bitscore colors: <40, 40-50 , 50-80, 80-200, >200
BLASTP 2.2.24+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
164,496 sequences; 82,071,388 total letters
Query= Eace_0185_orf1
Length=150
Score E
Sequences producing significant alignments: (Bits) Value
tgo:TGME49_034360 DNA topoisomerase I, putative ; K03163 DNA t... 185 6e-47
cpv:cgd7_3350 eukaryotic DNA topoisomerase I ; K03163 DNA topo... 163 2e-40
tpv:TP02_0198 DNA topoisomerase I; K03163 DNA topoisomerase I ... 144 1e-34
pfa:PFE0520c topoisomerase I (EC:5.99.1.2); K03163 DNA topoiso... 139 3e-33
xla:399263 top1.1, top1; topoisomerase (DNA) I, gene 1 (EC:5.9... 137 1e-32
bbo:BBOV_II007450 18.m06618; DNA topoisomerase (EC:5.99.1.2); ... 136 2e-32
dre:334557 fl27b11, wu:fl27b11; zgc:173742 136 2e-32
xla:734592 top1.2, MGC115546; topoisomerase (DNA) I, gene 2 136 2e-32
dre:553496 top1l, wu:fc66a02, zgc:136349; topoisomerase (DNA) ... 135 6e-32
dre:327179 top1, fd15f07, wu:fd15f07; topoisomerase (DNA) I 134 8e-32
hsa:7150 TOP1, TOPI; topoisomerase (DNA) I (EC:5.99.1.2); K031... 134 2e-31
cel:M01E5.5 top-1; TOPoisomerase family member (top-1); K03163... 133 2e-31
mmu:21969 Top1, AI467334, D130064I21Rik, Top-1; topoisomerase ... 130 1e-30
hsa:116447 TOP1MT; topoisomerase (DNA) I, mitochondrial (EC:5.... 127 9e-30
mmu:72960 Top1mt, 2900052H09Rik; DNA topoisomerase 1, mitochon... 126 2e-29
dre:415098 top1mt; mitochondrial topoisomerase I (EC:5.99.1.2) 125 6e-29
ath:AT5G55300 TOP1ALPHA (DNA TOPOISOMERASE I ALPHA); DNA topoi... 118 6e-27
ath:AT5G55310 TOP1BETA (DNA TOPOISOMERASE 1 BETA); DNA topoiso... 115 4e-26
sce:YOL006C TOP1, MAK1, MAK17; Top1p (EC:5.99.1.2); K03163 DNA... 115 5e-26
tgo:TGME49_088420 hypothetical protein 31.6 1.0
mmu:26414 Mapk10, C230008H04Rik, JNK3, JNK3B1, JNK3B2, SAPK(be... 30.8 1.5
mmu:434903 Mageb4, CN716893, Mage-b4, mMage-b4; melanoma antig... 30.4 2.2
mmu:110082 Dnahc5, AU022615, Dnah5, KIAA1603, Mdnah5, mKIAA160... 30.4 2.2
hsa:1767 DNAH5, CILD3, DNAHC5, FLJ46759, HL1, KIAA1603, KTGNR,... 30.0 3.0
dre:557486 histone deacetylase 5-like; K11406 histone deacetyl... 30.0 3.0
hsa:139422 MAGEB10, FLJ32965, MGC120394; melanoma antigen fami... 30.0 3.2
cel:ZC239.7 gcy-15; Guanylyl CYclase family member (gcy-15); K... 29.6 3.4
dre:100332402 cytoplasmic dynein 2 heavy chain 1-like; K10414 ... 29.6 3.7
dre:767722 foxred2, MGC153216, zgc:153216; FAD-dependent oxido... 29.6 3.9
cel:F22E5.3 gcy-21; Guanylyl CYclase family member (gcy-21); K... 29.6 3.9
cel:M142.5 hypothetical protein 29.6 3.9
hsa:5602 MAPK10, FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974, PR... 29.6 4.0
hsa:4112 MAGEB1, CT3.1, DAM10, MAGE-Xp, MAGEL1, MGC9322; melan... 29.3 5.1
cel:W02F12.5 hypothetical protein; K00658 2-oxoglutarate dehyd... 29.3 5.2
ath:AT1G11720 ATSS3; ATSS3 (starch synthase 3); starch synthas... 28.5 7.8
> tgo:TGME49_034360 DNA topoisomerase I, putative ; K03163 DNA
topoisomerase I [EC:5.99.1.2]
Length=953
Score = 185 bits (469), Expect = 6e-47, Method: Compositional matrix adjust.
Identities = 89/147 (60%), Positives = 108/147 (73%), Gaps = 6/147 (4%)
Query 7 TDEEADTVGCCSLRVEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGK 66
TDEEADTVGCCSLRVEH+ F +K+E+T DFLGKDSIRY+NTVK+ PQ FKN+ FC+GK
Sbjct 604 TDEEADTVGCCSLRVEHLTFDTEKQEVTFDFLGKDSIRYFNTVKVHPQVFKNVVGFCKGK 663
Query 67 KADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKLQPTLA------KF 120
K +DDVF+ INS +LNNHL+Q MPGLSAK+FRTYNASITLQ EL KL LA
Sbjct 664 KPEDDVFDKINSAALNNHLRQFMPGLSAKVFRTYNASITLQNELFKLDEALALRAQKAGK 723
Query 121 KEEVERERMKKEAKTKTKKAKTEPQAA 147
+ +E +K E K ++ + EP A
Sbjct 724 GVKKAKEEVKAETKAESSSGEDEPLVA 750
> cpv:cgd7_3350 eukaryotic DNA topoisomerase I ; K03163 DNA topoisomerase
I [EC:5.99.1.2]
Length=653
Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 75/107 (70%), Positives = 88/107 (82%), Gaps = 0/107 (0%)
Query 7 TDEEADTVGCCSLRVEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGK 66
TDEEADTVGCCSLRVEHI F + +K ITLDFLGKDSIRYYNTV IDP AF NL FCR K
Sbjct 337 TDEEADTVGCCSLRVEHITFNQQEKSITLDFLGKDSIRYYNTVVIDPSAFNNLTIFCRNK 396
Query 67 KADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
++VF+ IN +SLN +LK +MP LSAK+FRT+NASITL++EL K+
Sbjct 397 DKMENVFDQINMSSLNQYLKSIMPELSAKVFRTFNASITLERELSKI 443
> tpv:TP02_0198 DNA topoisomerase I; K03163 DNA topoisomerase
I [EC:5.99.1.2]
Length=1003
Score = 144 bits (363), Expect = 1e-34, Method: Compositional matrix adjust.
Identities = 69/117 (58%), Positives = 89/117 (76%), Gaps = 4/117 (3%)
Query 9 EEADTVGCCSLRVEHIAFGEDKKE-ITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKK 67
+EADTVGCCSLRVEHI F E K+ ITLDFLGKDSIRY+NTV ++ A+ NL FC KK
Sbjct 617 DEADTVGCCSLRVEHIKFSEKKQNTITLDFLGKDSIRYFNTVTLNDVAYDNLAKFCHRKK 676
Query 68 ADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKLQPTLAKFKEEV 124
A +++F IN+ LN +L++LM GLSAK+FRTYNASITLQ + +L+ +K+K +
Sbjct 677 ASEEIFNKINTNKLNEYLRELMDGLSAKVFRTYNASITLQNQFKRLR---SKYKRSI 730
> pfa:PFE0520c topoisomerase I (EC:5.99.1.2); K03163 DNA topoisomerase
I [EC:5.99.1.2]
Length=839
Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust.
Identities = 73/145 (50%), Positives = 89/145 (61%), Gaps = 33/145 (22%)
Query 8 DEEADTVGCCSLRVEHIAFGED-------KKE--------------------------IT 34
DEEADTVGCCSLRVEHI+F D KE IT
Sbjct 447 DEEADTVGCCSLRVEHISFAHDIPFKSVDSKEQKTNDEKVNKIPLPTNLESISSEDCYIT 506
Query 35 LDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKADDDVFESINSTSLNNHLKQLMPGLSA 94
LDFLGKDSIRY+NTVKID QA+ N+ FC+ K D+ VF+ I + LN +LK++MP LSA
Sbjct 507 LDFLGKDSIRYFNTVKIDKQAYINIIIFCKNKNRDEGVFDQITCSKLNEYLKEIMPTLSA 566
Query 95 KMFRTYNASITLQQELDKLQPTLAK 119
K+FRTYNASITL Q+L +++ K
Sbjct 567 KVFRTYNASITLDQQLKRIKEVYGK 591
> xla:399263 top1.1, top1; topoisomerase (DNA) I, gene 1 (EC:5.99.1.2);
K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=829
Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust.
Identities = 68/109 (62%), Positives = 84/109 (77%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHIA-FGE-DKKE--ITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEHI F E D +E + DF GKDSIRYYN V ++ + FKNLQ F
Sbjct 553 ETADTVGCCSLRVEHINLFQELDGQEFVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFME 612
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+ DDD+F+ +N++ LN HL+ LM GL+AK+FRTYNASITLQQ+LD+L
Sbjct 613 NKQPDDDLFDRLNTSILNKHLQDLMEGLTAKVFRTYNASITLQQQLDEL 661
> bbo:BBOV_II007450 18.m06618; DNA topoisomerase (EC:5.99.1.2);
K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=701
Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 65/106 (61%), Positives = 83/106 (78%), Gaps = 1/106 (0%)
Query 9 EEADTVGCCSLRVEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKA 68
+EADTVGCCSLRVEHI F ITLDFLGKDSIRY++TV +D A +NL FC+ KK
Sbjct 398 DEADTVGCCSLRVEHIKFDRKPNTITLDFLGKDSIRYFHTVTLDEVACRNLSEFCK-KKP 456
Query 69 DDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKLQ 114
+D+F+ IN+ LN++LK LM GL+AK+FRTYNASITL ++L +L+
Sbjct 457 TEDIFDKINTVKLNDYLKDLMTGLTAKVFRTYNASITLCRQLRRLK 502
> dre:334557 fl27b11, wu:fl27b11; zgc:173742
Length=609
Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 65/109 (59%), Positives = 79/109 (72%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHI----AFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEHI A + K + DFLGKD IRYYN V + + FKNL+ F
Sbjct 341 ETADTVGCCSLRVEHITLHDALDDQKCVVEFDFLGKDCIRYYNKVPVTKRVFKNLKLFME 400
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+ DD+F+ +N+ SLN HL LMPGL+AK+FRTYNASITLQQ+L +L
Sbjct 401 NKQGGDDLFDRLNTASLNKHLSSLMPGLTAKVFRTYNASITLQQQLKEL 449
> xla:734592 top1.2, MGC115546; topoisomerase (DNA) I, gene 2
Length=503
Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 67/110 (60%), Positives = 80/110 (72%), Gaps = 6/110 (5%)
Query 9 EEADTVGCCSLRVEHIAF-----GEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFC 63
E ADTVGCCSLRVEHI GE K + DFLGKDSIRYYN V ++ Q FKNLQ F
Sbjct 235 ESADTVGCCSLRVEHIKLYPELDGE-KHVVEFDFLGKDSIRYYNKVPVEKQVFKNLQLFM 293
Query 64 RGKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+ DD+F+ +N+ LN HL+ LM GL+AK+FRTYNASITLQQ+L +L
Sbjct 294 ENKEEGDDLFDRLNTPLLNKHLQSLMEGLTAKVFRTYNASITLQQQLQEL 343
> dre:553496 top1l, wu:fc66a02, zgc:136349; topoisomerase (DNA)
I, like; K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=758
Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust.
Identities = 64/109 (58%), Positives = 84/109 (77%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHIAFGE--DKKE--ITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEH+ D +E + DFLGKDSIRYYN V ++ + FKNLQ F
Sbjct 490 ETADTVGCCSLRVEHLTLHPEMDGQEFVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFME 549
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+ +DD+F+ +N++ LN HL++LM GL+AK+FRTYNASITLQQ+L++L
Sbjct 550 DKEPEDDLFDRLNTSILNKHLQELMDGLTAKVFRTYNASITLQQQLNEL 598
> dre:327179 top1, fd15f07, wu:fd15f07; topoisomerase (DNA) I
Length=748
Score = 134 bits (338), Expect = 8e-32, Method: Compositional matrix adjust.
Identities = 63/110 (57%), Positives = 85/110 (77%), Gaps = 6/110 (5%)
Query 9 EEADTVGCCSLRVEHIAF-----GEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFC 63
E ADTVGCCSLRVEHI G+D + DFLGKDSIRYYN + ++ + FKNLQ F
Sbjct 480 ETADTVGCCSLRVEHIKLHPQLDGQDYV-VEFDFLGKDSIRYYNKIPVEKRVFKNLQLFL 538
Query 64 RGKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+++DD+F+ +N++ LN +L++LM GL+AK+FRTYNASITLQQ+L++L
Sbjct 539 ENKQSEDDLFDRLNTSILNKYLQELMDGLTAKVFRTYNASITLQQQLNEL 588
> hsa:7150 TOP1, TOPI; topoisomerase (DNA) I (EC:5.99.1.2); K03163
DNA topoisomerase I [EC:5.99.1.2]
Length=765
Score = 134 bits (336), Expect = 2e-31, Method: Compositional matrix adjust.
Identities = 65/109 (59%), Positives = 81/109 (74%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHIAFGE--DKKE--ITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEHI D +E + DFLGKDSIRYYN V ++ + FKNLQ F
Sbjct 497 ETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFME 556
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+ +DD+F+ +N+ LN HL+ LM GL+AK+FRTYNASITLQQ+L +L
Sbjct 557 NKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKEL 605
> cel:M01E5.5 top-1; TOPoisomerase family member (top-1); K03163
DNA topoisomerase I [EC:5.99.1.2]
Length=806
Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust.
Identities = 64/118 (54%), Positives = 84/118 (71%), Gaps = 11/118 (9%)
Query 7 TDEEADTVGCCSLRVEHIAF-------GEDKKE----ITLDFLGKDSIRYYNTVKIDPQA 55
DE ADTVGCCSLRVEHI +DKKE + DFLGKDSIRY+N V ++ +
Sbjct 537 VDEAADTVGCCSLRVEHIKLFDSAKLNEDDKKEKEFVVEFDFLGKDSIRYFNRVSVEKRV 596
Query 56 FKNLQAFCRGKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
+KNL+ F GK DD+F+ +++ +LN+HL+ LM GL+ K+FRTYNASITLQ++L KL
Sbjct 597 YKNLKIFMEGKAPSDDLFDRLDTATLNDHLRSLMDGLTVKVFRTYNASITLQEQLIKL 654
> mmu:21969 Top1, AI467334, D130064I21Rik, Top-1; topoisomerase
(DNA) I (EC:5.99.1.2); K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=767
Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust.
Identities = 64/109 (58%), Positives = 80/109 (73%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHIAFGE--DKKE--ITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEHI D +E + DF GKDSIRYYN V ++ + FKNLQ F
Sbjct 499 ETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFME 558
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K+ +DD+F+ +N+ LN HL+ LM GL+AK+FRTYNASITLQQ+L +L
Sbjct 559 NKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKEL 607
> hsa:116447 TOP1MT; topoisomerase (DNA) I, mitochondrial (EC:5.99.1.2);
K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=601
Score = 127 bits (320), Expect = 9e-30, Method: Compositional matrix adjust.
Identities = 60/109 (55%), Positives = 77/109 (70%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHIAFGED----KKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEH+ + + + DFLGKD IRYYN V ++ +KNLQ F
Sbjct 333 EAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFME 392
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K DD+F+ + +TSLN HL++LM GL+AK+FRTYNASITLQ++L L
Sbjct 393 NKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRAL 441
> mmu:72960 Top1mt, 2900052H09Rik; DNA topoisomerase 1, mitochondrial
(EC:5.99.1.2); K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=593
Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 61/109 (55%), Positives = 78/109 (71%), Gaps = 4/109 (3%)
Query 9 EEADTVGCCSLRVEHIAF----GEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCR 64
E ADTVGCCSLRVEHI G + + LDFLGKDSIRY N V ++ F+NLQ F
Sbjct 326 ETADTVGCCSLRVEHIRLHAPAGGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFME 385
Query 65 GKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
K DD+F+++ ++SLN HL+ LM GL+AK+FRTYNAS+TLQ++L L
Sbjct 386 DKDPRDDLFDALTTSSLNKHLQDLMEGLTAKVFRTYNASVTLQEQLRVL 434
> dre:415098 top1mt; mitochondrial topoisomerase I (EC:5.99.1.2)
Length=600
Score = 125 bits (314), Expect = 6e-29, Method: Compositional matrix adjust.
Identities = 62/111 (55%), Positives = 79/111 (71%), Gaps = 6/111 (5%)
Query 8 DEEADTVGCCSLRVEHIAF-----GEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAF 62
DE ADTVGCCSLRVEHI G D + DFLGKDSIRYYN V ++ Q FKNL+ F
Sbjct 331 DESADTVGCCSLRVEHIRLHKHLDGLDH-VVEFDFLGKDSIRYYNKVPVEKQVFKNLKLF 389
Query 63 CRGKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKL 113
+ K +DD+F+ I++ +LN L + M GL+AK+FRT+NAS TLQ +L+KL
Sbjct 390 IKHKDPEDDLFDRISTVNLNKALTESMSGLTAKVFRTFNASTTLQDQLNKL 440
> ath:AT5G55300 TOP1ALPHA (DNA TOPOISOMERASE I ALPHA); DNA topoisomerase
type I; K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=916
Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust.
Identities = 55/103 (53%), Positives = 77/103 (74%), Gaps = 1/103 (0%)
Query 8 DEEADTVGCCSLRVEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKK 67
D+EADTVGCC+L+V ++ K I DFLGKDSI+Y NTV+++P +K + F GK
Sbjct 647 DDEADTVGCCTLKVGNVECIPPNK-IKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKS 705
Query 68 ADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQEL 110
DD+F+ ++++ LN HLK+L+PGL+AK+FRTYNASITL + L
Sbjct 706 KTDDLFDELDTSKLNAHLKELVPGLTAKVFRTYNASITLDEML 748
> ath:AT5G55310 TOP1BETA (DNA TOPOISOMERASE 1 BETA); DNA topoisomerase
type I; K03163 DNA topoisomerase I [EC:5.99.1.2]
Length=917
Score = 115 bits (289), Expect = 4e-26, Method: Compositional matrix adjust.
Identities = 55/105 (52%), Positives = 76/105 (72%), Gaps = 1/105 (0%)
Query 8 DEEADTVGCCSLRVEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKK 67
D+EADTVGCC+L+V ++ K + DFLGKDSI+Y NTV+++P +K + F GK
Sbjct 645 DDEADTVGCCTLKVGNVECIPPNK-LKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKS 703
Query 68 ADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDK 112
DD+F+ ++++ LN HLK+LM GL+AK+FRTYNASITL L K
Sbjct 704 KTDDLFDELDTSKLNTHLKELMAGLTAKVFRTYNASITLDLMLSK 748
> sce:YOL006C TOP1, MAK1, MAK17; Top1p (EC:5.99.1.2); K03163 DNA
topoisomerase I [EC:5.99.1.2]
Length=769
Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust.
Identities = 54/106 (50%), Positives = 75/106 (70%), Gaps = 2/106 (1%)
Query 7 TDEEADTVGCCSLRVEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRG- 65
+++EADTVGCCSLR EH+ + + DFLGKDSIR+Y V++D Q FKNL F R
Sbjct 426 SEDEADTVGCCSLRYEHVTL-KPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPP 484
Query 66 KKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELD 111
K+ +F+ ++ + LN +L+ MPGL+AK+FRTYNAS T+Q +LD
Sbjct 485 KQPGHQLFDRLDPSILNKYLQNYMPGLTAKVFRTYNASKTMQDQLD 530
> tgo:TGME49_088420 hypothetical protein
Length=1847
Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust.
Identities = 19/60 (31%), Positives = 29/60 (48%), Gaps = 9/60 (15%)
Query 41 DSIRYYNTVKIDPQAFKNLQAFCRGKKADDD-----VFESINSTSLNNHLKQLMPGLSAK 95
D R + IDPQA K + FC AD+D NS ++ +HL + GL+++
Sbjct 745 DDGRRKEEIYIDPQALKWMAPFC----ADEDQVLTRARRRRNSVTVFHHLHEQTKGLASR 800
> mmu:26414 Mapk10, C230008H04Rik, JNK3, JNK3B1, JNK3B2, SAPK(beta),
Serk2, p493F12, p54bSAPK; mitogen-activated protein kinase
10 (EC:2.7.11.24); K04440 c-Jun N-terminal kinase [EC:2.7.11.24]
Length=464
Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats.
Identities = 14/42 (33%), Positives = 25/42 (59%), Gaps = 0/42 (0%)
Query 108 QELDKLQPTLAKFKEEVERERMKKEAKTKTKKAKTEPQAAAA 149
++LD+ + T+ ++KE + +E M E KTK K +P + A
Sbjct 378 KQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGA 419
> mmu:434903 Mageb4, CN716893, Mage-b4, mMage-b4; melanoma antigen,
family B, 4
Length=556
Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust.
Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 0/37 (0%)
Query 23 HIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNL 59
HI FGE +K IT D + + + Y DP +F+ L
Sbjct 238 HIIFGEPRKLITRDLVKEKYLVYQKEANSDPPSFEFL 274
> mmu:110082 Dnahc5, AU022615, Dnah5, KIAA1603, Mdnah5, mKIAA1603;
dynein, axonemal, heavy chain 5
Length=4621
Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust.
Identities = 23/100 (23%), Positives = 47/100 (47%), Gaps = 9/100 (9%)
Query 32 EITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKADDD------VFESINSTSLNNHL 85
++ ++ + + + + N + P+A K+ QAF KK DD + E + S ++
Sbjct 1433 DVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKTIDDFSECCPLLEYMASNAMVERH 1492
Query 86 KQLMPGLSAKMFRTYNASITLQQELDKLQPTLAKFKEEVE 125
Q + L+ N + L+ + ++ L K+KEE+E
Sbjct 1493 WQRITALTGHSLDVGNETFKLR---NIMEAPLLKYKEEIE 1529
> hsa:1767 DNAH5, CILD3, DNAHC5, FLJ46759, HL1, KIAA1603, KTGNR,
PCD; dynein, axonemal, heavy chain 5
Length=4624
Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust.
Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 9/100 (9%)
Query 32 EITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKADDD------VFESINSTSLNNHL 85
E+ ++ + + + + N + P+A K+ QAF KK DD + E + S ++
Sbjct 1436 EVNIEKINNELLEFQNRCRKLPRALKDWQAFLDLKKIIDDFSECCPLLEYMASKAMMERH 1495
Query 86 KQLMPGLSAKMFRTYNASITLQQELDKLQPTLAKFKEEVE 125
+ + L+ N S L+ + ++ L K+KEE+E
Sbjct 1496 WERITTLTGHSLDVGNESFKLR---NIMEAPLLKYKEEIE 1532
> dre:557486 histone deacetylase 5-like; K11406 histone deacetylase
4/5 [EC:3.5.1.98]
Length=1115
Score = 30.0 bits (66), Expect = 3.0, Method: Composition-based stats.
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 10/80 (12%)
Query 71 DVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKLQPTLAKFKEEVERERMK 130
+V + L HLKQ L+AK QQEL++ + + EE+E++R++
Sbjct 117 EVLTRQHEVQLQEHLKQQQEILAAKR----------QQELEQKRKLEQQRHEEMEKQRLE 166
Query 131 KEAKTKTKKAKTEPQAAAAT 150
++ K K + A A+T
Sbjct 167 QQLIMLRNKEKGKESAIAST 186
> hsa:139422 MAGEB10, FLJ32965, MGC120394; melanoma antigen family
B, 10
Length=347
Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust.
Identities = 14/48 (29%), Positives = 24/48 (50%), Gaps = 4/48 (8%)
Query 21 VEHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKA 68
+EH FGE +K +T D + ++ + Y DP ++ F G +A
Sbjct 236 IEHFMFGEPRKLLTKDLVKENYLEYQQVPNSDPPRYQ----FLWGPRA 279
> cel:ZC239.7 gcy-15; Guanylyl CYclase family member (gcy-15);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1115
Score = 29.6 bits (65), Expect = 3.4, Method: Composition-based stats.
Identities = 21/65 (32%), Positives = 36/65 (55%), Gaps = 3/65 (4%)
Query 74 ESINSTSLNNHLKQLMPGLSAKMFRTY--NASITLQQELDKLQPTLAKFKEEVERERMKK 131
+ +N SL+ ++L P L+ + RT N +++ DKL+ +A+ EE+E E+ K
Sbjct 805 DPLNRPSLHQIKRKLKP-LTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEAEKAKS 863
Query 132 EAKTK 136
EA K
Sbjct 864 EALLK 868
> dre:100332402 cytoplasmic dynein 2 heavy chain 1-like; K10414
dynein heavy chain 2, cytosolic
Length=3301
Score = 29.6 bits (65), Expect = 3.7, Method: Composition-based stats.
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 4/48 (8%)
Query 68 ADDDVFE----SINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELD 111
DDD+ E + N T ++ HLK+L G+S+ F SIT + L+
Sbjct 1432 GDDDLLEILGQATNPTVIHTHLKKLFAGISSVEFDQSFQSITAMKSLE 1479
> dre:767722 foxred2, MGC153216, zgc:153216; FAD-dependent oxidoreductase
domain containing 2
Length=687
Score = 29.6 bits (65), Expect = 3.9, Method: Composition-based stats.
Identities = 14/44 (31%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query 35 LDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKADDDVFESINS 78
+DF G D + Y ++ DP+ FK+ GK + FE+ S
Sbjct 190 VDFRGSDLVEGYESIPTDPEEFKDQAVLILGK--GNSAFETAQS 231
> cel:F22E5.3 gcy-21; Guanylyl CYclase family member (gcy-21);
K01769 guanylate cyclase, other [EC:4.6.1.2]
Length=1119
Score = 29.6 bits (65), Expect = 3.9, Method: Composition-based stats.
Identities = 21/65 (32%), Positives = 36/65 (55%), Gaps = 3/65 (4%)
Query 74 ESINSTSLNNHLKQLMPGLSAKMFRTY--NASITLQQELDKLQPTLAKFKEEVERERMKK 131
+ +N SL+ ++L P L+ + RT N +++ DKL+ +A+ EE+E E+ K
Sbjct 751 DPLNRPSLHQIKRKLKP-LTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKS 809
Query 132 EAKTK 136
EA K
Sbjct 810 EALLK 814
> cel:M142.5 hypothetical protein
Length=209
Score = 29.6 bits (65), Expect = 3.9, Method: Compositional matrix adjust.
Identities = 28/117 (23%), Positives = 50/117 (42%), Gaps = 9/117 (7%)
Query 10 EADTVGCCSLRVEHIAFGEDKKEITLDF----LGKDSIRYYNT-----VKIDPQAFKNLQ 60
E +T S R I+F +K + LD + K IR +N+ +K+ +A + +
Sbjct 18 EIETTNGLSARGVVISFDTTRKVLVLDTKEMAINKPMIRIFNSEHLKNIKVLSEALEESE 77
Query 61 AFCRGKKADDDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKLQPTL 117
F R K +N T L + + L+ + ++ SI QQ +L+ T+
Sbjct 78 KFARAKTEQFAQNNPVNGTRTTERLDKTLGELTPNLMKSPAISIRGQQAYLQLKRTI 134
> hsa:5602 MAPK10, FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974,
PRKM10, p493F12, p54bSAPK; mitogen-activated protein kinase
10 (EC:2.7.11.24); K04440 c-Jun N-terminal kinase [EC:2.7.11.24]
Length=422
Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust.
Identities = 14/41 (34%), Positives = 25/41 (60%), Gaps = 0/41 (0%)
Query 108 QELDKLQPTLAKFKEEVERERMKKEAKTKTKKAKTEPQAAA 148
++LD+ + T+ ++KE + +E M E KTK K +P +A
Sbjct 378 KQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSA 418
> hsa:4112 MAGEB1, CT3.1, DAM10, MAGE-Xp, MAGEL1, MGC9322; melanoma
antigen family B, 1
Length=347
Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust.
Identities = 14/47 (29%), Positives = 24/47 (51%), Gaps = 4/47 (8%)
Query 22 EHIAFGEDKKEITLDFLGKDSIRYYNTVKIDPQAFKNLQAFCRGKKA 68
EH+ +GE +K IT D + + ++Y DP ++ F G +A
Sbjct 234 EHLIYGEPRKFITQDLVQEKYLKYEQVPNSDPPRYQ----FLWGPRA 276
> cel:W02F12.5 hypothetical protein; K00658 2-oxoglutarate dehydrogenase
E2 component (dihydrolipoamide succinyltransferase)
[EC:2.3.1.61]
Length=463
Score = 29.3 bits (64), Expect = 5.2, Method: Composition-based stats.
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 6/54 (11%)
Query 102 ASITLQQELDKLQP------TLAKFKEEVERERMKKEAKTKTKKAKTEPQAAAA 149
A +T +Q+L KLQP + A KEE + K+E+K K ++P AA
Sbjct 125 AKVTAKQKLYKLQPGAGGGSSSAPAKEEPKSAPAKEESKPAPAKEDSKPAVTAA 178
> ath:AT1G11720 ATSS3; ATSS3 (starch synthase 3); starch synthase/
transferase, transferring glycosyl groups (EC:2.4.1.21)
Length=1025
Score = 28.5 bits (62), Expect = 7.8, Method: Composition-based stats.
Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query 70 DDVFESINSTSLNNHLKQLMPGLSAKMFRTYNASITLQQELDKLQPTLAKFKEEVERERM 129
D VF + S NN K + M + + L+++L + Q LAK EE ERER
Sbjct 198 DFVFFNGQSVYDNNDSKDFCVEIKGGMDKVDFENFLLEEKL-REQEKLAK--EEAERERQ 254
Query 130 KKEA-KTKTKKAKTEPQAAAA 149
K+E + + +KA E A A
Sbjct 255 KEEKRRIEAQKAAIEADRAQA 275
Lambda K H
0.314 0.129 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 3134054208
Database: egene_temp_file_orthology_annotation_similarity_blast_database_966
Posted date: Sep 16, 2011 8:45 PM
Number of letters in database: 82,071,388
Number of sequences in database: 164,496
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40