+ FL S+EF + L + +
Sbjct 222 ATS-VGAIWGLDRATFRRIIVKNNAKKRRLYENFIESLPFLKSLEFSERLK------VVD 274
Query 267 ALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGK-----------DVRLLQKGDYF 315
+ +++ + I+ +G+ D +I++SG+ R+++ K ++ +G YF
Sbjct 275 VIGTKTYCDEEQIIAQGDGADSFFIVESGEVRITMKSKSKPDAETNEAVEIARYIRGQYF 334
Query 316 GERALLYDEPRSATIIAEEETVCVSI 341
GE AL+ ++PR+A+ A C+ +
Sbjct 335 GELALVTNKPRAASAYAVGNVKCLVM 360
> dre:100331387 cAMP-dependent protein kinase, regulatory subunit
beta 2-like; K04739 cAMP-dependent protein kinase regulator
Length=403
Score = 89.4 bits (220), Expect = 2e-17, Method: Compositional matrix adjust.
Identities = 47/200 (23%), Positives = 101/200 (50%), Gaps = 16/200 (8%)
Query 157 GDIVTKQGENGSYFFIVHSGEFEVIV----NDKVVNKIVEGQAFGEISLIHNSARTASIK 212
G+ + Q ++G F+++ G FE+++ + V +FGE++L++N+ R A+I
Sbjct 163 GEHIIDQDDDGDNFYVIERGMFEILLKADGTTRTVGSYDNRGSFGELALMYNTPRAATII 222
Query 213 TLSEKAALWGVQRQVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQS 272
S ALW + R FR + + +++ F+ ++ L +++ + + L +
Sbjct 223 ATS-PGALWCLDRLTFRRIIVKNNAKKRKMYEAFIGTLPLLTSLEVSERMKVVDVLSTKV 281
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGK-----------DVRLLQKGDYFGERALL 321
+ G+ I+ +G+ D YI++SG R+++ ++ +G YFGE AL+
Sbjct 282 YNGGEQIIAQGDLADCFYIVESGHVRITMKRSKSKNDTEDEEVEIATCSRGQYFGELALV 341
Query 322 YDEPRSATIIAEEETVCVSI 341
++PR+A+ A + C+ +
Sbjct 342 TNKPRAASAYAMDSVKCLVM 361
> ath:AT2G20050 ATP binding / cAMP-dependent protein kinase regulator/
catalytic/ protein kinase/ protein serine/threonine
phosphatase; K04345 protein kinase A [EC:2.7.11.11]
Length=1094
Score = 88.6 bits (218), Expect = 3e-17, Method: Compositional matrix adjust.
Identities = 69/242 (28%), Positives = 114/242 (47%), Gaps = 39/242 (16%)
Query 116 KTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHS 175
KT + + I L + + L DS+ + L + +Q GDIV KQG G F++V S
Sbjct 474 KTWEEEAHIERVLRDHFLFRKLTDSQCQVLLDCMQRLEANPGDIVVKQGGEGDCFYVVGS 533
Query 176 GEFEVIVN----DKVVNKIVEG------QAFGEISLIHNSARTASIKTLSEKAALWGVQR 225
GEFEV+ + V +I++ +FGE++L+HN AS++ + + LW ++R
Sbjct 534 GEFEVLATQDGKNGEVPRILQRYTAEKQSSFGELALMHNKPLQASVRAV-DHGTLWALKR 592
Query 226 QVFRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEK 285
+ FR L +S + + + L SV+ LT Q + + +L F GQ IV + +K
Sbjct 593 EDFRGIL--MSEFSNLASLKLLRSVDLLSRLTILQLSHVAESLSEACFSDGQTIVTKDQK 650
Query 286 GDILYILKSGKARVSIN-------------------------GKDVRL-LQKGDYFGERA 319
LY+++ G+ ++S G +V + +G YFGE A
Sbjct 651 LQGLYVIQKGRVKISFCTEVLESQNVSSLTTGITNEYDNLEIGTEVSIEKHEGSYFGEWA 710
Query 320 LL 321
LL
Sbjct 711 LL 712
> bbo:BBOV_II005430 18.m06452; cAMP-dependent protein kinase regulatory
subunit; K04739 cAMP-dependent protein kinase regulator
Length=317
Score = 82.4 bits (202), Expect = 2e-15, Method: Compositional matrix adjust.
Identities = 58/237 (24%), Positives = 112/237 (47%), Gaps = 8/237 (3%)
Query 114 REKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIV 173
EKT + I+ ++ + SS++ +++ L A + + G V +QG+ G +++
Sbjct 44 HEKTPEQATRIKETVLKCFLFSSVDAKDIDTLVKAFESSDVSAGTKVIQQGDPGDKLYLI 103
Query 174 HSGEFEVIVNDKVVNKIV------EGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQV 227
SG ++ EG FGE++L++N+ R S+ ++ LW + R
Sbjct 104 ESGTARFTKTSAATEQVHDLGTAGEGGCFGELALMYNAPRACSVVAETD-MKLWSLDRST 162
Query 228 FRETLKQLSSRNFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGD 287
F ++ + + L SV L + + +AL ++F + I+ EG+KG
Sbjct 163 FNHIVRNAVIKKREKYDSLLQSVALLSNLDPYDRCRLADALTEKTF-VDEDIIVEGDKGT 221
Query 288 ILYILKSGKARVSINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
++++ G A GK V+ +G YFGE AL+ PR++T+ A+ + V + R+
Sbjct 222 SVFMILEGNAEAYCQGKLVKSYSEGGYFGEIALIAQTPRASTVKAKGKCVVAELERE 278
> dre:100332846 acyl-CoA synthetase long-chain family member 6-like
Length=1391
Score = 77.4 bits (189), Expect = 7e-14, Method: Compositional matrix adjust.
Identities = 63/245 (25%), Positives = 122/245 (49%), Gaps = 24/245 (9%)
Query 123 LIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIV 182
LI S+L+ N L+ +++ L ++ +G + ++GE+G+ +IV G+ EV
Sbjct 110 LIESALAENECMKYLDRDQLQCLVDSAYPTMLKQGVCLFQEGEHGAQAYIVEEGKLEVSR 169
Query 183 NDKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLK--------- 233
+ ++ I G F E+ LIHN + ++ L+ + LW ++ QVF++ ++
Sbjct 170 AGQRLHIIESGMMFEELGLIHNHTCSTTVTALA-NSRLWVMEAQVFQKLMQKSSVITITQ 228
Query 234 --QLSSRN---FAENRQFLASVEFFQMLTEAQKNVITNALVVQ---SFRAGQPIVKEGEK 285
QL R+ EN+ + ++ + + A ++ +A + + G I+++G
Sbjct 229 SLQLLRRSGVTLIENKVHVRTLNMMRGIKPAFQDKCQSACSSEQKVHYSDGDYIIQDGSP 288
Query 286 GDILYILKSGKARV---SINGKD---VRLLQKGDYFGERALLYDEPRSATIIAEEETVCV 339
D L+IL G+ +V G+D V +L +GD FGE A D+ RS +++A + C+
Sbjct 289 ADKLFILSQGQVKVLEKQCVGEDSVMVCVLTRGDSFGESASQGDDVRSISVLAAGDVTCL 348
Query 340 SIGRD 344
I R+
Sbjct 349 LIDRE 353
> tgo:TGME49_019070 cAMP-dependent protein kinase regulatory subunit,
putative (EC:3.6.3.14 2.7.10.2 2.7.11.12)
Length=2634
Score = 71.2 bits (173), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 70/277 (25%), Positives = 127/277 (45%), Gaps = 45/277 (16%)
Query 81 PPKPGGERKVQKA-------IMQQDDTQAEDA---RLLSHLEKREKTGTDLSLIRSSLSA 130
P G E+K+Q+A I+Q+DD + RL+ LEK+E +L L+
Sbjct 2208 PTSQGDEQKIQEALKWEDMAIVQRDDHRTYPTCTKRLVDVLEKKEGF-MNLQLL------ 2260
Query 131 NLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVI----VNDKV 186
++ +A+ ++ KG V + G+ F GEF+++ +
Sbjct 2261 ----------QLRYVASTMRRECLAKGVRVMEAGDEACMVFCAW-GEFKILQAGLFGESE 2309
Query 187 VNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQLSSRNFA----- 241
V + + FG LI++S TAS+ T + + LW ++R + + ++ + A
Sbjct 2310 VGVVCPDECFGLSELINDSPLTASLVTEVDNSVLWVLERDTYNDLIRDMLEARRAVVPVI 2369
Query 242 ENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDIL-YILKSGKARVS 300
EN FL SV + ++E + + A +++F Q + + G GD+ +I K +
Sbjct 2370 EN--FLKSVPIVKDMSETEIQNVARACKIETFSPHQTVFRAGMAGDMFCFIFKGEITMLK 2427
Query 301 INGK-----DVRLLQKGDYFGERALLYDEPRSATIIA 332
G ++ LQ G YFGE A++ ++ R+A+IIA
Sbjct 2428 PMGAGQEPIELGRLQAGVYFGEMAVIKNQRRTASIIA 2464
Score = 62.0 bits (149), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 50/216 (23%), Positives = 99/216 (45%), Gaps = 20/216 (9%)
Query 144 ALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQA-----FGE 198
A+ +Q + G+ + + +N +IV +G +++ ++ + E ++ F E
Sbjct 1181 AMIKQMQKTVYQPGERIQEAQDNACPLYIVMTGSIQLLSPGLLMETVAEEKSAPQLLFSE 1240
Query 199 ISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQ---LSSRNFAENRQFLASVEFFQM 255
++ + ++K L+ ++ R+ F ++K +R+ A N + V
Sbjct 1241 -EMLEDKPNPFAVKALT-ATKVFAYSREDFVRSVKHEQIKRTRDVATNMALIKIVPVLSK 1298
Query 256 LTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKD---------- 305
LTE Q + ++F G+ I KE ++ D Y++K G+A V KD
Sbjct 1299 LTEVQARRLARTFGEETFEDGEAIFKEFDEPDNFYLVKKGEAAVVKYKKDPTTKEMEEVV 1358
Query 306 VRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSI 341
R+ Q G+YFGE ++L D+ R+AT+ A +S+
Sbjct 1359 FRIYQPGEYFGEISILRDQTRTATVKARGICTVLSL 1394
Score = 60.8 bits (146), Expect = 7e-09, Method: Compositional matrix adjust.
Identities = 60/243 (24%), Positives = 101/243 (41%), Gaps = 45/243 (18%)
Query 145 LANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEF--EVIVN-DKVVNKIVEGQA---FGE 198
+ A+ F + QGE F+++ +G E+ V K KI E + FGE
Sbjct 1506 IVKAMSLECFYPNTPIILQGEESQNFYVLKTGTVAAELYVGPGKPFRKIKEYNSTCYFGE 1565
Query 199 ISLIHNSARTASIKTLSEKAALWGVQRQVFRETL---------------------KQLSS 237
+S+I N R I T L+ + + F+E L +Q SS
Sbjct 1566 MSIIKNEPRGCYI-TAKSPVQLYSLTGEKFKELLEDCYPAFQEYAQAQYEQETLKRQASS 1624
Query 238 R-------------NFAENRQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGE 284
+ ++ E L V ML E +T A V+ ++ + I+ EG
Sbjct 1625 QLVSSEAVREEPTADYGEIMNLLVQVPVINMLDEDALQQLTRAFKVECYQEREVIIHEGT 1684
Query 285 KGDILYILKSGKARVS--INGKDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVCVS 340
+ +I+ SG V ++G V + L G+Y GE A L ++PR+A+ +A+ + +S
Sbjct 1685 PAEHFFIIFSGDVSVQKIVDGAPVEIVVLHAGEYLGEIAFLNEQPRTASCVAKSDVKLLS 1744
Query 341 IGR 343
+ R
Sbjct 1745 LTR 1747
Score = 45.8 bits (107), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 6/93 (6%)
Query 246 FLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSIN--- 302
L V + L+ ++ I A+ ++ F PI+ +GE+ Y+LK+G +
Sbjct 1488 LLEGVPVLKELSLERRKEIVKAMSLECFYPNTPIILQGEESQNFYVLKTGTVAAELYVGP 1547
Query 303 GKDVRLLQKGD---YFGERALLYDEPRSATIIA 332
GK R +++ + YFGE +++ +EPR I A
Sbjct 1548 GKPFRKIKEYNSTCYFGEMSIIKNEPRGCYITA 1580
Score = 42.7 bits (99), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 30/109 (27%), Positives = 54/109 (49%), Gaps = 4/109 (3%)
Query 107 LLSHLEKREKTGTDLSLIRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGEN 166
L+S RE+ D I + L V + L++ ++ L A + + + +++ +G
Sbjct 1626 LVSSEAVREEPTADYGEIMNLLVQVPVINMLDEDALQQLTRAFKVECYQEREVIIHEGTP 1685
Query 167 GSYFFIVHSGEFEV--IVNDKVVNKIV--EGQAFGEISLIHNSARTASI 211
+FFI+ SG+ V IV+ V +V G+ GEI+ ++ RTAS
Sbjct 1686 AEHFFIIFSGDVSVQKIVDGAPVEIVVLHAGEYLGEIAFLNEQPRTASC 1734
Score = 42.0 bits (97), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 28/90 (31%), Positives = 45/90 (50%), Gaps = 10/90 (11%)
Query 133 VCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVNDK------- 185
V S L + + LA TF G+ + K+ + F++V GE V+ K
Sbjct 1295 VLSKLTEVQARRLARTFGEETFEDGEAIFKEFDEPDNFYLVKKGEAAVVKYKKDPTTKEM 1354
Query 186 --VVNKIVE-GQAFGEISLIHNSARTASIK 212
VV +I + G+ FGEIS++ + RTA++K
Sbjct 1355 EEVVFRIYQPGEYFGEISILRDQTRTATVK 1384
> cel:C09G4.2 hypothetical protein
Length=617
Score = 68.2 bits (165), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 29/111 (26%), Positives = 67/111 (60%), Gaps = 1/111 (0%)
Query 124 IRSSLSANLVCSSLNDSEVEALANAVQFFTFTKGDIVTKQGENGSYFFIVHSGEFEVIVN 183
I ++L N +L+ +++E +++A+ G I+ +QG+ GS +++ G+ +V+ +
Sbjct 63 IGNALRLNSFLRNLDATQIEKISSAMYPVEVPAGAIIIRQGDLGSIMYVIQEGKVQVVKD 122
Query 184 DKVVNKIVEGQAFGEISLIHNSARTASIKTLSEKAALWGVQRQVFRETLKQ 234
++ V + +G FGE++++H+ RTA+++ + E LW ++R VF + +
Sbjct 123 NRFVRTMEDGALFGELAILHHCERTATVRAI-ESCHLWAIERNVFHAIMME 172
Score = 53.1 bits (126), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 30/93 (32%), Positives = 53/93 (56%), Gaps = 0/93 (0%)
Query 252 FFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQK 311
F + L Q I++A+ AG I+++G+ G I+Y+++ GK +V + + VR ++
Sbjct 72 FLRNLDATQIEKISSAMYPVEVPAGAIIIRQGDLGSIMYVIQEGKVQVVKDNRFVRTMED 131
Query 312 GDYFGERALLYDEPRSATIIAEEETVCVSIGRD 344
G FGE A+L+ R+AT+ A E +I R+
Sbjct 132 GALFGELAILHHCERTATVRAIESCHLWAIERN 164
> dre:795338 si:dkey-196h17.4
Length=1669
Score = 59.3 bits (142), Expect = 2e-08, Method: Composition-based stats.
Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 4/142 (2%)
Query 95 MQQDDTQAEDARLLSHLEKREKTGTDLSLIRSSLSANLVCSSLNDS-EVEALANAVQFFT 153
+Q+ TQ + LLS +E L + +LS + ND + LA V
Sbjct 988 IQRTTTQESEINLLSTVEITRAGKLSLPVFEMTLSKTWLEQLENDGCFIRLLAGGVSQCL 1047
Query 154 FTKGDIVTKQGENGSYFFIVHSGEFEVIVND--KVVNKIVEGQAFGEISLIHNSARTASI 211
+ D++ K+G+ GS + V GE EV+ N+ KV+ K+ GQ FGE SL+ + R A+I
Sbjct 1048 YRASDVIYKKGDCGSEVYFVEKGEVEVLSNNESKVLFKLSAGQYFGERSLLFHEPRAATI 1107
Query 212 KTLSEKAALWGVQRQVFRETLK 233
+ + + ++ + ++ E LK
Sbjct 1108 RA-ATNSEMYVLSQKSLHEILK 1128
Score = 50.8 bits (120), Expect = 8e-06, Method: Composition-based stats.
Identities = 27/62 (43%), Positives = 38/62 (61%), Gaps = 2/62 (3%)
Query 273 FRAGQPIVKEGEKGDILYILKSGKARVSINGKDVRL--LQKGDYFGERALLYDEPRSATI 330
+RA I K+G+ G +Y ++ G+ V N + L L G YFGER+LL+ EPR+ATI
Sbjct 1048 YRASDVIYKKGDCGSEVYFVEKGEVEVLSNNESKVLFKLSAGQYFGERSLLFHEPRAATI 1107
Query 331 IA 332
A
Sbjct 1108 RA 1109
Score = 43.9 bits (102), Expect = 8e-04, Method: Composition-based stats.
Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 4/97 (4%)
Query 244 RQFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSING 303
R + + F+ K ++ L ++ GQ + K GE LY +K G +V
Sbjct 140 RSLIKKAKLFRNTANGFKMALSLKLKTYTYIPGQTLAKAGEINQNLYYIKHGHVQVFSQN 199
Query 304 KDVRL--LQKGDYFGERALLYDEPRSATIIAEEETVC 338
+V + L G FGE LLY+ PR+ TI A T+C
Sbjct 200 PEVEIATLLPGTLFGEVHLLYEIPRNVTIRA--STLC 234
Score = 32.0 bits (71), Expect = 3.5, Method: Composition-based stats.
Identities = 22/91 (24%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query 245 QFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARVSINGK 304
++L S F T ++ + + F G+ I ++G+ G +Y L GK + ++ +
Sbjct 1542 EYLKSHHLFSHFTIPVMRELSARVTFRCFPVGECIYRKGDSGTEIYFLLIGKVNLCLDTR 1601
Query 305 DVRLLQ---KGDYFGERALLYDEPRSATIIA 332
+ Q +G FG+R ++ + R T IA
Sbjct 1602 GHEVYQRLCRGTAFGDR-IVIEHTRHDTAIA 1631
> cel:T20G5.5 epac-1; Exchange Protein Activated by Cyclic AMP
family member (epac-1); K04351 Rap guanine nucleotide exchange
factor (GEF) 4
Length=1234
Score = 58.2 bits (139), Expect = 4e-08, Method: Composition-based stats.
Identities = 32/81 (39%), Positives = 51/81 (62%), Gaps = 1/81 (1%)
Query 256 LTEAQKNVITNALVVQSF-RAGQPIVKEGEKGDILYILKSGKARVSINGKDVRLLQKGDY 314
L+ K ++N + V+ + AG + ++GE G YI+ G V++NGK V LL++GD
Sbjct 575 LSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGAVEVNVNGKIVCLLREGDD 634
Query 315 FGERALLYDEPRSATIIAEEE 335
FG+ AL+ D PR+ATI+ E+
Sbjct 635 FGKLALVNDLPRAATIVTYED 655
Score = 57.4 bits (137), Expect = 8e-08, Method: Composition-based stats.
Identities = 32/100 (32%), Positives = 56/100 (56%), Gaps = 5/100 (5%)
Query 157 GDIVTKQGENGSYFFIVHSGEFEVIVNDKVVNKIVEGQAFGEISLIHNSARTASIKTLSE 216
G +V +QGE G Y++IV G EV VN K+V + EG FG+++L+++ R A+I T +
Sbjct 596 GSVVFRQGEIGVYWYIVLKGAVEVNVNGKIVCLLREGDDFGKLALVNDLPRAATIVTYED 655
Query 217 KAALWGVQRQVFRETLKQLSS-----RNFAENRQFLASVE 251
+ V + F + L Q+ + +++ E+ L V+
Sbjct 656 DSMFLVVDKHHFNQILHQVEANTVRLKDYGEDVLVLEKVD 695
> tgo:TGME49_004470 cyclic nucleotide-binding domain containing
protein (EC:2.7.11.12)
Length=258
Score = 57.4 bits (137), Expect = 7e-08, Method: Compositional matrix adjust.
Identities = 33/104 (31%), Positives = 57/104 (54%), Gaps = 7/104 (6%)
Query 245 QFLASVEFFQMLTEAQKNVITNALVVQSFRAGQPIVKEGEKGDILYILKSGKARV----- 299
Q +++V F L EA + + +L +++ A Q + + G+ GD YI+ SG+ V
Sbjct 12 QVISNVNLFSKLDEATQKSLCRSLTYEAYAAKQVVFRYGDWGDKYYIILSGRVSVQAPLT 71
Query 300 --SINGKDVRLLQKGDYFGERALLYDEPRSATIIAEEETVCVSI 341
S + V +L+ G FGE AL+ ++PR+AT++ E T + I
Sbjct 72 PTSETFQQVAILESGGGFGEMALMENKPRAATVVCLETTGTLDI 115
Lambda K H
0.311 0.126 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 14664651540
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40